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放疗后早期肿瘤组织内^99Tc^m-r.-Annexin V分布与Sur.ivin、Casp.se-3蛋白表达的相关性研究

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同位素 2008年第1期21卷 29-35页

作者：张欣李亚明张延军季晓鹏陶莉张剑英赵贞贞朱毅杨春赵明田爱娟大连医科大学附属第一医院核医学科辽宁大连116011 中国医科大学附属第一医院核医学科辽宁沈阳110001 大连医科大学附属第二医院核医学科辽宁大连116023 北京师范大学化学学院放射性药物教育部重点实验室北京100875

采用^99Tc^m-r.-Annexin V作为凋亡显像示踪剂，观察小鼠放疗后早期肿瘤组织内Sur.ivin、Casp.se-3蛋白表达。结果显示，放疗组肿瘤组织内^99Tc^m-r.-Annexin V分布、TUNEL检测阳性细胞数及Casp.se-3蛋白表达均明显多于对照组，Sur.ivi... 详细信息

采用^99Tc^m-r.-Annexin V作为凋亡显像示踪剂，观察小鼠放疗后早期肿瘤组织内Sur.ivin、Casp.se-3蛋白表达。结果显示，放疗组肿瘤组织内^99Tc^m-r.-Annexin V分布、TUNEL检测阳性细胞数及Casp.se-3蛋白表达均明显多于对照组，Sur.ivin蛋白表达A组明显高于B组，差异均存在显著性（p.＜0．01）。相关性研究表明，肿瘤组织的放射性摄取与TUNEL阳性细胞数呈明显正相关（r.0．942，p.0．000）；肿瘤组织内Sur.ivin蛋白表达与Casp.se-3蛋白表达呈明显负相关（r.-0．836，p.0．000）。肿瘤组织内^99Tc^m-Annex-inV分布与Casp.se-3蛋白表达呈明显正相关（r.0．948，p.0．000），与Sur.ivin蛋白表达呈明显负相关（r.-0．819，p.0．01）。以上结果提示，肿瘤组织内^99Tcm—r.—Annexin V的分布可以反映放疗后早期肿瘤组织细胞凋亡的状况以及凋亡调控蛋白Sur.ivin、Casp.se-3表达水平的变化。

关键词： ^99Tc^m-r.-Annexin V sur.ivin casp.se-3 表达相关性

One-way quantum deficit and quantum coher.nce in the anisotr.p.c X Y chain

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Science china(p.ysics,Mechanics & Astr.nomy) 2017年第3期60卷 42-47页

作者： Biao-liang Ye Bo li li-Jun Zhao Hai-Jun Zhang Shao-ming Fei School of p.ysics and Electr.nic Infor.ation Shangrao Normal University Shangrao 334001 China School of mathematics.& Comp.ter.Science Shangrao Normal University Shangrao 334001 China School of Mathematical Sciences Capital Normal University Beijing 100048 China Max-p.anck-lnstitute for.mathematics.in the Sciences Leipzig 04103 Germany

In this study, we investigate p.ir.ise non-classical cor.elations measur.d using a one-way quantum deficit as well as quantum coher.nce in the XY sp.n-1/2 chain in a tr.nsver.e magnetic field for.both zer. and finite temp.r.tur.s. The analytical and numer.cal r.sults of our.investigations ar. p.esented. In the case when the temp.r.tur. is zer., it is shown that the one-way quantum deficit can char.cter.ze quantum p.ase tr.nsitions as well as quantum coher.nce. We find that these measur.s have a clear.cr.tical p.int at λ = 1. When λ 1, the one-way quantum deficit has an analytical exp.ession that coincides with the r.lative entr.p. of coher.nce. We also study an XX model and an Ising chain at the finite temp.r.tur.s.

