检索结果-南通市图书馆

Engineered tumor cell-derived vaccines against cancer: The art of combating poison with poison

Bioactive Materials 2023年第4期22卷 491-517页

作者： Xinyi Zhang Hengqing Cui Wenjun Zhang zhaoshen li Jie Gao Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai200433China Institute of Translational Medicine Shanghai UniversityShanghai200444China Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai200433China Department of Burns and Plastic Surgery Shanghai Changzheng HospitalShanghai200003China

Tumor vaccination is a promising approach for tumor immunotherapy because it presents high specificity and few side ***,tumor vaccines that contain only a single tumor antigen can allow immune system evasion by tumor *** antigens are complex and heterogeneous,and identifying a single antigen that is uniformly expressed by tumor cells is *** tumor cells can produce comprehensive antigens that trigger extensive tumor-specific immune ***,tumor cells are an ideal source of antigens for tumor vaccines.A better understanding of tumor cell-derived vaccines and their characteristics,along with the development of new technologies for antigen delivery,can help improve vaccine *** this review,we summarize the recent advances in tumor cell-derived vaccines in cancer immunotherapy and highlight the different types of engineered approaches,mechanisms,administration methods,and future *** discuss tumor cell-derived vaccines,including whole tumor cell components,extracellular vesicles,and cell membrane-encapsulated *** cell-derived vaccines contain multiple tumor antigens and can induce extensive and potent tumor immune ***,they should be engineered to overcome limitations such as insufficient immunogenicity and weak *** genetic and chemical engineering of tumor cell-derived vaccines can greatly enhance their targeting,intelligence,and functionality,thereby realizing stronger tumor immunotherapy *** advances in materials science,biomedicine,and oncology can facilitate the clinical translation of tumor cell-derived vaccines.

关键词： Vaccine Cancer Immunotherapy Immunogenicity Engineering Nanotechnology Biomaterials

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An antibiotic-free platform for eliminating persistent Helicobacter pylori infection without disrupting gut microbiota

引用

Acta Pharmaceutica Sinica B 2024年第7期14卷 3184-3204页

作者： Yongkang Lai Tinglin Zhang Xiaojing Yin Chunping Zhu Yiqi Du zhaoshen li Jie Gao Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Gastroenterology Ganzhou People’s Hospital Affiliated to Nanchang UniversityGanzhou 341000China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices Shanghai 200433China

Helicobacter pylori(***)infection remains the leading cause of gastric adenocarcinoma,and its eradication primarily relies on the prolonged and intensive use of two ***,antibiotic resistance has become a compelling health issue,leading to *** eradication treatment failure ***,the powerlessness of antibiotics against biofilms,as well as intracellular *** and the long-term damage of antibiotics to the intestinal microbiota,have also created an urgent demand for antibiotic-free ***,we describe an antibiotic-free,multifunctional copperorganic framework(HKUST-1)platform encased in a lipid layer comprising phosphatidic acid(PA),rhamnolipid(RHL),and cholesterol(CHOL),enveloped in chitosan(CS),and loaded in an ascorbyl palmitate(AP)hydrogel:AP@CS@lip@*** platform targets inflammatory sites where *** aggregates through electrostatic ***,hydrolysis by matrix metalloproteinases(MMPs)releases CS-encased nanoparticles,disrupting bacterial urease activity and membrane ***,RHL disperses biofilms,while PA promotes lysosomal acidification and activates host autophagy,enabling clearance of intracellular ***,AP@CS@lip@HKUST-1 alleviates inflammation and enhances mucosal repair through delayed Cu^(2+) release while preserving the intestinal ***,this platform presents an advanced therapeutic strategy for eradicating persistent *** infection without inducing drug resistance.

关键词： Helicobacter pylori infection Antibiotic-free Biofilms Autophagy Gastric mucosal repair Drug resistance Intestinal microbiota Anti-inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuro-protective effects of CNTF on hippocampal neurons via an unknown signal transduction pathway

引用

Chinese Science Bulletin 2006年第1期51卷 48-53页

作者： li Ping WANG Zongwen YAN Jin li zhaoshen JIANG Chunlei NI Xin YANG Yongji liU Fang LU Changlin Department of Psychology Second Military Medical University Shanghai 200433 China Changhai Hospital Second Military Medical University Shanghai 200433 China Laboratory of Stress Medicine Second Military Medical University Shanghai 200433 China School of Basic Medicine Second Military Medical University Shanghai 200433China

