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Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injuryinduced pathological vascular remodeling

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Chinese Journal of Natural Medicines 2024年第1期22卷 62-74页

作者： GUO Qiru li Jiali WANG zheng WU Xiao JIN Zhong ZHU Song li Hongfei ZHANG Delai HU Wangming XU Huan YANG Lan SHI liangqin WANG yong College of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 610000China Chengdu University of Traditional Chinese Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610000China

Pathological vascular remodeling is a hallmark of various vascular *** research has established the significance of andrographolide in maintaining gastric vascular homeostasis and its pivotal role in modulating endothelial barrier dysfunction,which leads to pathological vascular *** dehydroandrographolide succinate(PDA),a derivative of andrographolide,has been clinically utilized in the treatment of inflammatory diseases precipitated by viral *** study investigates the potential of PDA in regulating pathological vascular *** effect of PDA on vascular remodeling was assessed through the complete ligation of the carotid artery in C57BL/6 *** approaches,including rat aortic primary smooth muscle cell culture,flow cytometry,bromodeoxyuridine(BrdU)incorporation assay,Boyden chamber cell migration assay,spheroid sprouting assay,and Matrigel-based tube formation assay,were employed to evaluate the influence of PDA on the proliferation and motility of smooth muscle cells(SMCs).Molecular docking simulations and co-immunoprecipitation assays were conducted to examine protein *** results revealed that PDA exacerbates vascular injury-induced pathological remodeling,as evidenced by enhanced neointima *** treatment significantly increased the proliferation and migration of *** mechanistic studies disclosed that PDA upregulated myeloid differentiation factor 88(MyD88)expression in SMCs and interacted with T-cadherin(CDH13).This interaction augmented proliferation,migration,and extracellular matrix deposition,culminating in pathological vascular *** findings underscore the critical role of PDA in the regulation of pathological vascular remodeling,mediated through the MyD88/CDH13 signaling pathway.

关键词： Potassium dehydroandrographolide succinate Smooth muscle cell Myeloid differentiation factor 88 T-cadherin Pathological vascular remodeling

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Superplastic Tension Behavior of Dissimilar TC4/SP700 Laminate through Diffusion Bonding

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 353-363页

作者： Qianwen Zhang Tianle li Yanbin Han Wei zheng Xifeng li Jianjun Wu School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an710072China AVIC Xi’an Aircraft Industry Group Company Ltd Xi’an710089China Institute of Forming Technology and Equipment School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200030China

Superplastic forming is a practical method to manufacture complex-shaped parts of titanium alloys with large *** parts of dissimilar titanium alloys fabricated by superplastic forming can achieve excellent performance by combining the advantages of *** work displays the superplastic tension behavior and microstructural evolution of dissimilar TC4/SP700 laminate prepared by the diffusion bonding *** titanium alloys can achieve metallurgical bonding at parameters of 800℃/1 h/5 *** for dynamic recrystallization and grain growth behaviors upon superplastic tension,stress-induced phase transformation plays an important role inαtoβphase transformation apart from the elevated *** superplastic deformation can be attributed to the grain boundary sliding accommodated multiplex motion of *** addition,the retained strengths of all dissimilar TC4/SP700 laminates after superplastic deformation with different strain rates and temperatures range from 807 to 890 MPa.

关键词： TC4/SP700 laminate Diffusion bonding Microstructure Superplastic tension Strength

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Learning Scalable Task Assignment with Imperative-Priori Conflict Resolution in Multi-UAV Adversarial Swarm Defense Problem

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Journal of Systems Science & Complexity 2024年第1期37卷 369-388页

作者： ZHAO Zhixin CHEN Jie XIN Bin li li JIAO Keming zheng Yifan School of Electronics and Information Engineering Tongji UniversityShanghai 201804China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201804China School of Automation Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Autonomous Intelligent Unmanned Systems Beijing 100081China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201804China.

