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Study on TCM intervention of NF-κB signal pathway in the treatment of bronchial asthma

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Journal of Hainan Medical University 2022年第21期28卷 68-72页

作者： LAI Hai-yan YI Wei DENG Kun LONG Juan REN Meng-yao QIAO Yun ZHOU Bei li Wei-wei The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning 530299China Graduate School of Guangxi University of Chinese Medicine Nanning 530000China College of Acupuncture-Moxibustion and Tuina Guangxi University of Chinese MedicineNanning 530299China College of Pharmacy Guangxi University of Chinese MedicineNanning 530299China

Bronchial asthma(asthma for short)is a common chronic respiratory disease inchildren,which has adverse effects on children's physical and mental *** factorκB(NF-κB)signaling pathway is an important transcription factor in airway inflammation,and plays an important role in airway inflammation and airway remodeling in *** studies have found that traditional Chinese medicine has positive effects in the treatment of ***,this paper aims to review the literatures on the treatment of asthma through traditional Chinese medicine compound and single herbs and extracts by regulating the NF-κB signaling pathway for nearly a *** is found that traditional Chinese medicine can inhibit airway inflammation,relieve airway smooth muscle spasm and reduce airway resistance through the regulation of NF-κB signaling pathway,so as to play a key role in the treatment of asthma,and provide a scientific basis for the treatment of asthma with traditional Chinese medicine.

关键词： Bronchial asthma NF-κB Traditional Chinese medicine Research overview

Systematic analysis of strange single heavy baryons Ξ_(c) and Ξ_(b)

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Chinese Physics C 2023年第7期47卷 41-59页

作者：李振宇于国梁王志刚顾建中卢杰沈洪涛 School of Physics and Electronic Science Guizhou Education UniversityGuiyang 550018China Department of Mathematics and Physics North China Electric Power UniversityBaoding 071003China China Institute of Atomic Energy Beijing 102413China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541006China

Motivated by the experimental progress in the study of heavy baryons,we investigate the mass spectra of strange single heavy baryons in theλ-mode,using the relativistic quark model and the infinitesimally shifted Gaussian basis function *** show that experimental results are well captured using the predicted *** root mean square radii and radial probability density distributions of the wave functions are analyzed in ***,the mass spectra allow us to successfully construct the Regge trajectories in the(J,M^(2))*** also preliminarily assign quantum numbers to the recently observed baryons,includingΞ_(c)(3055),Ξ_(c)(3080),Ξ_(c)(2930),Ξ_(c)(2923),Ξ_(c)(2939),Ξ_(c)(2965),Ξ_(c)(2970),Ξ_(c)(3123),Ξ_(b)(6100),Ξ_(b)(6227),Ξ_(b)(6327),andΞ_(b)(6333).Finally,the spectral structure of strange single heavy baryons is ***,we predict several new baryons that may be observed in forthcoming experiments.

关键词： single heavy baryons mass spectra relativistic quark model

Experimental study of qishen yiqi drop pill combined with bone marrow mesenchymal stem cell transplantation on angiogenesis and cardiac function in mice with myocardial infarction

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Journal of Hainan Medical University 2021年第5期27卷 1-6页

作者： Gui-Xin He Ting Xiao Wei-Bin Qin lin lin Xiao-Yun Mo Qing-Wei Zhang Cheng-Qiang Wu Yong-Yan Shen li-YanYu Yu-Fei Feng Guangxi Medical University First Affiliated Hospital the second area of Cardiovascular Medicine Nanning 530022China Guangxi University of Chinese Medicine Nanning 530299China

