检索结果-南通市图书馆

Chinese Chemical Letters 2024年第6期35卷 365-369页

作者： Xing Tian Di Wu Wanheng Wei Guifu Dai zhanxian li Benhua Wang Mingming Yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of life Sciences Zhengzhou UniversityZhengzhou 450001China Shenzhen Research Institute of Central South University Shenzhen 518057China

Abnormal accumulation and metabolism of lipid droplets can lead to a variety of ***,a key parameter of the microenvironment,is closely associated with many diseases and dysfunctions in the *** is important to elucidate the relationship between the physiological activity of lipid droplets(LDs)and the polarity of the *** this work,based on push-pull mechanism,a fluorescent probe(E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one(PPTH)with aggregation-induced emission(AIE)properties for the detection of polarity changes in cells was *** not only visualize intracellular polarity fluctuation of iron death and inflammation but also distinguish between normal and fatty liver tissue.

关键词： lipid droplets AIE Polarity Ferroptosis Fatty liver

在线全文

学校读者我要写书评

暂无评论

力法原理在机器人碰撞点识别中的应用

组合机床与自动化加工技术 2024年第6期 86-92页

作者：朱博承王志军李占贤马文文华北理工大学机械工程学院唐山063210 华北理工大学河北省工业机器人产业技术研究院唐山063210

随着机器人技术、人机协同作业技术被广泛关注,如何实现一个人机共融的安全系统至关重要。想要实现真正的人机共融,保证安全性、做好碰撞点的识别工作是重点。针对皮肤传感器应用包覆性来感知外力的局限性,提出了一种人机协同作业时当... 详细信息

随着机器人技术、人机协同作业技术被广泛关注,如何实现一个人机共融的安全系统至关重要。想要实现真正的人机共融,保证安全性、做好碰撞点的识别工作是重点。针对皮肤传感器应用包覆性来感知外力的局限性,提出了一种人机协同作业时当碰撞连杆已知,引入一种新的求解碰撞点处外部接触力的方法。利用力法原理求解超静定结构的方式,只需借助机器人本体输出的部分参数信息,即可根据受力信息,得到碰撞点的位置信息。最后,搭载实验平台对所提出的算法进行仿真实验,实验结果表明通过受力信息锁定碰撞点位置时,其受力情况的误差范围在可接受的范围之内,满足机器人碰撞点识别算法的精度要求。

关键词：人机协作超静定结构力法求解碰撞点识别

在线全文

学校读者我要写书评

暂无评论

磁控触变流体的3D打印工艺研究

材料科学与工艺 2024年第2期32卷 55-65页

作者：张圣杰李振坤耿子健郭乙飞宋仲儒董珈皓李占贤华北理工大学机械工程学院河北唐山063210 北京交通大学机械与电子控制工程学院北京100044 河北省工业机器人产业技术研究院河北唐山063210

针对现有磁控智能流体无法应用于3D打印的问题,本文制备了一种在磁场调控下能够实现溶胶-凝胶可逆转变的新型磁控触变流体,并对其打印工艺进行了研究。采用全系统损耗润滑油、有机膨润土和Fe_(3)O_(4)颗粒制备了不同配比的打印样品,搭... 详细信息

针对现有磁控智能流体无法应用于3D打印的问题,本文制备了一种在磁场调控下能够实现溶胶-凝胶可逆转变的新型磁控触变流体,并对其打印工艺进行了研究。采用全系统损耗润滑油、有机膨润土和Fe_(3)O_(4)颗粒制备了不同配比的打印样品,搭建了直写式3D打印实验平台,研究其可打印性。流变学实验表明:磁控触变流体有机膨润土含量越高,触变性越强,剪切变稀越明显;磁场强度越强,屈服应力越高,储存模量越高。3种挤出方式下的打印实验结果表明,采用匀料恢复挤出方式打印的结构具备最高分辨率和最大高度。磁控触变流体在根据其流变特性设计的挤出装置下具有良好可打印性,为该材料应用于柔性传感、软体机器人个性化复杂结构设计与驱动、微流控检测等领域奠定了基础。

关键词：磁场调控磁控触变流体 3D打印打印工艺流变性能

维普期刊数据库博看期刊

Mobility matrix of a weakly coupled parallel multi-DIM isolator based on axial force solution