The multi-UAV adversary swarm defense(MUASD)problem is to defend a static base against an adversary UAV swarm by a defensive UAV *** the problem into task assignment and low-level interception strategies is a widely used ***-based approaches for task assignment are a promising *** studies on learning-based methods generally assume decentralized decision-making architecture,which is not beneficial for conflict *** contrast,centralized decision-making architecture is beneficial for conflict resolution while it is often detrimental to *** achieve scalability and conflict resolution simultaneously,inspired by a self-attention-based task assignment method for sensor target coverage problem,a scalable centralized assignment method based on self-attention mechanism together with a defender-attacker pairwise observation preprocessing(DAP-SelfAtt)is ***,an imperative-priori conflict resolution(IPCR)mechanism is proposed to achieve conflict-free ***,the IPCR mechanism is parallelized to enable efficient *** validate the algorithm,a variant of proximal policy optimization algorithm(PPO)is employed for training in scenarios of various *** experimental results show that the proposed algorithm not only achieves conflict-free task assignment but also maintains scalability,and significantly improve the success rate of defense.

关键词： Conflict resolution reinforcement learning scalability task assignment.

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Metarelation2vec:A Metapath-Free Scalable Representation Learning Model for Heterogeneous Networks

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Tsinghua Science and Technology 2024年第2期29卷 553-575页

作者： Lei Chen Yuan li yong Lei Xingye Deng School of Information and Electrical Engineering Hunan University of Science and TechnologyXiangtan 411201China School of Computer Science and Engineering Hunan University of Science and TechnologyXiangtan 411201China

Metapaths with specific complex semantics are critical to learning diverse semantic and structural information of heterogeneous networks(HNs)for most of the existing representation learning ***,any metapaths consisting of multiple,simple metarelations must be driven by domain *** sensitive,expensive,and limited metapaths severely reduce the flexibility and scalability of the existing models.A metapath-free,scalable representation learning model,called Metarelation2vec,is proposed for HNs with biased joint learning of all metarelations in a bid to address this ***,a metarelation-aware,biased walk strategy is first designed to obtain better training samples by using autogenerating cooperation probabilities for all metarelations rather than using expert-given ***,grouped nodes by the type,a common and shallow skip-gram model is used to separately learn structural proximity for each node ***,grouped links by the type,a novel and shallow model is used to separately learn the semantic proximity for each link ***,supervised by the cooperation probabilities of all meta-words,the biased training samples are thrown into the shallow models to jointly learn the structural and semantic information in the HNs,ensuring the accuracy and scalability of the *** experimental results on three tasks and four open datasets demonstrate the advantages of our proposed model.

关键词： metarelation random walk heterogeneous network metapath representation learning

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Local environment regulation of transition metal dichalcogenide-based single-atom catalysts

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Rare Metals 2024年第9期43卷 4019-4037页

作者： Ming-Hui li Jing li Xiao-Yu zheng Yao Zhou Advanced Research Institute of Multidisciplinary Science and School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China Laser Micro/Nano Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China

Single-atom catalysts have risen significant attention in the realm of green electrocatalytic energy conversion to address energy and environmental sustainability *** metal dichalcogenide(TMD)-based single-atom catalysts are considered highly effective in electrocatalysis due to the TMDs'notable specific surface area,tunable elemental species and efficient utilization of single *** order to enhance electrocatalytic performance,it is imperative to elaborately engineer the local environment surrounding the active sites of single atoms within *** this review,we initially explore the effects of synthesis methods on single-atom active sites and the influence of loading of single atoms on catalytic performance for *** modulation strategies of the local environment surrounding single-atom sites in TMDs are elaborated,including substitution engineering,surface adsorption,vacancies,spatial confinement and dual-atom site *** each modulation strategy,the effects of diverse local environments on various electrocatalytic applications are presented,such as the oxygen evolution reaction,oxygen reduction reaction,nitrogen reduction reaction,CO_(2)reduction reaction and CO ***,this study presents a comprehensive overview of the challenges encountered and the potential directions for the advancement of single-atom catalysts based on TMDs in the realm of electrocatalysis.

