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UM15 reinforces a lymphocyte-mimicking nanotrap for precise HIV-1 inhibition

Nano Research 2023年第7期16卷 9906-9920页

作者： Jinbang Zhang Zhengyang li Jiaxin li Hui li Junwei Che Te Zhao Pengfei Zou Jingwan Han Yang Yang Meiyan Yang Yuli Wang Wei Gong Haihua Xiao Zhiping li lin li Chunsheng Gao State key Laboratory of Toxicology and Medical Countermeasure Beijing Institute of Pharmacology and ToxicologyBeijing 100039China Pharmaceutical College Henan UniversityKaifeng 475001China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China School of Public Health and Health Management Gannan Medical UniversityGanzhou 341000China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China

Even the potential of T cell-mimicking nanotrap for long term viral control due to its overcoming of human immunodeficiency virus(HIV)genetic diversity and viral resistance,the robust HIV inhibition was not expected because these nanotraps displayed no obvious advantages compared with the infinite host ***,a glycoprotein 120(gp120)-targeting polypeptide UM15 reinforced lymphocyte-mimicking nanotrap was constructed,and its improved HIV-1 inhibiting efficacy was *** to the results,the constructed nanotraps exhibited evident escaping ability from uptake of the mononuclear phagocyte system and highly improved binding ability with gp120 *** constructed nanotraps neutralized all tested HIV-1 pseudo typed viruses with IC80 of 21.0μg/mL,and inhibited both X4-tropic and R5-tropic HIV-1 with IC80 of 34.4 and 20.6μg/mL,*** 40%of gp120 was observed to be shed from pseudo virus,and above 40%bystander T cells were prevented from gp120-induced death by the constructed *** safety of the constructed nanotraps was confirmed both in vitro and in ***,the constructed nanotraps could specifically neutralize free HIV-1,selectively bind with gp120 expressing HIV-1 infected cells,cause gp120 shedding,inhibit gp120-induced bystander T cell killing on the premise of safety,and were considered as promising therapeutic agents for precise inhibition of HIV.

关键词： nanotrap lymphocyte membrane UM15 human immunodeficiency virus-1(HIV-1) glycoprotein 120(gp120)

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Research on the Glass Transition Temperature and Mechanical Properties of Poly(vinyl chloride)/Dioctyl Phthalate (PVC/DOP) Blends by Molecular Dynamics Simulations

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Chinese Journal of Polymer Science 2019年第8期37卷 834-840页

作者： Jing li Shao-Hua Jin Guan-Chao Lan Zi-Shuai Xu Lu-Ting Wang Na Wang li-Jie li School of Materials Science and Engineering Beijing Institute of Technology Beijing 100081 China Research Institute of Gansu Yin Guang Chemical Industry Group Co.Ltd Baiyin 730900 China

To effectively improve the performance and expand the applications of polymers, molecular dynamics(MD) simulations with the COMPASS force field have been applied to predict the miscibility, glass transition temperature(Tg), and mechanical properties of poly(vinyl chloride)/dioctyl phthalate(PVC/DOP) blends. The solubility parameter values obtained are in good agreement with the reference data and the little difference(|Δδ|lity is improved. The mechanical properties can also be effectively improved by increasing the temperature, which may provide a more flexible mixture, with lower E, K, G but an increased ductility.

关键词： Poly(vinyl chloride)(PVC) Dioctyl phthalate (DOP) MD simulations Glass transition temperature Mechanical properties

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Research of li4SiO4 irradiation tritium production device

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Nuclear Science and Techniques 2013年第B12期24卷 83-87页

作者： ZHANG Zhihua MI Xiangmiao YE Mao QIAN Dazhi li Rundong FENG Qijie Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics Mianyang 621900 China

Tritium self-sustain and circulation is the core problem to use fusion energy peacefully. As the core component of the breeder in-pile irradiation test, the irradiation tritium production device provides irradiation space for breeders' tritium production and release. We take the li4SiO4 as the research object and design the structure of the irradiation device. We complete the physical parameters computation, the irradiation device safety analysis and the flow field analysis of the breeder refueling, realizing the adjusting of the breeder irradiation temperature and the tritium release temperature window and making the control of gas operational parameters come true. The data could provide reference for breeders' in-pile irradiation research.

