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Biomedical and Environmental Sciences 2022年第2期35卷 141-145页

作者： li yan yan DING Wen Hao BAI Yi Chun WANG Lei WANG Yong Bin Department of Epidemiology and Health Statistics School of Public HealthXinxiang Medical UniversityXinxiangHenanChina Center for Musculoskeletal Surgery Charité-Universitätsmedizin BerlinCorporate Member of Freie Universität BerlinHumboldt-Universität Zu Berlin and Berlin Institute of HealthBerlinGermany

Since the first case of acquired immune deficiency syndrome(AIDS)was detected in the United States in 1981,this disease has spread to every corner of the world.Despite the annual incidence of AIDS showing a slight decline since 1997,it remains a major cause of infectious disease-related death worldwide.Unlike global epidemiological trends,the number of notified AIDS cases has increased in recent years in China[1].Moreover,among the class B notifiable infectious diseases,AIDS was responsible for the highest mortality rate from 2008 to 2019,still failing to be identified as a vaccine-preventable disease[1].Thus,to provide more unambiguous and quantitative direction for the effective formulation of preventive planning strategies and for the reasonable allocation of limited resources,a forecasting model with high precision and accuracy to understand the future epidemic behaviors of AIDS is required.During the model-building process,accurate statistics are vital to ensure the forecasting accuracy of the model.

关键词： forecasting spite formulation

Application of cross-migration theory in limb rehabilitation of stroke patients with hemiplegia

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World Journal of Clinical Cases 2023年第19期11卷 4531-4543页

作者： yan-Hong Lu Yi Fu Jin Shu li-yan yan Hai-Jian Shen Geriatric Rehabilitation Department Shanghai Jing'an District Shibei HospitalShanghai 200040China Department of Nursing Shanghai Jing'an District Shibei HospitalShanghai 200040China

BACKGROUND Stroke is a common cause of neurological dysfunction,often resulting in hemiplegia.Thus,rehabilitation of limb function in stroke patients is an important step towards accelerating recovery and improving quality of life.AIM To investigate whether unilateral strength training in hemiplegic stroke patients could lead to cross-migration,an increase in bilateral muscle strength,and an improvement in lower limb motor function.METHODS We randomly divided 120 patients with hemiplegic stroke into two groups:Eexperimental and control groups,with 60 patients in each group.Both groups received routine rehabilitation treatment,while the experimental group additional-ly received ankle dorsiflexion resistance training on the healthy side for 6 wk.We measured the maximum voluntary contract(MVC),changes in surface electromyography(EMG),and the lower limb motor function using the simplified Fugl Meyer Motor Function Assessment Scale(FMA)before and within 1 wk after training.RESULTS The FMA score in the experimental group improved significantly compared to both their pre-training score and the control group's post-training score(Plis muscle and pulmonary intestine muscle in the experimental group were significantly different after training than before(Plis muscle on both the healthy and affected sides and the MVC of the pulmonary intestine muscle on both sides showed significant improvement compared with before training and the control group(Plis anterior muscle and antagonist's muscle,indicating a cross-migration phenomenon of strength training.Furthermore,this type of training can also improve lower limb motor function,providing a new exercise method for improving early ankle dorsiflexion dysfunction.

关键词： Stroke hemiplegia Cross migration Strength training Lower limb function Resistance training

Now-and Fore-casting the Secular Epidemiological Trends and Seasonality of the Comeback of Scarlet Fever in China:A 16-year Time Series Analysis

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Biomedical and Environmental Sciences 2022年第6期35卷 563-567页

作者： WANG Yong Bin li yan yan LU Hao TAO Ying Jun li Yu Hong WANG Lei liANG Wen Juan Department of Epidemiology and Health Statistics School of Public HealthXinxiang Medical UniversityXinxiang 453003HenanChina National Center for Tuberculosis Control and Prevention China Center for Disease Control and PreventionBeijing 102206China Center for Musculoskeletal Surgery Charité-Universitätsmedizin BerlinCorporate Member of Freie Universität BerlinHumboldt-Universität Zu Berlin and Berlin Institute of HealthBerlinGermany

Scarlet fever(SF)is a common communicable disease that results from group A Streptococcus(GAS)infections[1].SF accounted for the global loss of life among children 5–15 years of age in the 18th and 19th centuries[2].A rapid reduction in SF morbidity and mortality occurred due to the scale-up of effective antibiotics and improvements in sanitation and nutrition[3].The unexpected increase in the incidence of SF has attracted a renewed interest in infectious diseases[3].Because the triggers that cause SF outbreaks are not fully understood and there is a scarcity of available vaccines protecting susceptible populations from GAS infections,effective prevention and control plans are required to stop the continued spread of SF.