关键词： one-way quantum deficit quantum coher.nce quantum p.ase tr.nsitions XY chain

Quantum Fisher.infor.ation and coher.nce in one-dimensional XY sp.n models with Dzyaloshinsky-Mor.ya inter.ctions

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Science china(p.ysics,Mechanics & Astr.nomy) 2018年第11期61卷 8-14页

作者： Biao-liang ye Bo li Zhi-Xi Wang Xianqing li-Jost Shao-ming Fei Quantum Infor.ation r.sear.h Center School of Physics and Electronic Information Shangrao Normal University Shangrao 334001 China jiangxi p.ovince Key Labor.tor. of p.lymer.p.ep.r.tion and p.ocessing Shangrao 334001 China School of mathematics.and Comp.ter.Sciences Shangrao Normal University Shangrao 334001 China Max-p.anck-Institute for.mathematics.in the Sciences Leipzig 04103 Germany School of Mathematical Sciences Capital Normal University Beijing 100048 China School of mathematics.and Statistics Hainan Normal University Haikou 571158 China

We investigate quantum p.ase tr.nsitions in XY sp.n models using Dzyaloshinsky-Mor.ya(DM) inter.ctions. We identify the quantum cr.tical p.ints via quantum Fisher.infor.ation and quantum coher.nce, finding that higher.DM coup.2}ngs sup.r.ss quantum p.ase tr.nsitions. However. quantum coher.nce(char.cter.zed by the l_1-nor. and r.lative entr.p.) decr.ases as the DM coup.2}ng incr.ases. Her.in, we p.esent both analytical and numer.cal r.sults.

关键词： quantum Fisher.infor.ation quantum coher.nce XY sp.n models Dzyaloshinsky-Mor.ya inter.ctions

左归丸和右归丸对实验性自身免疫性脑脊髓炎大鼠中枢神经系统IL-10、TGF-β蛋白表达的研究

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首都医科大学学报 2010年第2期31卷 233-240页

作者：樊永平宋丽君叶明周莉王蕾龚海洋首都医科大学附属北京天坛医院中医科首都医科大学中医药学院方剂学教研室

目的观察大鼠实验性自身免疫性脑脊髓炎(exp.r.mental autoimmune encep.alomyelitis,EAE)模型脑、脊髓组织白细胞介素-10(inter.eukin-10,IL-10)与组织生长因子-β(tr.nsfor.3} gr.wth factor.β,TGF-β)免疫组化的表达,探讨滋阴补肾法(左归丸)与温阳补肾法(右归丸)治疗EAE的作用机制。方法用髓鞘碱性蛋白(myelin basic p.otein,MBp.免疫Lewis大鼠诱导EAE模型,120只大鼠采用数字表法随机分为正常组、模型组、激素组、左归丸组及右归丸组,正常对照组(n=24)和模型组(n=24)每天给予3mL0.9%氯化钠注射液灌胃;激素组(n=24)免疫后每天给予3mL0.9%氯化钠注射液灌胃,发病后改为醋酸泼尼松混悬液5mg/(kg.d-1)灌胃;左归丸组(n=24)免疫后给予左归丸混悬液2g/(kg.d-1);右归丸组(n=24)免疫后给予右归丸混悬液3g/(kg.d-1),直至处死。分别于免疫后15d(急性期发病)和免疫后27d(缓解期)选取各组大鼠,取脑和脊髓组织切片进行IL-10、TGF-β免疫组化染色。结果造模后15d,模型动物的脑和脊髓组织IL-10、TGF-β表达(指表达染色IOD值,下同)明显减少,第27天,模型动物脊髓组织IL-10表达明显减少。第15天,左归丸组与右归丸组大鼠脑组织IL-10表达较模型组明显升高(p.0.01);左归丸组大鼠脊髓组织IL-10表达也较模型组明显升高(p.0.05);右归丸组与激素组大鼠脑TGF-β表达较模型组升高,右归丸组大鼠脊髓TGF-β表达较模型组升高,差异均有统计学意义(p.0.05)。造模后27d,左归丸组、右归丸组、激素组脊髓组织IL-10表达均较模型组显著增高(p.0.01);左归丸组大鼠脊髓组织TGF-β表达较模型组与激素组升高(p.0.05)。模型组、激素组、左归丸组与右归丸组脊髓IL-10表达均较免疫后15d明显升高(p.0.05);左归丸组大鼠脊髓TGF-β表达较免疫后15d明显增高,差异有统计学意义(p.0.05)。结论左归丸和右归丸可上调EAE大鼠中枢神经系统IL-10、TGF-β表达,作用优于激素。两者整个病程中均对IL-10表达有促进作用,不同点为右归丸促进急性期脑组织TGF-β的表达,而左归丸则促进缓解期脊髓TGF-β的表达。

关键词：自身免疫性疾病实验性自身免疫性脑脊髓炎细胞因子中医药左归丸右归丸

Bip.r.ite Bell Inequality and Maximal Violationt

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Communications in Theor.tical p.ysics 2011年第3期55卷 418-420页

作者： liming FEI Shao-ming Xian-Qing li-Jost College of mathematics.and Comp.tational Science China University of Petroleum Dongying 257061 China School of Mathematical Sciences Capital Normal University Beijing 100048 China Max-p.anck-Institute for.mathematics.in the Sciences Leipzig 04103 Germany department of mathematics Hainan Normal University Haikou 571185 China

We p.esent new bell inequalities for.ar.itr.r. dimensional bip.r.ite quantum systems. The maximal violation of the inequalities is comp.ted. The Bell inequality is cap.ble of detecting quantum entanglement of both p.r...

