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Baicalin Antagonizes Prostate Cancer Stemness via Inhibiting Notch1/NF-κB Signaling Pathway

中国结合医学杂志:英文版 2023年第10期29卷 914-923页

作者： WU Ming-hui WU Kun ZHU Yuan-bing li da-chuan YANG Huan ZENG Hong Department of Urology Hubei University of Traditional Chinese MedicineWuhan430065China Department of Urology Chongqing Jiangjin District Hospital of Chinese MedicineChongqing402260China

Objective To investigate the molecular mechanisms underlying the effect of baicalin on prostate cancer(PCa)progression both in vivo and in *** The in situ PCa stem cells(PCSCs)-injected xenograft tumor models were established in BALB/c nude *** volume and weight were respectively checked after baicalin(100 mg/kg)***-eosin(HE)staining was used to observe the growth arrest and cell *** expression levels of acetaldehyde dehydrogenase 1(ALDH1),CD44,CD133 and Notch1 were determined by reverse transcription-polymerase chain *** expression levels of ALDH1,CD44,CD133,Notch1,nuclear factorκB(NF-κB)P65 and NF-κB p-P65 were detected by Western *** and subcellular location of ALDH1,CD44,CD133,Notch1 and NF-κB p65 were detected by immunofluorescence *** vitro,cell cycle distribution and cell apoptosis of PC3 PCSCs was assessed by flow cytometry after baicalin(125µmol/L)*** migration and invasion abilities of PCSCs were assessed using Transwell *** electron microscopy scanning was utilized to observe the structure and autophagosome formation of baicalin-treated *** addition,PCSCs were infected with lentiviruses expressing human *** Compared with the control group,the tumor volume and weight were notably reduced in mice treated with 100 mg/kg baicalin(Plin treatment significantly inhibited cell proliferation and promoted cell ***,baicalin treatment reduced mRNA and protein expression levels of CD44,CD133,ALDH1,and Notch1 as well as the protein expression of NF-κB p-P65 in the xenograft tumor(Pliferation of PCSCs was significantly attenuated after treatment with 125µmol/L baicalin for 72 h(Plin for 48 and 72 h(Plin notably induced cell apoptosis and seriously

关键词： baicalin prostate cancer cancer stemness Notch1/nuclear factorκB signaling

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圆型双组分弹力纤维(66/12)工艺探究

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聚酯工业 2024年第3期37卷 55-57,61页

作者：李传达金管范王永锋陈明周钢江苏恒力化纤股份有限公司新型纤维研究所江苏苏州215123

从纺丝、卷绕对圆孔PET/HSF(普通/高收缩)双组分弹性纤维(以下简称高收缩双弹纤维,规格66dtex/12f)进行工艺探究,通过A/B组分比例、卷绕速度、一辊速度、二辊温度等因素实验并对其相关指标(强伸度、沸水收缩率、卷曲性能)进行分析,从而... 详细信息

从纺丝、卷绕对圆孔PET/HSF(普通/高收缩)双组分弹性纤维(以下简称高收缩双弹纤维,规格66dtex/12f)进行工艺探究,通过A/B组分比例、卷绕速度、一辊速度、二辊温度等因素实验并对其相关指标(强伸度、沸水收缩率、卷曲性能)进行分析,从而找出最佳工艺条件。

关键词：圆型双组分弹力纤维卷绕速度一辊速度二辊温度

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Trace formula of the integro-differential operator on a quantum graph

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 311-318页

作者： WEI li-xiao YANG chuan-fu School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094China.

In this paper we study the eigenvalue problem for integro-differential operators on a lasso *** trace formula of the operator is established by applying the residual technique in complex analysis.

关键词： integro-differential operators eigenvalue trace formula

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Physiological and pathological functions of circular RNAs in the nervous system

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Neural Regeneration Research 2024年第2期19卷 342-349页

作者： Min Zhou Shi li chuan Huang School of life Sciences Chongqing UniversityChongqingChina

Circular RNAs(circRNAs)are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and *** play crucial roles in physiological and pathological processes by sponging microRNAs,modulating gene transcription,controlling the activity of certain RNA-binding proteins,and producing functional peptides.A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 ***,the precise role of circRNAs in the nervous system has yet to be comprehensively *** this review,we first summarize the recently described roles of circRNAs in brain development,maturity,and ***,we focus on the involvement of circRNAs in various diseases of the central nervous system,such as brain cancer,chronic neurodegenerative diseases,acute injuries of the nervous system,and neuropathic pain.A better understanding of the functionality of circRNAs will help us to develop potential diagnostic,prognostic,and therapeutic strategies to treat diseases of the nervous system.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis brain development circRNAs neuropathic pain Parkinson’s disease

