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Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment

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World Journal of Gastroenterology 2020年第18期26卷 2126-2137页

作者： li-Wei Qiu Yi-Fei liu Xiao-qing Cao Yan Wang Xiao-Hong Cui Xian Ye Shuo-wen Huang Hong-Jun Xie Hai-Jian Zhang Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Thoracic Surgery Beijing Chest HospitalCapital Medical University(Beijing Tuberculosis and Thoracic Tumor Research Institute)Beijing 101149China Emergency Department Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of General Surgery Shanghai Electric Power HospitalShanghai 200050China Medical School of Nantong University Nantong 226001Jiangsu ProvinceChina

Hepatocellular carcinoma(HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2(ANXA2), is found to promote cancer progression and therapeutic ***, the underlining mechanisms of ANXA2 in immune escape of HCC remain poorly understood up to now. Herein, we summarized the molecular function of ANXA2 in HCC and its relationship with prognosis. Furthermore, we tentatively elucidated the underlying mechanism of ANXA2 immune escape of HCC by upregulating the proportion of regulatory T cells and the expression of several inhibitory molecules, and by downregulating the proportion of natural killer cells and dendritic cells and the expression of several inhibitory molecules or effector molecules. We expect a lot of in-depth studies to further reveal the underlying mechanism of ANXA2 in immune escape of HCC in the future.

关键词： Annexin A2 Hepatocellular carcinoma Immune microenvironment Overall survival Chemotherapy resistance Checkpoint

Total synthesis of (±)-13-hydroxyneocembrene

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Chinese Science Bulletin 1998年第16期43卷 1403-1405页

作者： Xing, Yacheng Cen, wen li, Ying li, Yulin Department of Chemistry Qingdao University Qingdao China National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou University Lanzhou China

Current noises in a topological Josephson junction

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Science China(Physics,Mechanics & Astronomy) 2018年第9期61卷 75-81页

作者： Yu-Hang li Jie liu JunTao Song Hua Jiang qing-Feng Sun XinCheng Xie International Center for Quantum Materials School of Physics Peking University Beijing 100871 China Department of Applied Physics School of Science Xi'an Jiaotong University Xi'an 710049 China Department of Physics and Hebei Advanced Thin Film Laboratory Hebei Normal University Shijiazhuang 050024 China College of Physics Optoelectronics and Energy Soochow University Suzhou 215006 China Collaborative Innovation Center of Quantum Matter Beijing 100871 China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of Sciences Beijing 100190 China

We study the transport properties of a superconductor-quantum spin Hall insulator-superconductor Josephson junction both in the absence and in the presence of a DC bias voltage. As the system is predicted to host Majorana fermions at its interfaces,the Andreev bond states are supposed to exhibit a distinct 4π periodicity in the superconducting phase difference, namely the fractional Josephson effect. Using the non-equilibrium Green's function method, we calculate the current and the related current noise based on a tight-binding Hamiltonian. Our direct results show that the fractional Josephson effect can not be seen in equilibrium junctions. While in non-equilibrium junctions, this effect can be confirmed by the multiple Andreev reflections induced peaks of the non-equilibrium noise, which appear at discrete frequencies ω = ne V with n being an integer number.

关键词： Majorana fermions Josephson junction current noise non-equilibrium Green's function

Wear response of metastable b-type Ti–25Nb–2Mo–4Sn alloy for biomedical applications

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Rare Metals 2015年第8期34卷 564-568页

作者： Shun Guo Qi Zheng Xiu-li Hou Xiao-Nong Cheng Xin-qing Zhao Institute for Advanced Materials Jiangsu University School of Materials Science and Engineering Beihang University

