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Dual-responsive fiber-reinforced hydrogel actuators by direct ion patterning

Nano Research 2023年第12期16卷 13381-13391页

作者： Mingyuan Zhao Dong Han Yuan Meng Jing liu Yuting Zhu zhongxian li Kai li Wentao liu Zhuo Ao CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China College of life Sciences Beijing University of Chinese MedicineBeijing 100029China

Nature inspired deformable heterogeneous smart hydrogels have attracted much attention in many fields such as biomedicine devices and soft ***,normal spatial heterogeneous hydrogel structures can only respond to single factor and take one action as set in ***,we report a pre-stretched metal-liganded shape memory hydrogel with fiber reinforced,P(AAc-co-AAm)/CCNFs-Fe3+(CCNFs:carboxylated cellulose nanofibers,AAc:acrylic acid,AAm:acrylamide),which can conduct shape deformation by solvent induction and ultraviolet(UV)*** deformation pattern could be programmed by the deposing of ferroin ***,the pre-stretched shape memory hydrogels could effectively produce cyclic actuation or complex shape actuation by UV *** importantly,combining the solvent response with the light response enabled complex reversible actuations,such as simulating the bending and unfolding of *** addition of CCNFs significantly enhanced the mechanical properties of the *** hydrogels with 3 wt.%CCNFs showed an elongation at break of about 500%and a significant increase in tensile strength of 8.7-fold to 1.55 MPa after coordination with metal ions,which was able to meet the mechanical requirements of the bionic actuated *** work demonstrated that combining light-programmed and light-responsive shape-memory hydrogels,complemented by another independent response property,could achieve complex and reversible programmed actuations.

关键词： dual responsive hydrogel shape deformation metal ion pattern carboxylated cellulose nanofibers(CCNFs) light induction

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Chinese Medical Journal 2023年第10期136卷 1258-1260页

作者： Yujie Weng Rong Jia zhongxian li Wei liang Yucheng Ji Ying liang Pengfei Ning College of Computer and Information Inner Mongolia Medical UniversityHohhotInner Mongolia Autonomous Region 010110China

To the Editor:Breast cancer is one of the malignant diseases that cause death in women and is a severe threat to women’s *** the progress of medical treatment,there are many methods to treat breast cancer,such as drug therapy and hormone *** them,molecular targeted therapy has dramatically improved the treatment effect of breast ***,it is vital to find important molecular markers.[1]Breast cancer can be divided into four subtypes:triple-negative(TN),lumA,lumB,and HER2+.[2]HER2+breast cancer accounts for 15–20%of breast cancers,with a higher grade,a more aggressive phenotype,and a worse prognosis.

关键词： breast HER2 Breast

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丙烯酸酯增深剂的制备及在涤纶织物中的应用

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印染 2024年第1期50卷 57-61页

作者：刘小培王俊伟董学亮张彦昌靳瑞文宋跃李中贤河南省科学院高新技术研究中心河南省精细化工重点实验室河南郑州450002 河南省科学院河南郑州450046

利用乳液聚合法制备丙烯酸酯增深剂,并用于阿拉伯国家专用黑色涤纶织物增深整理。当增深剂质量浓度为40 g/L,焙烘温度为140℃,焙烘时间为3 min时,整理织物的增深比达39.46%,撕裂强力、耐摩擦和耐皂洗色牢度无明显变化,织物表面被一层颗... 详细信息

利用乳液聚合法制备丙烯酸酯增深剂,并用于阿拉伯国家专用黑色涤纶织物增深整理。当增深剂质量浓度为40 g/L,焙烘温度为140℃,焙烘时间为3 min时,整理织物的增深比达39.46%,撕裂强力、耐摩擦和耐皂洗色牢度无明显变化,织物表面被一层颗粒状微球组成的膜状物包覆,织物表面C元素质量分数从73.22%减少到70.17%,O元素质量分数从26.78%减少到25.44%,新引入了4.39%N元素。

