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Focusing on the meso-scales of multi-scale phenomena-In search for a new paradigm in chemical engineering

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Particuology 2010年第6期8卷 634-639页

作者： Jinghai li Wei ge Wei wang Ning Yang The EMMS Group State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences Beijing 100190 China

To celebrate the 90th birthday of Professor Mooson Kwauk, who supervised the multi-scale research at this Institute in the last three decades, we dedicate this paper outlining our thoughts on this subject accumulated from our previous studies. In the process of developing, improving and extending the energy- minimization multi-scale （EMMS） method, we have gradually recognized that meso-scales are critical to the understanding of the different kinds of multi-scale structures and systems. It is a common challenge not only for chemical engineering but also for almost all disciplines of science and engineering, due to its importance in bridging micro- and macro-behaviors and in displaying complexity and diversity. It is believed that there may exist a common law behind meso-scales of different problems, possibly even in different fields. Therefore, a breakthrough in the understanding of meso-scales will help materialize a revolutionary progress, with respect to modeling, computation and application.

关键词： Meso-scale Multi-scale Complex system EMMS Multi-phase High performance computation

Validation of a particle impact breakage model incorporating impact number effect

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Particuology 2023年第4期75卷 96-108页

作者： lianzhen Zhang li ge wang Yin wang Yi He Xizhong Chen College of Pipeline and Civil Engineering China University of PetroleumQingdaoChina Process Systems Enterprise HammersmithLondonUK Department of Chemical and Biological Engineering University of SheffieldSheffieldUK State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalianChina TenFong Technology Ltd ShenzhenChina

This paper presents validation of a particle impact breakage model *** and Peukert model with a focus on the impact *** Vogel and Peukert model developed based on mechanical and sta-tistical foundation has been widely used in various fields such as mineral engineering and chemical engineering but is barely studied in the application of repeated *** selective breakage data in the literature is collected to provide the database for model *** has shown that the Vogel and Peukert model is generally applicable to all the breakage cases considering the impact *** effect of impact number is further elaborated in the population balance model(PBM)whereas the particle dynamics are provided from Discrete Element Method(DEM)simulation of an impact pin *** global system analysis of impact number is carried out with the synergic effect from impact *** successful validation of Vogel and Peukert model incorporating the effect of impact number demon-strates its versatility whilst other key parameters such as impact energy and particle size can be considered in parallel.

关键词： Model validation Impact number Damage accumulation DEM-PBM coupling Global system analysis

Computer simulation of flow fields for quenching medium

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Chinese Science Bulletin 2003年第8期48卷 739-742页

作者： li Qiang, wang ge, CHEN Nailu, liAO Bo & wang Tongzhen College of Mechanical Engineering, Yanshan University, Qinhuangdao 066004, China Correspondence should be addressed to li Qiang (e-mail: liqiang@ ***) College of Mechanical Engineering Yanshan University Qinhuangdao China

Using finite element method (FEM), the com-plex flow fields of quenching medium in a quenching tank are calculated for the cases with and without a work-piece in it. The influence of the flow homogenization device on the flow fields is studied. The computer simulation results are in consistency with the actual measurement results. According to the simulated results, the structure of the quenching tank and the flow homogenization device are optimized and more uniform flow fields are obtained.

关键词：计算机仿真淬火剂有限元法 FEM 流场

Treatment of Cerebral Apoplectic Pseudobulbar Palsy with Consciousness-Restoring & Obstruction-Clearing Needling Technique: A Report of 300 Cases

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Journal of Acupuncture and Tuina Science 2003年第5期1卷 24-26页

作者： JIANG ge-li wang Guo-hua wang Hong-yun HAN Chou-ping The 464th Hospital of PLA Tianjin 300381 China The 464th Hospital of PLA Tianjin 300381 China The 464th Hospital of PLA Tianjin 300381 China