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A Deep Mantle Source for the Late Neoarchean Metamorphosed Basalts in Eastern Hebei,North China Craton:Insights from Whole-Rock Geochemistry and Sm-Nd Isotopes,and Zircon U-Pb-Hf Isotopes

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Journal of Earth Science 2024年第1期35卷 29-40页

作者： Zhuang li Chunjing Wei chuan Yang Xi Zhang College of Geosciences China University of PetroleumBeijing 102249China MOE Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing 100871China China Transport Telecommunications and Information Center Beijing 100011China

The basalts within the greenstone belt worldwide serve as an ideal target to decipher the nature of Archean mantle sources and further to extend the understanding of the early stages of Earth's *** provide important insights into the issues,we carried out a detailed investigation of whole-rock geochemistry and Sm-Nd isotopes,and zircon U-Pb-Hf isotopes for the Late Neoarchean metamorphosed basalts in eastern Hebei,North China Craton.U-Pb isotopic dating using the LA-ICPMS on zircons reveals that the basalts in eastern Hebei erupted at ca.2.48-2.51 Ga and subsequently experienced multiple regional metamorphic events at 2477 and 1798 Ma,*** metamorphosed basalts are featured by low SiO_(2),MgO,K_(2)O+Na_(2)O,and high Fe O contents,endowed with the subalkaline and high-Fe tholeiitic *** radiogenic initial Nd and Hf isotope values and correlations among V,Ni and Cr contents strongly imply that the basalts experienced significant clinopyroxene and olivine fractionation and minor crustal contamination during magma *** are also characterized by the relatively low total REE contents and exhibit significant depletions to moderate enrichments in the LREE contents,indicating the derivation from a deep mantle source in an Archean proto-mantle plume setting.

关键词： zircon U-Pb-Hf isotopes geochemistry Late Neoarchean basaltic magmatism North China Craton Archean proto-mantle plume

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Migration and distribution characteristics of soil heavy metal(loid)s at a lead smelting site

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Journal of Environmental Sciences 2024年第1期135卷 600-609页

作者： Chuxuan li Mu li Jiaqing Zeng Shanxin Yuan Xinghua Luo chuan Wu Shengguo Xue School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control and Treatment of Heavy Metal Pollution Central South UniversityChangsha 410083China

Heavy metal(loid)s contamination is a constant issue at smelting *** is essential to investigate the spatial distribution and migration characteristics of heavy metal(loid)s in the soil for environmental management and remediation strategies of non-ferrous smelting *** this study,203 soil samples from 57 sites were collected in a typical lead smelting *** findings demonstrated that there were significant Pb,Zn,Cd,and As contamination in soil *** spatial distribution of heavy metal(loid)s showed strong spatial heterogeneity,the contaminated soil areas of Pb,As,Cd,and Zn were 99.5%,98.9%,85.3%,and 72.4%,***,Cd,and As contamination of the soil reached a depth of 5 m,which migrated from the surface to deep soil *** leaching contents of Zn,Pb,and As decreased obviously in 3-4 m soil layer,but the leaching content of Cd was still high,which indicated the high migration of *** the increase of depth,the proportion of acid soluble fraction of heavy metal(loid)s decreased,and the residual fraction *** acid soluble fraction of Cd accounted for a higher proportion,and As mainly existed in reducible and residual fractions in *** to the calculation of the migration factor,the migration of heavy metal(loid)s in soils were ordered as Cd>Zn>Pb>*** outcomes are advantageous for risk reduction and site remediation for non-ferrous metal smelting sites.

关键词： Smelting sites Heavy metal(loid)s Spatial distribution Chemical speciation Migration characteristics

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Sedimentary Environment and Mineralization of the Black Shale Polymetallic Layer in the Early Cambrian,SW China:Constraints from in situ LA-ICP-MS Analysis of Pyrite

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 416-429页

作者： YANG Zhen FU Yong li Chao CAI Xi GUO chuan College of Eco-Environmental Engineering Guizhou Minzu UniversityGuiyang 550025China College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China Key Laboratory of Karst Georesources and the Environment Ministry of EducationGuizhou UniversityGuiyang 500025China National Research Center for Geoanalysis Chinese Academy of Geological SciencesBeijing 100037China

A polymetallic layer is usually developed at the bottom of the early Cambrian black shale in Guizhou *** mineral that makes up the polymetallic layer is related to the sedimentary *** analyze the differentiation mechanism between polymetallic deposits(Ni-Mo and V),the Zhijin Gezhongwu profile located in the outer shelf and the Sansui Haishan V deposit located in the lower slope are selected to study the in situ sulfur isotopes and trace elements of *** results show that δ^(34)S values of pyrite vary widely from−7.8‰to 28‰in the Gezhongwu profile,while the δ^(34)S values are relatively uniform(from 27.8‰to 38.4‰)in the Haishan *** isotopic S composition is consistent with the transition that occurs in the sedimentary phase from the shelf to the deep sea on the transgressive Yangtze platform;this indicates that the δ^(34)SO_(4)^(2−)values in seawater must be differently distributed in depositional *** sulfur in the Ni-Mo layer is produced after the mixing of seawater and hydrothermal fluid,while the V layer mainly originates from ***,the Ni-Mo and V deposits have been differentiated primarily on the basis of the combined effect of continental weathering and hydrothermal fluid.