In our previous study, we proposed that there may be an unknown pathway in the upper stream of the known signal transduction pathway of Ciliary neurotrophic factor (CNTF) that mediates the neuro-protective function of CNTF. In the present experiment, we observed that the neuro-protective function of the non-classic signal transduction path- way in a L-NMDA (a glutamic acid ion type receptor atagonist) induced hippocampal neuron injury model, using primary culture rat hippocampal neurons, con- tinuous photography and gp130 immunohistochemi- cal assay. The results showed that L-NMDA induced injurious reaction of hippocampal neurons, and CNTF was able to inhibit the toxic action of L-NMDA on hippocampal neurons. Additionally, when JAK/STATs in the known classic signal transduction pathway of CNTF were blocked by PTPi-2, the protective effect of CNTF against L-NMDA injury still existed. L-NMDA caused a rapid increase in the concentration of hip- pocampal intracellular free [Ca2+]i. CNTF was able to attenuate L-NMDA-induced elevation of [Ca2+]i, and blocking JAK/STATs in the known classic signal trans- duction pathway of CNTF did not affect L-NMDA- induced elevation of [Ca2+]i, indicating that, apart from the known classic signal transduction pathway, there may be some other transduction pathways for CNTF to exert the protective effect on hippocampal neurons, and this pathway is related to [Ca2+].

关键词： CNTF L-NMDA 海马神经元 JAK/STATs PTPi-2 NMDA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

New insights into non-invasive screening of esophageal squamous cell carcinoma

引用

Medical Review 2023年第5期3卷 366-368页

作者： Ye Gao Luowei Wang zhaoshen li Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghaiChina National Clinical Research Center for Digestive Disease ShanghaiChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityNo.168 Changhai RoadShanghai 200433China National Clinical Research Center for Digestive Disease No.168 Changhai RoadShanghai 200433China

Esophageal cancer remains a leading cause of cancer-related death *** incidence and mortality rank seventh and sixth among all cancers in 2020[1],*** geographical regions with most esophageal cancer cases and deaths include central and eastern Asia(known as the Asian esophageal cancer belt),parts of Africa,and some South American countries,with esophageal squamous cell carcinoma(ESCC)being the major histological subtype(comprising nearly 90%of cases).Due to the asymptomatic nature of early-stage lesions,more than 80%of ESCC were diagnosed at an advanced *** have led to an extremely poor prognosis of ESCC,with 5-year survival rates less than 20%in most countries.

关键词： esophageal squamous mortality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Capsule endoscopy in portal hypertension and varices

引用

Portal Hypertension & Cirrhosis 2024年第3期3卷 171-172页

作者： Jun Pan zhaoshen li Zhuan liao Department of Gastroenterology National Clinical Research Center for Digestive DiseasesNational Key Laboratory of Immunity and InflammationShanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical DevicesChanghai HospitalNaval Medical UniversityShanghaiChina

1|CAPSULE ENDOSCOPY VERSUS ESOPHAGOGASTRODUODENOSCOPY(EGD)FOR DIAGNOSING GASTROESOPHAGEAL VARICES(GEVs):CENTERS *** is the gold standard for diagnosing GEVs in patients with portal hypertension,but its invasiveness limits patients'*** the nature of noninvasiveness and direct visualization,capsule endoscopy has the potential to be an alternative to EGD for diagnosing varices.

关键词： endoscopy hypertension capsule

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neutrophil-derived PAD4 induces citrullination of CKMT1 exacerbates mucosal inflammation in inflammatory bowel disease

引用

Cellular & Molecular Immunology 2024年第6期21卷 620-633页

作者： Shuling Wang Yihang Song Zhijie Wang Xin Chang Haicong Wu Ziwei Yan Jiayi Wu Zixuan He Le Kang Wenjun Hu Tian Xia zhaoshen li Xingxing Ren Yu Bai National Clinical Research Center for Digestive Diseases Department of GastroenterologyChanghai HospitalNaval Medical UniversityShanghai200433China National Key Laboratory of Immunology and Inflammation Naval Medical UniversityShanghai200433China Changhai Clinical Research Unit Changhai HospitalNaval Medical UniversityShanghai200433China Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai200433China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei230027China