The wear response of a newly developed metastable b-type Ti–25Nb–2Mo–4Sn(abbreviated as Ti-2524) alloy was investigated and compared with that of(a+b)-type Ti–6Al–4V alloy. Experimental results show that solution-treated(ST) Ti-2524 specimen has the lowest wear rate due to the combined effects of excellent ductility and lubricative Nb2O5. Although similar Nb2O5 forms on the surface of the cold rolled plus annealed(CRA) Ti-2524 specimen, the beneficial effect of Nb2O5 on the wear resistance is counteracted by the increase in wear rate caused by low elongation. Thus, the wear rate of the CRA Ti-2524 alloy is higher than that of ST Ti-2524 *** for the ST Ti–6Al–4V alloy, no lubricative Nb2O5 forms on its worn surface owing to the absence of Nb. In addition, the ST Ti–6Al–4V alloy exhibits an elongation roughly similar to the CRA Ti-2524 specimen. Therefore,the ST Ti–6Al–4V specimen possesses a higher wear rate than the CRA Ti-2524 specimen.

关键词： Titanium alloy Wear response Low elastic modulus H

Discovery of four W UMa type eclipsing binaries in the field of open cluster ASCC 5

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Research in Astronomy and Astrophysics 2013年第9期13卷 1052-1062页

作者： Xiang-Song Fang Sheng-Hong Gu li-Yun Zhang qing-Feng Pi National Astronomical Observatories/Yunnan Observatory Chinese Academy of Sciences Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences University of Chinese Academy of Sciences College of Science/Department of Physics & NAOC-GZU-Sponsored Center for Astronomy Research Guizhou University

We carried out time-series photometric observations in the Re-band of the young, poorly studied open cluster ASCC 5 during November and December, 2012, to search for magnetically active stars, and discovered four eclipsing binary stars in this field. In order to characterize these four newly discovered binaries, we derived their orbital periods by their times of light minimum, estimated their effective tem- peratures based on their （J - H） colors and analyzed their light curves using the Wilson-Devinney light curve modeling technique. Our analyses reveal that all of them are contact binaries with short orbital periods of less than 0.5 d, with spectral types from late-F to mid-K. Among them, one is a typical A subtype contact binary with a mass ratio around 0.5 and a period of 0.44 d, and one is an H subtype contact binary with a high mass ratio around 0.9 and a short period of about 0.27 d. The other two systems show low amplitudes of light variation （Ant 〈0.11m）; their actual photomet- ric mass ratios could not be determined by the light curve modelings, probably due to their attributes of being partially eclipsing stars. A preliminary analysis for these two systems indicates that both of them are likely to be W subtype contact binaries with low orbital inclinations. In addition, both of these two low amplitude variables show asymmetric distorted light curves （e.g., O＇Connell effect of ARc --~0.02m） during the observing runs, suggesting the presence of starspots on these two systems. More inter- estingly, the one showing a large case of the O＇Connell effect presented a remarkable variation in the shape of the light curve on a time scale of one day, indicating that this star is in a very active state. Therefore, these two stars need spectroscopic observations to precisely determine their parameters, as well as further photometric observations to understand the properties of their magnetic activity, e.g., the evolution of starspots.

关键词： stars:binaries: close -- stars:binaries: eclipsing -- stars: spots

Synthesis and properties of polyfluorene copolymers bearing thiophene and porphyrin

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Chinese Chemical Letters 2007年第7期18卷 879-882页

作者： Xing Xu Hao Chen Xian Rong Cai Ying li qing Jiang College of Chemistry Sichuan University Chengdu 610064 China

To search for more wider absorption and higher charge carriers mobilities materials of polymer solar cell, a series of soluble alternating polyfluorene copolymers were synthesized by palladium-catalyzed Suzuki coupling reaction. Their structures were determined by 1H NMR, IR and UV-vis. And their UV-vis absorption spectra indicated that they had strong absorption over 600 nm spectral range and nearly cover 400-700 nm visible region. The band gaps of copolymers calculated according to cyclic voltammetry （CV） were between 1.96 and 2.03 eV. Polymer：TiO2 bulk-heterojunction films were made from mixtures of polymer and titanium isopropoxide, a precursor for TiO2, via hydrolysis in air overnight. The photoluminescence at 380-800 nm of the blend film of PT-TPP20 （5 mg/mL）：Ti（OC3H7）4 （80 μL/mL）（20% volume fraction） was significantly quenched in the 50% Ti（OC3H7）4 blend film, indicating that rapid and efficient separation of photoinduced electron-hole pairs.

