检索结果-南通市图书馆

Palmitic acid reduces the methylation of the FOXO1 promoter to suppress the development of diffuse large B-cell lymphoma via modulating the miR-429/DNMT3A axis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2024年第6期22卷 554-567页

作者： li Weiming GAO Ming XUE Weili li xiaoli CHANG Yu ZHANG Kaixin WEN Chenyu ZHANG Mingzhi Department of Oncology Henan University of Traditional Chinese MedicineZhengzhou 450000China Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China

Diffuse large B-cell lymphoma(DLBCL)is characterized by significant treatment *** acid(PA)has shown promising antitumor *** study aims to elucidate the molecular mechanisms by which PA influences DLBCL *** quantified the expression levels of microRNAs(miRNAs),Forkhead box protein O1(FOXO1),and DNA methyltransferase 3A(DNMT3A)in both untreated and PA-treated DLBCL tumors and cell *** were made of cell viability,apoptosis,and autophagy-related protein expression following PA *** analyses among miR-429,DNMT3A,and FOXO1 were conducted using luciferase reporter assays and methylation-specific(MSP)Polymerase chain reaction(PCR).After transfecting the miR-429 inhibitor,negative control(NC)inhibitor,shRNA against DNMT3A(sh-DNMT3A),shRNA negative control(sh-NC),over-expression vector for DNMT3A(oe-DNMT3A),or overexpression negative control(oe-NC),we evaluated the effects of miR-429 and DNMT3A on cell viability,mortality,and autophagy-related protein expression in PA-treated DLBCL cell *** efficacy of PA was also tested in vivo using DLBCL tumor-bearing mouse ***-429 and FOXO1 expression levels were downregulated,whereas DNMT3A was upregulated in DLBCL compared to the control *** treatment was associated with enhanced autophagy,mediated by the upregulation of miR-429 and downregulation of *** luciferase reporter assay and MSP confirmed that miR-429 directly inhibits DNMT3A,thereby reducing FOXO1 *** experiments demonstrated that PA promotes autophagy and inhibits DLBCL progression by upregulating miR-429 and modulating the DNMT3A/FOXO1 *** vivo PA signific-antly reduced the growth of xenografted tumors through its regulatory impact on the miR-429/DNMT3A/FOXO1 *** acid may modulate autophagy and inhibit DLBCL progression by targeting the miR-429/DNMT3A/FOXO1 signaling pathway,suggesting a novel therapeutic target for DLBCL management.

关键词： Palmitic acid Diffuse large B-cell lymphoma MiR-429 DNMT3A FOXO1 Autophagy

IRE1α regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 464-478页

作者： Mengtian Fan Nana Geng Xingyue li Danyang Yin Yuyou Yang Rong Jiang Cheng Chen Naibo Feng li liang xiaoli li Fengtao Luo Huabing Qi Qiaoyan Tan Yangli Xie Fengjin Guo Laboratory of Developmental Biology Department of Cell Biology and GeneticsSchool of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Laboratory of Stem Cells and Tissue Engineering School of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China Department of Orthopedics The 1st Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Wound Repair and Rehabilitation Medicine State Key Laboratory of TraumaBurns and Combined InjuryTrauma CenterResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Cartilage development is controlled by the highly synergistic proliferation and differentiation of growth plate chondrocytes,in which the Indian hedgehog(IHH)and parathyroid hormone-related protein-parathyroid hormone-1 receptor(PTHrP-PTH1R)feedback loop is *** inositol-requiring enzyme 1a/X-box-binding protein-1 spliced(IRE1α/XBP1s)branch of the unfolded protein response(UPR)is essential for normal cartilage ***,the precise role of ER stress effector IRE1α,encoded by endoplasmic reticulum to nucleus signaling 1(ERN1),in skeletal development remains ***,we reported that loss of IRE1α accelerates chondrocyte hypertrophy and promotes endochondral bone ***1 acts as a negative regulator of chondrocyte proliferation and differentiation in postnatal growth *** deficiency interrupted PTHrP/PTH1R and IHH homeostasis leading to impaired chondrocyte hypertrophy and ***1s,produced by p-IRE1α-mediated splicing,binds and up-regulates PTH1R and IHH,which coordinate cartilage ***,ER stress cannot be activated normally in ERN1-deficient *** conclusion,ERN1 deficiency accelerates chondrocyte hypertrophy and cartilage mineralization by impairing the homeostasis of the IHH and PTHrP/PTH1R feedback loop and ER ***1 may have a potential role as a new target for cartilage growth and maturation.