Objective: To study the therapeutic effect of treating apoplectic pseudobulbar paralysis with ***: Consciousness-restoring & obstruction-clearing needling technique and points Fengchi (GB 20), Yifeng (TE 17), wangu (GB 12), Neiguan (PC 6), Shuigou (GV 26), Sanyinjiao (SP 6), Shanglianquan (Ex-HN), Jinjin (Ex-HN 12), Yuye (Ex-HN 13) and Baihui (GV 20) were selected to treat 300 cases of apoplectic pseudobulbar ***: Cure: 189 cases, marked effect: 71 cases, effective: 32 cases, no effect: 8 cases and the whole effective rate is 97.3%.Conclusion: Consciousness-restoring & obstruction-clearing needling technique is effective in treating apoplectic pseudobulbar paralysis. Key Words Cerebral Hemorrhage/complications - Hemiplegia - Acupuncture Therapy - Pseudobulbar Palsy - Cerebral Infarction/complications JIANG ge-li, MD of acupuncture, senior consultant doctor, professor, engages in the theoretical study of psychosomatic medicine and clinical treatment method of hyperplastic spine arthrosis and apoplexy sequelae.Translator: HAN Chou-ping

关键词： Cerebral Hemorrhage/complications Hemiplegia Acupuncture Therapy Pseudobulbar Palsy Cerebral Infarction/complications

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai wang Shao-Jiang wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian Gu Haoyu li Mengyao li Yude wang National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Chemical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Technologies Yunnan University

Aqueous zinc-ion batteries are highly favored for grid-level energy storage owing to their low cost and high safety,but their practical application is limited by slow ion *** address this,a strategy has been developed to create a cation-accelerating electric field on the surface of the cathode to achieve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on the surface of BaV6O16·3H2O nanowires,the directional built-in electric field generated at the heterointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into the active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3H2O@MoS2(7.5×10～8cm2s-1) surpasses that of most reported V-based ***,MoS2serving as a cathodic armor extends the cycling life of the Zn-CC@BaV6O16·3H2O@MoS2full batteries to over 10000 *** work provides valuable insights into optimizing ion diffusion kinetics for high-performance energy storage devices.

关键词： Internal electric field Cationic accelerator Ion diffusion kinetics Cathode modification strategy Aqueous zinc ion battery

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi li Jiaying Lu Jingjie ge Mingjia Chen Ruixin Yao Mei Tian Jian wang Fengtao liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi li Jing Xue Yuejia Ma Ke Ye Xue Zhao Fangliang ge Feifei Zheng Lulu liu Xu Gao Dayong wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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污泥-锯末共热解生物炭的制备及土壤应用

现代化工 2017年第1期37卷 147-150,152页

作者：王忠科李刚王格格陆江银王建俊新疆大学化学化工学院石油天然气精细化工教育部重点实验室新疆乌鲁木齐830046 新疆乌鲁木齐昆仑环保集团有限公司新疆乌鲁木齐830021

利用外热式反应釜,以城市污泥和白杨木锯末混合物为原料共热解制备生物炭。研究了共热解工艺条件对生物炭产率和吸附性能的影响,对最佳工艺条件下所制备生物炭的比表面积、孔结构、表面形貌进行了表征,并且分析了生物炭的营养物质、p H... 详细信息

利用外热式反应釜,以城市污泥和白杨木锯末混合物为原料共热解制备生物炭。研究了共热解工艺条件对生物炭产率和吸附性能的影响,对最佳工艺条件下所制备生物炭的比表面积、孔结构、表面形貌进行了表征,并且分析了生物炭的营养物质、p H、重金属质量分数。结果表明,最佳共热解工艺条件:锯末掺混比为20%,热解温度为400℃,催化剂质量分数为6%,反应时间为30 min。最佳生物炭表面存在较多的孔隙结构,中大孔较多,比表面积为6.411 m2/g,碘吸附值为311.63 mg/g,亚甲基蓝吸附值为95.42 mg/g。最佳生物炭中速效氮、速效磷和有机质质量分数分别为115.5 mg/kg、287 mg/kg和535.63 g/kg,呈碱性,p H为9.88,重金属质量分数除Zn外均远低于农用土壤二级标准,可作为土壤改良剂或肥料使用。

关键词：污泥锯末共热解生物炭改良土壤