关键词：照射生产设备硅酸锂氚生产装置温度调节科研育种饲养员

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Enhanced photocatalytic performance by regulating the Ce^(3+)/Ce^(4+)ratio in cerium dioxide

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 75-87页

作者： Zhi li Dongsheng Jia Wei Zhang Ying li Mitang Wang Dongliang Zhang School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai200093China

Cerium dioxide(CeO_(2))photocatalysts are used in treating environmental pollution and addressing the energy crisis due to their excellent oxygen storage capacities and abundant oxygen *** this paper,CeO_(2)precursors were synthesized with different water-alcohol ratios via a solvothermal method,and CeO_(2)photocatalysts with different Ce^(3+)/Ce^(4+)ratios were obtained by changing the precursor calcination atmospheres(air,Ar)as well as the calcination *** effects of CeO_(2)with different Ce^(3+)/Ce^(4+)ratios in photocatalytic degradations of methylene blue under visible light were investigated.X-ray photoelectron spectroscopy results showed that the surfaces of the samples calcined under Ar had higher Ce^(3+)/Ce^(4+)ratios and oxygen vacancy concentrations,which reduced the band gaps of the catalysts and improved their utilization of visible *** addition,the many Ce^(3+)/Ce^(4+)redox centers and oxygen vacancies on the sample surfaces improved the separation and transfer efficiencies of the photogenerated *** sample C2-Ar calcined under Ar showed a high adsorption capacity and excellent photocatalytic activity by removing 96%of the methylene blue within 120 min,which was more than twice the degradation rate of the sample(C2-air)prepared via calcination under *** experiments showed that photogenerated holes played a key role in the photocatalytic *** addition,a synergistic photocatalytic mechanism for the Ce^(3+)/Ce^(4+)redox centers and oxygen vacancies was elucidated in detail,and the sensitization of cerium dioxide by dyes aided the degradation of methylene blue.

关键词： CeO_(2) oxygen vacancies Ce^(3+)/Ce^(4+)ratios photocatalytic dye-sensitization

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A method for predicting the water-flowing fractured zone height based on an improved key stratum theory

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International Journal of Mining Science and Technology 2023年第1期33卷 61-71页

作者： Jianghui He Wenping li Kaifang Fan Wei Qiao Qiqing Wang liangning li State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China School of Earth and Environment Anhui University of Science and TechnologyHuainan 232001China Institute of Mine Water Hazards Prevention and Controlling Technology School of Resources and GeosciencesChina University of Mining and TechnologyXuzhou 221116China Department of Geotechnical Engineering Nanjing Hydraulic Research InstituteNanjing 210024China

In the process of using the original key stratum theory to predict the height of a water-flowing fractured zone(WFZ),the influence of rock strata outside the calculation range on the rock strata within the calculation range as well as the fact that the shape of the overburden deformation area will change with the excavation length are *** this paper,an improved key stratum theory(IKS theory)was proposed by fixing these two ***,a WFZ height prediction method based on IKS theory was established and ***,the range of overburden involved in the analysis was determined according to the tensile stress distribution range above the ***,the key stratum in the overburden involved in the analysis was identified through IKS ***,the tendency of the WFZ to develop upward was determined by judging whether or not the identified key stratum will *** proposed method was applied and verified in a mining case study,and the reasons for the differences in the development patterns between the WFZs in coalfields in Northwest and East China were also fully explained by this method.

