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Combined effects of climate and land-use changes on the alpha and beta functional diversities of terrestrial mammals in China

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Science China(life Sciences) 2024年第10期67卷 2224-2233页

作者： Chao Zhang yumei li Wei Wang Zexuan Gao Hanqing liu Yonggang Nie Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China College of life Sciences Hebei UniversityBaoding 071002China University of Chinese Academy of Sciences Beijing 100049China

Climate and land-use changes are predicted to impact biodiversity,threatening ecosystem services and ***,their combined effects on the functional diversity of mammals at the regional scale remain unclear,especially at the beta ***,we use projected climate and land-use changes in China to investigate their potential effects on the alpha and beta functional diversities of terrestrial mammals under low-and high-emission *** the current projection,we showed strong positive spatial correlations between functional richness and species *** evenness(FEve),functional specialization(FSpe),and functional originality(FOri)decreased with species richness,and functional divergence(FDiv)increased first and then *** beta diversity was dominated by its nestedness component,in contrast to the taxonomic *** changes in species richness are more strongly influenced by land-use change under the low-emission scenario,while under the high-emission scenario,they are more strongly influenced by climate *** in functional richness(FRic)were inconsistent with those in species richness,with a magnitude of decreases greater than predicted from species ***,mammal assemblages showed potential functional differentiation(FD)across the country,and the trends exceeded those towards taxonomic differentiation(TD).Our findings help us understand the processes underlying biodiversity responses to global changes on multiple facets and provide new insight for conservation plans.

关键词： climate change land-use change functional diversity terrestrial mammals biodiversity conservation

Vegetation and environment changes inferred from pollen records since 3000 cal. yr BP in Kanas wetland, Xinjiang

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Journal of Plant Ecology 2019年第5期12卷 907-916页

作者： yumei li Yun Zhang Zhaochen Kong Long Zhao li Wang Yuanyuan li lixin Chen State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of SciencesBeijing 100093China College of Earth Sciences Jilin UniversityChangchun 130061China Beijing Geological and Mineral Exploration and Development Bureau Beijing 100195China College of life Sciences University of Chinese Academy of SciencesBeijing 100049China

Aims climate change can significantly affect the vegetation ***,paleovegetation and paleoclimate reconstruction should consider the quantitative relationship between modern vegetation and *** specific objectives of this study were(i)to assess the influence of environmental variables on pollen assemblages in the Kanas region,(ii)to reconstruct the evolution of vegetation over the past 3000 years using pollen records and(iii)to quantify historical climate change(including mean annual temperature and total annual precipitation)using a weighted averaging partial least squares regression method(WAPLS)applied to fossil pollen data from the Kanas wetland in Xinjiang,*** A total of 65 surface and 50 fossil samples were collected from the Kanas wetland and analysed for 14c,pollen and grain *** com-bining these data with those obtained from 214 samples of surface pollen assemblages in north Xinjiang,the late Holocene climate was reconstructed using a WAPLS *** Findingsthe vegetation in Kanas was dominated by forest for the past 3000 years,undergoing an arbour-vegetation transition from predominantly pine to spruce over that *** WAPLS model showed that the paleoclimate progressed from cold-wet to warm-dry and subsequently back to *** to 1350 calibrated years before the present(*** BP),the climate of Kanas was cold and wet,and conditions became increasingly warm and dry until 870 *** *** temperature reconstruction model indicated that a‘little Ice Age’occurred~380 *** *** data will help us improve the understanding of abrupt climate change and provide important information regarding the prediction of climate.

关键词： climate change Kanas wetland north Xinjiang pollen grain size

A new polynomial algorithm for a parallelidentical scheduling problem

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控制理论与应用（英文版） 2007年第4期5卷 345-350页

作者： yumei li Hongxing li Vincent C. YEN School of Information Engineering Beijing Technology and Business University Beijing 100037 China School of Mathematical Sciences Beijing Normal University Beijing 100875 China Department of Management Science and Information Systems Wright State University Dayton Ohio 45435-0001 USA

A precedence order is defined based on the release dates of jobs＇ direct successors. Using the defined precedence order and Heap Sort, a new polynomial algorithm is provided which aims to solve the parallel scheduling problem P｜pj = 1, r j, outtree｜ ∑Cj Cj. The new algorithm is shown to be more compact and easier to implement.

