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ATM Activation is Key in Vasculogenic Mimicry Formation by Glioma Stem-like Cells

Biomedical and Environmental Sciences 2024年第8期37卷 834-849页

作者： Jing Xie Jiaxin Tang Yuan li Xue Kong Wei Wang Haibo Wu Department of Pathology the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036AnhuiChina Intelligent Pathology Institute Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230036AnhuiChina

Objective Vasculogenic mimicry(VM)is a novel vasculogenic process integral to glioma stem cells(GSCs)in glioblastoma(GBM).However,the relationship between VM and ataxia-telangiectasia mutated(ATM)serine/threonine kinase activation,which confers chemoradiotherapy resistance,remains *** We investigated VM formation and phosphorylated ATM(pATM)levels by CD31/GFAPperiodic acid-Schiff dual staining and immunohistochemical staining in 145 GBM *** stem-like cells(GSLCs)derived from the formatted spheres of U87 and U251 cell lines and their pATM level and VM formation ability were examined using western blot and three-dimensional *** the examination of the function of pATM in VM formation by GSLCs,ATM knockdown by shRNAs and deactivated via ATM phosphorylation inhibitor KU55933 were *** VM and high pATM expression occurred in 38.5% and 41.8% of tumors,respectively,and were significantly associated with reduced progression-free and overall *** with VM-positive GBMs exhibited higher pATM levels(r_(s)=0.425,P=0.01).The multivariate analysis established VM as an independent negative prognostic factor(P=0.002).Furthermore,GSLCs expressed high levels of pATM and formed vascular-like networks in *** inactivation or knockdown hindered VM-like network formation concomitant with the downregulation of pVEGFR-2,VE-cadherin,and laminin *** VM may predict a poor GBM prognosis and is associated with pATM *** propose that pATM promotes VM through extracellular matrix modulation and VE-Cadherin/pVEGFR-2 activation,thereby highlighting ATM activation as a potential target for enhancing anti-angiogenesis therapies for GBM.

关键词： Glioblastoma Vasculogenic mimicry Ataxia-telangiectasia mutated(ATM) Glioma stem-like cell

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CA IX-targeted Ag_(2)S quantum dots bioprobe for NIR-II imaging-guided hypoxia tumor chemo-photothermal therapy

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Journal of Pharmaceutical Analysis 2024年第6期14卷 878-888页

作者： Xinyue Cui Zhuang Hu Ruihan li Peng Jiang Yongchang Wei Zilin Chen Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University and School of Pharmaceutical SciencesWuhan UniversityWuhan430071China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of EducationHubei Province Engineering and Technology Research Center for Fluorinated PharmaceuticalsWuhan430071China

Hypoxia is the common characteristic of almost all solid tumors,which prevents therapeutic drugs from reaching the ***,the development of new targeted agents for the accurate diagnosis of hypoxia tumors is widely *** carbonic anhydrase IX(CA IX)is abundantly distributed on the hypoxia tumor cells,it is considered as a potential tumor biomarker.4-(2-Aminoethyl)benzenesulfonamide(ABS)as a CA IX inhibitor has inherent inhibitory activity and good targeting *** this study,Ag_(2)S quantum dots(QDs)were used as the carrier to prepare a novel diagnostic and therapeutic bioprobe(Ag_(2)S@polyethylene glycol(PEG)-ABS)through ligand exchange and amide condensation ***_(2)S@PEG-ABS can selectively target tumors by surface-modified ABS and achieve accurate tumor imaging by the near infrared-II(NIR-II)fluorescence characteristics of Ag_(2)S *** modification of Ag_(2)S QDs greatly improves its water solubility and stability,and therefore achieves high photothermal stability and high photothermal conversion efficiency(PCE)of 45.17%.Under laser irradiation,Ag_(2)S@PEG-ABS has powerful photothermal and inherent antitumor combinations on colon cancer cells(CT-26)in *** also has been proved that Ag_(2)S@PEG-ABS can realize the effective treatment of hypoxia tumors in vivo and show good ***,it is a new efficient integrated platform for the diagnosis and treatment of hypoxia tumors.