关键词： Cartilage development ER stress ERN1 IHH PTHrP/PTH1R

g-C_(3)N_(4)表面氨基化改性光催化增强机制

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

复合材料学报 2024年第6期41卷 3070-3078页

作者：李晓莉西安石油大学理学院西安710065

以g-C_(3)N_(4)为光催化剂进行分解水制氢和污染物降解的研究受到广泛关注,但如何采用简单易行的方法制备出高效、稳定且具有良好光热稳定性的催化剂是本领域的研究热点和难点。本文采用一种简单的水热法在g-C_(3)N_(4)表面引入更多的氨... 详细信息

以g-C_(3)N_(4)为光催化剂进行分解水制氢和污染物降解的研究受到广泛关注,但如何采用简单易行的方法制备出高效、稳定且具有良好光热稳定性的催化剂是本领域的研究热点和难点。本文采用一种简单的水热法在g-C_(3)N_(4)表面引入更多的氨基,通过SEM、TEM等研究表面氨基化对g-C_(3)N_(4)表面形貌的影响,发现氨基化对其边缘位置的形貌影响较大;XRD、FTIR、UV-vis、XPS等分析表明表面氨基化反应对g-C_(3)N_(4)的主体结构没有破坏;光催化分解水制氢和罗丹明B降解性能表明,当采用浓度为15wt%的氨水处理时,g-C_(3)N_(4)对罗丹明B(RhB)的光催化降解性能也达到最优,90 min的降解率为98.12%,是g-C_(3)N_(4)的1.55倍(63.28%),过高或过低的氨水浓度均不能使光催化性能达到最优;同时其分解水制氢速率性能最优(180.24μmol·g^(-1)·h^(-1)),为g-C_(3)N_(4)的1.46倍(123.04μmol·g^(-1)·h^(-1));光电性能测试结果发现表面氨基化后光催化性能的增强机制可归结为:氨基是供电子基团,氨基含量的增加有利于光催化反应的发生,过度的氨基化导致离域三嗪环结构的破坏,光催化性能大幅降低。

关键词： g-C_(3)N_(4) 光催化水分解产氢有机污染物降解催化机制

Constituents from leaves of Macaranga hemsleyana

在线全文

学校读者我要写书评

暂无评论

Chinese Herbal Medicines 2024年第3期16卷 481-486页

作者： Joseph Sakah Kaunda Jia liu Yaojun Xu Yuansi Chen Chenfang Yue Xingjie Zhang Ruihan Zhang Muhammad Amin Weilie Xiao Hongliang li xiaoli li Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Characteristic Plant Extraction LaboratoryYunnan Provincial Center for Research&Development of Natural ProductsState Key Laboratory for Conservation and Utilization of Bio-Resources in YunnanSchool of PharmacySchool of MedicineChemical Science and TechnologyYunnan UniversityKunming 650500China Yunnan Key Laboratory of Pharmacology for Natural Products Haiyuan CollegeKunming Medical UniversityKunming 650500China