关键词： Scheduling problem Precedence order Heap sort Algorithm

日本地震预警业务规定和技术系统发展历程及最新进展

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地震科学进展 2025年第1期55卷 30-34页

作者：朱林连尉平李玉梅陈洪波中国地震局发展研究中心北京100036

日本地震预警业务规定和技术系统近年来依然在不断更新发展。2023年2月1日起,日本地震预警发布内容中正式加入长周期地震动预测信息。2015年以来海底观测网相继纳入预警系统,有效缩短了发生在日本海沟沿岸地震的预警首报发布时间。2018... 详细信息

日本地震预警业务规定和技术系统近年来依然在不断更新发展。2023年2月1日起,日本地震预警发布内容中正式加入长周期地震动预测信息。2015年以来海底观测网相继纳入预警系统,有效缩短了发生在日本海沟沿岸地震的预警首报发布时间。2018年引入PLUM法,使系统在传统方法失效时也能够作出地震动预报。目前正在重点解决地震动预测过大情况依然时有发生的问题,日本气象厅在2023年底前后引入一体化集成IPF法以降低预测地震动过大比率。当前日本地震预警技术和应用发展中遇到的一些问题,以及设想的未来重点发展方向,也是我国地震预警发展的有益参考。

关键词：日本地震预警技术改进评估

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Downregulation of KCTD12 contributes to melanoma stemness by modulating CD271

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Cancer Biology & Medicine 2019年第3期16卷 498-513页

作者： Weiyu Shen yumei li Bifei li liping Zheng Xiaodong Xie Jingqing Le Yusheng Lu Tao li Fan Chen Lee Jia Cancer Metastasis Alert and Prevention Center College of Chemistry and Fujian Provincial Key Laboratory of CancerMetastasis Chemoprevention and ChemotherapyFuzhou UniversityFuzhou350108China Department of Pharmacy Fujian Provincial Maternity and Children’s HospitalFuzhou350001China Institute of Oceanography Minjiang UniversityFuzhou350108China

Objective: Cancer metastasis remains the primary cause of cancer-related death *** a previous study, we found that levels of BTB/POZ domain-containing protein KCTD12 are lower in metastatic melanoma cells than in parental melanoma *** purpose of this study was to identify the roles of KCTD12 in cancer ***: The Cancer Genome Atlas(TCGA) datasets were used to evaluate the relationship between KCTD12 and skin cutaneous melanoma(SKCM) *** effects of endogenous KCTD12 on biological behaviors were examined using the MTT *** impacts of KCTD12 on melanoma stemness were explored using spheroid formation ***12 knockout A375 cells were generated to confirm the inhibitory effect of KCTD12 on CD271, and a mouse metastatic model was used to determine the impact of KCTD12 on melanoma metastasis in ***: KCTD12 levels were lower in lung metastatic cells than in paired parental melanoma cells, and low KCTD12 expression indicated a poor prognosis in *** metastasis-related capacities were higher in lung metastatic cells than in parental melanoma ***, KCTD12 knockdown enhanced tumor growth and metastasis both in vitro and in ***, the interaction between KCTD12 and CD271 might be responsible for the stemness transformation after KCTD12 ***: This study identifies for the first time the role of the interaction between KCTD12 and CD271 in inducing melanoma cell stemness ***, KCTD12 repression enhances melanoma cell growth, adhesion, migration and invasion.

