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Heterotrimeric G protein α subunit is involved in rice brassinosteroid response

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Cell Research 2006年第12期16卷 916-922页

作者： Lei wang~(1.2) Yun-Yuan Xu~1.Qi-Bin Ma~(1.2) Dan {1.~(1.2) Zhi-Hong Xu~(1.3) Kang {1.~(1.3) 1.Key Laboratory of Photosynthesis and Environmental Molecular Physiology,Institute of Botany,Chinese Academy of sciences,Nanxincun 20,Xiangshan,Beijing 1.0093,china,2 Graduate School of the Chinese Academv of sciences,1.0046 Beijing,china 3 National Plant Gene Research center (Beijing),Beijing 1.0093,china KeyLaboratoryofPhotosynthesisandEnvironmentalMolecularPhysiology InstituteofBotanyChineseAcademyofSciencesNanxincun20XiangshanBeijing100093China GraduateSchooloftheChineseAcademyofsciences 100046BeijingChina

Heterotrimeric G proteins are known to function as messengers in numerous signal transduction *** nullmutation of RGA(rice heterotrimeric G protein α subunit),which encodes the α subunit of heterotrimeric G proteinin rice,causes severe dwarfism and reduced responsiveness to gibberellic acid in ***,less is known aboutheterotrimeric G protein in brassinosteroid(BR)signaling,one of the well-understood phytohormone *** thepresent study,we used root elongation inhibition assay,lamina inclination assay and coleoptile elongation analysis todemonstrated reduced sensitivity of dl mutant plants(caused by the null mutation of RGA)to 24-epibrassinolide(24-epiBL),which belongs to brassinosteroids and plays a wide variety of roles in plant growth and ***,RGA transcript level was decreased in 24-epiBL-treated seedlings in a dose-dependent *** results show thatRGA is involved in rice brassinosteroid response,which may be beneficial to elucidate the molecular mechanisms of Gprotein signaling and provide a novel perspective to understand BR signaling in higher plants.

关键词： heterotrimeric G protein α subunit dl mutant BR signaling rice

Artificial intelligence for geoscience:Progress,challenges,and perspectives

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The Innovation 2024年第5期5卷 136-160,135页

作者： Tianjie Zhao Sheng wang Chaojun Ouyang Min Chen Chenying {1.u Jin Zhang Long Yu Fei wang Yong Xie Jun {1. Fang wang Sabine Grunwald Bryan MWong Fan Zhang Zhen Qian Yongjun Xu Chengqing Yu Wei Han Tao Sun Zezhi Shao Tangwen Qian Zhao Chen Jiangyuan Zeng Huai Zhang Husi Letu Bing Zhang {1. wang Lei Luo chong Shi Hongjun Su Hongsheng Zhang Shuai Yin Ni Huang Wei Zhao Nan {1. Chaolei Zheng Yang Zhou Changping Huang Defeng Feng Qingsong Xu Yan Wu Danfeng Hong Zhenyu wang Yinyi {1.n Tangtang Zhang Prashant Kumar Antonio Plaza Jocelyn Chanussot Jiabao Zhang Jiancheng Shi {1.zhe wang Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China School of Computer Science China University of GeosciencesWuhan 430078China State Key Laboratory of Mountain Hazards and Engineering Resilience Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610299China Key Laboratory of Virtual Geographic Environment(Ministry of Education of PRC) Nanjing Normal UniversityNanjing 210023China Data Science in Earth Observation Technical University of Munich80333 MunichGermany The National Key Laboratory of Water Disaster Prevention Yangtze Institute for Conservation and DevelopmentHohai UniversityNanjing 210098China Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China School of Geographical sciences Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Soil Water and Ecosystem Sciences DepartmentUniversity of FloridaPO Box 110290GainesvilleFLUSA Materials Science Engineering Program Cooperating Faculty Member in the Department of Chemistry and Department of Physics Astronomy University of CaliforniaCaliforniaRiversideCA 92521USA Institute of Remote Sensing and Geographical Information System School of Earth and Space SciencesPeking UniversityBeijing 100871China Key Laboratory of Computational Geodynamics University of Chinese Academy of SciencesBeijing 100049China International Research center of Big Data for Sustainable Development Goals Beijing 100094China College of Geography and Remote Sensing Hohai UniversityNanjing 211100China Department of Geography The University of Hong KongHong Kong 999077SARChina Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Nanjing 210044China School of Environmental Science and Engineering Nanjing University of Information Science&TechnologyNanjing 210044China Collaborative Inno