关键词： Coal mining Water-flowing fractured zone height Prediction method Improved key stratum theory

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Electrochemical Formation of AI-li Alloys by Codeposition of AI and li from liCI-KCI-AIF3 Melts at 853 K

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Chemical Research in Chinese Universities 2013年第2期29卷 324-328页

作者： SUN Yi ZHANG Mi-lin HAN Wei li Mei YANG Yu-sheng Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University Harbin 150001 P. R. China

The electrochemical behavior of AI（III） ions was studied in molten liC1-KC1 melts on a molybdenum electrode. Cyclic voltammetry, chronopotentiometry and chronoamperometry were used to explore the deposition mechanism of A1 and li. Cyclic voltammetry expriment indicates that under potential deposition（UPD） of lithium on pre-deposited aluminium led to the formation of liquid A1-li alloys at 853 K. The diffusion coefficient of AI（III） ions at 853 K in liC1-KC1-AIF3（I%, mass fraction） melts was determined to be （2.79~0.05）x 10_5 cm2/s. Chronopotentio- grams and chronoamperograms demonstrate that the codeposition of AI（III） and li（I） ions formed A1-li alloys at ca- thodic current densities higher than -0.28 A/cm2 or cathodic potentials more negative than -2.20 V. X-Ray diffrac- tion（XRD） pattern indicates that A1-li alloys with different phases formed via galvanostatic electrolysis. Inductively coupled plasma（ICP） analyses of the samples obtained by electrolysis show that lithium and aluminium contents of A1-li alloys could be controlled by A1F3 concentration and current intensity.

关键词： Electrochemistry A1-li alloy Codeposition Cyclic voltammetry

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Interactive method research of dual mode information coordination integration for astronaut gesture and eye movement signals based on hybrid model

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Science China(Technological Sciences) 2023年第6期66卷 1717-1733页

作者： ZHUANG HongChao XIA YiLu WANG Ning li WeiHua DONG Lei li Bo School of Mechanical Engineering Tianjin University of Technology and EducationTianjin 300222China School of Information Technology Engineering Tianjin University of Technology and EducationTianjin 300222China School of Automotive Engineering Harbin Institute of Technology(Weihai)Weihai 264209China Tianjin Institute of Aerospace Mechanical and Electrical Equipment Tianjin 300458China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150000China

The lightweight human-robot interaction model with high real-time,high accuracy,and strong anti-interference capability can be better applied to future lunar surface exploration and construction *** on the feature information inputted from the monocular camera,the signal acquisition and processing fusion of the astronaut gesture and eye-movement modal interaction can be *** with the single mode,the human-robot interaction model of bimodal collaboration can achieve the issuance of complex interactive commands more *** optimization of the target detection model is executed by inserting attention into YOLOv4 and filtering image motion *** central coordinates of pupils are identified by the neural network to realize the human-robot interaction in the eye movement *** fusion between the astronaut gesture signal and eye movement signal is performed at the end of the collaborative model to achieve complex command interactions based on a lightweight *** dataset used in the network training is enhanced and extended to simulate the realistic lunar space interaction *** human-robot interaction effects of complex commands in the single mode are compared with those of complex commands in the bimodal *** experimental results show that the concatenated interaction model of the astronaut gesture and eye movement signals can excavate the bimodal interaction signal better,discriminate the complex interaction commands more quickly,and has stronger signal anti-interference capability based on its stronger feature information mining *** with the command interaction realized by using the single gesture modal signal and the single eye movement modal signal,the interaction model of bimodal collaboration is shorter about 79%to 91%of the time under the single mode *** of the influence of any image interference item,the overall judgment accuracy of the proposed model can be maintained a

关键词： human-robot interaction gesture and eye movement hybrid model YOLOv4 CBAM

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Recent Research Progress of n-Type Conjugated Polymer Acceptors and All-Polymer Solar Cells

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Chinese Journal of Polymer Science 2023年第5期41卷 640-651,I0006页

作者： Xiao-Jun li Guang-Pei Sun Yu-Fei Gong Yong-Fang li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Science University of Chinese Academy of SciencesBeijing 100049China Laboratory of Advanced Optoelectronic Materials Suzhou Key Laboratory of Novel Semiconductor Materials and DevicesCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