关键词：增深剂丙烯酸酯涤纶织物

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Thoracic interstitial injection of drug-liposomes in mice for treating atherosclerosis

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Nano Research 2023年第4期16卷 5311-5321页

作者： Tun Yan Huizhen Sun Yahong Shi Ya Gao Xi Lu Kai li Yuting Zhu Qiang Zhang Tingting li zhongxian li Xiaohan Zhou Yuting Guo Yinglu Ji Xiaoli Shi Dong Han College of life Science Beijing University of Chinese MedicineBeijing 100029China CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China College of Pharmacy Baotou Medical CollegeBaotou 10040China Hebei Key Laboratory of Nanobiotechnology Yanshan UniversityQinhuangdao 066004China University of Chinese Academy of Sciences Beijing 100049China

Intervaginal space injection(ISI)is a novel mode of administration investigated over the last *** injecting nanoparticles into the intervaginal space,they can be transported along low flow resistance channels into the interstitial *** transport has a certain delivery direction,and site-specific injection can work on specific organs or *** this study,the thorax,a new ISI site in the interstitial surrounding the internal thoracic artery named the thoracic interstitial injection(tISI)was *** prove the targeting ability of the tISI,two sizes of gold nanoparticles(AuNPs)(47 and 87 nm)were administered to *** 1 h,the biodistribution of AuNPs in the tissues was measured via single particle inductively coupled plasma mass spectrometry(spICP-MS).The results showed that the concentration of AuNPs in the aorta after tISI injection was significantly higher than that after intravenous ***,fewer nanoparticles with larger particle sizes were observed to have entered the blood and were better targeted to the ***,tanshinone IIa sodium sulfonate liposomes were administered for the treatment of aortic *** proportion of aortic plaques in atherosclerotic Apoe-/-mice administered via tISI was significantly lower than that in other model animals(P<0.001).Furthermore,the proteoglycan content and CD68-positive cell count in the plaques were significantly *** vascular elastic fibers at the plaque site were thickened,and fractures were *** was,therefore,determined to be an effective strategy for the treatment of atherosclerotic aortic plaques.

关键词： thoracic intervaginal space injection(tISI) gold nanoparticle(AuNP) tanshinone IIa sodium sulfonate liposome atherosclerosis adventitia

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疏肝调神针刺法治疗肝郁气滞型广泛性焦虑障碍40例

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中国针灸 2024年第5期44卷 546-548页

作者：周夏芸张潘胡零三陈锐明石国傲周逸夫吉祥李仲贤阎路达周鹏广州中医药大学第七临床医学院广东深圳518100 深圳市宝安区中医院针灸科广东深圳518100 深圳市宝安区针灸临床研究中心广东深圳518100 深圳市政府“医疗卫生三名工程”广东省中医院符文彬教授团队深圳518100

目的:观察疏肝调神针刺法治疗肝郁气滞型广泛性焦虑障碍的临床疗效。方法:纳入肝郁气滞型广泛性焦虑障碍患者40例,采用疏肝调神针刺法(百会、印堂、合谷、太冲、引气归元)治疗,每次30 min,每日1次,每周连续治疗3次,共治疗8周。分别于治... 详细信息

目的:观察疏肝调神针刺法治疗肝郁气滞型广泛性焦虑障碍的临床疗效。方法:纳入肝郁气滞型广泛性焦虑障碍患者40例,采用疏肝调神针刺法(百会、印堂、合谷、太冲、引气归元)治疗,每次30 min,每日1次,每周连续治疗3次,共治疗8周。分别于治疗前,治疗4、8周后,治疗结束后4周(随访)评定患者汉密尔顿焦虑量表(HAMA)评分、焦虑自评量表(SAS)评分;分别于治疗前后检测血清谷氨酸(Glu)、γ-氨基丁酸(GABA)和5-羟色胺(5-HT)水平,测定大脑皮层静息运动阈值(rMT),评定中医证候评分;并于随访时评定临床疗效。结果:治疗4、8周后及随访时,患者HAMA、SAS评分均较治疗前降低(P<0.001),且后一时间点评分均低于前一时间点(P<0.001)。与治疗前比较,患者治疗后血清Glu水平、rMT值、中医证候评分降低(P<0.001,P<0.05),血清GABA、5-HT水平升高(P<0.001,P<0.01)。随访时,总有效率为90.0%(36/40)。结论:疏肝调神针刺法能有效改善广泛性焦虑障碍患者的临床症状,近远期疗效稳定。

