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白细胞介素-17基因多态性与山西东南地区汉族人群2型糖尿病的相关性

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实用医学杂志 2024年第5期40卷 695-701页

作者：李燕王琦郑路冯李慧马丽魏健刘良姝长治医学院附属和平医院内分泌科山西长治046000 长治医学院内分泌代谢性疾病研究所山西长治046000

目的研究山西省东南地区汉族人群白细胞介素-17(IL-17)基因单核苷酸多态性及其与2型糖尿病(T2DM)的相关性。方法收集健康对照组和T2DM组受试者基本信息及临床资料,提取全血DNA,采用聚合酶链反应-高温连接酶反应对IL-17基因4个位点(rs2... 详细信息

目的研究山西省东南地区汉族人群白细胞介素-17(IL-17)基因单核苷酸多态性及其与2型糖尿病(T2DM)的相关性。方法收集健康对照组和T2DM组受试者基本信息及临床资料,提取全血DNA,采用聚合酶链反应-高温连接酶反应对IL-17基因4个位点(rs2275913、rs3819024、rs4711998和rs8193036)进行多态性检测。结果两组IL-17基因4个SNP位点基因型和等位基因频率分布差异均无统计学意义(P> 0.05),在校正年龄、BMI、WC和血脂异常等因素后,两组研究对象在不同遗传模型下的基因型及等位基因频率分布差异亦无统计学意义(P> 0.05)。进一步分析显示,T2DM组rs2275913位点AA基因型FPG和HOMA-IR显著低于AG和GG基因型,三组间差异有统计学意义(P 0.05)。此外,T2DM组rs3819024位点AA基因型WC、HOMA-IR显著高于GG基因型,差异有统计学意义(P <0.05)。结论 IL-17基因rs2275913、rs3819024、rs4711998、rs8193036多态性与山西省东南地区汉族人群T2DM可能无关,IL-17 rs2275913位点AA基因型、rs3819024位点GG基因型分别与山西东南地区汉族T2DM患者FPG和HOMA-IR、WC和HOMA-IR相关,可能是IL-17影响糖代谢的潜在基因型。

关键词： 2型糖尿病白细胞介素-17 基因多态性

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输变电智能巡检体系的构建与实施

农村电气化 2024年第9期 33-38页

作者：李俊马琪媛郑勇周志钢代怡婷国网湖北潜江市供电公司湖北潜江433100

为推进数字化转型,落实国家电网公司“十四五”发展规划,且由于传统巡检难以对输变电设备进行全方位的检测并存在一定缺陷。文章介绍了输变电智能体系的构建与实施,做到对设备信息进行实时调取与监控,有助于随时应对各种突发问题与特殊... 详细信息

为推进数字化转型,落实国家电网公司“十四五”发展规划,且由于传统巡检难以对输变电设备进行全方位的检测并存在一定缺陷。文章介绍了输变电智能体系的构建与实施,做到对设备信息进行实时调取与监控,有助于随时应对各种突发问题与特殊情况,推进输变电巡检的自动化进程,减少人力资源投入,降低维保费用及维修成本。

关键词：智能巡检数字化自动化

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跆拳道后横踢动作运动员膝关节肌肉用力特征

医用生物力学 2024年第5期39卷 969-977页

作者：贾孟尧马勇熊俊刘林彭骞蔺世杰郑伟涛武汉体育学院运动健康智能装备湖北省工程研究中心武汉430079 武汉体育学院国家体育总局体育工程重点实验室武汉430079 武汉体育学院湖北省运动装备工程技术研究中心武汉430079 武汉体育学院竞技体育学院武汉430079 西北工业大学体育部智能体育工程研究中心西安710072

目的探索跆拳道后横踢动作膝关节的肌肉发力特征。方法通过DaeDo电子打分系统并配合Vicon光学动作捕捉系统、Kistler三维测力台,采集12名高水平竞技跆拳道运动员后横踢动作运动学和动力学数据,通过OpenSim软件进行模拟,计算膝关节的肌... 详细信息

目的探索跆拳道后横踢动作膝关节的肌肉发力特征。方法通过DaeDo电子打分系统并配合Vicon光学动作捕捉系统、Kistler三维测力台,采集12名高水平竞技跆拳道运动员后横踢动作运动学和动力学数据,通过OpenSim软件进行模拟,计算膝关节的肌肉力、关节力矩、关节刚度及肌肉协同工作模式。结果进攻腿在提膝和击打时刻膝关节冠状轴力矩较大,矢状轴力矩在击打时刻达到峰值;支撑腿在提膝时刻膝关节冠状轴力矩最高,矢状轴力矩在击打时刻达峰值。进攻腿半膜肌和股二头肌长头在击打时段力量较大,支撑腿半膜肌和腓肠肌内侧头则在回收时段力更大。跆拳道后横踢动作中存在5种肌肉协同模式。结论后横踢动作运动员执行后横踢动作时,进攻腿、支撑腿的膝关节肌群肌肉力、关节力矩等存在较大差异,肌肉之间存在复杂的协同关系。

