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Optical coherence tomography angiography characteristics in Waldenström macroglobulinemia retinopathy:A case report

World Journal of Clinical Cases 2020年第23期8卷 6071-6079页

作者： Jun li Rui Zhang Feng Gu zhe-li liu Peng Sun Department of Ophthalmology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Hematology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Waldenström macroglobulinemia(WM)is a distinct clinicopathologic entity characterized by the infiltration of the bone marrow by clonal lymphoplasmacytic cells that produce monoclonal immunoglobulin M(IgM)in the blood,and patients may present with symptoms related to the infiltration of the hematopoietic tissues or the effects of monoclonal IgM in the *** abnormalities were noted in some of the patients due to hyperviscosity or other retinal *** coherence tomography angiography(OCTA)as a noninvasive imaging tool can give qualitative and quantitative information about the status of retinal and choroidal vessels,which might be useful for diagnosing patients with WM-associated *** SUMMARY The patient was a 67-year-old man who presented with sudden visual disturbance in both *** tests showed that best corrected visual acuity(BCVA)for this patient was 20/100 in the right eye and 20/1000 in the left *** examination,optical coherence tomography(OCT),and OCTA revealed substantial bilateral optic disc edema,dilated and tortuous retinal veins,and diffuse intraretinal blot hemorrhages and edema which were consistent with bilateral central retinal vein occlusion(CRVO).Meanwhile,remarkable bilateral serous macular detachments(SMD)were noticed on *** examinations showed that the patient had anemia and extremely high level of monoclonal IgM and infiltration of clonal lymphoplasmacytic cells in bone *** diagnosis of WM with hyperviscosity and retinopathy was made based on the clinical manifestation and laboratory *** was subsequently treated with intravitreal ranibizumab injection,plasmapheresis,and bortezomib plus rituximab with *** months after treatments,the central macular volume decreased by 16.1%in the right eye and 28.6%in the left eye on OCT,and the patient’s BCVA was improved to 20/60 in the right eye and 20/400 in the left *** good partial response was obtained a

关键词： Waldenström macroglobulinemia Retinal vein occlusion Ranibizumab Optical coherence tomography angiography Ophthalmology Case report

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Hydrogenic-Donor Impurity States in GaAs/Al xGa 1−xAs Quantum Dots in the Presence of an Electric Field

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Chinese Physics Letters 2011年第8期28卷 217-220页

作者： PAN Jiang-Hong liU li-zhe liU Min College of Physical and Technology Guangxi Normal UniversityGuilin 541004

We report a calculation of binding energy of the ground state of a hydrogenic donor in a quantum cylindrical GaAs dot surrounded by Ga1−xAlxAs with finite confinement potentials,in the presence of a uniform electric field applied parallel to the dot *** binding energy increases inchmeal as the radius of the dot decreases until a maximum value for a certain value of the quantum dot radii,then begins to drop *** for the binding energies and electronic wave function density of the hydrogenic-donor as functions of the impurity position,dot thickness and applied electric field are also presented.

关键词： donor quantum radius

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Controllable synthesis of MnO_(2)/iron mesh monolithic catalyst and its significant enhancement for toluene oxidation

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Chinese Chemical Letters 2023年第2期34卷 338-341页

作者： Meijuan Qi zhe li Zhang Zhang Yanshan Gao Qiang Wang Beijing Key Lab for Source Control Technology of Water Pollution College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China Engineering Research Center for Water Pollution Source Control&Eco-remediation College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China Beijing Municipal Ecological and Environmental Monitoring Center Beijing 100048China

A series of monolithic MnO_(2)/iron mesh (IM) catalysts for oxidation of toluene were successfully prepared by using in situ hydrothermal ***_(2)can grow firmly on the IM substrates surface with a shedding rate of only 0.14%.Due to the highest O_(ads) and high-valent Mn^(4+) and Fe^(3+) elements,the temperature at 50% and 90% toluene conversion (T_(50%) and T_(90%)) was 252 and 265℃,respectively for the best performance catalyst (hydrothermal temperature of 80℃,hydrothermal time of 12 h,and precursor manganese ion concentration of 0.03 mol/L).The catalysts also presented good water resistance and cycle ***-situ DRIFTS results suggesting that toluene was first rapid transformed into the reaction intermediate species (benzoate species) and then converted to CO_(2)and H_(2)***,this work provides a new direction for the research and application of IM-based monolithic catalysts.