Peptidyl arginine deiminase 4(PAD4)plays a pivotal role in infection and inflammatory diseases by facilitating the formation of neutrophil extracellular traps(NETs).However,the substrates of PAD4 and its exact role in inflammatory bowel disease(IBD)remain *** this study,we employed single-cell RNA sequencing(scRNA-seq)and substrate citrullination mapping to decipher the role of PAD4 in intestinal inflammation associated with *** results demonstrated that PAD4 deficiency alleviated colonic inflammation and restored intestinal barrier function in a dextran sulfate sodium(DSS)-induced colitis mouse ***-seq analysis revealed significant alterations in intestinal cell populations,with reduced neutrophil numbers and changes in epithelial subsets upon PAD4 *** expression analysis highlighted pathways related to inflammation and epithelial cell ***,we found that neutrophil-derived extracellular vesicles(EVs)carrying PAD4 were secreted into intestinal epithelial cells(IECs).Within IECs,PAD4 citrullinates mitochondrial creatine kinase 1(CKMT1)at the R242 site,leading to reduced CKMT1 protein stability via the autophagy *** action compromises mitochondrial homeostasis,impairs intestinal barrier integrity,and induces IECs ***-specific depletion of CKMT1 exacerbated intestinal inflammation and apoptosis in mice with *** analysis of IBD patients revealed elevated levels of PAD4,increased CKMT1 citrullination,and decreased CKMT1 *** summary,our findings highlight the crucial role of PAD4 in IBD,where it modulates IECs plasticity via CKMT1 citrullination,suggesting that PAD4 may be a potential therapeutic target for IBD.

关键词： Peptidyl-arginine deiminase-4 Citrullination Mitochondrial creatine kinase 1 Intestinal epithelial cells Inflammatory bowel disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

特殊环境对生物钟和肠道菌群影响的研究进展

引用

海军军医大学学报 2024年第9期45卷 1051-1058页

作者：张颂李兆申海军军医大学(第二军医大学)第一附属医院消化内科上海200433

生物活动随地球自转表现出的接近24 h的节律性波动被称为生物钟。肠道菌群为寄生于人体胃肠道的微生物群落,其平衡对维持机体稳态有重要作用。特殊环境包括外部环境的改变(如处于极地特殊昼夜光照、高原缺氧环境下)和生活方式发生改变(... 详细信息

生物活动随地球自转表现出的接近24 h的节律性波动被称为生物钟。肠道菌群为寄生于人体胃肠道的微生物群落,其平衡对维持机体稳态有重要作用。特殊环境包括外部环境的改变(如处于极地特殊昼夜光照、高原缺氧环境下)和生活方式发生改变(如轮班、失眠、跨时区飞行)等均会对生物钟产生不良影响,导致生物钟紊乱和肠道菌群失调。生物钟紊乱与菌群失调协同作用,进一步导致机体内环境稳态失衡,增加代谢性疾病的发生风险。阐明特殊环境下生物钟和肠道菌群的变化能够为特殊环境下作业人群生物钟和机体稳态的维持提供新思路。

关键词：生物钟肠道菌群生理学特殊环境代谢性疾病

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

胰腺疾病内镜诊疗的难点与进展

引用

临床肝胆病杂志 2020年第8期36卷 1681-1687页

作者：李兆申上海市胰腺疾病研究所上海200433 第二军医大学附属长海医院消化内科上海200433

胰腺疾病主要包括急性胰腺炎、慢性胰腺炎、胰腺癌和胰腺囊肿等,在全球范围内发病率呈上升趋势,是人类健康的重要威胁。早期诊断,早期干预,延缓病情重症化、慢性化和恶性化趋势是胰腺疾病临床诊治的重点。近年来,经内镜逆行胰胆管造影... 详细信息

胰腺疾病主要包括急性胰腺炎、慢性胰腺炎、胰腺癌和胰腺囊肿等,在全球范围内发病率呈上升趋势,是人类健康的重要威胁。早期诊断,早期干预,延缓病情重症化、慢性化和恶性化趋势是胰腺疾病临床诊治的重点。近年来,经内镜逆行胰胆管造影、超声内镜及其相关技术的不断发展使胰腺疾病的诊断效率大大提高。内镜介入手术利用人体自然腔道,减少了对周围组织的损伤,目前已部分取代外科手术,成为治疗的首选。然而,胰腺疾病病情复杂,内镜诊疗方式以及干预时机的选择等问题仍未完全解决,是目前研究的热点和难点。拟就主要胰腺疾病内镜诊疗的难点与研究进展作一阐述。