关键词：跆拳道后横踢动作关节力矩关节刚度肌肉协同肌肉力

Overexpression of transcription factor 3 drives hepatocarcinoma development by enhancing cell proliferation via activating Wnt signaling pathway

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 378-386页

作者： Xing-Yu Pu Dao-Feng zheng Tao Lv yong-Jie Zhou Jia-Yin Yang li Jiang Department of liver Surgery and liver Transplantation Center West China HospitalSichuan UniversityChengdu 610041China Laboratory of liver Transplantation Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China

Background:Transcription factor 3(TCF3)plays pivotal roles in embryonic development,stem cell maintenance and ***,its role in hepatocellular carcinoma(HCC)remains largely *** study aimed to analyze the correlation between TCF3 expression and clinicopathological features of HCC,and further explore the underlying mechanism in HCC ***:The expression of TCF3 was collected from the Cancer Genome Atlas(TCGA)and the Gene Expression Omnibus(GEO)HCC datasets,and further confirmed by immunostaining and Western blotting *** correlation between TCF3 expression and the clinicopathological features was *** analysis and in vitro experiments were conducted to explore the potential role of TCF3 in HCC ***:Both the mRNA and protein levels of TCF3 were significantly higher in HCC tumor tissues compared to tumor adjacent tissues(Plinical stage and grade,and patients with high TCF3 expression had shorter overall survival(P=0.012),disease-specific survival(P=0.022)and progression-free survival(P=0.013).Similarly,the immunostaining results revealed that the high expression of TCF3 was closely correlated with tumor size(P=0.001)and TNM stage(P=0.002),and TCF3 was an independent risk factor of *** vitro study exhibited that TCF3 knockdown dramatically suppressed cancer cell proliferation,and the underlying mechanism might be that the silencing of TCF3 reduced the expression of critical regulating proteins towards cell cycle and proteins involved in Wnt signaling ***:TCF3 expression is significantly elevated in HCC and positively associated with the tumor size and TNM stage,as well as poor prognosis of HCC *** mechanism might be that TCF3 promotes cancer cell proliferation via activating Wnt signaling pathway.

关键词： Hepatocellular carcinoma Proliferation Cell and molecular biology

PD-1抑制剂联合颅脑放疗治疗NSCLC脑转移的效果

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哈尔滨医科大学学报 2024年第3期58卷 260-264页

作者：张聪郑桂丽李娜中国人民解放军联勤保障部队第九六○医院放疗科山东济南250031 中国人民解放军联勤保障部队第九六○医院肿瘤科山东济南250031 中国人民解放军联勤保障部队第九六○医院呼吸科山东济南250031

目的探讨程序性死亡蛋白1(programmed death protein-1,PD-1)抑制剂联合颅脑放疗治疗非小细胞肺癌(non-small cell lung cancer,NSCLC)合并脑转移的临床效果。方法选取中国人民解放军联勤保障部队第九六〇医院2021年9月~2023年5月收治... 详细信息

目的探讨程序性死亡蛋白1(programmed death protein-1,PD-1)抑制剂联合颅脑放疗治疗非小细胞肺癌(non-small cell lung cancer,NSCLC)合并脑转移的临床效果。方法选取中国人民解放军联勤保障部队第九六〇医院2021年9月~2023年5月收治的68例NSCLC合并脑转移患者,按治疗方法不同分为2组,其中对照组(n=33)采取全身化疗联合颅脑放疗治疗,观察组(n=35)全身化疗联合颅脑放疗加用PD-1抑制剂治疗,两组均治疗4个疗程,比较两组疗效。结果观察组客观缓解率(objective response rate,ORR)较对照组高(P0.05),观察组6个月生存率97.14%较对照组78.79%为高(χ^(2)=3.886,P=0.049)。结论对NSCLC合并脑转移患者采取全身化疗加用PD-1抑制剂联合颅脑放疗,可显著改善肿瘤标志物,用药安全性较好,6个月生存率较高,值得推广。

关键词：程序性死亡蛋白抑制剂颅脑放疗非小细胞肺癌脑转移

Analysis of working behavior of Jinping-I Arch Dam during initial impoundment

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Water Science and Engineering 2016年第3期9卷 240-248页

作者： Shi-yong Wu Wei Cao Jiang zheng Yalong River Hydropower Development Company Ltd.