Objective:To study constituents of the leaves of Macaranga hemsleyana,and evaluate their inhibitory effects against NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome activation,and antiproliferative ***:The constituents were isolated and purified by column chromatography on MCI gel CHP20P/P120,silica gel,Sephadex LH-20,and *** structures of compounds were determined by 1D,2D NMR,and HR-ESI-MS *** inhibitory effect of compounds on inflammasome activation was determined by lactate dehydrogenase(LDH)*** antiproliferative activity was evaluated using MTT ***:The study led to the isolation of 23 compounds,including one new compound,identified as(2Z)-3-[4-(β-D-glucopyranosyloxy)-2′-hydroxy-5′-methoxyphenyl]-2-propenoic acid(1),together with 22 known compounds recognized as 1,4-dihydro-4-oxo-3-pyridinecarbonitrile(2),methyl 4-methoxynicotinate(3),4-methoxynicotinonitrile(4),1-(3-O-β-D-glucopyranosyl-4,5-dihydroxyphenyl)-ethanone(5),neoisoastilbin(6),isoastilbin(7),aromadendrin(8),neoastilbin(9),astilbin(10),quercitrin(11),neoschaftoside(12),apigenin 6,8-bis-C-α-L-arabinoside(13),vitexin(14),bergenin(15),scopoletin(16),glucopyranoside salicyl(17),koaburside(18),benzylβ-D-glucoside(19),icariside B5(20),roseoside(21),loliolide(22),and adenosine(23).The tested compounds did not show LDH inhibition nor antiproliferative ***:Compound 1 was a new *** 2 and 3 were obtained for the first time from natural *** 22 known compounds constituted of alkaloids(2–4,23),phenolics(5,15,17,18),flavonoids(6–14),coumarin(16),benzyl glycoside(19),and norsesquiterpenes(20–22).All the compounds,1–23,were revealed from *** for the first *** is the initial uncovering of molecules 1–10,12,13,17–19,and 23 from the genus *** isolated compounds,11,14–16,and 20–22 established taxonomic classification of *** in Euphorbiaceae *** were outstanding as

关键词： antiproliferative activity chemotaxonomic significance flavonoids glycoside Macaranga hemsleyana Pax et Hoffm NLRP3 inflammasome

基于非线性互补算法的太阳能电池储能系统设计与网络建模

在线全文

学校读者我要写书评

暂无评论

储能科学与技术 2024年第1期13卷 339-341页

作者：李晓丽河南轻工职业学院河南郑州450002

太阳能是一种环保型能源,利用储能系统,将太阳能转化为电能并用于驱动其他设备元件,有助于实现能源的高效利用。针对上述背景,研究基于非线性互补算法的太阳能电池储能系统设计与网络建模方法。分析太阳能储能系统的研究现状及发展趋势... 详细信息

太阳能是一种环保型能源,利用储能系统,将太阳能转化为电能并用于驱动其他设备元件,有助于实现能源的高效利用。针对上述背景,研究基于非线性互补算法的太阳能电池储能系统设计与网络建模方法。分析太阳能储能系统的研究现状及发展趋势,结合等价非线性互补原则,确定储能部件的能量转化收敛性,实现基于非线性互补算法的电池储能收敛性研究。选用合适的电池储能元件,并在此基础上,完善动态储能模型,完成太阳能电池储能系统的网络建模与设计。

关键词：非线性互补算法太阳能电池储能系统网络建模

维普期刊数据库博看期刊

Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia:a multicenter,randomized,open-label,phase 3 trial

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2669-2678页

作者： Biqi Zhou Jia Chen Tianhui liu Yishan Ye Yanming Zhang Yiyang Ding Hong liu MingQing Zhu Xiao Ma xiaoli li Longfei Zhao Zhihong lin He Huang Yang Xu Depei Wu National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina Institute of Blood and Marrow Transplantation Collaborative Innovation Center of HematologySoochow UniversitySuzhouChina Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Hematology The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’anHuai’anChina Soochow Hopes Hematology Hospital SuzhouChina Department of Hematology Hygeia Suzhou Yongding HospitalSuzhouChina