关键词： sedimentary environment black shale polymetallic layer pyrite early Cambrian

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Resonant Beam Communications:A New Design Paradigm and Challenges

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Journal of Communications and Information Networks 2024年第1期9卷 80-87页

作者： Yuanming Tian Dongxu li chuan Huang Qingwen liu Shengli Zhou Future Network of Intelligence Institute and School of Science and Engineering the Chinese University of Hong KongShenzhen 518172China School of Science and Engineering and the Future Network of Intelligence Institute the Chinese University of Hong KongShenzhen 518172China College of Electronics and Information Engineering Tongji UniversityShanghai 201804China Department of Electrical and Computer Engineering University of ConnecticutStorrsCT 06250USA

Resonant beam communications (RBCom), which adopts oscillating photons between two separate retroreflectors for information transmission, exhibits potential advantages over other types of wireless optical communications (WOC). However, echo interference generated by the modulated beam reflected from the receiver affects the transmission of the desired information. To tackle this challenge, a synchronization-based point-to-point RBCom system is proposed to eliminate the echo interference, and the design for the transmitter and receiver is discussed. Subsequently,the performance of the proposed RBCom is evaluated and compared with that of visible light communications(VLC)and free space optical communications (FOC). Finally, future research directions are outlined and several implementation challenges of RBCom systems are highlighted.

关键词： resonant beam communications(RBCom) wireless optical communications(WOC) echo interference elimination mobility multiple access

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Sliced Average Variance Estimation for Tensor data

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 630-655页

作者： chuan-quan li Pei-wen XIAO Chao YING Xiao-hui liU School of Statistics Jiangxi University of Finance and EconomicsNanchang 330013China Key Laboratory of data Science in Finance and Economics Jiangxi University of Finance and EconomicsNanchang 330013China Biostatistics and Medical Informatics University of Wisconsin MadisonMadison 53726USA

Tensor data have been widely used in many fields,e.g.,modern biomedical imaging,chemometrics,and economics,but often suffer from some common issues as in high dimensional *** to find their low-dimensional latent structure has been of great interest for *** this end,we develop two efficient tensor sufficient dimension reduction methods based on the sliced average variance estimation(SAVE)to estimate the corresponding dimension reduction *** first one,entitled tensor sliced average variance estimation(TSAVE),works well when the response is discrete or takes finite values,but is not■consistent for continuous response;the second one,named bias-correction tensor sliced average variance estimation(CTSAVE),is a de-biased version of the TSAVE *** asymptotic properties of both methods are derived under mild *** and real data examples are also provided to show the superiority of the efficiency of the developed methods.

关键词： tensor data sliced average variance estimation sufficient dimension reduction central subspace

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Carbon-based interface engineering and architecture design for high-performance lithium metal anodes

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Carbon Energy 2024年第1期6卷 207-235页

作者： Na Zhu Yuxiang Yang Yu li Ying Bai Junfeng Rong chuan Wu SINOPEC Research Institute of Petroleum Processing Co. Ltd.BeijingChina Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijingChina Yangtze Delta Region Academy of Beijing Institute of Technology JiaxingChina

Metallic lithium(li)is considered the“Holy Grail”anode material for the nextgeneration of li batteries with high energy density owing to the extraordinary theoretical specific capacity and the lowest negative electrochemical ***,owing to inhomogeneous li-ion flux,li anodes undergo uncontrollable li deposition,leading to limited power output and practical *** materials and their composites with controllable structures and properties have received extensive attention to guide the homogeneous growth of li to achieve high-performance li *** this review,the correlation between the behavior of li anode and the properties of carbon materials is ***,we review emerging strategies for rationally designing high-performance li anodes with carbon materials,including interface engineering(stabilizing solid electrolyte interphase layer and other functionalized interfacial layer)and architecture design of host carbon(constructing three-dimension structure,preparing hollow structure,introducing lithiophilic sites,optimizing geometric effects,and compositing with li).Based on the insights,some prospects on critical challenges and possible future research directions in this field are *** is anticipated that further innovative works on the fundamental chemistry and theoretical research of li anodes are needed.

关键词： carbon materials dendrites hosts interfacial layers li metal anodes

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