关键词：广泛性焦虑障碍,肝郁气滞针刺疏肝调神

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Simplified Analysis for Reflective Overpressure on Walls of Rectangle-Section Tunnel due to Its Inner-Explosion

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Transactions of Tianjin University 2008年第5期14卷 363-370页

作者：田力李忠献周清 School of Civil Engineering Tianjin University

Based on the constructing thought of the displacement model of isoparametric finite element, an extended interpolating algorithm is deduced for calculating the overpressure history of an optional point on the walls of the rectangle-section tunnel under an optional point-explosion in its internal space. According to the working principle, the overpressure histories of all nodes on the walls of a tunnel with the equal width and height of 2 m, induced by a reference-charge explosion at each node in this tunnel's cross section, are computed using the LS-DYNA software, and then are gathered to establish a reference database, which makes it possible to set optionally the positions of the explosive and the overpressure-observed point. In addition, some variation factors of peak values and durations of overpressure on the walls, reflecting some changes on the charge weight and the sizes of width and height of the section, are included in this algorithm in order to simulate approximately the overpressure responses on the walls under the optional charge weight and cross-section size. Some example analyses indicate the rapidity and validity of this method, and therefore this will bring it a good prospect in engineering application.

关键词： rectangle-section tunnel reference database explosion overpressure charge weight

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Catalytic oxidation of toluene by manganese oxides:Effect of K^(+)doping on oxygen vacancy

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Journal of Environmental Sciences 2024年第8期142卷 43-56页

作者： Zhenzhen Huang Haiyang li Xuejun Zhang Yanli Mao Yinghan Wu Wei liu Hongrun Gao Mengru Zhang zhongxian Song Faculty of Environmental and Municipal Engineering Henan Key Laboratory of Water Pollution Control and Rehabilitation TechnologyHenan University of Urban ConstructionPingdingshan 467036China College of Environmental and Safety Engineering Shenyang University of Chemical TechnologyShenyang 110142China

Alkali metal potassium was beneficial to the electronic regulation and structural stability of transition metal ***,K ions were introduced into manganese oxides by different methods to improve the degradation efficiency of *** results of activity experiments indicated that KMnO_(4)-HT(HT:Hydrothermal method)exhibited outstanding low-temperature catalytic activity,and 90%conversion of toluene can be achieved at 243℃,which was 41℃and 43℃lower than that of KNO_(3)-HT and Mn-HT,*** largest specific surface area was observed on KMnO_(4)-HT,facilitating the adsorption of *** formation of cryptomelane structure over KMnO_(4)-HT could contribute to higher content of Mn^(3+)and lattice oxygen(Olatt),excellent low-temperature reducibility,and high oxygen mobility,which could increase the catalytic ***,two distinct degradation pathways were ***Ⅰ(KMnO_(4)-HT):toluene→benzyl→benzoic acid→carbonate→CO_(2)and H2O;PathwayⅡ(Mn-HT):toluene→benzyl alcohol→benzoic acid→phenol→maleic anhydride→CO_(2)and *** intermediates were detected on KMnO_(4)-HT,indicating its stronger oxidation capacity of toluene,which was originated from the doping of K^(+)and the interaction between *** intermediates were observed on Mn-HT,which can be attributed to the weaker oxidation ability of pure *** results indicated that the doping of K^(+)can improve the catalytic oxidation capacity of toluene,resulting in promoted degradation of intermediates during the oxidation of toluene.