关键词： prevention mortality continued

Overexpression of Brassica napus cytosolic fructose-1,6-bisphosphatase and sedoheptulose-1,7-bisphosphatase genes significantly enhanced tobacco growth and biomass

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Journal of Integrative Agriculture 2022年第1期21卷 49-59页

作者： li yan-yan GUO li-na liANG Cheng-zhen MENG Zhi-gang Syed TAHIRA GUO San-dui ZHANG Rui Biotechnology Research Institute Chinese Academy of Agricultural Sciences/National Key Facility for Crop Gene Resources and Genetic ImprovementBeijing 100081P.R.China

Elevated activities of cytosolic fructose-1,6-bisphosphatase(cyFBPase) and sedoheptulose-1,7-bisphosphatase(SBPase)are associated with higher yields in plants. In this study, the expression levels of the cyFBPase and SBPase genes were increased by overexpressing rape(Brassica napus) cDNA in tobacco(Nicotiana tabacum) plants. The transgenic plants coexpressing cy FBPase and SBPase(TpFS), or expressing single cy FBPase(TpF) or SBPase(TpS) had 1.77-, 1.55-, 1.23-fold cyFBPase and 1.45-, 1.12-, 1.36-fold SBPase activities as compared to the wild-type(WT), respectively. Photosynthesis rates of TpF, TpS and TpFS increased 4, 20 and 25% compared with WT plants. The SBPase and cyFBPase positively regulated each other and functioned synergistically in transgenic tobacco plants. In addition, the sucrose contents of the three transgenic plants were higher than that of WT plants. The starch accumulation of the TpFS and TpS plants was improved by 53 and 37%, but slightly decreased in TpF plants. Moreover, the transgenic tobacco plants harbouring SBPase and/or cyFBPase genes showed improvements in their growth, biomass, dry weight, plant height, stem diameter, leaf size,flower number, and pod weight. In conclusion, co-expression of SBPase and cyFBPase may pave a new way for improving crop yield in agricultural applications.

关键词： tobacco cytosolic fructose-1,6-bisphosphatase(cy FBPase) sedoheptulose-1,7-bisphosphatase(SBPase) overexpression transformation

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基于自适应聚合距离的多目标进化算法

控制与决策 2024年第4期39卷 1113-1122页

作者：曾亮曾维钧李燕燕全睿王珊珊湖北工业大学电气与电子工程学院武汉430068 太阳能高效利用及储能运行控制湖北省重点实验室武汉430068 襄阳湖北工业大学产业研究院湖北襄阳441100

随着目标数的增多,种群收敛性与分布性的冲突愈加激烈,传统的多目标进化算法的选择算子难以平衡种群的收敛性与分布性.对此,提出一种基于自适应聚合距离的多目标进化算法.首先,采用参考点支配关系替代原有的Pareto支配关系,以增加选择压... 详细信息

随着目标数的增多,种群收敛性与分布性的冲突愈加激烈,传统的多目标进化算法的选择算子难以平衡种群的收敛性与分布性.对此,提出一种基于自适应聚合距离的多目标进化算法.首先,采用参考点支配关系替代原有的Pareto支配关系,以增加选择压力,加强收敛性;其次,提出自适应聚合距离,通过动态变化的惩罚参数来自适应调整收敛性与分布性的比例;最后,设计一种带有淘汰算子的方法以改进小生境选择策略,根据自适应聚合距离的大小进行选择和淘汰操作.为验证算法的可行性,将所提出算法在测试问题上与其他4种优秀的多目标进化算法进行比较,并应用于两个实际应用中,仿真结果表明,所提出算法的综合性能更优,能有效平衡种群的收敛性与分布性.

关键词：多目标进化算法参考点支配自适应聚合距离淘汰算子收敛性与分布性

Higher-Dimensional Integrable Systems Arising from Motions of Curves on S^2(R)and S^3(R)

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Communications in Theoretical Physics 2008年第10期50卷 841-843页

作者： QU Chang-Zheng li yan-yan Center for Nonlinear Studies Northwest University Xi＇an 710069 China Department of Mathematics Northwest University Xi＇an 710069 China

We show that higher-dimensional integrable systems including the (2+1)-dimensional generalized sine-Gordon equation and the (2+1)-dimensional complex mKdV equation are associated with motions of surfaces inducedby end... 详细信息

关键词：高维数可积分系统曲线运动复合体数学

Sensitive and Rapid Quantification of Felodipine by High-performance liquid Chromatography-tandem Mass Spectrometry(HPLC-MS/MS) and Its Pharmacokinetics in Healthy Chinese Volunteers