关键词： KCTD12 MITF CD271 melanoma cancer metastasis cancer stem cell

Genome-wide Analysis of MYB Gene Family in Potato Provides Insights into Tissue-specific Regulation of Anthocyanin Biosynthesis

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Horticultural Plant Journal 2021年第2期7卷 129-141页

作者： yumei li Jun liang Xiangzhi Zeng Han Guo Youwei Luo Philip Kear Shouming Zhang Guangtao Zhu Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China Yunnan Key Lab for Potato Biology The CAAS-YNNU Joint Academy of Potato SciencesYunnan Normal UniversityKunming650500China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhenGuangdong518124China Yunnan Dehong Dai and Jinpo Nationality Institute of Agricultural Sciences DehongYunnan678400China International Potato Center(CIP) CIP China Center for Asia PacificBeijing100081China

The MYB transcription factor is one of the largest gene families in plants,playing an important role in regulating plant growth,development,response to stress,senescence,and especially the anthocyanin *** this study,A total of 217 MYB genes,including 901R-MYBs,124 R2R3-MYBs,and 3 R1R2R3-MYBs have been identified from the potato *** 1R-MYB and R2R3-MYB family members could be divided into 20 and 35 subgroups *** of gene structure and protein motifs revealed that members within the same subgroup presented similar exon/intron and motif organization,further supporting the results of phylogenetic *** is an ideal plant to reveal the tissue-specific anthocyanins biosynthesis regulated by MYB,as the anthocyanins could be accumulated in different tissues,showing colorful *** pairs of colored and colorless tissues,stigma,petal,stem,leaf,and tuber flesh,were applied to the transcriptomic analysis.A total of 70 MYB genes were found to be differentially expressed between colored and colorless tissues,and these differentially expressed genes were suspected to regulate the biosynthesis of anthocyanin of different ***-expression analysis identified numerous potential interactive regulators of anthocyanins biosynthesis,involving 39 MYBs,24 bHLHs,2 WD-repeats,and 29 biosynthesis ***-wide association study(GWAS)of tuber flesh color revealed amajor signal at the end of Chromosome 10,which was co-localized with reported I gene(StMYB88),controlling tuber peel *** of DEGs(Differentially Expression Genes)revealed that both StMYB88 and StMYB89 were closely related to regulating anthocyanin biosynthesis of tuber *** work offers a comprehensive overview of the MYB family in potato and will lay a foundation for the functional validation of these genes in the tissue-specific regulation of anthocyanin biosynthesis.

关键词： potato MYB transcription factor anthocyanin differentially expressed co-expression tuber flesh

Population-scale genetic control of alternative polyadenylation and its association with human diseases

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Quantitative Biology 2022年第1期10卷 44-54页

作者： Lei li yumei li Xudong Zou Fuduan Peng Ya Cui Eric J.Wagner Wei li Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen 518055China Division of Computational Biomedicine Department of Biological ChemistrySchool of MedicineUniversity of CaliforniaIrvineCA 92697USA Department of Biochemistry&Molecular Biology University of Texas Medical BranchGalvestonTX 77555USA

Background:Genome-wide association studies(GWAS)have identified thousands of genomic non-coding variants statistically associated with many human traits and diseases,including ***,the functional interpretation of these non-coding variants remains a significant challenge in the post-GWAS *** polyadenylation(APA)plays an essential role in post-transcriptional regulation for most human *** employing different poly(A)sites,genes can either shorten or extend the 3'-UTRs that contain cu-regulatory elements such as miRNAs or RNA-binding protein binding ***,APA can affect the mRNA stability,translation,and cellular localization of ***-scale studies have revealed many inherited genetic variants that potentially impact APA to further influence disease susceptibility and phenotypic diversity,but systematic computational investigations to delineate the connections are in their earliest ***:Here,we discuss the evolving definitions of the genetic basis of APA and the modern genomics tools to identify,characterize,and validate the genetic influences of APA events in human *** also explore the emerging and surprisingly complex molecular mechanisms that regulate APA and summarize the genetic control of APA that is associated with complex human diseases and ***:APA is an intermediate molecular phenotype that can translate human common non-coding variants to individual phenotypic variability and disease susceptibility.