关键词：胰腺疾病内窥镜检查诊断治疗学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

胆源性胰腺炎内镜治疗现状和发展趋势

引用

中国实用外科杂志 2020年第11期40卷 1234-1239页

作者：李兆申海军军医大学附属长海医院消化内科上海200433

急性胆源性胰腺炎(ABP)是急性胰腺炎的最主要类型,占急性胰腺炎50%以上。ABP以胆道疾病为诱发因素,其中胆道微结石是最常见的原因。鉴于消化内镜治疗在胆胰疾病中的广泛应用,其在ABP的诊疗全过程中所起的作用越来越重要。从内镜下辅助AB... 详细信息

急性胆源性胰腺炎(ABP)是急性胰腺炎的最主要类型,占急性胰腺炎50%以上。ABP以胆道疾病为诱发因素,其中胆道微结石是最常见的原因。鉴于消化内镜治疗在胆胰疾病中的广泛应用,其在ABP的诊疗全过程中所起的作用越来越重要。从内镜下辅助ABP治疗决策、ABP病因治疗、处理ABP并发症、预防ABP复发以及进行ABP肠道营养5方面对内镜治疗ABP进行剖析:超声内镜(EUS)可从病因诊断和预后判断辅助ABP治疗决策;内镜逆行胰胆管造影(ERCP)是目前伴随胆管炎或者胆管梗阻的ABP首选治疗方式;EUS或ERCP下建立通道引流减压及后期内镜下清创可缓解胰周液体积聚和胰腺坏死所带来的严重并发症;腹腔镜下胆囊切除术可显著降低ABP的复发率;内镜下放置肠内营养管可保证ABP肠道屏障功能障碍的营养供给。随着内镜微创理念的普及、内镜微创技术的成熟、内镜器械的研发,有望建立内镜贯穿ABP诊治全过程的微创"升阶梯"治疗模式。

关键词：急性胆源性胰腺炎内镜逆行胰胆管造影超声内镜腹腔镜

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Utilization and quality assessment of digestive endoscopy in China:results from 5-year consecutive nationwide surveys

引用

Chinese Medical Journal 2022年第16期135卷 2003-2010页

作者： Lei Xin Ye Gao Zhiyuan Cheng Tianjiao Wang Han lin Yanan Pang Chang Sun Zengjun Fu zhaoshen li Xudong Ma Luowei Wang Department of Gastroenterology Digestive Endoscopy CenterChanghai HospitalNaval Medical UniversityShanghai 200433China Graduate School Naval Medical UniversityShanghai 200433China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200240China National Digestive Endoscopy Improvement System Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Medical Qualty Medical and Health AdministrationNational Health Commission of ChinaBejing 100044China.

Background:Worldwide,the volume and availability of digestive endoscopy have undergone dramatic development in recent years,with increasing attention on quality *** investigated the utilization and quality of digestive endoscopy in China from 2015 to 2019 and developed a quantitative quality evaluation tool for medical ***:We invited all tertiary/secondary hospitals in Chinese mainland to participate in the survey *** questionnaires included the personnel,annual volume,and quality indicators of *** endoscopy quality index(EQI)was developed based on recorded quality indicators using principal component analysis to determine the relative ***:From 2015 to 2019,806,1412,2644,2468,and 2541 hospitals were respectively enrolled in this *** average annual volume of endoscopy increased from 12,445 to 16,206(1.30-fold)and from 2938 to 4255(1.45-fold)in tertiary and secondary hospitals,*** most obvious growth was observed in diagnostic colonoscopy(1.44-fold for all hospitals after standardization).The proportion of early cancer among all esophageal and gastric cancers during diagnostic esophagogastroduodenoscopy increased from 12.3%(55,210/448,861)to 17.7%(85,429/482,647)and from 11.4%(69,411/608,866)to 16.9%(107,192/634,235),*** adenoma detection rate of diagnostic colonoscopy increased from 14.9%(2,118,123/14,215,592)to 19.3%(3,943,203/20,431,104).The EQI model included 12 quality indicators,incorporating 64.9%(7.792/12)of the total variance into one comprehensive *** to the EQI measurements,the quality of endoscopy was higher in tertiary hospitals and hospitals in developed areas with higher volume or more endoscopists than that in other ***:Digestive endoscopy in China has developed considerably in recent years in terms of both volume and *** EQI is a promising tool to quantify the quality of endoscopy at different hospitals.

关键词： Endoscopy,gastrointestinal Health care surveys Principal component analysis Quality control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：