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Chemical Research in Chinese Universities 2006年第4期22卷 479-483页

作者： li yan-yan YIN Yi-zi SUN Zhi-hui li Xin HU li-gang li Peng-fei ZHONG Da-fang The First Hospital Jilin University Changchun 130021 P.R. China Research Center for Drug Metabolism Jilin University Changchun 130021 P. R. China

To investigate the pharmacokinetics of felodipine in the plasma of healthy Chinese volunteers, 30 healthy volunteers received a single oral dose of 5 mg of extended release felodipine tablets. The felodipine was extracted from the matrix with a liquid-liquid extract procedure and analyzed by high-performance liquid chromatography-tandem mass spectrometry in the multiple reaction monitoring（MRM） mode using an electrospray ion source with positive ion detection. The method was validated over a felodipine concentration range of 0. 05-10.00 ng/mL in human plasma. Its main pharmacokinetic parameters values were： ρmax = （ 1.67 ± 0. 84 ） ng/mL, occurring at （ 3.93 3± 2. 49 ） h; the plasma elimination half-life：（23. 08 3± 9. 48） h and the area under the plasma concentration versus time curve：（29. 94 ± 14. 39） ng · h/mL. The validation results demonstrated that this method showed a satisfactory precision and accuracy across the calibration range. The procedure involved minimal drug administration, sample preparation, and a 2. 5-min chromatographic run time. It was well suited to clinical studies of the drug involving large numbers of samples.

关键词： Felodipine liquid chromatography-tandem massspectrometry Pharmacokinetics

有机无机肥配施对城郊设施甜玉米地N_(2)O排放的影响

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农业现代化研究 2024年第2期45卷 326-335页

作者：李粤丰闫鹏沈健林李言言王聪王娟吴金水广西大学林学院广西森林生态与保育重点实验室亚热带农业生物资源保护与利用国家重点实验室广西南宁530004 中国科学院亚热带农业生态研究所亚热带农业生态过程重点实验室/长沙农业环境观测研究站湖南长沙410125

本文以长沙近郊设施菜地为研究对象,设置不施肥(CK)、常规施肥(CON)、30%牛粪有机肥氮+70%无机肥氮(CM)、30%鸡粪有机肥氮+70%无机肥氮(NM)4个处理,采用静态暗箱—气相色谱法监测甜玉米(Zea mays var.rugosa Bonaf.)生长季土壤氧化亚氮(... 详细信息

本文以长沙近郊设施菜地为研究对象,设置不施肥(CK)、常规施肥(CON)、30%牛粪有机肥氮+70%无机肥氮(CM)、30%鸡粪有机肥氮+70%无机肥氮(NM)4个处理,采用静态暗箱—气相色谱法监测甜玉米(Zea mays var.rugosa Bonaf.)生长季土壤氧化亚氮(N_(2)O)的排放通量,同时测定土壤铵态氮、硝态氮、可溶性有机碳(DOC)含量和作物产量及吸氮量,探讨有机肥与化肥配施对甜玉米季N_(2)O排放的影响。结果表明,甜玉米季表现出较高的N_(2)O排放量,为24.6~33.6 kg/hm^(2)。与CON处理相比,CM处理单位面积N_(2)O累积排放量显著减少了26.9%,而NM处理减排不显著;CM和NM处理单位产量N_(2)O排放量分别减少了35.7%和19.0%。与CON处理相比,CM和NM处理土壤铵态氮含量分别减少60.7%和50.1%,NM处理土壤硝态氮含量显著减少了40.4%,而CM和NM处理土壤DOC含量无显著变化。随机森林模型和主成分分析结果表明,N_(2)O排放通量与土壤铵态氮、硝态氮和DOC含量呈显著正相关,表明化肥配施有机肥能通过降低土壤无机氮供给,减少N_(2)O产生。另外,较CK处理而言,CON、CM和NM处理的玉米产量分别增产了156.5%、191.8%和188.2%,且CM、NM处理较CON处理分别增加了13.8%和12.4%,CM的氮肥利用率相较于CON处理提高了15.2%。综上,30%有机肥+70%化肥能有效降低甜玉米地N_(2)O排放和增加产量,且牛粪较佳。

关键词：有机无机肥配施氧化亚氮氮肥利用率产量设施菜地

乳腺癌患者血清甲状腺激素与肿瘤标志物之间的关系及对肿瘤转移的预测价值

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罕少疾病杂志 2024年第6期31卷 59-60,73页

