检索结果-南通市图书馆

Insights into spinal muscular atrophy from molecular biomarkers

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu xiandeng li Mi li xian Wu Xiaohui Huang Ajing Xu Yan liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

导电聚合物在纤维状能源器件中的应用进展(英文)

在线全文

学校读者我要写书评

暂无评论

物理化学学报 2017年第2期33卷 329-343页

作者：廖春荣熊峰李贤军吴义强罗勇锋中南林业科技大学理学院长沙410018 复旦大学聚合物分子工程国家重点实验室和先进材料实验室上海200438 中南林业科技大学材料科学与工程学院长沙410018

导电聚合物由于成本低、安全环保、比电容高和电化学性能稳定等特点,已经被广泛应用于纤维状能源器件中。导电聚合物具有良好的机械、电学和光学性能,同时具有方便可控的化学和电化学过程,可作为能源器件的电极材料。本文综述了导电聚... 详细信息

导电聚合物由于成本低、安全环保、比电容高和电化学性能稳定等特点,已经被广泛应用于纤维状能源器件中。导电聚合物具有良好的机械、电学和光学性能,同时具有方便可控的化学和电化学过程,可作为能源器件的电极材料。本文综述了导电聚合物在纤维状能源器件中的最新研究进展,如纤维状超级电容器、纤维状太阳能电池和纤维状集成能源器件。同时根据纤维状能源器件的性能要求,对相关材料、制备技术、纤维结构、电子输运以及机械性能等进行了全面总结。

关键词：导电聚合物纤维超级电容器太阳能电池纤维状能源器件

IPv4-IPv6过渡技术下基于CIDF的入侵检测系统研究

在线全文

学校读者我要写书评

暂无评论

广西大学学报（自然科学版） 2011年第A1期36卷 190-194页

作者：任宏晖李英壮李先毅大连理工大学网络与信息化中心辽宁大连116024

随着互联网下一代协议IPv6的应用越来越广泛,IPv4和IPv6之间的过渡技术将被大量使用,这势必会对网络安全提出新的挑战。传统的入侵检测系统主要检测对象是IPv4协议下的数据,针对过渡时期隧道技术中所存在的安全隐患,提出了一个实际可行... 详细信息

随着互联网下一代协议IPv6的应用越来越广泛,IPv4和IPv6之间的过渡技术将被大量使用,这势必会对网络安全提出新的挑战。传统的入侵检测系统主要检测对象是IPv4协议下的数据,针对过渡时期隧道技术中所存在的安全隐患,提出了一个实际可行的基于CIDF框架的入侵检测系统的设计方案。通过先期对网络中数据包的高速捕获,从中识别出隧道数据包,并采用协议分析对其各层协议进行层层解析,分析各个协议的包头和数据部分。然后结合改进的特征模式匹配的检测方法对数据包进行检测,该方法将一定时间间隔内匹配次数较多的入侵模式导入到一个优先匹配表中进行先行匹配,这样会大大提高匹配的效率。小型局域网内的实验表明,该系统不仅可以对隧道数据包中的安全威胁做出检测,且检测效率相对改进匹配策略之前有较大的提高。

关键词： IPv6 过渡技术网络安全入侵检测

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen li Leilei liang Baoshan Zhang yi Yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

基于OpenFlow技术的QoS管理系统的设计与实现

在线全文

学校读者我要写书评

暂无评论

广西大学学报（自然科学版） 2011年第A1期36卷 42-46页

作者：李英壮孙梦李先毅汪楠大连理工大学网络与信息化中心辽宁大连116024

随着网络上多媒体应用的大量涌现,人们对于网络服务质量提出了更高的要求,网络服务质量管理因此成为现代网络管理中必不可少的一部分。在使用传统的QoS管理系统来管理网络时,往往会因为网络的复杂性而使路由器的工作负载过重,从而成为... 详细信息

随着网络上多媒体应用的大量涌现,人们对于网络服务质量提出了更高的要求,网络服务质量管理因此成为现代网络管理中必不可少的一部分。在使用传统的QoS管理系统来管理网络时,往往会因为网络的复杂性而使路由器的工作负载过重,从而成为网络管理的桎梏。针对这种现状,设计了一种新型的QoS管理系统——OF-QoS系统,并通过实验来证明OF-QoS系统不仅能够完成传统QoS管理系统的管理功能,还能有效地降低路由器的工作负载。OF-QoS系统利用了现有的OpenFlow技术来解决路由器的负载问题,它共由2分部分构成,分别是测量控制部分和指令执行部分,其中测量控制部分包括网络测量模块、评估模块和资源预留模块,指令执行部分由指令执行模块构成。

关键词： QoS OpenFlow 路由器工作负载

Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

在线全文

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma yi liang Kaiwen Bao Kai Qu xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin