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PFOA和PFOS对青海弧菌Q67的毒性作用评估

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桂林理工大学学报 2015年第1期35卷 121-125页

作者：刘红艳秦光军莫凌云易忠胜李子院张飞桂林理工大学化学与生物工程学院广西桂林541004

以淡水发光菌——青海弧菌(Vibrio qinghaiensis sp.-Q67)为检测生物,应用VeritasTM微板光度计分别测定了全氟辛酸(PFOA)和全氟辛烷磺酸(PFOS)对Q67的毒性效应。结果表明:全氟辛酸为典型的S型剂量-效应关系,利用Weibull非线性函数进行... 详细信息

以淡水发光菌——青海弧菌(Vibrio qinghaiensis sp.-Q67)为检测生物,应用VeritasTM微板光度计分别测定了全氟辛酸(PFOA)和全氟辛烷磺酸(PFOS)对Q67的毒性效应。结果表明:全氟辛酸为典型的S型剂量-效应关系,利用Weibull非线性函数进行曲线模拟,模拟函数可以有效估计化合物的半抑制毒性效应值EC50。全氟辛烷磺酸对Q67的毒性为非单调的U型剂量-效应关系,运用最优权重理论和三次曲线回归方法,通过SPSS统计软件对剂量-效应曲线进行拟合,得到其三次回归曲线方程。结果表明:在浓度介于(5.031E-4)^(7.133E-3)mol/L,全氟辛烷磺酸对Q67毒性效应为自稳态区域,表现为Q67的发光强度增强,即在低浓度作用条件下,PFOA对Q67的毒性表现为抑制作用,而PFOS则表现为刺激兴奋作用。

关键词：全氟辛酸全氟辛烷磺酸青海弧菌剂量-效应最优权重

基于孟德尔随机化的血脂六项与冠心病因果关系研究

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现代预防医学 2023年第10期50卷 1736-1742+1753页

作者：王浩桦丁子琛包绮晗周立文李承圣王廉源丛慧文杨毅王素珍石福艳潍坊医学院公共卫生学院

目的探究血脂六项指标(甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白、载脂蛋白A、载脂蛋白B)与冠心病之间的因果关系，为血脂六项指标与冠心病发病风险关联提供遗传学证据支持。方法研究采用MR-Egger回归、加权中位数法(weight m... 详细信息

目的探究血脂六项指标(甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白、载脂蛋白A、载脂蛋白B)与冠心病之间的因果关系，为血脂六项指标与冠心病发病风险关联提供遗传学证据支持。方法研究采用MR-Egger回归、加权中位数法(weight median estimator, WME)、随机效应逆方差加权法(inverse-variance weighted, IVW)、加权模型4种回归模型对血脂六项指标与冠心病的因果关系进行孟德尔随机化分析。结果 IVW模型显示甘油三酯(OR=1.402)、总胆固醇(OR=1.414)、低密度脂蛋白(OR=1.867)、载脂蛋白B(OR=1.738)为冠心病的危险因素，高密度脂蛋白(OR=0.791)为冠心病的保护因素，IVW模型则显示载脂蛋白A为有统计学意义的影响因素；MR-Egger回归截距项P值均>0.05,即筛选出的SNP不存在基因多效性，因此孟德尔随机化在本研究中为因果推断的有效方法；异质性检验结果P值均<0.001,故应重点关注随机效应IVW模型。结论利用两样本孟德尔随机化方法排除混杂因素和反向因果关联后，得到无偏估计的结果，据此可以确定甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白、载脂蛋白B与冠心病之间存在因果关系。

关键词：血脂指标冠心病因果推断孟德尔随机化

Sc，Gd和Lu-配合物的有机电致发光及光伏特性研究

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功能材料 2008年第9期39卷 1418-1419页

作者：王丹李文连初蓓苏子生李天乐苏文明朱健卓毕德峰陈一仁杨栋芳张东煜颜飞中国科学院长春光学精密机械与物理研究所激发态物理重点实验室

研究了稀土(RE)配合物(RE=Sc、Gd或Lu)(RE-配合物中的RE离子为三价离子)的有机二极管,在电驱动和紫外光照射下分别表现出电致发光(EL)和光伏(PV)特性。作为EL二极管时,m-MT-DATA(4,4′,4-″tris[3-methyl-pheny(phenyl)-amino]triphenyl-amine)和稀土配合物分别用作空穴和电子传输材料,EL发射仅仅来自m-MTDATA和稀土配合物层间界面激基复合物,当配合物的中心金属分别为Sc、Gd或Lu时,EL发射峰分别为656、607~590nm。作为PV二极管时,m-MTDATA和稀土配合物分别作为电子给体(D)和受体(A),它们的开路电压(Voc)分别为1.17、1.65和1.92V。还讨论了EL和PV特性与配合物中中心稀土离子的核电荷数关系。