关键词： Toluene oxidation Iron mesh monoliths catalysts MnO_(2) Resistance properties Reaction mechanism

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FeNi nanoparticles on Mo_(2)TiC_(2)T_(x)MXene@nickel foam as robust electrocatalysts for overall water splitting

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Nano Research 2021年第10期14卷 3474-3481页

作者： Jiayang Wang Peilei He Yongli Shen linxiu Dai zhe li Yue Wu Changhua An Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical EngineeringTianjin University of TechnologyTianjin 300384China Department of Chemical and Biological Engineering Iowa State UniversityIA 50011USA

The development of cost-effective electrocatalysts for overall water splitting is highly desirable,remaining a critical challenge at current ***,a class of composite FeNi@MXene(Mo_(2)TiC_(2)T_(x))@nickel foam(NF)has been synthesized through introducing Fe2+ions and in-situ combining with surface nickel atoms on nickel *** obtained FeNi@Mo_(2)TiC_(2)T_(x)@NF exhibited high activity with overpotentials of 165 and 190 mV for the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)at a current density of 10 mA·cm^(-2),*** synergetic effects of Mo_(2)TiC_(2)T_(x)and FeNi nanoalloys lead to increasing catalytic activities,where MXene provides high active surface area and rich active sites for HER,and FeNi nanoalloys promote the *** simulation of electron exchange capacity between FeNi and MXene in FeNi@Mo_(2)TiC_(2)T_(x)catalyst shows that electrons transferred from surface Mo atoms to the interface between FeNi and MXene,indicating that the electrons are accumulated near the FeNi *** kind of electronic distribution facilitates the formation of intermediate of ***,(H++e-)is more inclined onto Mo-Ni interfaces for *** Gibbs free energy changes for H*to HER and potential-limiting step for-OOH intermediate in OER over FeNi@Mo_(2)TiC_(2)T_(x)are much less than those on bare *** catalyst can be further used for overall water splitting in alkaline solution,realizing a current density of 50 mA·cm^(-2)at 1.74 *** work provides a facile strategy to achieve efficient and cheap catalysts for new energy production.

关键词： MXene FeNi water splitting electrocatalysis

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Diagonal Dominance for Flight Control Systems of Canard Aircraft in Finite Frequency Range

Diagonal Dominance for Flight Control Systems of Canard Airc...

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第25届中国控制与决策会议

作者： zhe li Jiuxiang Dong Guang-Hong Yang College of Information Science and Engineering Northeastern University State Key Laboratory of Synthetical Automation for Process Industry

ISBN: (纸本)9781467355322

This paper presents a new method for determining a constant precompensator for reducing the effects of interactions of the flight control systems in Canard Aircraft. However, the previous methods achieve diagonal dominance either at a certain suitable frequency or across the entire frequency domain. Taking the practical engineering situation into consideration, it is necessary to achieve diagonal dominance among a specific section instead of the whole of the frequency domain. This paper combines the LMIs and the Generalized KYP Lemma to obtain a new method to solve the problem. The algorithm is then modified to reduce the conservatism by the introduction of a path-shaping matrix. The path-shaping matrix enables a designer to find an optimal precompensator to achieve a specific forward path structure and a satisfactory output response. The algorithm is applied to a Canard Aircraft flight control system. Simulations show the new approach can more effectively decouple the Canard Aircraft system than other approaches.

关键词： Diagonal dominance frequency domain inequality GKYP Lemma linear matrix inequalities (LMIs).

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^(188)Re-LABELED HYPERBRANCHED POLYSULFONAMINE AS A ROBUST TOOL FOR TARGETED CANCER DIAGNOSIS AND RADIOIMMUNOTHERAPY

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Chinese Journal of Polymer Science 2013年第3期31卷 530-540页

作者： Nan li Yue Jin li-zhe Xue 李培勇 De-yue Yan 朱新远 Department of Nuclear Medicine Ruijin HospitalSchool of MedicineShanghai Jiao Tong University School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong University