关键词： CA IX-targeted Hypoxia tumor combination therapy NIR-II imaging Photothermal effect

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A strategy for strengthening chaotic mixing of dual shaft eccentric mixers by changing non-Newtonian fluids kinetic energy distribution

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Chinese Journal of Chemical Engineering 2024年第5期69卷 122-134页

作者： Songsong Wang Tong Meng Qian Zhang Changyuan Tao Yundong Wang Zequan li Zuohua liu School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 400044China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing 400044China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Efficiently modulating the velocity distribution and flow pattern of non-Newtonian fluids is a critical challenge in the context of dual shaft eccentric mixers for process intensification,posing a significant barrier for the existing ***,this work reports a convenient strategy that changes the kinetic energy to controllably regulate the flow patterns from radial flow to axial *** showed that the desired velocity distribution and flow patterns could be effectively obtained by varying the number and structure of baffles to change kinetic energy,and a more uniform velocity distribution,which could not be reached normally in standard baffle dual shaft mixers,was easily ***,a comparative analysis of velocity and shear rate distributions is employed to elucidate the mechanism behind the generation of flow patterns in various dual-shaft eccentric ***,there is little difference in the power number of the laminar flow at the same Reynolds number,meaning that the baffle type has no effect on the power consumption,while the power number of both unbaffle and U-shaped baffle mixing systems decreases compared with the standard baffle mixing system in the transition ***,at the same rotational condition,the dimensionless mixing time of the U-shaped baffle mixing system is 15.3%and 7.9%shorter than that of the standard baffle and the unbaffle mixing system,respectively,which shows the advantage of the U-shaped baffle in stirring rate.

关键词： Dual shaft “U-shaped”baffle Flow pattern Mixing time Power demand

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Synergistic effect of Zr and Mo on precipitation and high-temperature properties of Al-Si-Cu-Mg alloys

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China Foundry 2024年第1期21卷 71-81页

作者： Chao Gao Bing-rong Zhang Yin-ming li Zhi-ming Wang Xiang-bin Meng Faculty of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Hebei Ounai Machinery Mould Co.Ltd. Xingtai 054500HebeiChina

This study focuses on finding a solution to the sharp decline in mechanical properties of Al-Si-Cu-Mg alloys due to rapid coarsening of traditional intermediate phases at high temperature.A new type of modified al oy,to be used in automobile engines at high temperatures,was prepared by adding Zr and Mo into Al-Si-Cu-Mg *** synergistic effects of Zr and Mo on the microstructure evolution and high-temperature mechanical properties were *** show that the addition of Zr and Mo generates a series of intermetallic phases dispersed in the *** can improve the strength of the alloy by hindering dislocation movement and crack *** addition,some nano-strengthened phases show coherent interfaces with the matrix and improve grain *** addition of Mo greatly improves the heat resistance of the *** extremely low diffusivity of Mo enables it to improve the thermal stability of the intermetallic phases,inhibit precipitation during aging,reduce the size of the precipitates,and improve the heat resistance of the alloy.

关键词： Al-Si-Cu-Mg alloy high-temperature properties Zr-Mo-rich intermetallics nano-strengthening phases

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Enhancing microseismic/acoustic emission source localization accuracy with an outlier-robust kernel density estimation approach

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International Journal of Mining Science and Technology 2024年第7期34卷 943-956页

作者： Jie Chen Huiqiong Huang Yichao Rui Yuanyuan Pu Sheng Zhang Zheng li Wenzhong Wang State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Chongqing UniversityChongqing 400044China School of Resources and Safety Engineering Central South UniversityChangsha 410083China Chongqing City Construction Investment Group Co. Ltd.Chongqing 400023China Coal Geological Exploration Institute of Gansu Lanzhou 730000China

Monitoring sensors in complex engineering environments often record abnormal data,leading to significant positioning *** reduce the influence of abnormal arrival times,we introduce an innovative,outlier-robust localization method that integrates kernel density estimation(KDE)with damping linear correction to enhance the precision of microseismic/acoustic emission(MS/AE)source *** approach systematically addresses abnormal arrival times through a three-step process:initial location by 4-arrival combinations,elimination of outliers based on three-dimensional KDE,and refinement using a linear correction with an adaptive damping *** validate our method through lead-breaking experiments,demonstrating over a 23%improvement in positioning accuracy with a maximum error of 9.12 mm(relative error of 15.80%)—outperforming 4 existing *** under various system errors,outlier scales,and ratios substantiate our method’s superior *** blasting experiments also confirm the practical applicability,with an average positioning error of 11.71 m(relative error of 7.59%),compared to 23.56,66.09,16.95,and 28.52 m for other *** research is significant as it enhances the robustness of MS/AE source localization when confronted with data *** also provides a practical solution for real-world engineering and safety monitoring applications.