The active layer of all polymer solar cells(all-PSCs)is composed of a blend of a p-type conjugated polymer(p-CP)as donor and an n-type conjugated polymer(n-CP)as ***-PSCs possess the advantages of light weight,thin active layer,mechanical flexibility,low cost solution processing and high stability,but the power conversion efficiency(PCE)of the all-PSCs was limited by the poor photovoltaic performance of the n-CP acceptors before *** the report of the strategy of polymerized small molecule acceptors(PSMAs)in 2017,the photovoltaic performance of the PSMA-based n-CPs improved rapidly,benefitted from the development of the A-DA’D-A type small molecule acceptors(SMAs).PCE of the all-PSCs based on the PSMA acceptors reached 17%-18%*** this review article,we will introduce the development history of the n-CPs,especially the recent research progress of the ***,the structure-property relationship of the PSMAs is introduced and ***,current challenges and prospects of the n-CP acceptors are analyzed and discussed.

关键词： n-Type conjugated polymers All-polymer solar cells Polymer acceptors Polymerized small molecule acceptors

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Decarbonization options of the iron and steelmaking industry based on a three-dimensional analysis

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International Journal of Minerals,Metallurgy and Materials 2023年第2期30卷 388-400页

作者： Xin Lu Weijian Tian Hui li Xinjian li Kui Quan Hao Bai Department of Metallurgy Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China China Metallurgical Industry Planning and Research Institute(MPI) Beijing 100711China Carbon Dioxide Research Division CISDI Research&Development Co.Ltd.Chongqing 401122China

Decarbonization is a critical issue for peaking CO_(2) emissions of energy-intensive industries,such as the iron and steel *** decarbonization options of China’s ironmaking and steelmaking sector were discussed based on a systematic three-dimensional low-carbon analysis from the aspects of resource utilization(Y),energy utilization(Q),and energy cleanliness which is evaluated by a process general emission factor(PGEF)on all the related processes,including the current blast furnace(BF)-basic oxygen furnace(BOF)integrated process and the specific sub-processes,as well as the electric arc furnace(EAF)process,typical direct reduction(DR)process,and smelting reduction(SR)*** study indicates that the three-dimensional aspects,particularly the energy structure,should be comprehensively considered to quantitatively evaluate the decarbonization road map based on novel technologies or *** scrap utilization(improvement of Y)and the substitution of carbon-based energy(improvement of PGEF)in particular is *** terms of process scale,promoting the development of the scrap-based EAF or DR-EAF process is highly encouraged because of their lower *** three-dimensional method is expected to extend to other processes or industries,such as the cement production and thermal electricity generation industries.

关键词： peak CO_(2)emission low carbon management decarbonization option energy-intensity industry ironmaking and steelmaking

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Tailoring two-dimensional surfaces with pillararenes based host-guest chemistry

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Chinese Chemical Letters 2020年第12期31卷 3095-3101页

作者： Run-Hao li Junkai Ma Yue Sun Haibing li Hubei Key Laboratory of Catalysis and Materials Science College of Chemistry and Material SciencesSouth-Central University for NationalitiesWuhan 430074China Hubei Key Laboratory of Wudang Local Chinese Medicine Research Department of ChemistrySchool ofPhannacyHubei University of MedicineShiyan 442000China Key Laboratory of Pesticide and Chemical Biology(CCNU) Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China

The two-dimensional surfaces have been fueled by the infinite possibility they offe red fo r basic re search,and for novel technologies in *** realize many of these promises,the effective strategies were to design and control their surface chemistry,which plays a vital role in determining the chemical and physical *** host-guest chemistry with the reversible noncovalent interactions between macrocyclic hosts and suitable guests can be readily used for constructing multifunctional *** pillararenes,possessed the unique structure,have attracted the attentions of researchers in recent *** feature article covers the recent development of pillararene-based twodimensional inte rfaces,including the fabrication and function of the hybrid *** combination of pillararenes and materials platform exhibited the novel property because of the characte ristic of cavity of macrocyclic host and confined spaces of *** anticipate that this review will be helpful to the researchers working in the fields of supramolecular chemistry and materials science.

关键词： Pillararenes Host-guest chemistry Two-dimensional surfaces

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