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Chinese Journal of Polymer Science 2012年第1期30卷 101-111页

作者： Ya—li Zhang xiao-yun lu Qian-qian liu Ming-chuan li Zhi-qian Yang Jian-gang Ma Department of Biological Science and Bioengineering Key Laboratory of Biomedicai Information Engineering of Ministry of Education School of Life Science and Technology Xi ＇an Jiaotong University Xi ＇an 710049 China

A novel natural-synthetic hybrid block copolymer was synthesized by Aeromonas hydrophila 4AK4 in poly（ethylene glycol）（PEG,M_n=200） modified *** hybrid biomaterial consists of the natural hydrophobic polymer poly（3-hydroxybutyrat-co-3-hydroxyhexanoate）（PHBHHx） end-capped with hydrophilic PEG,which has the increased flexibility as well as the improved thermal *** of diethylene glycol（DEG） and ethylene glycol could not result in the accumulation of hybrid block *** and ethylene glycol,together with PEG-200,could cause a reduction of molar mass of PHBHHx,resulting in a series of low molecular weight polymer and the reduction of the polymer yield as well as the cellular *** vitro degradation of PHBHHx and PHBHHx-PEG with different molecular weight showed that the decrease of molecular weight accelerated the degradation of copolymers,but PEG modification has little effect on its degradation *** results in this study provided a convenient and direct method to produce a series of PHBHHx and PHBHHx-PEG materials with adjustable molecular weight and broad molecular weight distribution which will be very useful for the biomedical applications.

关键词： Biopolyester Biodegradable Molecular weight Polyhydroxyalkanoates Polyethylene glycol

Cells derived from iPSC can be immunogenic -- Yes or No？

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Protein & Cell 2014年第1期5卷 1-3页

作者： Jiani Cao xiaoyan li xiao lu Chao Zhang Honghao Yu Tongbiao Zhao State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China

The induced pluripotent stem cells （iPSCs）, derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejections. However, our recent studies have found that even syn- geneic iPSC-derived cells can be immunogenic in syn- geneic hosts by using a teratoma transplantation model （Nature 474：212-215, 2011）. Recently two research groups differentiated the iPSCs into different germ lay- ers or cells, transplanted those cells to the syngeneic hosts, and evaluated the immunogenicity of those cells. Both of the two studies support our conclusions that some certain but not all tissues derived from iPSCs can be immunogenic, although they claimed either ＂negli- gible＂ or ＂lack of＂ immunogenicity in iPSC derivatives （Nature 494：100-104, 2013; Cell Stem Cell 12：407-412, 2013）. To test the immunogenicity of clinically valuable cells differentiated from human iPSCs are emergenUy required for translation of iPSC technology to clinics.

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Tocilizumab promotes corneal allograft survival in rats by modulating Treg-Th17 balance

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1823-1831页

作者： xiao-Song Wu xiao-li lu Jing Wu Ming Ma Jian Yu Zhen-Yu Zhang Dpartment of Ophthalmology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Huiqiao Building Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Guangdong Women And Children Hospital Guangzhou 511400Guangdong ProvinceChina

AIM: To examine the therapeutic effects of tocilizumab on experimental corneal transplantation and its effect on Treg/Th17 balance. METHODS: Allograft corneal graft was performed between host Sprague Dawley and Wistar donor *** rats were randomly divided into four groups: normal,autograft, allograft, and allograft treated with ***-Meier was performed to draw the survival *** protein levels of interleukin-17A(IL-17A), vascular endothelial growth factor(VEGF), and forkhead box protein3(Foxp3) were measured by *** mRNA levels of IL-17A, VEGF, retinoid-related orphan receptor gammat(RORγt), interleukin-6(IL-6) and Foxp3 were detected by reverse transcription real-time polymerase chain reaction(RT-PCR). The Treg and Th17 cells were investigated by flow cytometry. RESULTS: The survival time of tocilizumab group was(24±1.27 d) longer than that of allograft group(10±0.55 d).Moreover, immunohistochemical examination revealed that IL-17A and VEGF protein levels in the allograft group were significantly higher than that of tocilizumab group(Plizumab treated group(Plizumab group(Plizumab group(Plizumab treated group was significantly higher than other groups(PluSION: These findings suggest that tocilizumab may promote corneal allograft survival, possibly by modulating Treg-Th17 balance.

