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Mechanical effects of needle texture on acupoint tissue

Journal of Integrative Medicine 2023年第3期21卷 254-267页

作者： ming-zhu Sun Xin Wang ying-chen li Wei Yao Wei Gu Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function Department of Aeronautics and AstronauticsFudan UniversityShanghai 200433China Department of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China

Objective:This study aims to clarify how the stimulation of acupuncture points is achieved by needles with different surface texture during acupuncture;it also seeks to lessen injury at the insertion site and increase the therapeutic efficacy of acupuncture,by simulating the mechanical effects of various needle surface patterns on Zusanli(ST36)without changing the radius of acupuncture ***:Five acupuncture needle models with different surface patterns,including the smooth needle,the lined needle,the ringed needle,the left-hand threaded needle and the right-hand threaded needle,and a layered model of the Zusanli acupoint were used to investigate how to reduce tissue damage and increase stimulation during acupuncture treatment,Puncturing of the skin as well as liftinginserting and twisting needle manipulations were simulated using these models,and the degree of damage and force of stimulation caused by the acupuncture needles with different surface patterns during ***:The smooth needle and the lined needle caused the least tissue damage during insertion,while the left-hand threaded and the right-hand threaded needles caused the most *** ringed needle,the left-hand threaded needle and the right-hand threaded needle stimulated the acupoint tissue more during lifting-inserting manipulations,while the lined needle and the smooth needle produced less *** stimulation of the lined needle on the acupoint tissue was the largest during twisting manipulation,whereas the left-hand threaded needle and the right-hand threaded needle had smaller *** lifting-inserting and twisting manipulations,both the left-hand threaded needle and right-hand threaded needle provided more stimulation,but the torsion direction in which they produced better stimulation was ***:According to the simulation results,the ringed pattern enhances stimulation best in the lifting-inserting manipulation,whereas the lined patter

关键词： Biomechanics Finite elementmethod Acupuncture Needle roughness Mechanical effects

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Effect of proppant pumping schedule on the proppant placement for supercritical CO_(2) fracturing

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Petroleum Science 2022年第2期19卷 629-638页

作者： Yong Zheng Hai-Zhu Wang ying-Jie li Gang-Hua Tian Bing Yang Cheng-ming Zhao ming-Sheng liu State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China CNPC Offshore Engineering Co.Ltd. Beijing100028China

Supercritical CO_(2)fracturing is a potential waterless fracturing technique which shows great merits in eliminating reservoir damage,improving shale gas recovery and storing CO_(2)*** insight into the proppant-transport behavior of CO_(2)is required to better apply this technique in the engineering *** the present paper,we adopted a coupled Computational Fluid Dynamics and Discrete Element Method(CFD-DEM)approach to simulate the proppant transport in a fracking fracture with multiple perforation *** experiments were first simulated to benchmark the CFD-EDM approach,and then various pumping schedules and injection parameters(injection location,multi-concentration injection order,multi-density injection order and injection temperature)were investigated to determine the placement characteristics of *** indicate that the swirling vortex below the injection tunnels dominates the proppant diffusion in the *** velocity of fluid flow across the proppant bank surface in multi-concentration injection shows a positive correlation with the proppant *** high-density proppant first can promote the transportation of low-density proppant injected later in the fracture to a certain *** the initial injection temperature of supercritical CO_(2)slurry helps enhance the particle-driving effect of fluid and improve the performance of supercritical CO_(2)in carrying proppant.

关键词： Supercritical CO_(2)fracturing Proppant placement CFD-DEM Unconventional natural gas CO_(2)utilization

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Application and Prospect of Platelet Multi-omics Technology in Study of Blood Stasis Syndrome

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Chinese Journal of Integrative Medicine 2022年第2期28卷 99-105页

作者： li ying SUN ming-qian li Lei ZHANG Ye-hao MIAO Lan liU Jian-xun Beijing Key Laboratory of Pharmacology of Chinese Materia Region Xiyuan HospitalChina Academy of Chinese Medical SciencesNational Clinical Research Center for Chinese Medicine CardiologyBeijing(100091)China

The abnormality of platelet function plays an important role in the pathogenesis and evolution of blood stasis syndrome(BSS).The explanation of its mechanism is a key scientific issue in the study of cardiovascular and cerebrovascular diseases and *** biology technology provides a good technical platform for further development of platelet multi-omics,which is conducive to the scientific interpretation of the biological mechanism of *** article summarized the pathogenesis of platelets in BSS,the mechanism of action of blood activating and stasis resolving drugs,and the application of genomics,proteomics,and metabonomics in platelet research,and put forward the concept of"plateletomics in BSS".Through the combination and cross-validation of multi-omics technology,it mainly focuses on the clinical and basic research of cardiovascular and cerebrovascular diseases;through the interactive verification of multi-omics technology and system biology,it mainly focuses on the platelet function and secretion *** article systematically explains the molecular biological mechanism of platelet activation,aggregation,release,and other stages in the formation and development of BSS,and provides a new research idea and method for clarifying the pathogenesis of BSS and the mechanism of action of blood activating and stasis resolving drugs.