作者：李妍妍开封市人民医院检验科河南开封475000

目的探讨乳腺癌患者血清甲状腺激素与肿瘤标志物之间的关系及对肿瘤转移的预测价值。方法选取我院2019年4月至2022年6月进行乳腺癌根治术的157例(均完成6个月随访)患者为研究对象,根据术后6个月是否发生转移分为转移组(43例)和未转移组(... 详细信息

目的探讨乳腺癌患者血清甲状腺激素与肿瘤标志物之间的关系及对肿瘤转移的预测价值。方法选取我院2019年4月至2022年6月进行乳腺癌根治术的157例(均完成6个月随访)患者为研究对象,根据术后6个月是否发生转移分为转移组(43例)和未转移组(114例)。比较两组术后血清甲状腺激素[抗甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、促甲状腺激素受体抗体(TRAb)]与肿瘤标志物[癌胚抗原(CEA)、糖类抗原15-3(CA153)、糖类抗原125(CA125)]水平,分析血清甲状腺激素水平与肿瘤标志物及术后转移的相关性,偏回归分析乳腺癌患者术后转移的影响因素,根据受试者工作特征(ROC)分析血清TPOAb、TGAb、TRAb水平联合检测对乳腺癌患者术后转移的预测价值。结果与未转移组相比,转移组术后血清TPOAb、TGAb、TRAb、CEA、CA153、CA125水平均较高(P67.69IU/m L)、TGAb(>28.80IU/m L)、TRAb(>3.88IU/L)水平是乳腺癌患者术后发生转移的危险因素(P<0.05);术后血清TPOAb、TGAb、TRAb水平联合预测乳腺癌患者术后转移的价值良好。结论乳腺癌患者术后血清TPOAb、TGAb、TRAb水平与CEA、CA153、CA125水平紧密相关,联合检测能有效提高乳腺癌患者术后转移的诊断敏感度、特异度,为临床干预提供数据参考。

关键词：乳腺癌转移 TPOAb TGAb TRAb

以保护理论为基础的管理模式对原发性高血压患者血压、生活质量及不良事件的影响

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心血管康复医学杂志 2024年第3期33卷 289-294页

作者：安秦锐李飞李燕妮李艳艳中国人民解放军空军军医大学第一附属医院综合诊疗科陕西西安710032 中国人民解放军空军军医大学第一附属医院心血管内科陕西西安710032

目的:探讨基于保护理论的管理模式对原发性高血压(EH)患者血压、生活质量及不良事件的影响。方法:前瞻性选择2022年4月到2023年4月本院收治的96例EH患者的临床资料,随机分为对照组(n=46,采用常规管理干预)和保护组(n=50,采用以保护理论... 详细信息

目的:探讨基于保护理论的管理模式对原发性高血压(EH)患者血压、生活质量及不良事件的影响。方法:前瞻性选择2022年4月到2023年4月本院收治的96例EH患者的临床资料,随机分为对照组(n=46,采用常规管理干预)和保护组(n=50,采用以保护理论为基础的管理模式干预),两组均干预2个月。比较干预前后两组患者血压及血脂指标变化;采用健康调查简表(SF-36)、心血管健康评分、高血压病人自我管理行为测评量表(HPSMBRS)评估两组患者干预前后生活质量、心血管健康程度、自我管理能力。比较两组患者干预后不良事件发生率。结果:与对照组相比,保护组干预后收缩压(SBP)[(137.80±5.12)mmHg比(118.82±6.65)mmHg]、舒张压(DBP)[(82.26±4.15)mmHg比(75.99±3.91)mmHg]、平均动脉压(MAP)[(115.25±5.70)mmHg比(99.64±5.15)mmHg]、总胆固醇(TC)[(4.18±1.35)mmol/L比(3.39±1.56)mmol/L]、胰岛素样生长因子-1(IGF-1)[(115.09±17.97)ng/ml比(99.86±8.87)ng/ml]、甘油三酯(TG)[(1.94±0.67)mmol/L比(1.60±0.61)mmol/L]显著更低(P<0.05或<0.01);SF-36总分[(66.93±10.25)分比(72.44±14.11)分]、心血管健康评分[(7.98±1.71)分比(9.96±1.67)分]及HPSMBRS评分[(109.20±6.82)分比(149.22±7.23)分]显著更高(P<0.05或<0.01)。保护组不良事件发生率(12.00%比28.26%)显著低于对照组(χ^(2)=3.991,P=0.046)。结论:以保护理论为基础的管理模式能够显著降低EH患者的血压水平,降低不良事件发生率,改善生活质量、心血管健康程度及自我管理能力,具有临床推广价值。

关键词：高血压护理血压生活质量