Objective:To investigate the effects ofQishengyiqi drop pill combined with bone marrow mesenchymal stem cell transplantation on angiogenesis and cardiac function in mice after myocardial infarction through in vitro cell molecular biology ***:The animals used in this experiment were male mice with eGFP+/-.Sixty mice were randomly divided into three groups(n=20):myocardial infarction group(MI+PBS),myocardial infarction+mesenchyme plasma stem cell transplantation group(MI+MSCs)and myocardial infarction+Qishenyiqi drip pill combined with mesenchymal stem cell transplantation group(MI+MSCs+QSYQ).Qishenyiqi dripping pills were prepared into a medicinal solution with a concentration of 3.9 mg/mL with distilled *** MI+MSCs+QSYQ group was orally administered with 0.1 mL/kg/day,and the other two groups were orally administered with an equal amount of normal *** in each group were adaptively fed continuously for 2 weeks,and the myocardial infarction model was established by ligation of the anterior descending coronary artery by thoracic ***-four hours after the model was established,bone marrow mesenchymal stem cells were isolated from the tibia of the mice and injected intracardiacly Bone marrow-derived mesenchymal stem cells were transplanted,and multiple injections were made around the myocardial infarction area of *** control group was injected with the same amount of PBS.0h,3 days,7 days,and 14 days after cell transplantation,observe the stem cell morphology under a microscope;on day 7 of cell transplantation,track the expression of eGFP-positive cells with a fluorescence microscope;before modeling,14 and 21 days after cell transplantation,use Cardiac function was measured by *** 21 days of modeling,the mice were sacrificed,and heart samples were *** angiogenesis of the mice was observed by immunohistochemical staining and microvascular density ***:The morphological growth of transpl

关键词： Stem cells Transplantation Bone marrow mesenchymal stem cells Qishenyiqi drop pills Myocardial infarction Angiogenesis Cardiac function

Detection and Analysis of Routine Blood Indexes in guike Pig

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Agricultural Biotechnology 2018年第3期7卷 95-98,103页

作者： Qianlian SU Bin li Jiaxing liANG Yingning ZHOU Zhongwei CHEN Yibin QIN Bingxia LU Ying HE Qunpeng DUAN Dongfu JIANG Jingzhuan LU Wu ZHAO Guangxi Veterinary Research Institute/Guangxi Key kahoratory of Veterinary Biotechnology Nanning 530001 China

[Objectives] In this study,routine blood indexes of guike pig were detected to clarify quantity variation and morphology distribution of different functional cells（ red blood cells,white blood cells and platelets）,thus providing reference data for immunological evaluation and disease resistance research of guike pig. [Methods] Blood samples were collected from forty-four 49-day-old healthy guike pigs（ 22 males and 22 females） once a week for seven consecutive weeks to detect routine blood indexes,and the results were compared with routine blood indexes of Landrace pig and Enshi black pig. [Results]Among red blood cell indexes of guike pig at different day ages,red blood cell count（ RBC） and hemoglobin count（ HGB） both reached the lowest levels（ 6. 85 × 10^12/L and 97. 1 g/L）at 70 days of age,which were significantly lower than the corresponding indexes at 49,56,63,84 and 91 days of age（ P 〈 0. 05,similarly hereinafter）; mean corpuscular hemoglobin（ MCH） and mean corpuscular hemoglobin concentration（ MCHC） demonstrated basically the same variation pattern,which both reached the lowest levels（ 15. 11 pg and 275. 70 g/L） at 70 days of age and reached the highest levels（ 16. 40 pg and 314. 30 g/L） at 91 days of age; hematocrit（ HCT）,mean corpuscular volume（ MCV） and red blood cell distribution width（ RDW） exhibited relatively stable changes with no significant differences among different day ages（ P 〉 0. 05,similarly hereinafter）. Among white blood cell indexes of guike pig at different day ages,white blood cell count（ WBC） reached the lowest level（ 13. 71 × 10^9/L） at 63 days of age and reached the highest level（ 17. 52 × 10^9/L） at 84 days of age,with significant differences; neutrophil count（ NEUT）reached the lowest level（ 3. 61 × 10^9/L） at 70 days of age,which was significantly lower than that at 49,56 and 77 days of age; lymphocyte count（ LYMPH） exhibited relatively stable changes and was not significantly affected by the increase in day age. Among platelet indexe

关键词： guike pig Landrace pig Enshi black pig Routine blood indexes Detection and analysis

