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埃克替尼对肺动脉高压大鼠右心室重构的保护作用

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中国临床药理学杂志 2024年第12期40卷 1784-1788页

作者：胡霞顾文强严静静黄维琳李先伟安徽中医药高等专科学校基础教学部安徽芜湖241000 皖南医学院药学院药理学教研室安徽芜湖241002

目的研究埃克替尼对野百合碱(MCT)诱导的肺动脉高压(PH)大鼠右心室重构的影响。方法将SD大鼠随机分为对照组(0.3%羧甲基纤维素钠)、模型组和低、高剂量实验组(30、60 mg·kg^(-1)埃克替尼),每组8只。模型组和低、高剂量实验组单次腹腔注... 详细信息

目的研究埃克替尼对野百合碱(MCT)诱导的肺动脉高压(PH)大鼠右心室重构的影响。方法将SD大鼠随机分为对照组(0.3%羧甲基纤维素钠)、模型组和低、高剂量实验组(30、60 mg·kg^(-1)埃克替尼),每组8只。模型组和低、高剂量实验组单次腹腔注射60 mg·kg^(-1)MCT建立大鼠肺动脉高压模型。MCT注射后连续给药4周。检测各组大鼠血流动力学指标,以原位末端标记法(TUNEL)染色检测右心室细胞凋亡情况,以蛋白质印迹法检测右心室B细胞淋巴瘤2(Bcl-2)、Bcl-2相关X蛋白(Bax)、活化的胱天蛋白酶-3(cleaved-caspase-3)、表皮生长因子受体(EGFR)、磷酸化EGFR(p-EGFR)、视神经萎缩症蛋白1(Opa1)和线粒体融合蛋白2(Mfn2)的蛋白表达情况。结果低、高剂量实验组和对照组、模型组右心室收缩压分别为(38.58±4.98)、(34.15±3.88)、(23.66±2.45)和(45.07±5.78)mmHg;平均肺动脉压分别为(27.85±3.77)、(24.25±3.09)、(17.33±2.46)和(33.07±4.15)mmHg;右心室/(左心室+室间隔)分别为(36.38±5.51)%、(33.63±4.69)%、(22.25±2.96)%和(42.50±7.33)%;右心室/胫骨长度分别为(69.33±7.86)、(62.69±7.17)、(49.12±6.42)和(78.22±9.07)mg·cm^(-1)。低、高剂量实验组的上述指标与模型组比较,在统计学上差异均有统计学意义(均P<0.01)。低、高剂量实验组Bcl-2、Bax、cleaved caspase-3、p-EGFR、Opa1、Mfn2与模型组相比,在统计学上差异均有统计学意义(P<0.05,P<0.01)。结论埃克替尼能够抑制MCT诱导的PH大鼠右心室重构,其机制可能与其降低右心室p-EGFR水平、缓解线粒体功能紊乱、抑制心肌细胞凋亡有关。

关键词：埃克替尼右心室重构表皮生长因子受体线粒体功能障碍

基于盲肠内容物代谢组学的炙红芪干预脾气虚大鼠的作用研究

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中国临床药理学杂志 2024年第4期40卷 584-588页

作者：孙宇靖宋沁洁王彦钧边甜甜张育贵李咸慰李国峰李越峰甘肃中医药大学科研实验中心甘肃兰州730000 甘肃中医药大学药学院甘肃兰州730000

目的以脾气虚大鼠的盲肠内容物为研究对象,筛选炙红芪干预脾气虚大鼠肠道功能的潜在生物标记物,分析其代谢途径。方法将60只SD雄性大鼠随机分为空白组、模型组、实验组和对照组,除空白组外,其余大鼠均用三因素复合造模法建立脾气虚模... 详细信息