关键词：有机电致发光光伏稀土离子配合物

甲磺酸帕珠沙星注射液健康人体单次给药的药动学研究

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中国新药杂志 2006年第10期15卷 821-824页

作者：王进肖永红吕媛康子胜张明刘燕夏亚红李天云北京大学第一医院临床药理研究所北京100083

目的:研究甲磺酸帕珠沙星注射液在健康人体内单次给药的药动学特征。方法:12例受试者按拉丁法随机分为三组,先后静脉点滴甲磺酸帕珠沙星注射液250,500,750 mg,采用高效液相色谱法测定给药后不同时间的血、尿浓度,计算主要药动学参数。结... 详细信息

目的:研究甲磺酸帕珠沙星注射液在健康人体内单次给药的药动学特征。方法:12例受试者按拉丁法随机分为三组,先后静脉点滴甲磺酸帕珠沙星注射液250,500,750 mg,采用高效液相色谱法测定给药后不同时间的血、尿浓度,计算主要药动学参数。结果:受试者静脉点滴250,500,750 mg的甲磺酸帕珠沙星后,C_(max)分别是(7．23±1．56),(13．50±2．15)和(21．97±3．62)mg·L^(-1);AUC_(0-∞)分别为(17．72±3．91),(35．92±5．71)和(61．23±18．08)mg·L^(-1)·h;t_(1/2)β为(2．03±0．12),(2．06±0．30)和(1．99±0．26)h;CL为(15．63±2．99),(14．76±2．63)和(13．22±3．03)L·h^(-1)·kg^(-1);V_1为(16．48±5．65),(17．29±9．01)和(14．87±8．04)L,除C_(max)和AUC_(0-∞)外,其他参数3个剂量组之间的差异经统计学处理无显著性差异(P＞0．05)。250,500和750 mg的甲磺酸帕珠沙星静脉点滴12 h后尿中原形药物累积排泄百分率分别为(93．85±1．71)%,(93．14±1．82)%和(93．24±1．74)%,表明给药后有＞90%的药物以原形从尿中排出。结论:根据药动学参数计算,结合体外抗菌活性结果,认为采用bid,每次静脉点滴帕珠沙星500 mg的给药方式,预期对临床常见细菌感染能够取得良好的疗效。

关键词：甲磺酸帕珠沙星注射液药动学高效液相色谱法

Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao Song Chen yan-Fen Chai Xiao-Hui Chen Yu-Guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding yang Deng Jie Fu Bang-Jiang Fang Mai-ying Fan li Gui Ping Gong Wei Guo Shu-Bin Guo liang Huang Ji-yuan Han Zhong Ji Xian-Fei Ji Xin-Cai Ji Hong-Xu Jin Xin-Jun Jiang Wang-Xiang Jiang Jia-liang liu Xiao-Ran liu Zhi liu Chuan-Zhu Lv Feng Lu Tan-Shi li Xin li Yong li Shang-Lun li Shuang-Ming li Xiao-Gang li Bao-Jun li Pei-Wu li Chun-sheng li Zhi-Jun li Chang-Luo li Xiang-Min li yin-Ping li Zong-Jun Lu Zu-Xun Lu Zhong-Qiu Lu Zhi-Qian Luo Xiao-Xing liao Jian-Bo Lei Tao Ma Yu Ma Yue-Feng Ma Qing-Bian Ma lin-Hao Ma Jun-Qi Ma Shi-Nan Nie Jie-Miao Ou-yang Peng Peng Qiao Pei Shu-Ming Pan Guo-Zhong Qing li-Jie Qin Wu-ying Qiao Fei Shao Wei Song Xing-Yue Song Zhen-Ju Song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao Guo-Gang tian ying-Ping tian Jian-Guang tian Chao-yang Tong zi-Ren Tang Meng-Xiong Tang Guo-Ping Wu Zhi Wan Tao Wang Xin Wang Peng Wang Zhong Wang Tong Wang Ri-Xing Wang yi-Xin Wang Xiao-Dan Wang ling Wu Wei Wei Hua Xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu Wen yi li-Shan yang Shi-Jiao yan Jin-Jian Yao Shou-Chun yan Xue-Zhong Yu Xian-Zhi Ye Xian-liang yan Fu-Bing zhou Rong-Bin zhou Ming zhou Qiang zhou Jin zhou Ping zhou Chang-Ju Zhu Hua-Dong Zhu Ji-Hong Zhu Hong Zhang Mao Zhang Hua Zhang Na Zhang Guo-Qiang Zhang Guo-Xiu Zhang Jin-Song Zhang Wen-Wu Zhang Wen-Zhong Zhang Jian-Feng Zhang yi-Min Zhu Jun Zeng yuan Zheng Zhi-Jie Zheng Shen Zhao yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of hainan Trauma and Disaster Rescue Key Laboratory of Trauma of hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