This paper explores the evolution of geoscientific inquiry,tracing the progression from traditional physics-based models to modern data-driven approaches facilitated by significant advancements in artificial intelligence(AI)and data collection *** models,which are grounded in physical and numerical frameworks,provide robust explanations by explicitly reconstructing underlying physical ***,their limitations in comprehensively capturing Earth’s complexities and uncertainties pose challenges in optimization and real-world *** contrast,contemporary data-driven models,particularly those utilizing machine learning(ML)and deep learning(DL),leverage extensive geoscience data to glean insights without requiring exhaustive theoretical *** techniques have shown promise in addressing Earth science-related ***,challenges such as data scarcity,computational demands,data privacy concerns,and the“black-box”nature of AI models hinder their seamless integration into *** integration of physics-based and data-driven methodologies into hybrid models presents an alternative *** models,which incorporate domain knowledge to guide AI methodologies,demonstrate enhanced efficiency and performance with reduced training data *** review provides a comprehensive overview of geoscientific research paradigms,emphasizing untapped opportunities at the intersection of advanced AI techniques and *** examines major methodologies,showcases advances in large-scale models,and discusses the challenges and prospects that will shape the future landscape of AI in *** paper outlines a dynamic field ripe with possibilities,poised to unlock new understandings of Earth’s complexities and further advance geoscience exploration.

关键词： Earth utilizing landscape

Combination of CTLA4-FasL gene transfer and allogeneic bone marrow transplantation led to durable macrochimerism and donor-specific tolerance in mouse model

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Science Bulletin 2005年第20期 57-63页

作者： FENG Yougang1. wang Guangming2, HAO Jie2, {1. Ai{1.ng2, YUAN Guohong2, {1. {1.2, ZENG Fuqing1.& XIE Shusheng2 1. Institute of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, china 2. Department of Immunology, Peking University Health Science center, Beijing 1.0083, china

Mixed hemopoietic chimerism is capable of inducing donor specific tolerance, thus eliminating the chronic immunosuppressive therapy following organ trans- plantation. As yet no safe and effective tolerance protocol is available for clinical implementation. Here we describe an alternative nonmyeloablative based strategy of using a single injection of recombination adenovirus vector encoding CTLA4-FasL fusing gene and donor bone marrow cells to promote durable mixed macrochimerism (>20% on 1.0 d). Chimeras exhibited robust donor-specific tolerance, as evi- denced by acceptance of fully allogeneic skin grafts (the mean survival time (MST)>200 d) and rejection of third- party skin grafts in a normal manner (MST1. d). In this model, the frequencies of helper T lymphocyte precursor (HTLp) and cytotoxic T lymphocyte precursor (CTLp) were greatly reduced on day 1. after transplantation, suggesting that CTLA4-FasL led to rapid systemic peripheral tolerance to facilitate the bone marrow engraftment, while both HTLp and CTLp remained at low level only in recipient mice with mixed chimerism on day 1.0 after transplantation, demon- strating that long-term skin grafts tolerance was associated with stable mixed chimerism, and central deletion of donor specific T cell may be the main mechanism for tolerance maintenance.

关键词： transplantation tolerance mixed macrochimerism CTLA4-FasL gene transfer skin transplantation.