关键词： Single-atom catalysts Transition metal dichalcogenide Local environment Electrocatalysis

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Highly reversible photomodulated hydrosoluble stiff-stilbene supramolecular luminophor induced by cucurbituril

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Chinese Chemical Letters 2024年第8期35卷 235-239页

作者： Guoxing liu Yixin li Changming Tian yongmei Xiao lijie liu Zhanqi Cao Song Jiang Xin zheng Caoyuan Niu Yun-Lai Ren liangru Yang Xianfu zheng yong Chen College of Science Henan Agricultural UniversityZhengzhou 450002China College of Chemistry and Chemical Engineering Henan University of TechnologyZhengzhou 450001China College of Chemistry State Key Laboratory of Elemento-Organic ChemistryNankai UniversityTianjin 300071China

A photochromic molecular rotor based on stiff-stilbene(SSB-FMR)was handily prepared through coupled reaction,and further self-assembled with cucurbit[8]uril(CB[8])to form a 2:2 quaternary supramolecu-lar complex(SSB-FMR/CB[8]).Significantly,the intervention of CB[8]on SSB-FMR achieved dual functions that assembly-induced emission enhancement and assembly-induced improvement of photoisomerized performance(especially reversibility)of stiff-stilbene molecular *** supramolecular strategy further facilitated the assembly as a photoresponsive fluorescence switch with outstanding fatigue resis-tance,which was expediently applied in high-security-level QR code anti-counterfeiting and controllable lysosome targeted *** study unprecedentedly provides a supramolecular method for highly effi-ciently improving photoisomerized performance especially reversibility of molecular photoswitches based on stiff-stilbene,and is of vital significance for the construction of intelligent materials with excellent ca-pability.

关键词： Host-guest complexation Cucurbituril Fluorescence switch Stiff-stilbene Fluorescence enhancement

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Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function

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National Science Review 2024年第2期11卷 145-154页

作者： Farong Ye Cheng li Feng-liang liu Xinliang liu Peng Xu Rong-Hua Luo Wenping Song yong-Tang zheng Tianlei Ying Biao Yu Ping Wang Center for Chemical Glycobiology Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study School of Chemistry and Chemical Engineering Shanghai Jiao Tong University MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection Shanghai Institute of Infectious Disease and BiosecurityShanghai Engineering Research Center for Synthetic ImmunologySchool of Basic Medical Sciences Shanghai Medical College Fudan University Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Center for Biosafety Mega-Science Kunming Institute of ZoologyChinese Academy of Sciences State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular Synthesis Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shenzhen Research Institute of Shanghai Jiao Tong University

Vaccines have been the primary remedy in the global fight against coronavirus disease 2019（COVID-19）.The receptor-binding domain（RBD） of the spike protein, a critical viral immunogen, is affected by the heterogeneity of its glycan structures and relatively low immunogenicity. Here, we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD, facilitating the elucidation of carbohydrate structure–function relationships. Five homogeneously glycosylated RBDs bearing biantennary glycans were prepared, three of which were conjugated to T-helper epitope(Tpep) from tetanus toxoid to improve their weak immune response. Relative to natural HEK293-derived RBD, synthetic RBDs with biantennary N-glycan elicited a higher level of neutralising antibodies against SARS-CoV-2 in mice. Furthermore, RBDs containing Tpepelicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2. Our collective data suggest that trimming the N-glycans and Tpepconjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection.

关键词： peptide ligation glycosylation glycoprotein

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Construction technology for deep tunnels crossing superhigh-temperature fault zones with high water surges

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1267-1280页

作者： yong ZHAO Tingyu ZHU li YU Ming LU Sichuan–Xizang Railway Co. Ltd.Linzhi 860000China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610036China

The harsh environment in tunnels with high geothermal temperatures and humidity can adversely impact machinery,personnel,and *** main causes of specific problems are the unknown mechanisms of local geothermal formation,inappropriate temperature control measures,and insufficient systematic *** this study,three work sections relating to a high geothermal tunnel are:the tunnel face,middle-of-tunnel section,and outside-oftunnel section.A cooling strategy is proposed to offer technical support in achieving comprehensive cooling,overall as well as for each of the ***,a comprehensive geological survey explores the mechanism and exact location of the heat ***,grouting and centralized drainage measures are used to control the heat release of hot *** ventilation,ice chillers and other applicable measures are used to control the ambient ***,a monitoring and early warning system is established to prevent *** cooling strategy has been applied in the field with good results.