关键词： GWAS eQTL disease alternative polyadenylation

Straw mulching alters the composition and loss of dissolved organic matter in farmland surface runoff by inhibiting the fragmentation of soil small macroaggregates

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Journal of Integrative Agriculture 2024年第5期23卷 1703-1717页

作者： Shanshan Cai Lei Sun Wei Wang Yan li Jianli Ding liang Jin yumei li Jiuming Zhang Jingkuan Wang Dan Wei College of Land and Environment Shenyang Agricultural UniversityShenyang 110866China Heilongjiang Academy of Black Soil Conservation and Utilization Harbin 150086China Institute of Plant Nutrition Resources and EnvironmentBeijing Academy of Agricultural and Forestry SciencesBeijing 100097China

Straw mulching is a widespread practice for reducing the soil carbon loss caused by ***,the effects of straw mulching on dissolved organic matter(DOM)runoff loss from black soil are not well *** straw mulching affects the composition and loss of runoff DOM by changing soil aggregates remains largely ***,a straw mulching treatment was compared to a no mulching treatment(as a control)on sloping farmland with black soil erosion in Northeast *** divided the soil into large macroaggregates(>2 mm),small macroaggregates(0.25-2 mm),and microaggregates(like acid and protein-like *** straw mulching treatment,the protein-like components in small macroaggregates accumulated and the protein-like components in runoff declined with rain *** spectroscopy technology may help in understanding the hydrological paths of rain events by capturing the dynamic changes of runoff and soil DOM characteristics.A variation partitioning analysis(VPA)indicated that the DOM concentration and composition of microaggregates explained 68.2%of the change in runoff DOM from no mulching plots,while the change in runoff DOM from straw mulching plots was dominated by small macroaggregates at a rate of 55.1%.Taken together,our results demonstrated that straw mulching reduces the fragmentation of small macroaggregates and the loss of microaggregates,thus effecting DOM compositions in soil and reducing the DOM loss in *** results provi

关键词： dissolved organic matter black soil surface runoff aggregates fluorescence spectrum

Potentials of ribosomopathy gene as pharmaceutical targets for cancer treatment

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Journal of Pharmaceutical Analysis 2024年第3期14卷 308-320页

作者： Mengxin Wang Stephen Vulcano Changlu Xu Renjian Xie Weijie Peng Jie Wang Qiaojun liu Lee Jia Zhi li yumei li Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province Gannan Medical UniversityGanzhouJiangxi341000China School of Rehabilitation Medicine Gannan Medical UniversityGanzhouJiangxi341000China Autoimmunity and Inflammation Program HSS Research InstituteHospital for Special Surgery New YorkNew YorkNY10021USA Division of Oral and Systemic Health Sciences School of DentistryUniversity of CaliforniaLos AngelesCA90095USA School of Medical Information Engineering Gannan Medical UniversityGanzhouJiangxi341000China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Institute of Innovative DrugsInstitute for Liver Diseases of Anhui Medical UniversitySchool of PharmacyAnhui Medical UniversityHefei230032China School of Basic Medicine Gannan Medical UniversityGanzhouJiangxi341000China Institute of Oceanography Minjiang UniversityFuzhou350108China

Ribosomopathies encompass a spectrum of disorders arising from impaired ribosome biogenesis and reduced *** or dysexpression of the genes that disturb any finely regulated steps of ribosome biogenesis can result in different types of ribosomopathies in clinic,collectively known as ribosomopathy *** data suggest that ribosomopathy patients exhibit a significantly heightened susceptibility to *** ribosome biogenesis and dysregulation of some ribosomopathy genes have also been found to be intimately associated with cancer *** correlation between ribosome biogenesis or ribosomopathy and the development of malignancies has been well *** work aims to review the recent advances in the research of ribosomopathy genes among human cancers and meanwhile,to excavate the potential role of these genes,which have not or rarely been reported in cancer,in the disease development across *** plan to establish a theoretical framework between the ribosomopathy gene and cancer development,to further facilitate the potential of these genes as diagnostic biomarker as well as pharmaceutical targets for cancer treatment.

关键词： Ribosome biogenesis Ribosomopathy gene Cancer treatment target Pharmaceutical target