Association analysis of an anti-obesity mechanism and key ripened Pu-erh tea bioactive components by mimicking human general tea drinking

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Food Science and Human Wellness 2024年

作者： Junyu liu Zhengyang Song Haihong Chen Wen Zeng Guirong Han Wei li Bing Xu Yuan Lu Canyang Zhang Zhenglian Xue Bin Lü chong Zhang Song Yang Yi {1. Xinhui Xing Institute of Biomedical Health Technology and Engineering Shenzhen Bay Laboratory MOE Key Laboratory for Industrial Biocatalysis， Centre for Synthetic and Systems Biology， Department of Chemical Engineering， Tsinghua University Shenzhen International Graduate School， Tsinghua University Shandong Province Key Laboratory of Applied Mycology， Qingdao International {1. on Microbes Utilizing Biogas， School of life {1.， Qingdao Agricultural University Anhui University of Technology Yunnan Shujian Tea Co.， Ltd.

Pu-erh tea， a traditional Chinese beverage， performs an anti-obesity function， but the correlation between its components and efficacy remains unknown. Here， we screened two Pu-erh teas with significant anti-obesity efficacies from 1. teas. In vitro experiments revealed that lipid accumulation in L02 cells and lipid synthesis in 3T3-L1.cells were significantly better inhibited by Tea-B than Tea-A. Further in vivo experiments using model mice revealed that the differences in chemical components generated two pathways in the anti-obesity efficacy and mechanism of Pu-erh teas. Tea-A changes the histomorphology of brown adipose tissue (BAT) and increases the abundance of Coriobacteriaceae＿UCG＿002 and cyclic AMP in guts through high chemical contents of cyclopentasiloxane， decamethyl， tridecane and 1.2，3-trimethoxybenzene， eventually increasing BAT activation and fat browning gene expression; the high content of hexadecane and 1.2-dimethoxy-benzene in Tea-B reduces white adipose tissue (WAT) accumulation and the process of fatty liver， increases the abundance of Odoribacter and sphinganine 1.phosphate， inhibits the expression of lipid synthesis and transport genes. These mechanistic findings on the association of the representative bioactive components in Pu-erh teas with the anti-obesity phenotypes， gut microbes， gut metabolite structure and anti-obesity pathways， which were obtained for the first time， provide foundations for developing functional Pu-erh tea.

关键词：

蚯蚓粪和生物有机肥对土壤养分及夏玉米产量的调控作用

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土壤通报 2011年第5期42卷 1179-1183页

作者：李欢向丹李晓林王冲董明明中国农业大学资源与环境学院北京100193 中国科学院生态环境研究中心北京100085

在中国农业大学曲周实验站设置了优化施肥(CK)、优化施肥添加蚯蚓粪(VC)和优化施肥添加生物有机肥(MOF)的田间试验,测定了夏玉米产量,并动态监测了玉米拔节期、大喇叭口期、抽雄期和收获期地上部生物量、土壤有效磷和矿质态氮、有机质... 详细信息

在中国农业大学曲周实验站设置了优化施肥(CK)、优化施肥添加蚯蚓粪(VC)和优化施肥添加生物有机肥(MOF)的田间试验,测定了夏玉米产量,并动态监测了玉米拔节期、大喇叭口期、抽雄期和收获期地上部生物量、土壤有效磷和矿质态氮、有机质和微生物量碳的变化,并计算了氮肥效率。结果表明,施用蚯蚓粪和生物有机肥产量分别比优化施肥(CK)提高了6.8%和8.2%。在整个生育期内,施用生物有机肥的处理土壤有效磷含量显著高于对照处理,是增产的主要因素;施用蚯蚓粪的处理在作物生长的中后期对土壤微生物量碳的调节作用十分显著,对作物增产意义重大。添加蚯蚓粪和生物有机肥能够提高氮肥的利用效率,减少施氮量,应用前景广阔。

关键词：玉米蚯蚓粪生物有机肥微生物量碳

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沿海城市台风暴雨时空变化致涝特征模拟

水科学进展 2024年第3期35卷 440-452页

作者：李冰雪史超侯精明王添陈光照王兴桦申若竹西安理工大学西北旱区生态水利国家重点实验室陕西西安710048 宁波市海曙区水旱灾害防御中心浙江宁波315000 宁夏首创海绵城市建设发展有限公司宁夏固原756000