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单次注射比阿培南在健康人体的药代动力学

中国临床药理学杂志 2012年第3期28卷 171-174页

作者：朱燕肖永红吕媛魏敏吉张朴康子胜刘燕梁军张薇张曼李天云北京大学第一医院临床药理研究所北京100034

目的研究注射用比阿培南(碳青霉烯类抗生素)在健康人群单次给药药代动力学。方法用分层随机、三交叉、拉丁方设计、空腹给药的试验方法,12名健康受试者单次静脉滴注比阿培南150,300,600 mg,HPLC法测定给药后血、尿药物浓度,DAS软件计算... 详细信息

目的研究注射用比阿培南(碳青霉烯类抗生素)在健康人群单次给药药代动力学。方法用分层随机、三交叉、拉丁方设计、空腹给药的试验方法,12名健康受试者单次静脉滴注比阿培南150,300,600 mg,HPLC法测定给药后血、尿药物浓度,DAS软件计算药代动力学参数。结果受试者静滴比阿培南150,300,600 mg后药代动力学参数如下,Cmax分别是(8.49±1.03),(16.31±1.83),(34.51±3.74)mg.L-1;Tmax均为(1.00±0.00)h;t1/2β分别为(1.08±0.80),(0.89±0.14),(0.93±0.08)h;AUC0-t分别(13.49±2.29),(28.91±4.92),(60.85±8.72)mg.L-1.h;CL分别是(11.09±1.58),(10.54±1.85),(9.98±1.39)***-1。12 h尿排出率分别为61.9%,62.1%,62.8%。结论注射用比阿培南药代动力学符合二室开放模型,药代动力学参数与剂量呈线性相关,受试者耐受性良好。

关键词：注射用比阿培南药代动力学高效液相色谱法

基于硬脆材料加工的金刚石涂层硬质合金刀具制备及切削性能研究

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稀有金属与硬质合金 2018年第4期46卷 78-82,86页

作者：陆峰查丽琼刘鲁生王宜豹袁子尧闫广宇黄楠沈阳建筑大学机械工程学院辽宁沈阳110000 中国科学院金属研究所沈阳材料科学国家(联合)实验室辽宁沈阳110000 长安大学材料科学与工程学院陕西西安710000

利用热丝化学气相沉积法,在硬质合金球头铣刀表面制备出不同碳源浓度的金刚石涂层,研究了碳源浓度对金刚石涂层微观结构及刀具切削性能的影响。利用扫描电子显微镜、拉曼光谱吸收仪和X射线衍射仪分析了刀具表面金刚石涂层的表面形貌、... 详细信息

利用热丝化学气相沉积法,在硬质合金球头铣刀表面制备出不同碳源浓度的金刚石涂层,研究了碳源浓度对金刚石涂层微观结构及刀具切削性能的影响。利用扫描电子显微镜、拉曼光谱吸收仪和X射线衍射仪分析了刀具表面金刚石涂层的表面形貌、组成成分和晶粒取向,并利用制备的金刚石涂层铣刀进行石材加工实验。结果表明:与2%、3%碳源浓度相比,1%碳源浓度所制备金刚石涂层的晶粒尺寸较大,微米级金刚石晶型完整;3%碳源浓度金刚石涂层表面生成了大量纳米金刚石晶粒。碳源浓度为3%的金刚石涂层铣刀的后刀面磨损量最大,而1%碳源浓度金刚石涂层铣刀的涂层与基体结合力高,铣刀后刀面磨损量最小,金刚石涂层未明显剥落,切削寿命最长。