To study the stress, deformation, and seepage pressure during the initial impoundment of the Jinping-I Arch Dam, monitoring analysis and numerical calculation were used in a dam behavior analysis that focused on the working behavior of the dam during the late period of the initial impoundment up to the end of November 2014. The numerical calculation was performed based on feedback analysis of the deformation and stress of the arch dam through inversion of the elastic moduli(E) of the dam body and foundation, using a three-dimensional finite element model for the linear elastic material of the arch dam. The main monitoring indices presented insignificant changes in the late period of the initial impoundment, and the results of feedback analysis were consistent with monitoring results. Analysis results also show that the deformations of the dam body and dam foundation were within the design range; the dam stress distributions were normal, with values lower than the design control criteria; and the seepage flows through the dam body and dam foundation were lower than the design drainage capacity of the deep-well pump house, demonstrating that the Jinping-I Arch Dam was in good working condition, and the initial impoundment had been successfully completed. The results of the working behavior analysis of the Jinping-I hydropower project during the initial impoundment can provide references for safe operation of similar projects.

关键词： Dam safety monitoring Working behavior Elastic modulus Dam impoundment Jinping-I hydropower project

Development and validation of a nomogram based on perioperative risk factors for the prediction of early thrombotic complications following pediatric liver transplantation

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Chinese Medical Journal 2024年第16期137卷 1993-1995页

作者： Qiang You Enze Qu Kaining Zeng Jianrong liu Qing Yang Hui Tang Xiao Feng Jia Yao Xinru Huang Tong Zhang Binsheng Fu Hua li Hui Zhao Jun zheng Shuhong Yi Yang Yang Department of Hepatic Surgery and liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong Province Engineering Laboratory for Transplantation MedicineGuangzhouGuangdong 510630China Guangdong Key Laboratory of liver Disease Research Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education InstitutesThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China Department of Ultrasound The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510630China Surgical ICU of the Third Affiliated Hospital of Sun Yat-sen University GuangzhouGuangdong 510630China

To the Editor:Despite dramatic improvements in the prognosis of pediatric liver transplantation(LT),postoperative complications are still a leading cause of death in grafts and *** recipients were shown to have a higher risk of thrombotic complications than in adult recipients,due to differences in etiology,narrowed hepatic vessels due to hypoplasia,more meticulous surgical techniques,and other factors.[1]Thrombotic complications include hepatic artery thrombosis(HAT).

关键词： complications pediatric hepatic

剖宫产术后皮肤病理性瘢痕的影响因素研究进展

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中国美容医学 2024年第5期33卷 191-194页

作者：李湧(综述) 向英(审校) 重庆医科大学附属第一医院医疗美容科重庆400016

剖宫产术后皮肤瘢痕是目前普遍存在但易被忽视的现象,一旦发生会影响产妇身体状况、生活质量和心理健康。早期识别影响因素有助于降低剖宫产术后皮肤病理性瘢痕的发生率,提高产妇生活质量,使其获得积极的产后体验,对于促进适龄女性的生... 详细信息

剖宫产术后皮肤瘢痕是目前普遍存在但易被忽视的现象,一旦发生会影响产妇身体状况、生活质量和心理健康。早期识别影响因素有助于降低剖宫产术后皮肤病理性瘢痕的发生率,提高产妇生活质量,使其获得积极的产后体验,对于促进适龄女性的生育信心具有重要意义。本文就剖宫产术后皮肤病理性瘢痕的发生现况及其影响因素进行综述。

关键词：剖宫产腹部瘢痕切口愈合影响因素相关因素

同方期刊数据库博看期刊评论

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寻找基层治理现代化的内在动力

中国机构编制 2024年第7期 21-23页

作者：任勇李苏婕华东政法大学政府管理学院

习近平总书记指出:“基层强则国家强,基层安则天下安,必须抓好基层治理现代化这项基础性工作。”基层是推进国家治理的“最后一公里”和最基本的单元,基层治理现代化是国家治理体系和治理能力现代化的基础性工程,直接影响着国家治理现... 详细信息

习近平总书记指出:“基层强则国家强,基层安则天下安,必须抓好基层治理现代化这项基础性工作。”基层是推进国家治理的“最后一公里”和最基本的单元,基层治理现代化是国家治理体系和治理能力现代化的基础性工程,直接影响着国家治理现代化建设的效能。可以说,没有基层治理现代化,就无法实现国家治理现代化。

关键词：基层治理现代化国家治理体系和治理能力现代化国家治理现代化最后一公里内在动力基础性工程基础性工作习近平总书记