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环磷酰胺有关物质的合成

中国医药工业杂志 2022年第5期53卷 665-668,671页

作者：陈成仲金璐程天星李响程青芳江苏海洋大学药学院江苏连云港222005 连云港贵科药业有限公司江苏连云港222000

为了控制环磷酰胺的质量,制备了5种有关物质:N,N-双(2-氯乙基)-N′-(3-羟丙基)磷酸二酰胺酰氯(有关物质A)、N,N-双(2-氯乙基)-N′,N″-双(3-羟丙基)磷酸三酰胺(有关物质B)、N,N-双(2-氯乙基)氨基氯磷酸(3-氨基丙基)酯(有关物质C)、N,N-... 详细信息

为了控制环磷酰胺的质量,制备了5种有关物质:N,N-双(2-氯乙基)-N′-(3-羟丙基)磷酸二酰胺酰氯(有关物质A)、N,N-双(2-氯乙基)-N′,N″-双(3-羟丙基)磷酸三酰胺(有关物质B)、N,N-双(2-氯乙基)氨基氯磷酸(3-氨基丙基)酯(有关物质C)、N,N-双(2-氯乙基)氨基磷酸二(3-氨基丙基)酯(有关物质D)、双(2-氯乙基)氨基磷酸(3-氨基丙基)酯(有关物质E),并通过MS和NMR对结构进行了确证。

关键词：环磷酰胺抗肿瘤药有关物质合成

Determination of the Content of Five Active Components in Toad Skin

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Medicinal Plant 2023年第4期14卷 38-40页

作者： Xue JIANG Wenli li Yong CHEN Jiabao MA The First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning 530023China Guangxi University of Chinese Medicine Nanning 530200China The Second People's Hospital of Qinzhou Qinzhou 535009China

[Objectives] To establish a method for the determination of active components in toad skin. [Methods] HPLC method was used to determine the content of five active components (bufotalin, cinobufotalin, bufalin, cinobufagin and resibufogenin) in toad skin. [Results] Chromatographic conditions are as follows: Agilent ZORBAX SB-C 18 chromatographic column was used;acetonitrile (A)-0.3% glacial acetic acid (B) gradient elution (0-15 min, 28%A-54%A;15-35 min, 54%A-54%A) was conducted;the flow rate was 0.6 mL/min;the detection wavelength was 296 nm;the column temperature was 30 ℃;the sample size was 10 μL. Under the above conditions, the determination method of the five components can be established at one time. [Conclusions] The method was stable and reliable, and can provide experimental basis for the development and utilization of active ingredients in toad skin.

关键词： Toad skin High performance liquid chromatography Determination of content

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基于核函数的稀疏属性选择算法

计算机科学 2019年第2期46卷 62-67页

作者：张善文文国秋张乐园李佳烨广西师范大学计算机科学与信息工程学院广西多源信息挖掘与安全重点实验室广西桂林541004

鉴于传统属性选择算法无法捕捉属性之间的关系的问题,文中提出了一种非线性属性选择方法。该方法通过引入核函数,将原始数据集投影到高维的核空间,因在核空间内进行运算,进而可以考虑到数据属性之间的关系。由于核函数自身的优越性,即... 详细信息

鉴于传统属性选择算法无法捕捉属性之间的关系的问题,文中提出了一种非线性属性选择方法。该方法通过引入核函数,将原始数据集投影到高维的核空间,因在核空间内进行运算,进而可以考虑到数据属性之间的关系。由于核函数自身的优越性,即使数据通过高斯核投影到无穷维的空间中,计算复杂度亦可以控制得较小。在正则化因子的限制上,使用两种范数进行双重约束,不仅提高了算法的准确率,而且使得算法实验结果的方差仅为0.74,远小于其他同类对比算法,且算法更加稳定。在8个常用的数据集上将所提算法与6个同类算法进行比较,并用SVM分类器来测试分类准确率,最终该算法得到最少1.84%,最高3.27%,平均2.75%的提升。

关键词：核函数属性选择稀疏 L1范数 L 2 1范数

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2个发育阶段的克氏原螯虾卵巢转录组学分析

南方农业学报 2023年第3期54卷 784-796页

作者：黄瑾陈晓汉闭显达吴铁军梁正高雪梅陈田聪王卉李旻陈秀荔广西大学动物科学技术学院广西南宁530004 广西水产科学研究院/广西水产遗传育种与健康养殖重点实验室广西南宁530021