关键词： high geothermal tunnels cooling strategy comprehensive cooling measures safety and security

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Three-Dimensional Sound Source Location Algorithm for Subsea Leakage Using Hydrophone

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China Ocean Engineering 2024年第2期38卷 326-337页

作者： li Hao-jie CAI Bao-ping YUAN Xiao-bing KONG Xiang-di liU yong-hong Javed Akbar KHAN CHU zheng-de YANG Chao TANG An-bang College of Mechanical and Electronic Engineering China University of PetroleumQingdao 266580China Shenzhen Urban Public Safety Technology Institute Shenzhen 518000China Institute of Hydrocarbon Recovery Universiti Teknologi PETRONASBandar Seri IskandarPerak Darul Ridzuan 32610Malaysia

Leakages from subsea oil and gas equipment cause substantial economic losses and damage to marine ecosystem,so it is essential to locate the source of the ***,due to the complexity and variability of the marine environment,the signals collected by hydrophone contain a variety of noises,which makes it challenging to extract useful signals for *** solve this problem,a hydrophone denoising algorithm is proposed based on variational modal decomposition(VMD)with grey wolf ***,the average envelope entropy is used as the fitness function of the grey wolf optimizer to find the optimal solution for the parameters K andα.Afterward,the VMD algorithm decomposes the original signal parameters to obtain the intrinsic mode functions(IMFs).Subsequently,the number of interrelationships between each IMF and the original signal was calculated,the threshold value was set,and the noise signal was removed to calculate the time difference using the valid signal obtained by ***,the arrival time difference is used to locate the origin of the *** localization accuracy of the method in finding leaks is investigated experimentally by constructing a simulated leak test rig,and the effectiveness and feasibility of the method are verified.

关键词： grey wolf optimizer variational modal decomposition mean envelope entropy correlation coefficient time difference of arrival

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Coordinated responses of leaf and nodule traits contribute to the accumulation of N in relay intercropped soybean

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Journal of Integrative Agriculture 2024年第6期23卷 1910-1928页

作者： Ping Chen Qing Du Benchuan zheng Huan Yang Zhidan Fu Kai Luo Ping lin Yilin li Tian Pu Taiwen yong Wenyu Yang College of Agronomy Sichuan Agricultural University/Sichuan Engineering Research Center for Crop Strip Intercropping System/Key Laboratory of Crop Ecophysiology and Farming System in SouthwestMinistry of Agriculture and Rural AffairsChengdu 611130China Crop Research Institute Sichuan Academy of Agricultural SciencesChengdu 610066China

Maize(Zea mays L.)-soybean(Glycine max ***.)relay intercropping provides a way to enhance land ***,the late-planted soybean suffers from shading by the *** maize harvest,how the recovery growth influences the leaf and nodule traits remains unclear.A three-year field experiment was conducted to evaluate the effects of genotypes,i.e.,supernodulating(nts1007),Nandou 12(ND12),and Guixia 3(GX3),and crop configurations,i.e.,the interspecific row spacing of 45(I45),60(I60),75 cm(I75),and sole soybean(SS),on soybean recovery growth and N *** results showed that intercropping reduced the soybean total leaf area(LA)by reducing both the leaf number(LN)and unit leaflet area(LUA),and it reduced the nodule dry weight(NW)by reducing both the nodule number(NN)and nodule diameter(ND)compared with the *** correlation and principal component analysis(PCA)indicated a co-variability of the leaf and nodule traits in response to the genotype and crop configuration *** the recovery growth stages,the compensatory growth promoted soybean growth to reduce the gaps of leaf and nodule traits between intercropping and *** relative growth rates of ureide(RGR_U)and nitrogen(RGR_N)accumulation were higher in intercropping than in *** achieved more significant sucrose and starch contents compared with ***12 and GX3 showed more robust compensatory growth than nts1007 in *** the recovery growth of relay intercropping soybean improved biomass and nitrogen accumulation,ND12 gained a more significant partial land equivalent ratio(pLER)than *** I60 treatment achieved more robust compensation effects on biomass and N accumulation than the other ***,I60 showed a higher nodule sucrose content and greater shoot ureide and N accumulation than ***,intercropping ND12 with maize using an interspecific row spacing of 60 cm was optimal for both yield advantage and N accumulation.

关键词： relay intercropping genotype crop configuration symbiotic nitrogen fixation soybean nodule

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