目的以脾气虚大鼠的盲肠内容物为研究对象,筛选炙红芪干预脾气虚大鼠肠道功能的潜在生物标记物,分析其代谢途径。方法将60只SD雄性大鼠随机分为空白组、模型组、实验组和对照组,除空白组外,其余大鼠均用三因素复合造模法建立脾气虚模型。实验组灌胃给予12.60 g·kg^(-1)蜜炙红芪水提物;对照组灌胃给予0.63 g·kg^(-1)双歧杆菌乳杆菌三联活菌片混悬液;空白组和模型组均灌胃给予等剂量蒸馏水。检测动物体质量、肛温,计算免疫脏器指数。用超高效液相色谱-四极杆-静电场轨道阱高分辨质谱联用技术检测大鼠盲肠内容物代谢物,通过正交偏最小二乘法-判别分析,输入“京都基因与基因组百科全书”数据库,筛选出潜在差异代谢物及可能的代谢通路。结果干预结束后,实验组、对照组、模型组和空白组的平均体质量分别为(216.87±7.85)、(210.96±9.03)、(159.47±5.18)和(293.51±22.98)g,肛温分别为(36.14±0.48)、(35.40±0.64)、(34.50±0.78)和(36.61±0.34)℃,胸腺指数分别为(1.19±0.20)、(1.24±0.25)、(0.47±0.15)和(1.31±0.21)mg·g^(-1),脾指数分别为(1.95±0.33)、(2.18±0.28)、(1.61±0.27)和(2.29±0.24)mg·g^(-1);与模型组相比,实验组和对照组大鼠的上述指标均显著升高(均P<0.01)。筛选出14种炙红芪干预脾气虚大鼠的潜在生物标志物,主要通过氨基酸代谢、核黄素代谢及腺苷酸活化蛋白激酶代谢等途径发挥作用。结论炙红芪可通过改善脾气虚大鼠盲肠内容物代谢水平,保护肠黏膜屏障,减少肠道炎症反应,从而发挥健脾补气的作用。

关键词：炙红芪脾气虚证盲肠内容物代谢组学

Type B polycyclic polyprenylated acylphloroglucinols from the roots of Hypericum beanii

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Chinese Journal of Natural Medicines 2021年第5期19卷 385-390页

作者： li wei-xian XU Wen-Jun LUO Jun YANG Lei KONG ling-Yi Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

Two new type B polycyclic polyprenylated acylphloroglucinols(PPAPs)(1 and 2)and a known biogenetic precursor hyperbeanol Q(3)were isolated from the root extract of Hypericum beanii,a medicinal plant widespread in southwest *** chemical structures were elucidated by 1 D/2 D NMR and HRESIMS data analysis,and absolute configurations were determined through detailed electric circular dichroism(ECD)analysis including ECD exciton chirality,Mo2(OAc)4-induced ECD,and ECD *** these compounds,hyperbeone A(1)is a typical[3.3.1]-type B PPAP with an unusual C-1 geranyl side chain,and hyperberin C(2)possesses a rare bicyclo[5.3.1]hendecane *** compound 3 as a starting point,a plausible biosynthetic pathway to the bicyclic type B frameworks of 1 and 2 was proposed.

关键词： Polyprenylated acylphloroglucinol Hypericum beanii Hyperbeone A ECD

Microstructure Evolution and Nanomechanical Behavior of Micro-Area in Molten Pool of Selective Laser Melting(CoCrNi)_(82)Al_(9)Ti_(9)High-Entropy Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 1019-1033页

作者： Hong-wei Zhang li-wei Lan Zhe-Yu Yang Chang-Chun li Wen-xian Wang College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan030024China Ministry of Education Key Laboratory of Interface Science and Engineering in Advanced MaterialsTaiyuan University of TechnologyTaiyuan030024China Shanxi-Zhejiang University New Materials and Chemical Research Institute Taiyuan030032China

In this work,the phase evolution mechanism and nanomechanical properties of(CoCrNi))(82)Al_(9)Ti_(9)high-entropy alloy(HEA)prepared by selective laser melting(SLM)in the molten pool were *** HEA contains multiple primary elements and undergoes high-temperature gradient and rapid cooling during *** leads to significant inhomogeneity of nano-scale microstructure characteristics and instability of *** optimizing process parameters,the microstructure evolution at the optimal parameter volume energy density of 440 J/mm^(3)was studied.A phase transition from BCC to FCC occurred in the melt *** the micro-area of the melt pool results in a temperature rise and the combustion-induced loss of Al ***,the Ni element content increases significantly outside the melt *** process enhances the phase stability of FCC and facilitates phase ***,rapid cooling leads to the formation of distinctive ultrafine equiaxial crystals inside the melt pool,accompanied by the generation of intracrystalline needle-like nano-scale *** the melt pool,the accumulation of energy results in the formation of coarse ***,the nano-hardness inside the molten pool is remarkably high at 11.79 GPa,while the outside the molten pool is reduced to 9.58 *** the fracture toughness outside the melt pool also *** with inside the melt pool,the residual stress outside the melt pool changed from compressive to tensile stress and decreased from 603.28 to 322.84 MPa.