Hyperbranched polysulfonamine （HPSA） is a promising biomaterial due to its highly branched spherical architecture and efficient intracellular translocation. To realize the fianctionalization of HPSA, both N-succinimidyl 3-（2- pyridyldithio） propionate （SPDP） for tethering the human-mouse chimeric monoclonal antibody CH12 and N-hydroxy succinimidyl S-acetylmercaptoacetyltriglycinate （NHS-MAG3） for labeling 188Re were sequentially grafted onto the primary amine terminals of HPSA via covalent linkages, attaining the SPDP-HPSA-MAG3 intermediate. In order to reserve the structural integrity of CH12, the fragment crystallizable （Fc） region was also processed by oxidation of oligosaccharide moieties with sodium periodate and then reacted with N-（κ-maleimidoundecanoic acid） hydrazide （KMUH）. After chelating 188Re with MAG3 group, the SPDP was reduced to PDP and connected onto the maleinimide group at the Fc region. As a result, both the epidermal growth factor receptor viii （EGFRvIII） targeted monoclonal antibody CH12 and the radionuclide 188Re were conjugated to the HPSA-based vehicles, forming the 188Re-labeled and CH12-tethered HPSA （CH12-HPSA- 188Re）. The molecular weight and in vitro stability of CH12-HPSA-188Re were evaluated by gel electrophoresis and paper chromatography. On one hand, the CH12-HPSA-188Re could specifically bind to the EGFRvliI-positive human hepatocarcinoma cells in vitro. On the other hand, it could also target at the tumor tissue of nude mice in vivo. Hence, the CH12-HPSA-188Re could effectively target at the human hepatocarcinoma and facilitate the tumor detection and targeted radioimmunotherapy.

关键词： Hyperbranched polymer Nuclear imaging Active targeting Single photon emission computed tomography (SPECT).

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阿拉善双峰驼脓肿病病原分离鉴定与药敏试验

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动物医学进展 2025年第1期46卷 43-47页

作者：李明哲王立华明亚娟崔阿拉腾乌拉彭丽娟胡文平李泉荣李国中内蒙古阿拉善左旗巴润别立镇综合保障和技术推广中心内蒙古阿拉善750308 内蒙古阿拉善左旗动物疫病预防控制中心内蒙古阿拉善750300 内蒙古阿拉善左旗农畜产品质量安全中心内蒙古阿拉善750300

近年来,双峰驼脓肿病呈现高发趋势,严重威胁骆驼养殖产业的健康发展。论文基于阿拉善双峰驼脓肿病自然病例,采集其脓液与痂皮进行病原分离纯化,采用形态学和扫描电镜观察分离菌形态特征,扩增分离菌16S rDNA进行碱基序列比较分析,并结合C... 详细信息

近年来,双峰驼脓肿病呈现高发趋势,严重威胁骆驼养殖产业的健康发展。论文基于阿拉善双峰驼脓肿病自然病例,采集其脓液与痂皮进行病原分离纯化,采用形态学和扫描电镜观察分离菌形态特征,扩增分离菌16S rDNA进行碱基序列比较分析,并结合CLSI标准进行药物敏感性试验。结果显示,从病料样品中分离得到3种病原菌,经形态学和分子生物学鉴定为金黄色葡萄球菌、松鼠葡萄球菌和奇异变形杆菌。药物敏感性试验表明,16种抗菌药物中环丙沙星和左氧氟沙星对3种病原菌均表现敏感,对指导临床兽医合理用药具有重要实用价值。

关键词：阿拉善双峰驼脓肿病病原分离与鉴定药敏试验

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Ultralight and hyperelastic SiC nanofiber aerogel spring for personal thermal energy regulation

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Journal of Advanced Ceramics 2022年第8期11卷 1235-1248页

作者： limeng SONG Bingbing FAN Yongqiang CHEN Qiancheng GAO zhe li Hailong WANG Xinyue ZHANG li GUAN Hongxia li Rui ZHANG School of Material Science and Engineering Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Luoyang Institute of Science and TechnologyLuoyang 471023China School of Materials Science and Engineering Zhengzhou University of AeronauticsZhengzhou 450015China Sinosteel Luoyang Institute of Refractories Research Co. Ltd.Luoyang 471039China

Multifunctionalization is the development direction of personal thermal energy regulation equipment in the ***,it is still a huge challenge to effectively integrate multiple functionalities into one *** this study,a simple thermochemical process was used to prepare a multifunctional SiC nanofiber aerogel spring(SiC NFAS),which exhibited ultralow density(9 mg/cm3),ultralow thermal conductivity(0.029 W/(m·K)at 20℃),excellent ablation and oxidation resistance,and a stable three-dimensional(3D)structure that composed of a large number of interlacing 3C-SiC nanofibers with diameters of 300–500 nm and lengths in tens to hundreds of ***,the as-prepared SiC NFAS displayed excellent mechanical properties,with a permanent deformation of only 1.3%at 20℃after 1000 ***,the SiC NFAS exhibited robust hyperelasticity and cyclic fatigue resistance at both low(~-196℃)and high(~700℃)*** to its exceptional thermal insulation performance,the SiC NFAS can be used for personal thermal energy *** results of the study conclusively show that the SiC NFAS is a multifunctional material and has potential insulation applications in both low-and high-temperature environments.