关键词： blood stasis syndrome platelet transcriptomics metabonomics proteomics

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Dynamic Properties of Two-Dimensional Polydisperse Granular Gases

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Communications in Theoretical Physics 2007年第2X期48卷 343-347页

作者： li Rui ZHANG Duan-ming HUANG ming-Tao SU Xiang-ying CHEN Zhi-Yuan ZHU Hong-ying ZHANG lin Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

We propose a two-dimensional model of polydisperse granular mixtures with a power-law size distribution in the presence of stochastic driving. A fractal dimension D is introduced as a measurement of the inhomogeneity of the size distribution of particles. We define the global and partial granular temperatures of the multi-component mixture. By direct simulation Monte Carlo, we investigate how the inhomogeneity of the size distribution influences the dynamic properties of the mixture, focusing on the granular temperature, dissipated energy, velocity distribution, spatial clusterization, and collision time. We get the following results： a single granular temperature does not characterize a multi-component mixture and each species attains its own ＂granular temperature＂; The velocity deviation from Gaussian distribution becomes more and more pronounced and the partial density of the assembly is more inhomogeneous with the increasing value of the fractal dimension D; The global granular temperature decreases and average dissipated energy per particle increases as the value olD augments.

关键词： fractal fractal dimension polydisperse mixture

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Trace analysis of anions in organic matrices by ion chromatography coupled with a novel reversed-phase column for on-line sample pretreatment

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Chinese Chemical Letters 2011年第4期22卷 461-464页

作者： ying ying Zhong Wen Fang Zhou Xue ling Zeng ming li Ye Yan Zhu Department of Chemistry Zhejiang UniversityHangzhou 310028China Ningbo Entry-Exit Inspection and Quarantine Bureau Ningbo 315012China

An ion chromatography（IC） system coupled with on-line column-switching technique was used to determine anions ofμg/g levels in organic chemicals of analytical reagent grade.A novel polystyrene-divinylbenzene-carbon nanotube（PS-DVB-CNT） stationary phase was utilized for matrix elimination.A calibration study was conducted by preparing and analyzing eight concentrations（between 10 and 5000μg/L） of eight standards in deionized *** linearity was between 0.9978 and *** the detection limits ranged from 1.54μg/L to 10.02μg/L.A spiking study was performed on two representative organic *** recoveries were between 84.3%and 119.6%.

关键词： Ion chromatography Column switching Trace anions Organic matrix Polymer stationary phase

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Modified gelatin with quaternary ammonium salts containing epoxide groups

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Chinese Chemical Letters 2014年第8期25卷 1193-1197页

作者： Ya-ming liu Xiao Cui Chuan-ming Hao Fu-Rong Tao Jun-ying li Shandong Provincial Key Laboratory of Fine Chemicals Qilu University of Technology School of Marine Science and Engineering Tianjin University of Science and Technology

An EPDDMAC-GE polymer （hydrophilic molecule） has been synthesized based on epoxypropyl dodecyl dimethyl ammonium chloride （EPDDMAC） and gelatin. A DEEPSAC-GE polymer （hydrophobic molecule） has been synthesized based on diethyl-2,3-epoxypropyl-[3-methyldimethoxyl] silpropyl ammonium chloride （DEEPSAC） and gelatin. Compared with initial gelatin, the gelatin modified with quaternary ammonium salts containing epoxide groups exhibits stronger antibacterial activity.

关键词： Quaternary ammonium salts Epoxide group Gelatin Modified

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Hydrogen trapping and electrochemical corrosion behavior of V–N microalloyed X80 pipeline steels consisting of acicular ferrite and polygonal ferrite

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Journal of Iron and Steel Research International 2022年第10期29卷 1683-1693页

作者： ming-ming Wang Xiu-hua Gao li-ying Song Cheng-lin Zhu lin-xiu Du Raja Devesh Kumar Misra State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina Laboratory for Excellence in Advanced Steel Research Department of MetallurgicalMaterials and Biomedical EngineeringUniversity of Texas at El PasoEl PasoTX79968USA

Hydrogen trapping behavior of V–N microalloyed X80 pipeline steels was studied by means of hydrogen permeation and hydrogen induced cracking(HIC)*** addition,the electrochemical performance of the steels in 3.5 wt.%NaCl solution was *** indicated that the microstructure of experimental steels mainly consisted of acicular ferrite and polygonal ferrite(PF).When the fraction of PF was 9.1%and 30.4%,hydrogen effective diffusion coefficient was 1.624×10^(−6) and 3.121×10^(−6) cm^(2)/s,*** pipeline steels were not susceptible to *** potential hydrogen traps distributed in homogeneous dispersion were conducive to high HIC *** increasing the fraction of PF from 9.1%to 30.4%,the corrosion current density increased from 5.39×10^(−6) to 9.49×10^(−6) A cm^(−2),the corrosion potential decreased from−0.48 to−0.57 V,and the charge transfer resistance decreased from 2301 to 2068Ωcm^(2),*** fraction of PF was disadvantageous for corrosion resistance because of galvanic corrosion.