Coinfusion of unrelated cord blood(UCB)units in haploidentical hematopoietic cell transplantation(haplo-HCT)(haplo-cord HCT)for hematopoietic malignancies showed promising results in previous reports,but the efficiency of haplo-cord HCT in acute myeloid leukemia(AML)still lacks sufficient *** multicenter,randomized,phase 3 trial(*** NCT03719534)aimed to assess the efficacy and safety of haplo-cord HCT in AML patients.A total of 268 eligible patients aged 18-60 years,diagnosed with measurable residual disease in AML(excluding acute promyelocytic leukemia),with available haploidentical donors and suitable for allotransplantation,were randomly allocated(1:1)to receive haplo-cord HCT(n=134)or haplo-HCT(n=134).The 3-year overall survival(OS)was the primary endpoint in this *** median follow-up was 36.50 months(IQR 24.75-46.50).The 3-year OS of Haplo-cord HCT group was better than haplo-HCT group(80.5%,95%confidence interval[CI]:73.7-87.9 vs.67.8%95%CI 60.0-76.5,p=0.013).Favorable progression-free survival(70.3%,95%CI 62.6-78.8 vs.57.6%,95%CI 49.6-67.0,p=0.012)and cumulative incidence of relapse(12.1%,95%CI 12.0-12.2 vs.30.3%,95%CI 30.1-30.4,p=0.024)were observed in haplo-cord HCT *** 3-4 adverse events(AEs)within two years posttransplantation in the two groups were ***-cord HCT patients exhibited a faster cumulative incidence of neutrophil recovery(p=0.026)and increased T-cell reconstitution in the early period ***-cord HCT can improve OS in AML patients without excessive AEs,which may exert additional benefits for recipients of haplo-HCT.

关键词： hematopoietic acute phase

International standard of Traditional Chinese Medicine Techniques: Traditional Chinese Medicine guidelines for acute primary headache(2022)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medicine 2024年第4期44卷 839-850页

作者： YAO Yuning CAO Kegang ZHANG Genming liU Jianping CHEN Wei CAO Junling YANG Wenming YAN Yongmei GENG Chang JU Yi ZHAO Dexi QU Miao li xiaoli SUN li HAN Zhenyun HE liyun CUI Fangyuan FU Caihong ZHOU Bo liAO Shuqin Department of Geriatrics Jilin Academy of Traditional Chinese Medicine Department of Neurology Shenzhen Hospital of Beijing University of Chinese Medicine Institute of Basic Research in Clinical Medicine China Academy Of Chinese Medical Sciences Department of Rehabilitation Shunyi HospitalBeijing Traditional Chinese Medicine Hospital Department of Neurology Xiyuan Hospital of China Academy of Chinese Medical Sciences Department of Neurology Dongzhimen Hospital of Beijing University of Chinese Medicine Centre for Evidence-Based Chinese Medicine Beijing University of Chinese Medicine Encephalopathy center First Affiliated Hospital of Anhui University of Chinese Medicine Department of Neurology Affiliated Hospital of Shaanxi University of Chinese Medicine Department of Neurology Beijing Changping District Hospital of Traditional Chinese Medicine Neurology center Beijing Tiantan HospitalCapital Medical University Department of Neurology Affiliated Hospital of Changchun University of Chinese Medicine Department of Neurology Xuanwu HospitalCapital Medical University Department of Neurology Beijing University of Chinese Medicine Third Affiliated Hospital

OBJECTIVE: To summarize the evidence from Traditional Chinese Medicine(TCM) practice in the treatment of acute primary headache and provide clinical practice guidance. METHODS: The guidelines were developed in accordance with the World Health Organization guideline development manual. After the establishment of steering committee, panel and the registration and protocol formulation, the evidence on TCM for acute primary headache from published guidelines, clinical evidence, and expert experience and consensus were collected. The grading of recommendations assessment, development and evaluation method was used to grade the evidence and make the recommendations. RESULTS: Based on the available evidence, the guidelines recommended three TCM herbal decoctions, six Chinese patent medicines, and two kinds of external application of Chinese herbal medicines. Diagnostic recommendations based on the expert experience and consensus were also included in the guidelines. CONCLUSION: TCM diagnosis and treatment of decoction, Chinese patent medicine and external application for treating acute primary headache were recommended. We hope these guidelines will be helpful in standardize the TCM acute treatment of primary headache.