关键词： Microseismic source/acoustic emission(MS/AE) Kernel density estimation(KDE) Damping linear correction Source location Abnormal arrivals

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Selenium nanoparticles biosynthesized by Eurotium cristatum with antimicrobial activity

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Food Science and Human Wellness 2024年

作者： Nanyang li Yanru Yang Jianrui Qi Jiahui li Yifan Cheng Zhao li Tianli Yue Yahong Yuan College of Food Science and Engineering， Northwest A&F University College of Food Science and Technology， Northwest University Xi'an College of Bioengineering and Biotechnology， Tianshui Normal University

Selenium nanoparticles (SeNPs) are increasingly recognized for their exceptional antibacterial properties. This study aimed to develop a green， safe， and efficient method for the biosynthesis of SeNPs using the fungus Eurotium cristatum (E. cristatum)， a novel approach in SeNP synthesis. The process yielded (36.4 ± 4.22) mg of SeNPs per 1.2 mmol/L sodium selenite supplementation. These SeNPs exhibited an average diameter of 231.7 nm and a negative charge， and they remained stable when stored at 4℃. UV-vis revealed a maximum absorption peak at 212 nm， suggesting effective nanoparticle formation. FT-IR indicated that proteins and carbohydrates in the mycelium contributed to the SeNP synthesis. Concentrations of SeNPs below 50 μg Se/mL did not exhibit cytotoxic effects on the growth and proliferation of human hepatocyte L-02 cells. The minimum inhibitory concentration of SeNPs was found to be 2 mg/mL against both Methicillin-resistant Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative). The SeNPs compromised the cellular integrity of test strains， causing leakage of intracellular contents and disruption of the oxidative stress system， leading to irreversible damage. Our results demonstrate the potential of SeNPs biosynthesized by E. cristatum to act as effective antibacterial agents， signifying a novel and promising approach to developing natural antimicrobial solutions.

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Uncertainty quantification of inverse analysis for geomaterials using probabilistic programming

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 895-908页

作者： Hongbo Zhao Shaojun li Xiaoyu Zang Xinyi liu lin Zhang Jiaolong Ren School of Civil Engineering and Geomatics Shandong University of TechnologyZibo255000China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

Uncertainty is an essentially challenging for safe construction and long-term stability of geotechnical *** inverse analysis is commonly utilized to determine the physico-mechanical ***,conventional inverse analysis cannot deal with uncertainty in geotechnical and geological *** this study,a framework was developed to evaluate and quantify uncertainty in inverse analysis based on the reduced-order model(ROM)and probabilistic *** ROM was utilized to capture the mechanical and deformation properties of surrounding rock mass in geomechanical *** programming was employed to evaluate uncertainty during construction in geotechnical engineering.A circular tunnel was then used to illustrate the proposed framework using analytical and numerical *** results show that the geomechanical parameters and associated uncertainty can be properly obtained and the proposed framework can capture the mechanical behaviors under ***,a slope case was employed to demonstrate the performance of the developed *** results prove that the proposed framework provides a scientific,feasible,and effective tool to characterize the properties and physical mechanism of geomaterials under uncertainty in geotechnical engineering problems.

关键词： Geological engineering Geotechnical engineering Inverse analysis Uncertainty quantification Probabilistic programming

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Delta Compression Correction Method for Covert Communication in IoT

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China Communications 2024年第9期21卷 60-74页

作者： Hu Zhijuan liu Shuangyu Xu Fei liu liqiang li Guiping School of Computer Science and Engineering Xi’an Technological UniversityXi’an 710021China

Covert communication can conceal the existence of wireless transmission and thus has the ability to address information security transfer issue in many applications of the booming Internet of Things(IoT).However,the proliferation of sensing devices has generated massive amounts of data,which has increased the burden of covert *** the spatiotemporal correlation of data collection causing redundancy between data,eliminating duplicate data before transmission is beneficial for shortening transmission time,reducing the average received signal power of warden,and ultimately realizing covert *** this paper,we propose to apply delta compression technology in the gateway to reduce the amount of data generated by IoT devices,and then sent it to the cloud *** this end,a cost model and evaluation method that is closer to the actual storage mode of computer systems is been *** on which,the delta version sequence obtained by existing delta compression algorithms is no longer compact,manifested by the still high *** this situation,we designed the correction scheme based on instructions merging(CSIM)correction to save costs by merging ***,the delta version sequence is divided into five categories and corresponding merge rules were ***,for any COPY/ADD class delta compression algorithm,merge according to strict to relaxed to selection rules while generating ***,a more cost-effective delta version sequence can be *** experimental results on random data show that the delta version sequences output by the CSIM corrected 1.5-pass and greedy algorithms have better performance in cost reducing.