【目的】通过转录组测序分析筛选出与克氏原螯虾(Procambarus clarkii)卵巢发育相关的主要代谢通路及特异表达基因,为揭示克氏原螯虾卵巢发育分子机制提供理论依据。【方法】采集发育至Ⅲ期或Ⅳ期的克氏原螯虾卵巢组织样品,用石蜡包埋... 详细信息

【目的】通过转录组测序分析筛选出与克氏原螯虾(Procambarus clarkii)卵巢发育相关的主要代谢通路及特异表达基因,为揭示克氏原螯虾卵巢发育分子机制提供理论依据。【方法】采集发育至Ⅲ期或Ⅳ期的克氏原螯虾卵巢组织样品,用石蜡包埋法进行组织学观察;同时提取RNA构建cDNA文库,通过Illumina NovaSeq 6000完成转录组测序,筛选出差异表达基因(DEGs),然后进行GO功能注释分析和KEGG代谢通路富集分析,并通过实时荧光定量PCR验证转录组数据的准确性。【结果】克氏原螯虾Ⅲ期和Ⅳ期卵巢的卵巢指数分别为0.22%和2.70%,对应的卵母细胞分别以生长期卵母细胞和成熟期卵母细胞为主要时相;转录组测序分别获得49716560和44573146条有效序列(Clean reads),各样本Clean reads与克氏原螯虾参考基因组序列的匹配率均超过92.00%。从克氏原螯虾Ⅲ期和Ⅳ期卵巢组织中筛选出1508个DEGs(762个DEGs为上调表达,746个DEGs为下调表达),GO功能注释分析发现DEGs主要注释在薄膜部分、结合、催化活性和细胞部分等功能条目上;KEGG代谢通路富集分析显示,上调DEGs富集在247条代谢通路上,主要包括溶酶体、抗原处理和呈递、胰腺分泌、鞘磷脂代谢、PI3K-Akt信号通路等;下调DEGs富集在270条代谢通路上,主要有系统性红斑狼疮、溶酶体、TGF-β信号通路、GnRH信号通路等。筛选出10个与克氏原螯虾卵巢发育相关的保守基因,分别是H2A、S3a、IR93a、FOXL、nanos、RPB1、piwi、insulin、scylla和serine基因。【结论】在克氏原螯虾卵巢从Ⅲ期发育至Ⅳ期的过程中,抗原处理和呈递、PI3K-Akt信号通路、溶酶体、鞘磷脂代谢和TGF-β等通路协调合作促进卵巢发育;H2A、S3a、IR93a、FOXL、nanos、RPB1、piwi、insulin、scylla和serine等10个与克氏原螯虾卵巢发育相关的保守基因在克氏原螯虾Ⅲ期和Ⅳ期卵巢组织中高表达,推测其参与调控卵巢发育过程的卵黄物质积累及卵母细胞成熟。

关键词：克氏原螯虾卵巢发育阶段转录组差异表达基因(DEGs)

The Reaction ^(55)Mn+^(159)Tb:Preparation for the Synthesis of New Elements

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IMP & HIRFL Annual Report 2022年第1期 30-31页

作者： Sun Luchong Chen lixin Xu Suyang Zhang Zhiyuan Wang Jianguo Huang Minghui Zhang Mingming Ma Long Yang Huabin Yang Chunli Wu Xiaolei Zhou Houbing Zhao Zhen Huang Xinyuan Zhou Hao Zhang Xu li Zongchi and Gan Zaiguo Department of Physics Guangxi Normal UniversityGuilin 541004GuangdongChina CAS Key Laboratory of High Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory of Nuclear Physics and Technology Guangxi Normal UniversityGuilin 541004GuangxiChina

In recent decades,much experimental progress has been made in the synthesis of SHEs and several attempts have been ***,none of these experiments provide evidence for the successful synthesis of the new *** order to produce the new elements with proton number Z=119 or 120,IMP-CAS(Institute of Modern Physics,Chinese Academy of Sciences)constructed the China Accelerator Facility for superheavy Elements(CAFE2).The beams with medium mass,such as ^(50)Ti,^(51)V,^(54)Cr,^(55)Mn.

关键词： synthesis elements (1