在线全文

学校读者我要写书评

暂无评论

High Technology Letters 2020年第3期26卷 335-341页

作者： li Desheng Yu Jiangtao Huang Baowang li zhanxian Wang Zhijun College of Mechanical Engineering North China University of Science and TechnologyTangshan 063210P.R.China

A mobility matrix modeling strategy based on axial force solution for a weakly coupled parallel multi-dimentional(multi-DIM)isolator is *** power flow and transmissibility through the isolator are derived from the mob... 详细信息

关键词： mobility matrix weak-coupling parallel multi-dimentional(multi-DIM)isolator axial force mobility power flow

Dynamic analysis of double-layer and pre-stressed multi-limb six-axis force sensor

在线全文

学校读者我要写书评

暂无评论

High Technology Letters 2019年第2期25卷 189-196页

作者： Wang Zhijun He Jing Cui Bingyan li zhanxian College of Mechanical Engineering North China University of Science and TechnologyTangshan 063210P.R.China Tangshan Polytechnic College Tangshan 063299P.R.China Hebei Province Research Institute of Industrial Robot Industry Technology Tangshan 063210P.R.China

In order to adapt to the specific task, the six-axis dynamic contact force between end-effectors of intelligent robots and working condition needs to be perceived. Therefore, the dynamic property of six-axis force sensor which is installed on the end-effectors of intelligent robots will have influence on the veracity of detection and judgment to working environment contact force by intelligent robots directly. In this paper, dynamic analysis to double-layer and pre-stressed multi-limb six-axis force sensor is conducted. First, the structure of the sensor is introduced, and the limb number is confirmed by introducing the related definitions of convex analysis. Then, based on vibration of multiple-degree-of-freedom system, a mechanical vibration simplified model of double-layer and pre-stressed multiple limb six-axis force sensor is set up. After that, movement differential equations of sensor and the response of analytical expression are deduced, and the movement differential equations is solved. Finally, taking the double-layer and pre-stressed seven limb six-axis force sensor as an example, numerical calculation and simulation of deriving result is conducted, which verify the correctness and feasibility of the theoretical analysis.

关键词： six-axis force sensor multi-limb pre-stressed mechanical vibration dynamic analysis

基于鳄雀鳝议题的“生态系统的稳定性”SSI教学设计

在线全文

学校读者我要写书评

暂无评论

生物学通报 2024年第1期59卷 33-37页

作者：袁洪玉李展贤林媛伊珍珍华南师范大学生命科学学院广东广州510631

以鳄雀鳝(Atractosteus spatula)议题在“生态系统的稳定性”一节中的应用为例,借助一定的框架选择议题内容,使用情境教学和问题驱动教学,通过热点话题导入、构建概念模型、多重因果推理、整体分析现象、讨论社会议题、明确概念关系等... 详细信息

以鳄雀鳝(Atractosteus spatula)议题在“生态系统的稳定性”一节中的应用为例,借助一定的框架选择议题内容,使用情境教学和问题驱动教学,通过热点话题导入、构建概念模型、多重因果推理、整体分析现象、讨论社会议题、明确概念关系等教学环节,帮助学生逐步形成概念、应用概念、深化对概念的理解,促进学生核心素养的培养,探讨社会性科学议题在“生物与环境”模块中的应用。

关键词：社会性科学议题生态系统的稳定性问题驱动情境创设

FRET-based ratiometric fluorescent detection of arginine in mitochondrion with a hybrid nanoprobe

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2020年第2期31卷 443-446页

作者： Yueyue li Yanan Ban Ruihui Wang Zheng Wang zhanxian li Chenjie Fang Mingming Yu College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences Capital Medical UniversityBeijing 100069China

A ratiometric fluorescent hybrid nanoprobe CDs-1 for arginine(Arg),exhibiting high sensitivity(the limit of detection,LOD,being 6.5×10^-8 mol/L) and excellent selectivity and anti-interference ability,was fabricated through fluorescence resonance energy transfer(FRET) and the electrostatic attraction between positively-charged hemicyanine molecules and negatively-charged carbon dots(CDs).Arg can be quantitatively detected in the concentration range from 6.0×10^-5 mol/L to 2.7×10^-4 mol/***,due to its ability to target mitochondrion and low cytotoxicity,intracellular Arg was succes s fully tracked through ratiometric fluorescence imaging.