关键词： High-entropy alloys Selective laser melting Microstructure evolution Nanoindentation

Enhancing Deep Learning Soil Moisture Forecasting Models by Integrating Physics-based Models

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Advances in Atmospheric Sciences 2024年第7期41卷 1326-1341页

作者： Lu li Yongjiu DAI Zhongwang wei wei SHANGGUAN Nan wei Yonggen ZHANG Qingliang li xian-xiang li School of Atmospheric Sciences Sun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Guangzhou 510275China Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Guangzhou 510275China Institute of Surface-Earth System Science School of Earth System ScienceTianjin UniversityTianjin 300072China College of Computer Science and Technology Changchun Normal UniversityChangchun 130123China

Accurate soil moisture(SM)prediction is critical for understanding hydrological ***-based(PB)models exhibit large uncertainties in SM predictions arising from uncertain parameterizations and insufficient representation of land-surface *** addition to PB models,deep learning(DL)models have been widely used in SM predictions ***,few pure DL models have notably high success rates due to lacking physical ***,we developed hybrid models to effectively integrate the outputs of PB models into DL models to improve SM *** this end,we first developed a hybrid model based on the attention mechanism to take advantage of PB models at each forecast time scale(attention model).We further built an ensemble model that combined the advantages of different hybrid schemes(ensemble model).We utilized SM forecasts from the Global Forecast System to enhance the convolutional long short-term memory(ConvLSTM)model for 1–16 days of SM *** performances of the proposed hybrid models were investigated and compared with two existing hybrid *** results showed that the attention model could leverage benefits of PB models and achieved the best predictability of drought events among the different hybrid ***,the ensemble model performed best among all hybrid models at all forecast time scales and different soil *** is highlighted that the ensemble model outperformed the pure DL model over 79.5%of in situ stations for 16-day *** findings suggest that our proposed hybrid models can adequately exploit the benefits of PB model outputs to aid DL models in making SM predictions.

关键词： soil moisture forecasting hybrid model deep learning ConvLSTM attention mechanism

Hybrid vibration isolation optimization of a flexible manipulator based on neural network agent model

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Chinese Journal of Aeronautics 2024年第5期37卷 482-505页

作者： Yongxin ZHANG liang li Dingguo ZHANG wei-Hsin liAO xian GUO School of Science Nanjing University of Science and TechnologyNanjing 210094China Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong KongChina

Segmented Active Constrained Layer Damping(SACLD)is an intelligent vibration-damping structure,which could be applied to the sectors of aviation,aerospace,and transportation engineering to reduce the vibration of flexible ***,machine learning technology is widely used in the engineering field because of its efficient multi-objective *** dynamic simulation of a rotational segmental flexible manipulator system is presented,in which enhanced active constrained layer damping is carried out,and the neural network model of Genetic Algorithm-Back Propagation(GA-BP)algorithm is *** suppression and structural optimization of the SACLD manipulator model are studied based on vibration mode and damping *** modal responses of the SACLD manipulator model at rest and rotation are *** addition,the four model indices are optimized using the GA-BP neural network:axial incision size,axial incision position,circumferential incision size,and circumferential incision ***,the best model for vibration suppression is obtained.

关键词： Machine learning Vibration suppression Flexible manipulator Segmented active constrained layer damping Structural optimization

Particle distributions in Lamb wave based acoustofluidics

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Nanotechnology and Precision Engineering 2024年第2期7卷 60-68页

作者： Chuanchao Zhang xian Chen wei wei Xuejiao Chen Quanning li Xuexin Duan Key Laboratory of Precision Measuring Technology and Instruments College of Precision Instrument and Optoelectronics EngineeringTianjin UniversityTianjin300072China

Acoustic streaming enabled by a Lamb wave resonator(LWR)is efficient for particle trapping and enrichment in microfluidic ***,because Lamb waves combine the features of bulk acoustic waves and surface acoustic waves,the resulting acoustic streaming in the LWR occurs in multiple planes,and the particle flow behavior in this acoustofluidic system is largely *** here are numerical simulations and laboratory experiments conducted to investigate the boundary conditions for particle motion inside a microvortex induced by an *** dynamic capture,the particles’trajectories become orbital paths within an acoustic *** suspended particles encounter two distinct acoustic phenomena,i.e.,the drag force resulting from acoustic streaming and the acoustic radiation force,which exert forces in various directions on the *** the acoustic radiation force and the fluid drag force are dominant for large and small particles in a mixed solution,respectively,the large particles reside within the vortex while the small particles remain at its ***,when the acoustic radiation force is dominant for both types of particles,the distribution pattern is reversed.