关键词： tocilizumab corneal transplantation Th17/Treg rats

Coarsening of M_(23)C_6 Precipitates in an Fe-Cr-C Ternary Alloy

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Journal of Iron and Steel Research International 2012年第9期19卷 62-67页

作者： ZHU Na-qiong , lu li , HE Yan-lin , li lin , lu xiao-gang ( Department of Materials Science and Engineering , Shanghai University , Shanghai 200072 , China ) Department of Materials Science and Engineering Shanghai University Shanghai 200072 China

Coarsening of M23C6precipitates in an Fe-12.4Cr-0.13Cternary alloy has been investigated ageing at 780℃ up to *** of M23C6carbides at different ageing times was determined experimentally using transmission electron *** size distribution was obtained with different measuring *** of coarsening of M23C6precipitates were carried out using computational thermodynamics and *** showed low coarsening rates for M23C6precipitates in the Fe-Cr-C ternary *** energy of M23C6 / ferrite interface is between 0.1and 0.3J · m -2 for the coarsening of M23C6ageing at 780℃.

关键词： M23C6 coarsening PSD interfacial energy

Differential generation of hydrogen peroxide upon exposure to zinc and cadmium in the hyperaccumulating plant specie(Sedum alfredii Hance)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第3期9卷 243-249页

作者： Yue-en CHAO Min ZHANG Sheng-ke TIAN ling-li lu xiao-e YANG MOE Key Laboratory of Environmental Remediation and Ecosystem Health College of Environmental and Resource Sciences Zhejiang University Hangzhou 310029 China

Sedum alfredii Hance has been identified as zinc(Zn) and cadmium(Cd) *** this paper the relationships of Zn or Cd hyperaccumulation to the generation and the role of H2O2 in Sedum alfredii *** *** results show that Zn and Cd contents in the shoots of Sedum alfredii *** with 1000 μmol/L Zn2+ and/or 200 μmol/L Cd2+ increased linearly within 15 *** of total S,glutathione(GSH) and H2O2 in shoots also increased within 15 d,and then *** S and GSH contents in shoots were higher under Cd2+ treatment than under Zn2+ ***,reverse trends of H2O2 content in shoots were obtained,in which much higher H2O2 content was observed in Zn2+-treated shoots than in Cd2+-treated ***,the microscopic imaging of H2O2 accumulation in leaves using H2O2 probe technique showed that much higher H2O2 accumulation was observed in the Zn2+-treated leaf than in the Cd2+-treated *** results suggest that there are different responses in the generation of H2O2 upon exposure to Zn2+ and Cd2+ for the hyperaccumulator Sedum alfredii *** this is the first report that the generation of H2O2 may play an important role in Zn hyperaccumulation in the *** results also imply that GSH may play an important role in the detoxification of dissociated Zn/Cd and the generation of H2O2.

关键词： Hydrogen peroxide (H2O2) Glutathione (GSH) Sedum alfredii Hance Zinc (Zn) Cadmium (Cd) Hyperaccumulator

Comprehensive Analysis of Key mRNAs and lncRNAs in Osteosarcoma Response to Preoperative Chemotherapy with Prognostic Values

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Current Medical Science 2021年第5期41卷 916-929页

作者： Mi li Wei-ting CHENG Hao li Zhi ZHANG xiao-li lu Si-si DENG Jian li Cai-hong YANG Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Oncology Department Wuhan No.1 Hospital Wuhan 430030China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Institute of Experimental Immunology University Clinic of Rheinische Friedrich-Wilhelms-UniversityBonn D-53127Germany

Objective:Osteosarcoma is one of the most common types of bone sarcoma with a poor ***,identifying the predictive factors that contribute to the response to neoadjuvant chemotherapy remains a significant ***:A public data series(GSE87437)was downloaded to identify differentially expressed genes(DEGs)and differentially expressed lncRNAs(DElncRNAs)between osteosarcoma patients that do and do not respond to preoperative ***,functional analysis of the transcriptome expression profile,regulatory networks of DEGs and DElncRNAs,competing endogenous RNAs(ceRNA)and protein-protein interaction networks were ***,the function,pathway,and survival analysis of hub genes was performed and drug and disease relationship prediction of DElncRNA was carried ***:A total of 626 DEGs,26 DElncRNAs,and 18 hub genes were ***,only one gene and two lncRNAs were found to be suitable as candidate gene and lncRNAs ***:The DEGs,hub genes,candidate gene,and candidate lncRNAs screened out in this context were considered as potential biomarkers for the response to neoadjuvant chemotherapy of osteosarcoma.