关键词： correction method covert communica-tion delta compression Internet of Things(IoT)

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Using restored two-dimensional X-ray images to reconstruct the three-dimensional magnetopause

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Earth and Planetary Physics 2024年第1期8卷 133-154页

作者： RongCong Wang JiaQi Wang Dalin li TianRan Sun XiaoDong Peng YiHong Guo National Space Science Center Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing100049China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China

Astronomical imaging technologies are basic tools for the exploration of the universe,providing basic data for the research of astronomy and space *** Soft X-ray Imager(SXI)carried by the Solar wind Magnetosphere Ionosphere link Explorer(SMILE)aims to capture two-dimensional(2-D)images of the Earth’s magnetosheath by using soft X-ray ***,the observed 2-D images are affected by many noise factors,destroying the contained information,which is not conducive to the subsequent reconstruction of the three-dimensional(3-D)structure of the *** analysis of SXI-simulated observation images shows that such damage cannot be evaluated with traditional restoration *** makes it difficult to establish the mapping relationship between SXIsimulated observation images and target images by using mathematical *** propose an image restoration algorithm for SXIsimulated observation images that can recover large-scale structure information on the *** idea is to train a patch estimator by selecting noise–clean patch pairs with the same distribution through the Classification–Expectation Maximization algorithm to achieve the restoration estimation of the SXI-simulated observation image,whose mapping relationship with the target image is established by the patch *** Classification–Expectation Maximization algorithm is used to select multiple patch clusters with the same distribution and then train different patch estimators so as to improve the accuracy of the *** results showed that our image restoration algorithm is superior to other classical image restoration algorithms in the SXI-simulated observation image restoration task,according to the peak signal-to-noise ratio and structural *** restoration results of SXI-simulated observation images are used in the tangent fitting approach and the computed tomography approach toward magnetospheric reconstruction techniques,significantly improving

关键词： Solar wind Magnetosphere Ionosphere link Explorer(SMILE) soft X-ray imager magnetopause image restoration

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Biochanin A attenuates spinal cord injury in rats during early stages by inhibiting oxidative stress and inflammasome activation

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Neural Regeneration Research 2024年第9期19卷 2050-2056页

作者： Xigong li Jing Fu Ming Guan Haifei Shi Wenming Pan Xianfeng Lou Department of Orthopedics The First Affiliated Hospital of Zhejiang UniversityHangzhouZhejiang ProvinceChina Department of Stomatology Xixi HospitalHangzhouZhejiang ProvinceChina Department of Orthopedics and Spine Surgerythe Affiliated Hospital of Xuzhou Medical Schoolthe Second People’s Hospital of ChangshuChangshuJiangsu ProvinceChina

Previous studies have shown that Biochanin A,a flavonoid compound with estrogenic effects,can serve as a neuroprotective agent in the context of cerebral ischemia/reperfusion injury;howeve r,its effect on spinal cord injury is still unclea r. In this study,a rat model of spinal cord injury was established using the heavy o bject impact method,and the rats were then treated with Biochanin A(40 mg/kg) via intrape ritoneal injection for 14 consecutive *** res ults showed that Biochanin A effectively alleviated spinal cord neuronal injury and spinal co rd tissue injury,reduced inflammation and oxidative stress in spinal cord neuro ns,and reduced apoptosis and *** addition,Biochanin A inhibited the expression of inflammasome-related proteins(ASC,NLRP3,and GSDMD)and the Toll-like receptor 4/nuclear factor-κB pathway,activated the Nrf2/heme oxygenase 1 signaling pathway,and increased the expression of the autophagy markers LC3 Ⅱ,Beclin-1,and *** r,the therapeutic effects of Biochanin A on early post-s pinal cord injury were similar to those of *** findings suggest that Biochanin A protected neurons in the injured spinal cord through the Toll-like receptor 4/nuclear factor κB and Nrf2/heme oxygenase 1 signaling *** findings suggest that Biochanin A can alleviate post-spinal cord injury at an early stage.

关键词： apoptosis autophagy Biochanin A heme oxygenase 1 inflammation Nrf2 protein nuclear factor kappa-B oxidative stress spinal cord injury Toll-like receptor 4

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