为探明台风暴雨时空变化对中国沿海城市内涝过程的影响,应用地表水及其伴随输移过程数值模型,以中国沿海城市宁波中心商贸商务区为研究对象,进行多种移动台风降雨情景和静止台风降雨情景下的城市内涝研究。结果表明:(1.不同移动方向下... 详细信息

为探明台风暴雨时空变化对中国沿海城市内涝过程的影响,应用地表水及其伴随输移过程数值模型,以中国沿海城市宁波中心商贸商务区为研究对象,进行多种移动台风降雨情景和静止台风降雨情景下的城市内涝研究。结果表明:(1.不同移动方向下的降雨会导致内涝监测点积水时间滞后,向正西方向及西北方向移动时,积水时间滞后0~0.5 h;向正北方向移动时,积水时间滞后1.5 h;向北偏东30°方向移动时,积水时间滞后1.5~2 h。(2)在92%的模拟工况下降雨的移动会削减积水量和积水深度,水深峰值最大削减率达4.46%;降雨重现期从5 a增大到50 a时,积水水深峰值削减率从0.49%下降到0.1.%。(3)双峰型降雨与单峰型降雨对城市内涝积水的影响规律相似,但前者的影响作用更小。因此,在受台风暴雨侵袭的城市区域,防灾减灾部门应考虑台风暴雨的时空移动特征,进一步提高城市抗洪能力,减少灾害损失。

关键词：台风暴雨降雨移动城市内涝数值模拟沿海城市

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苦参碱对椎间盘退变大鼠髓核细胞凋亡的影响

中国组织工程研究 2024年第27期28卷 4281-4287页

作者：王冲孔丽崔学超鲍铁周河南中医药大学骨伤学院河南省郑州市450000 河南省洛阳正骨医院(河南省骨科医院)颈肩腰腿痛中心河南省洛阳市471002

背景:髓核细胞凋亡是引发椎间盘退变的主要病理基础,炎症和过氧化反应是导致髓核细胞凋亡的重要因素。研究表明苦参碱具有抗氧化、衰老、炎症和细胞凋亡等作用,可作为治疗椎间盘退变的潜在药物。目的:观察苦参碱调节环状GMP-AMP合成酶-... 详细信息

背景:髓核细胞凋亡是引发椎间盘退变的主要病理基础,炎症和过氧化反应是导致髓核细胞凋亡的重要因素。研究表明苦参碱具有抗氧化、衰老、炎症和细胞凋亡等作用,可作为治疗椎间盘退变的潜在药物。目的:观察苦参碱调节环状GMP-AMP合成酶-干扰素基因刺激因子(cGAS-STING)信号通路对椎间盘退变大鼠髓核细胞凋亡的影响。方法:①将处于对数生长期的大鼠髓核细胞分6组处理:除对照组外,模型组、苦参碱低剂量组、苦参碱高剂量组、空载组、苦参碱高剂量+cGAS过表达组采用氧糖剥夺建立椎间盘退变细胞模型,造模同时苦参碱低剂量组、苦参碱高剂量组分别给予0.4,0.8 mmol/L苦参碱处理,空载组转染空载质粒,苦参碱高剂量+cGAS过表达组给予0.8 mmol/L苦参碱处理并转染cGAS过表达质粒。处理24 h后,检测细胞活性与凋亡,细胞内活性氧、超氧化物歧化酶、肿瘤坏死因子α及白细胞介素1.水平,以及细胞内凋亡蛋白、cGAS-STING通路蛋白表达。②将60只SD大鼠随机分为6组,每组1.只:除对照组外,模型组、苦参碱低剂量组、苦参碱高剂量组、空载组、苦参碱高剂量+cGAS过表达组建立椎间盘退变模型;造模1.周后,苦参碱低剂量组、苦参碱高剂量组分别灌胃给予60,1.0 mg/kg苦参碱(1./d),空载组尾静脉注射空载质粒(2次/周),苦参碱高剂量+cGAS过表达组灌胃给予1.0 mg/kg苦参碱+尾静脉注射cGAS过表达质粒,连续治疗3周。给药结束后取材,检测细胞凋亡,活性氧、超氧化物歧化酶、肿瘤坏死因子α及白细胞介素1.水平,以及凋亡蛋白、cGAS-STING通路蛋白表达。结果与结论:①与对照组比较,模型组细胞活性、超氧化物歧化酶水平降低(P1.水平及cGAS、STING、cleaved caspase-3和Bax蛋白表达升高(P<0.05);苦参碱可呈剂量依赖性地改善上述因细胞造模造成的各指标变化(P<0.05),而cGAS过表达可部分拮抗高剂量苦参碱的改善作用。②在动物实验中获得了与体外细胞实验类似的结果。③结果表明,苦参碱可通过阻断cGAS-STING信号传导抑制炎症和氧化应激反应,进而减轻椎间盘退变大鼠髓核细胞凋亡、提升其活性。