关键词： osteosarcoma preoperative chemotherapy competing endogenous RNAs differentially expressed genes survival analysis

Identification of Key Blood Biomarkers linking Di(2-ethylhexyl)Phthalate and Autoimmune Diseases in Adolescents Mice

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Biomedical and Environmental Sciences 2024年第5期37卷 521-525页

作者： XU xiao Mei li xiao lu HU Die CAI xiao Yue li Qi Meng ZHENG Yuan Zhuo CAI Yang QI Yin Yin XU Tao ZHAO ling li NING Xia Department of Infectious Diseases Anhui Provincial Children’s HospitalHefei 231000AnhuiChina Department of Toxicology School of Public HealthKey Laboratory of Environmental Toxicology of Anhui Higher Education InstitutesAnhui Medical UniversityHefei 231000AnhuiChina School of Biology Food and EnvironmentHefei UniversityHefei 230601AnhuiChina

Di(2-ethylhexyl)phthalate(DEHP)is a widely used plasticizer known for its reproductive developmental and immune system toxicity,mainly through esophagal,dermal,and respiratory exposure^([1-3]).Maternal exposure to DEHP during pregnancy can lead to adverse birth outcomes in offspring,including impacts on the thyroid system of adolescent offspring^([2-4]).

关键词： Blood respiratory pregnancy

Ferroelectric effect and equivalent polarization charge model of PbZr_(0.2)Ti_(0.8)O_(3)on AlGaN/GaN MIS-HEMT

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Chinese Physics B 2021年第5期30卷 602-606页

作者： Yao-Peng Zhao Chong Wang Xue-Feng Zheng xiao-Hua Ma Ang li Kai liu Yun-Long He xiao-li lu Yue Hao Key Laboratory of Wide Band-Gap Semiconductor Materials and Devices School of MicroelectronicsXidian UniversityXi'an 710071China

PbZr_(0.2)Ti_(0.8)O_(3)(PZT)gate insulator with the thickness of 30 nm is grown by pulsed laser deposition(PLD)in AlGaN/GaN metal-insulator-semiconductor high electron mobility transistors(MIS-HEMTs).The ferroelectric effect of PZT AlGaN/GaN MIS-HEMT is *** polarization charge in PZT varies with different gate *** equivalent polarization charge model(EPCM)is proposed for calculating the polarization charge and the concentration of two-dimensional electron gas(2DEG).The threshold voltage(V_(th))and output current density(I_(DS))can also be obtained by the *** theoretical values are in good agreement with the experimental results and the model can provide a guide for the design of the PZT *** polarization charges of PZT can be modulated by different gate-voltage stresses and the V_(th)has a regulation range of 4.0 *** polarization charge changes after the stress of gate voltage for several *** the gate voltage is stable or changes at high frequency,the output characteristics and the current collapse of the device remain stable.

关键词： PZT AlGaN/GaN MIS-HEMT equivalent polarization charge model(EPCM)

Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： xiao Wang Jia Zeng Donglin Gan Kun ling Mingfang He Jianshu li Yongping lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

发动机冷却系统流固耦合稳态传热三维数值仿真

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内燃机学报 2007年第3期25卷 252-257页

作者：李迎俞小莉陈红岩李孝禄中国计量学院机电工程学院浙江杭州310018 浙江大学机械与能源工程学院浙江杭州310027

为解决发动机传热计算时冷却水与缸套、机体之间的流动与传热耦合边界问题,建立了发动机活塞组—缸套—冷却水—机体三维流固耦合系统,并利用有限元分析软件的流固耦合计算功能,把单个零件的传热外边界条件处理成内边界,使得传热仿真更... 详细信息

为解决发动机传热计算时冷却水与缸套、机体之间的流动与传热耦合边界问题,建立了发动机活塞组—缸套—冷却水—机体三维流固耦合系统,并利用有限元分析软件的流固耦合计算功能,把单个零件的传热外边界条件处理成内边界,使得传热仿真更合理更简单。以某增压柴油机为例,用有限元分析软件ANSYS对建立的三维流固耦合模型进行了稳态传热数值仿真,得到了耦合系统的温度场和流场云图。与标定工况下活塞和缸套的温度场测量数据进行了对比分析,结果表明:仿真结果与实测数据吻合较好,误差控制在800/以内。由此说明应用流固耦合仿真方法可以较好地模拟发动机稳态传热。

关键词：流固耦合稳态传热数值仿真发动机