关键词： Pipeline steel V-N microalloying Hydrogen induced cracking susceptibility Hydrogen permeation Electrochemical corrosion

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Retrospective analysis of interventional treatment of hepatic metastasis from gastroenteropancreatic neuroendocrine tumors

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Chinese Journal of Cancer Research 2017年第6期29卷 581-586页

作者： Peng liu Xu Zhu Jie li ming Lu Jiahua Leng ying li Jiangyuan Yu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Interventional Therapy Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Department of Gastroenterological Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Center of Gastrointestinal Surgery Unit III Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Department of Radiolog Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Department of NuclearMedicine Peking University Cancer Hospital&InstituteB eijing 100142China

Objective： To analyze the angiography appearance of liver metastases from gastroenteropancreatic neuroendocrine tumors （GEP-NETs）, and evaluate the clinical efficacy and prognostic factors of interventional treatment for hepatic metastases. Methods： Fifty GEP-NETs patients with hepatic metastases were treated from January 2012 to December 2016, and received transarterial embolization （TAE） in the hepatic tumor or hepatic arterial infusion chemotherapy （HAIC）. All patients received 179 times of the intervention therapy in total. Results： Blood supplies were identified in the 50 eases with angiography, which showed that 35 cases had abundant vessels, while 15 eases had poor blood supply. Twenty-two cases were found either collateral blood supply, or portal vein invasion or arterial-portal vein fistula. The best curative efficacy was complete remission （CR） in 4 cases, partial remission （PR） in 28 cases and stable disease （SD） in 18 eases during the process of treatment. The angiography （P=0.047） and the frequency of intervention （P=0.037） showed significantly statistical difference with Kaplan-Meier analysis. The Cox analysis showed that more than 3 times of interventional therapy was an independent prognostic factor. Conclusions： Interventional treatment is safe and effective for GEP-NETs, and is beneficial to patients with main hepatic metastases after endocrine therapy.

关键词： Gastroenteropancreatic neuroendocrine tumors hepatic metastasis angiography interventionaltreatment retrospective analysis

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Existence of Stick-Slip Periodic Solutions in a Dry Friction Oscillator

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Chinese Physics Letters 2011年第3期28卷 28-30页

作者： li Qun-Hong CHEN Yu-ming QIN Zhi-ying College of Mathematics and Information Science Guangxi UniversityNanning 530004 School of Mechanical and Electrical Engineering Hebei University of Science and TechnologyShijiazhuang 050054

The stick-slip behavior in friction oscillators is very complicated due to the non-smoothness of the dry friction,which is the basic form of motion of dynamical systems with *** this paper,the stick-slip periodic solution in a single-degree-of-freedom oscillator with dry friction is investigated in *** the assumption of kinetic friction being the Coulomb friction,the existence of the stick-slip periodic solution is considered to give out an analytic criterion in a class of friction systems.A two-parameter unfolding diagram is also ***,the time and states of motion on the boundary of the stick and slip motions are semi-analytically obtained in a single stick-slip period.

关键词： smoothness Periodic Existence

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EXPERIMENTAL STUDY OF EFFECTS OF AIR CONTENT ON CAVITATION AND PRESSURE FLUCTUATIONS

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Journal of Hydrodynamics 2010年第5期22卷 634-638页

作者： YE Jin-ming XIONG ying li Fang CHEN Shuang-qiao College of Naval Architecture and Power Naval University of Engineering Wuhan 430033 China

This article studies the effects of air content on propeller cavitation and pressure fluctuations. The cavitation is observed while the pressure fluctuations on the hull are measured. When adjusting the air content, the sheet cavitation range does not change distinctly, but the pressure fluctuations see obvious differences. The amplitudes of the pressure fluctuations increase with the decrease of the air content. The results indicate that the air content has little effect on the sheet cavitation range but has an important effect on the bubble cavitation and the tip vortex cavitation. When the air content decreases, the water tensile force increases, which results in the instability of the bubble cavitation and the tip vortex cavitation and the increase of the pressure fluctuations. To minimize the scale effects, the experiments should be run at a high Reynolds number with a high nuclei content. The high Reynolds number is often realized by increasing the flow velocity and the propeller rotation speed, and the high nuclei content is often made by increasing the dissolved air content.

关键词： cavitation pressure fluctuations model test air content

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