关键词：金刚石涂层硬质合金刀具热丝化学气相沉积碳源浓度切削性能石材

The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： Xiao Chen Bin Lu Hui-Xian li Xue-ying li Yu-Wei Wang Francisco Xavier Castellanos li-Ping Cao Ning-Xuan Chen Wei Chen Yu-Qi Cheng Shi-Xian Cui Zhao-Yu Deng yi-Ru Fang Qi-Yong Gong Wen-Bin Guo Zheng-Jia-yi Hu li Kuang Bao-Juan li Le li Tao li Tao lian yi-Fan liao yan-Song liu Zhe-Ning liu Jian-Ping Lu Qing-Hua Luo Hua-Qing Meng Dai-Hui Peng Jiang Qiu Yue-Di Shen tian-Mei Si yan-Qing Tang Chuan-Yue Wang Fei Wang Hua-Ning Wang Kai Wang Xiang Wang ying Wang zi-Han Wang Xiao-Ping Wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-Feng Xu Hong yang Jian yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui yuan Ke-Rang Zhang Wei Zhang Zhi-Jun Zhang Jun-Juan Zhu Xi-Nian Zuo Jing-Ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing Hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

Reciprocating Magnetic Fields in the Pulsar Wind Observed from the Black Widow Pulsar J1720-0534

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Research in Astronomy and Astrophysics 2023年第10期23卷 255-266页

作者： Chen-Chen Miao Victoria Blackmon Wei-Wei Zhu Dong-zi li Ming-Yu Ge Xiao-Peng You Maura McLaughlin Di li Na Wang Pei Wang Jia-Rui Niu M.Cruces Jian-Ping yuan Jun-Tao Bai D.J.Champion Yu-Tong Chen Ming-Min Chi P.C.C.Freire yi Feng Zhen-Ye Gan M.Kramer Fei-Fei Kou Yu-Xi li Xue-li Miao ling-Qi Meng Chen-Hui Niu sheng-Nan Sun Zhong-yi Sun H.M.Tedila Shuang-Qiang Wang Qing-Dong Wu Jing-Bo Wang Zhi-Gang Wen Shen Wang Ya-Biao Wang Cheng-Jie Wang Meng-Yao Xue You-ling Yue Mao yuan Ju-Mei Yao Wen-Ming yan Ru-Shuang Zhao Lei Zhang De Zhao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China West Virginia University 1500 University AveMorgantownWV 26506USA Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Cahill Center for Astronomy and Astrophysics California Institute of Technology1216 E California BoulevardPasadenaCA 91125USA Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physical Science and Technology Southwest UniversityChongqing 400715China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Max-Planck Institut für Radioastronomie Auf dem Hügel 69D-53121 BonnGermany School of Computer Science Fudan UniversityShanghai 200433China Tencent Youtu Lab Shanghai 200233China College of Physical Science and Technology Central China Normal UniversityWuhan 430079China Institute of Optoelectronic Technology Lishui UniversityLishui 323000China Guizhou Normal University Guiyang 550001China

We report the radio observations of the eclipsing black widow pulsar J1720-0534, a 3.26 ms pulsar in orbit with a low mass companion of mass 0.029 to 0.034 M⊙. We obtain the phase-connected timing ephemeris and polarization profile of this millisecond pulsar(MSP) using the Five-hundred-meter Aperture Spherical radio Telescope(FAST), the Green Bank Telescope(GBT), and the Parkes Telescope. For the first time from such a system, an oscillatory polarization angle change was observed from a particular eclipse egress with partial depolarization, indicating 10-milliGauss-level reciprocating magnetic fields oscillating in a length scale of 5 ×10^(3)km(assuming an orbital inclination angle of 90°) outside the companion's magnetosphere. The dispersion measure variation observed during the ingresses and egresses shows the rapid raising of the electron density in the shock boundary between the companion's magnetosphere and the surrounding pulsar wind. We suggest that the observed oscillatory magnetic fields originate from the pulsar wind outside the companion's magnetosphere.

关键词： (stars:)pulsars:general (stars:)pulsars:individual(J1720-0534) (stars:)binaries:eclipsing