关键词： FRET Ratiometric Arg Mitochondrion Nanoprobe Cell imaging

Multi-organelle-targeting pH-dependent NIR fluorescent probe for lysosomal viscosity

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第3期34卷 378-382页

作者： Huili Wang Yishuo Sun Xuemei lin Wei Feng zhanxian li Mingming Yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersInstitutes of Biomedical Sciences&Collaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200433China

The normal operation of lysosome, mitochondria, Golgi apparatus and endoplasmic reticulum plays a significant role in maintaining cell homeostasis. Reflecting the state and function of lysosomes, viscosity is a pivotal parameter to assess the stability of microenvironment. Herein, based on TICT mechanism,a new NIR pH-dependent fluorescent probe DCIC with push-pull electronic moiety was synthesized to identify the lysosomes viscosity. In viscous media, DCIC was highly sensitive to viscosity, fluorescence intensity increased by 180 times as viscosity increased from 1.0 cp to 438.4 cp. In addition, DCIC have high localization ability for lysosome, mitochondria, Golgi apparatus, and endoplasmic reticulum and can monitor lysosomal viscosity fluctuations with laser confocal microscopy.

关键词： NIR Lysosomal viscosity PH-dependent Multi-organelle localization

Luminescence interference-free lifetime nanothermometry pinpoints in vivo temperature

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2021年第6期64卷 974-984页

作者： Mengya Kong Yuyang Gu Yingjie Chai Jiaming Ke Yulai liu Xincheng Xu zhanxian li Wei Feng Fuyou li Department of Chemistry Institutes of Biomedical SciencesState Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

Luminescence nanothermometry makes non-invasive and real-time temperature readings possible in living ***,the spectral fluctuation in tissues and fluids,as well as the interaction between fluorophores and environment hinders accuracy of the ***,we report a luminescence lifetime-based nanothermometry which specifically addresses this problem.A temporal based calibration(lifetime sensing)in the NIR range,an endogenous thermal response as well as a polymer encapsulation evading environmental factors,altogether help to pinpoint temperature in *** to the highly condensed NdYb ions in a well-protected tiny core-shell nanocrystal(overall 11 nm),a temperature sensitivity about 2.07%K^(-1)(with 5%Yb^(3+)doped nanoparticles)and an accuracy of 0.27 K(with 25%Yb^(3+)doped nanoparticles)in biological fluids are ***,combining thermally activated energy transfer nanothermometer with anti-interference lifetime thermometry would provide a more accurate temperature measurement for biological and preclinical studies.

关键词： luminescence nanothermometry NIR lifetime imaging lanthanide-doped nanocrystals thermal sensing

基于调和函数的偏置曲柄滑块机构非线性诺模图设计

在线全文

学校读者我要写书评

暂无评论

机械设计 2024年第6期41卷 139-143页

作者：李德胜黄宝旺于江涛李占贤王志军冯永利华北理工大学机械工程学院河北唐山063210

文中给出了偏置曲柄滑块机构的非线性诺模图。首先,对机构基本方程引入无量纲参数和过渡函数,将机构数学模型整理成适合诺模图求解的标准形式;其次,对过渡函数采用构造调和函数并解析的策略,寻求较优尺度模量,弱化和规避关键标尺刻度的... 详细信息

文中给出了偏置曲柄滑块机构的非线性诺模图。首先,对机构基本方程引入无量纲参数和过渡函数,将机构数学模型整理成适合诺模图求解的标准形式;其次,对过渡函数采用构造调和函数并解析的策略,寻求较优尺度模量,弱化和规避关键标尺刻度的非均匀分布和过度集中现象;最后,使用两种不同类型无量纲参数的案例,对所给非线性诺模图进行验证。结果表明:该诺模图不仅可直接用于快速设计不同目标的偏置曲柄滑块机构,还可对所做设计的正确性与合理性予以快速校验。

关键词：偏置曲柄滑块机构非线性诺模图调和函数尺度模量无量纲参数