关键词： entanglement bip.r.ite system Bell inequality

Telep.r.ation with an Ar.itr.r. Mixed r.sour.e as a Tr.ce-p.eser.ing Quantum Channel

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Communications in Theor.tical p.ysics 2002年第3期38卷 301-304页

作者： Ser.io Albever.o FEI Shao-ming YANG Wen-li Institut fiir.Angewandte Mathematik Universitat Bonn D-53115 Germany Institut fiir Angewandte Mathematik Universitat Bonn D-53115 Germany department of mathematics Capital Normal University Beijing 100037 China Physikalisches Institut der Universitat Bonn 53115 Bonn Germany Institute of Moder. p.ysics Northwest University Xi'an 710069 China

Gener.l conditions ar. given in or.0}r.to p.r.or. a p.r.ect telep.r.ation p.ocess in the case wher. theHilber. sp.ces involved have differ.nt dimensions. An exp.1}cit exp.ession is obtained for.the quantum channel associatedwith the standar. telep.r.ation p.otocol To with an ar.itr.r. mixed state r.sour.e. The tr.nsmission fidelity of thecor.esp.nding quantum channel is given.

关键词： telep.r.ation, fidelity

Cor.elation Between Hyalur.nic Acid,Hyalur.nic Acid Synthase And Human r.nal Clear.Cell Car.inoma

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Chinese Jour.al of Cancer.r.sear.h 2011年第1期23卷 59-63页

作者： Jian-liang Cai ming li Yan-qun Na p.king university.Wu Jiep.ng Ur.logical Center Peking University Shougang HospitalBeijing 100144China Key labor.tor. of Car.inogenesis and Tr.nslational r.sear.h(Ministr. of Education) Department of UrologyPeking University School of OncologyBeijing Cancer Hospital ＆ InstituteBeijing 100142China

Objective：To study the cor.elation between hyalur.nic acid（HA）,hyalur.nic acid synthase（HAS） and human r.nal clear.cell car.inoma（r.CC）.Methods：The exp.ession of thr.e HAS isofor.s＇ gene and HA in 93 r.CC tissues,27 nep.r.dial tissues by the side of r.CC fr.m two hosp.tals wer. measur.d with r.al-Time r.-p.r.Wester. Blot and immunohistochemical methods and ***：All r.CC and adjacent normal tissues exp.essed thr.e HASs＇ mr.A p.otein;at the mr.A level,both r.CC and adjacent normal tissues,exp.essed mor. HAS3 than HAS1 or.HAS2,their.differ.nces wer. statistically significant（all p.values 0.05）;but,at the p.otein level,all HAS isofor.s p.esented the equivalent *** with the adjacent non-neop.astic kidney tissues,the exp.ession of all HAS isofor.s＇ mr.A in r.CC tissues wer. incr.ased evidently and their.differ.nces wer. significant（all p.values 0.0001）;but at the p.otein level,only the exp.ession of HAS3 incr.ased evidently（p.0.022）.In all adjacent normal tissues,mor. than 80% r.nal tubular.cells str.ngly exp.essed HA,however.only the minor.ty r.CC cases（16/93） p.esented weakly p.sitive HA staining in few cancer.nests（5%-30%）,the differ.nce wer. significant（p..0001）.In r.CC tissues subgr.up.d accor.ing to clinical stage,p.thological gr.de,lymp.atic metastasis or.not and distant metastasis or.not,the HASs＇ mr.A p.otein differ.ntial exp.ession all had no statistical significance（all p.values 0.05）.Conclusion：Differ.nt fr.m other.malignancy,HA and HASs（excep. for.HAS3） may not p.ay imp.r.ant r.les in the biological p.ogr.ss of human r.CC.

关键词： r.nal clear.cell car.inoma Hyalur.nic acid Hyalur.nic acid synthase Gene

Tighter.constr.ints of multiqubit entanglement in ter.s of r.nyi-α entr.p.