关键词：苦参碱 cGAS-STING通路椎间盘退变髓核细胞细胞凋亡

Integrin was involved in the signaling events of GDNF

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Integrin was involved in the signaling events of GDNF

CL-20及其共晶炸药热力学稳定性与爆轰性能的理论研究

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Jun-Ping CAO~1.Jing-Kao YU~1.chong {1.~2,Yu SUN~1.Hong-Hua YUAN~1.Hong-Jun {1.~1.Dian-Shuai GAO~(1.) 1.Research center for Neurobiology,2 Research center for Biochemistry and Molecular Biology,Xuzhou Medical College, Xuzhou 221.02,china

Glial cell line-derived neurotrophic factor(GDNF) is a potent neurotrophic factor for midbrain dopamine(DA) neurons. GDNF exerts its biologic effects through a multi-component receptor system includin

关键词： glial cell line-derived neurotrophic factor integrin dopamine neurons

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含能材料 2018年第6期26卷 464-470页

作者：张蕾赵艳红姜胜利余一王星赵寒月李重阳陈军中国工程物理研究院高性能数值模拟软件中心北京100088 北京应用物理与计算数学研究所北京100088 湘潭大学材料科学与工程学院湖南湘潭411105

基于自主研发的第一性原理软件研究了六硝基六氮杂异伍兹烷(CL-20)炸药五种晶相、苯并三氧化呋咱(BTF)炸药晶体及CL-20/BTF共晶炸药结构的热力学稳定性、力学性能和爆轰性能。研究表明,弱氢键的静电吸引作用使CL-20/BTF共晶的分子间结... 详细信息

基于自主研发的第一性原理软件研究了六硝基六氮杂异伍兹烷(CL-20)炸药五种晶相、苯并三氧化呋咱(BTF)炸药晶体及CL-20/BTF共晶炸药结构的热力学稳定性、力学性能和爆轰性能。研究表明,弱氢键的静电吸引作用使CL-20/BTF共晶的分子间结合能相对于无氢BTF晶体增加39%,提升了共晶结构的热力学稳定性并较大地改变了其体弹模量和声速等力学性能。CL-20/BTF共晶虽与纯BTF晶体有相近的密度,但由于共晶的氧平衡系数得到优化,因此其爆压、爆速分别相对提高约1.%、5%;与β-CL-20晶体相比,共晶的密度与氧平衡均有所下降,因而其爆压、爆速分别相对下降约1.%、6%。设计新型钝感共晶炸药应避免共价键强度极弱的分子和具有高密度振动谱特征峰的结构,应有效利用氢键对分子空间堆积的热力学稳定效应,同时适量控制氢元素含量以保障炸药的高能量密度。

关键词：六硝基六氮杂异伍兹烷(CL-20) 共晶分子相互作用宏观物性爆轰性能