关键词： Acoustofluidics Lamb wave resonator Particle manipulation Microvortex

litterfall,litter Decomposition,and Nutrient Dynamics in Two Subtropical Bamboo Plantations of China

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Pedosphere 2014年第1期24卷 84-97页

作者： TU li-Hua HU Hong-ling HU Ting-Xing ZHANG Jian li xian-wei liU li XIAO Yin-Long CHEN Gang li Ren-Hong College of Forestry Sichuan Agricultural University Institute of Ecological Forestry College of ForestrySichuan Agricultural UniversityChengdu CampusWenjiang District Personnel Department Sichuan Agricultural University Sichuan Forestry Inventory and Plan Institute

Bamboos are one of the fast-growing and multiple use species in the world, and thus bamboo forests/plantations play an important role in C sequestration at regional and global levels. We studied aboveground litterfall, litter decomposition and nutrient dynamics for two years in two subtropical bamboo ecosystems in Southwest China so as to test the hypothesis that litter quality determine the rate and nutrient dynamics during decomposition of different litter fractions. Mean annual total aboveground litter production ranged from 494 to 434 g m-2 in two bamboo stands （P stand, dominated by Pleioblastus amarus and H stand, hybrid bamboo dominated by Bambusa pervariabilis x Dendrocalamopsis daii）. Bulk （-80%） of litter production was contributed by leaf litter in two stands followed by twigs and sheathes. Different litter fractions represented considerable variations in the rates of mass loss and nutrient release. Variation of the mass remaining after 2 years of decomposition was significantly explained by initial C/N ratio and initial P concentration. Initial concentrations of N, P, Ca, and Mg explained 57.9%, 95.0%, 99.8% and 98.1%, respectively, of the variations of these elements mass remaining after 2 years of decomposition. The patterns of nutrient dynamics and the final amount remaining were mainly determined by their initial litter substrate quality in tl^ese two subtropical bamboo plantations.

关键词： C/N ratio litter fraction litter substrate mass loss Pleioblastus amarus

桃园不同生境天敌对梨小食心虫卵致死效能的影响

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应用昆虫学报 2024年第1期61卷 137-144页

作者：武爱华赵钰张文琳孔维娜相会明刁红亮胡荣山何江马瑞燕李先伟山西农业大学植物保护学院太谷030801 山西省蒲县农业资源开发中心蒲县041299

【目的】为明确桃园不同生境中天敌对梨小食心虫(以下简称梨小)卵致死效能的影响。【方法】在自然混栽、清耕混栽、套种单植和清耕单植4种桃园中,定期悬挂梨小卵卡,周年动态监测梨小卵的被寄生率、被捕食率和自然死亡率。【结果】4-9月... 详细信息

【目的】为明确桃园不同生境中天敌对梨小食心虫(以下简称梨小)卵致死效能的影响。【方法】在自然混栽、清耕混栽、套种单植和清耕单植4种桃园中,定期悬挂梨小卵卡,周年动态监测梨小卵的被寄生率、被捕食率和自然死亡率。【结果】4-9月自然混栽、清耕混栽、套种单植和清耕单植果园梨小卵总死亡率分别为45.4%、25.3%、28.6%、34.6%;其中自然死亡率为12.0%、15.3%、14.7%、16.1%,各生境果园无显著差异(P>0.05);桃果生长期4种果园梨小卵的被寄生率分别为8.0%、1.1%、1.5%、2.7%,被捕食率分别为18.6%、4.6%、6.3%、2.4%;自然混栽果园梨小卵被寄生率、被捕食率均显著高于其他3种果园。桃果采收期4种果园梨小卵的被寄生率分别为5.5%、6.9%、15.4%、26.8%,被捕食率分别为39.2%、10.6%、8.7%、14.1%;自然混栽果园梨小卵被捕食率显著高于其他3种果园。寄生梨小卵的寄生蜂种类为松毛虫赤眼蜂Trichogrammadendrolimi和暗黑赤眼蜂Trichogrammapintoi,所占比例分别为50.8%和49.2%。【结论】复杂的果园生境能有效提高梨小卵的被寄死亡率和被捕食率,松毛赤眼蜂和暗黑赤眼蜂是果园昆虫卵期优势寄生性天敌。

关键词：梨小食心虫果园生草生物防治套种生物多样性