关键词： acute primary headache medicine, Chinese traditional practice guideline

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

基于深度AttLSTM网络的脱硫过程建模

北京工业大学学报 2024年第2期50卷 140-151页

作者：刘泉伯李晓理王康北京工业大学信息学部北京100124 计算智能与智能系统北京市重点实验室北京100124 数字社区教育部工程研究中心北京100124

脱硫过程是具有高度动态非线性和较大延迟时间的复杂工业过程,为了解决烟气脱硫过程的建模问题,设计了注意力机制下的深度长短期记忆(attention mechanism-based long short-term memory,AttLSTM)网络,并基于该网络设计自动编码器,完成... 详细信息

脱硫过程是具有高度动态非线性和较大延迟时间的复杂工业过程,为了解决烟气脱硫过程的建模问题,设计了注意力机制下的深度长短期记忆(attention mechanism-based long short-term memory,AttLSTM)网络,并基于该网络设计自动编码器,完成脱硫过程异常点的检测。该文首次提出使用AttLSTM网络自编码器对脱硫过程进行离群点检测,并且该网络模型同样首次应用于脱硫过程的辨识任务中。从更深的意义上讲,该文尝试使用深度学习模型对复杂系统进行辨识,所建立的AttLSTM网络之前未出现在系统辨识领域,该网络的出现可以丰富辨识模型的选择,同时为人工智能技术在系统辨识领域和控制领域的应用与推广提供参考。实验结果表明,相比于之前文献出现的脱硫过程建模方法,所提方法在不同性能指标上均具有更好的表现,由此可以证明深度AttLSTM网络在脱硫场景下的有效性。

关键词：湿法烟气脱硫过程建模长短期记忆网络注意力机制自动编码器大气污染

STXBP1基因相关脑病患儿的临床表型和基因变异分析

在线全文

学校读者我要写书评

暂无评论

临床儿科杂志 2024年第2期42卷 127-132页

作者：李小丽张晓莉李肖韩瑞徐丹甘玲贾天明郑州大学第三附属医院小儿神经内科河南郑州450052

目的探讨STXBP 1基因相关脑病患儿的临床表型和基因变异情况。方法回顾性总结2015年10月至2022年5月收治的11例STXBP 1基因相关脑病患儿的临床资料,分析其临床表型、基因结果、治疗及疗效情况。结果11例患儿中男4例,女7例,10例患儿存在... 详细信息

目的探讨STXBP 1基因相关脑病患儿的临床表型和基因变异情况。方法回顾性总结2015年10月至2022年5月收治的11例STXBP 1基因相关脑病患儿的临床资料,分析其临床表型、基因结果、治疗及疗效情况。结果11例患儿中男4例,女7例,10例患儿存在癫痫发作伴发育迟缓,1例患儿仅表现为发育迟缓。癫痫首发年龄为3天~1岁半,3个月以内起病者6例,3~12个月起病者3例,1岁以上起病者1例。常见的发作类型为痉挛和局灶发作。11例患儿均存在脑电图异常包括背景慢、多灶放电、爆发抑制和高度失律等。2例早期为大田原综合征,后期演变为婴儿痉挛症,5例为婴儿痉挛症,余为不能分型的癫痫综合征。4例患儿头颅MRI存在非特异性异常,包括髓鞘化发育落后、额颞部蛛网膜下隙增宽。所有患儿均存在STXBP1基因变异,共有11种突变类型,其中错义突变7例、移码突变1例、剪切突变1例、缺失突变2例,7例患儿的突变位点尚未见文献报道,分别为c.1694T>A、c.1115T>G、C.133_135del、C.1543 dupG、6-17号外显子杂合缺失、C.429+1 G>C、C.855 C>G及c.842_843 insGGACGACGGCCTGTGGATAGC ACT。随访中11例患儿均存在不同程度发育迟缓,2例患儿已死亡,4例患儿存在孤独症样表现。10例癫痫患儿均应用左乙拉西坦治疗,1例为单独应用完全缓解,5例患儿部分有效,4例患儿无效。3例患儿癫痫发作完全缓解,余7例为药物难治性癫痫。结论STXBP1脑病患儿发育迟缓相对严重,婴儿痉挛症表型最常见,癫痫治疗效果存在明显异质性,7个未报道突变位点丰富了STXBP1脑病的基因谱。

关键词： STXBP1基因发育性癫痫性脑病发育迟缓