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Chinese p.ysics B 2020年第7期29卷 251-256页

作者： Meng-li Guo Bo li Zhi-Xi Wang Shao-ming Fei department of mathematics East China University of TechnologyNanchang 330013China School of mathematics.and Comp.ter.Science Shangrao Normal UniversityShangrao 334001China School of Mathematical Sciences Capital Normal UniversityBeijing 100048China Max-p.anck-Institute for.mathematics.in the Sciences 04103LeipzigGermany

Quantum entanglement p.ays essential r.les in quantum infor.ation *** monogamy and p.lygamy r.lations char.cter.ze the entanglement distr.butions in the multip.r.ite *** p.esent a class of monogamy inequalities r.lated to theµ-th p.wer.of the entanglement measur. based on r.nyi-αentr.p.,as well as p.lygamy r.lations in ter.s of theµ-th p.wer.of r.nyi-αentanglement of *** monogamy and p.lygamy r.lations ar. shown to be tighter.than the existing ones.

关键词： monogamy r.lations p.lygamy r.lations r.nyi-αentr.p. Hamming weight

Effect of cor.nar. ar.er. r.vascular.zation on in-hosp.tal outcomes and long-ter. p.ognoses in acute myocar.ial infar.tion p.tients with p.ior.ischemic str.ke

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Jour.al of Ger.atr.c Car.iology 2016年第2期13卷 145-151页

作者： Bo-Yu li Xiao-ming li Yan ZHANG Zhan-Yun WEI Jing li Qi HUA department of Car.iology Xuanwu Hospital Capital Medical University Beijing China School of Nur.ing Capital Medical University Beijing China department of Ger.atr.cs Xuanwu Hospital Capital Medical University Beijing China

Objective To investigate whether.cor.nar. ar.er. r.vascular.zation ther.p.es （CAr.）, including p.r.utaneous cor.nar. inter.ention （p.I） and cor.nar. ar.er. byp.ss gr.fting （CABG）, can imp.ove the in-hosp.tal and long-ter. outcomes for.acute myocar.ial infar.tion （AMI） p.tients with p.ior.ischemic str.ke （IS）. Methods A total of 387 AMI p.tients with p.ior.IS wer. enr.lled consecutively fr.m Januar. 15, 2005 to december.24, 2011 in this cohor. study. All p.tients wer. categor.zed into the CAr. gr.up.（n = 204） or.the conser.ative medications （CM） gr.up.（n = 183）. In-hosp.tal car.iocer.br.l events and long-ter. mor.ality of the two gr.up. after.an aver.ge follow-up.of 36 months wer. r.cor.10}d by Kap.an-Meier.sur.ival cur.es and comp.r.d by Logistic r.gr.ssion and the Cox r.gr.ssion model. r.sults The CAr. p.tients wer. younger.（66.5 ± 9.7 year. vs. 71.7 ± 9.7 year., p.〈 0.01）, had less non-ST segment elevation myocar.ial infar.tion （11.8% vs. 20.8%, p.= 0.016） and mor. multip.e-vascular.cor.nar. lesions （50% vs. 69.4%, p.= 0.031）. The hosp.talization incidence of car.iocer.br.l events in the CAr. gr.up.was 9.3% while 26.2% in the CM gr.up.（p.〈 0.01）. CAr. significantly r.duced the r.sk of in-hosp.tal car.iocer.br.l events by 65% [adjusted odds r.tio （Or. = 0.35, 95% CI： 0.13-0.92]. By the end of follow-up. 57 cases （41.6%） died in CM gr.up.（n = 137） and 24 cases （12.2%） died in CAr. gr.up.（n = 197）. Cox r.gr.ssion indicated that CAr. decr.ased the long-ter. mor.ality by 72% [adjusted hazar. r.tio （Hr. = 0.28, 95% CI： 0.064）.46], while categor.cal analysis indicated no s{gnificant dif- fer.nce between p.I and CABG. Conclusions CAr. has a significant effect on imp.oving the in-hosp.tal and long-ter. p.ognoses for.AMI p.tients with p.ior.IS.

关键词： Acute myocar.ial infar.tion Conser.ative medications Cor.nar. ar.er. byp.ss gr.fting Cor.nar. ar.er. r.vascular.zation Ischemic str.ke p.r.utaneous cor.nar. inter.ention