关键词： SiC nanofiber aerogel spring(SiC NFAS) mechanical property thermal insulation personal thermal energy regulation

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Etiological characteristics and treatment of tardive dyskinesia

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Neural Regeneration Research 2006年第6期1卷 549-552页

作者： zhe li Xueli Sun Che Zhou Mental Health Center West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

OBJECTIVE ： The pathogenesis of tardive dyskinesia （TD） is complicated and uncertain, Thus, there is not any effective treatment for it. The psychiatrists pay more and more attention to TD, which lasts for a long time and is difficult to treat. DATA SOURCES： A computer-based online search of Medline database was undertaken to identify articles about the feature of etiology and the progression of treatment for TD published in English by using the keywords of ＂rD, etiology, pathogenesis＂ and ＂TD, therapy, drug treatment＂. Meanwhile, Chinese articles about the feature of etiology and the progression of treatment for TD were searched in Wanfang database and China journal full-text database, and the keywords were ＂TD, etiology, pathogenesis＂ and ＂TD, therapy, drug Treatment＂ in Chinese. STUDY SELECTION： Articles met the following inclusion criteria were selected in this paper. Inclusion criteria：（1） Researches of randomized blind control design, before and after control design and retrospective. （2） Researches of the feature of etiology and the progression of treatment for TD. Exclusion criteria： the repetitive researches and individual reports. DATA EXTRACTION ： Totally 65 articles related the feature of etiology and the progression of treatment for TD of randomized blind control design, before and after control design and retrospective studies were collected, and 53 of them were accorded with the inclusion criteria. Of the 12 excluded ones, 8 were concerning with genetics, 4 were repetitive researches. DATA SYNTHESIS ： The feature of etiology for TD includes：（1） Hypothesis of dopamine receptor super-sensitivity： The dopamine receptor is persistently blocked, so it will result in functional disorder in CNS, and then TD may take place. （2）） Hypothesis of neuronal degeneration： The concentration of aminosuccinic acid and glutamic acid will increase after the antipsychotic used for a long time and this will result in neuronal degeneration through glutamic acid rec

关键词： dopamine receptor neuronal degeneration control design therapeutic effect free radicals radical scavenger gene polymorphism prevention of glutamic acid retrospective studies tardive dyskinesia cytotoxic effect corpus striatum calcium ions nerve cells amino acid vitamin E

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Exosomes from bone marrow mesenchymal stem cells are a potential treatment for ischemic stroke

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Neural Regeneration Research 2023年第10期18卷 2246-2251页

作者： Chang liu Tian-Hui Yang Hong-Dan li Gong-zhe li Jia liang Peng Wang liaoning Provincial Key Laboratory of Neurodegenerative Diseases and Department of Neurobiology Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina Institute of life Science Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina College of Pharmacy Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina

Exosomes derived from human bone marrow mesenchymal stem cells(MSC-Exo)are characterized by easy expansion and storage,low risk of tumor formation,low immunogenicity,and anti-inflammatory *** therapeutic effects of MSC-Exo on ischemic stroke have been widely ***,the underlying mechanism remains *** this study,we established a mouse model of ischemic brain injury induced by occlusion of the middle cerebral artery using the thread bolt method and injected MSC-Exo into the tail *** found that administration of MSC-Exo reduced the volume of cerebral infarction in the ischemic brain injury mouse model,increased the levels of interleukin-33(IL-33)and suppression of tumorigenicity 2 receptor(ST2)in the penumbra of cerebral infarction,and improved neurological *** vitro results showed that astrocyte-conditioned medium of cells deprived of both oxygen and glucose,to simulate ischemia conditions,combined with MSC-Exo increased the survival rate of primary cortical ***,after transfection by IL-33 siRNA or ST2 siRNA,the survival rate of primary cortical neurons was markedly *** results indicated that MSC-Exo inhibited neuronal death induced by oxygen and glucose deprivation through the IL-33/ST2 signaling pathway in *** findings suggest that MSC-Exo may reduce ischemia-induced brain injury through regulating the IL-33/ST2 signaling ***,MSC-Exo may be a potential therapeutic method for ischemic stroke.

关键词： astrocytes bone marrow mesenchymal stem cells brain injury exosome IL-33 inflammation ischemic stroke neurological function neuron ST2

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