关键词： Catalytic oxidation Preparation method Cryptomelane Mn^(3+)and lattice oxygen

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符文彬教授从阳论治焦虑相关性失眠经验撷要

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针灸临床杂志 2024年第7期40卷 92-96页

作者：吉祥李仲贤陈锐明石国傲阎路达周鹏符文彬广州中医药大学第七临床医学院深圳市宝安区中医院广东深圳518133 广东省中医院广东广州510120

本研究介绍符文彬教授运用精灸技术治疗焦虑相关性失眠的临证经验。符文彬教授认为焦虑相关性失眠的基本病机在于“阴阳失和,气血失调”,更指出“阳虚”是其发病的本质。治疗焦虑相关性失眠,符文彬教授重视阳气与神之间的关系,主张从阳... 详细信息

本研究介绍符文彬教授运用精灸技术治疗焦虑相关性失眠的临证经验。符文彬教授认为焦虑相关性失眠的基本病机在于“阴阳失和,气血失调”,更指出“阳虚”是其发病的本质。治疗焦虑相关性失眠,符文彬教授重视阳气与神之间的关系,主张从阳论治,以阳驭神,以温阳开郁、调畅神机为治法。在长期的临床实践中提出一种“精而效验”的精灸技术,常选用引气归元、五脏俞以及大接经等穴位治疗,收获良效。本研究总结了符文彬教授治疗焦虑相关性失眠的经验,旨在进一步探讨精灸技术在诊疗中的应用,为临床治疗焦虑相关性失眠提供新的思路。

关键词：从阳论治精灸技术失眠焦虑符文彬

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The Enlightenment of the Research on the Relationship between Residents’ Drinking and Emotional and Spiritual Problems

The Enlightenment of the Research on the Relationship betwee...

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作者： zhongxian li Shaohui Chen Yunnan Land & Resources Vocational College The Cooperation of Chinese and Western medicine hospital of Yunnan province medical department

This paper analyses people who are aged 50,living in three communities of Kunming,and its theme is to find out the relations between old residents’ drinking and emotional and mental problems in present *** study of the influences of such residents’ drinking frequency,quantity,type,age of starting drinking,drinking age on emotional and mental problems,comes to the conclusion that can be useful for community health service centers and related health ways of life,and the education sector to provide the theoretical basis and policy *** this study,1039 residents aged 50 and above in three communities of tangshuang,yiyuan and jinjiang road in Kunming city were selected as subjects by using the whole group sampling *** were investigated by questionnaire survey from two aspects:drinking situation,emotional and mental *** final conclusion is that frequency,quantity,type of drinking,age of starting drinking and age of abstaining are not the influencing factors of emotional and mental problems,and there is no correlation between drinking and residents’ emotional and mental *** Suggestions for dealing with adverse events related to alcohol consumption are put forward.

关键词： Drinking Emotional and spiritual problems Analysis of current situation Enlightenment

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Methods for Progressive Collapse Analysis of Building Structures Under Blast and Impact Loads

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Transactions of Tianjin University 2008年第5期14卷 329-339页

作者：李忠献师燕超 School of Civil Engineering Tianjin University

Progressive collapse of building structures under blast and impact loads has attracted great attention all over the world. Progressive collapse analysis is essential for an economic and safe design of building structures against progressive collapse to blast and impact loads. Because of the catastrophic nature of progressive collapse and the potentially high cost of constructing or retrofitting buildings to resist it, it is imperative that the progressive collapse analysis methods be reliable. For engineers, their methodology to carry out progressive collapse evaluation need not only be accurate and concise, but also be easily used and works fast. Thus, many researchers have been spending lots of effort in developing reliable, efficient and straightforward progressive collapse analysis methods recently. In the present paper, current progressive collapse analysis methods available in the literature are reviewed. Their suitability, applicability and reliability are discussed. Our recent proposed new method for progressive collapse analysis of reinforced concrete frames under blast loads is also introduced.

关键词： progressive collapse analysis building structures blast load impact load

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