关键词： Polyfluorene copolymers Synthesis Absorption Bulk-heterojunction

Fe-Catalyzed Pictet-Spengler-Type Cyclization via Selective Four-Electron Reductive Functionalization of CO_(2)

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Chinese Journal of Chemistry 2021年第3期39卷 614-620页

作者： wen-Duo li Jie Chen Dao Yong Zhu Ji-Bao Xia State Key Laboratory for Oxo Synthesis and Selective Oxidation Center for Excellence in Molecular SynthesisSuzhou Research Institute of LICPLanzhou Institute of Chemical Physics(LICP)Chinese Academy of SciencesLanzhouGansu 730000China University of Chinese Academy of Sciences Beijing 100049China

Main observation and conclusion Herein,we describe a novel catalytic Pictet-Spengler-type cyclization using CO_(2) as a nontoxic and sustainable C1 feedstock with envi-ronmentally benign and non-precious-metal iron as *** reaction is achieved by selective four-electron reduction of CO_(2) into methylene level intermediate through carefully tuning the reaction parameters.A variety of tetrahydro-B-carbolines and other nitro-gen-containing heterocycles can be easily obtained under mild *** studies have shown that tetrahy-dro-B-carbolines are probably obtained via spiroindolenine intermediates.

关键词： Carbon dioxide Iron catalysis Four-electron reduction Pictet-Spengler-type cyclization Tetrahydro-B-carboline

Efficacy of Sitagliptin on Nonalcoholic Fatty liver Disease in High-fat-diet-fed Diabetic Mice

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Current Medical Science 2022年第3期42卷 513-519页

作者： Shu-tong ZHOU wen CUI li KONG Xun YANG Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing100050China Department of Cardiology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Department of Quality Management Zhumadian Central HospitalHuanghuai UniversityZhumadian 463000China

Objective Nonalcoholic fatty liver disease(NAFLD)is a common cause of clinical liver dysfunction and an important prepathological change of liver *** obesity,type 2 diabetes mellitus,dyslipidemia,and metabolic syndrome are the major risk factors for ***(Sig)is a novel hypoglycemic agent that improves blood glucose levels by increasing the level of active *** has been shown to prevent the development of fatty livers in mice on a fructose-rich *** purpose of this study was to observe the efficacy of Sig on NAFLD in type 2 diabetic *** The diet-induced obesity mouse model was established,and the diabetic mice were screened by an intraperitoneal glucose tolerance *** mice were randomly divided into four groups for 8 weeks of intervention:high-fat diet(HFD)group,Sig group,metformin(Met)group,and Sig+Met *** the intervention,the liver function indexes as well as the blood glucose and blood lipid levels of the mice were *** addition,the wet weight of the liver was measured;the pathological sections of the liver tissues were stained to observe the hepatocyte fatty degeneration,inflammation,necrosis,and fibrosis;and the hepatic histological injury was recorded as the NAFLD activity score(NAS).Results Compared with the normal control group,the body weight,liver weight,blood glucose level,insulin resistance(IR),blood lipid level,and transaminase level of the mice in the HFD group were significantly increased,showing typical metabolic *** treatment with Sig and/or Met,the mice gained less weight,had lower levels of blood glucose,triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and transaminase,and had improved IR compared with the HFD *** liver pathological NASs in the Sig group(P=0.01),Met group(P=0.028),and Sig+Met group(Pliver inflamm

关键词： nonalcoholic fatty liver disease sitagliptin insulin resistance nonalcoholic fatty liver disease activity score

Three New Complexes Based on the Flexible Zwitterionic Dicarboxylate ligand： Synthesis, Structures, and Properties

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Chinese Journal of Chemistry 2016年第2期34卷 225-232页

作者： qing Wang Bao Mu Dandan Yang Lei Lv Changxia li Rudan Huang Key Laboratory of Cluster Science of Ministry of Education School of Chemistry Beijing Institute of Technology Beijing 100081 China

Three new complexes have been prepared based on the transition metals and zwitterionic dicarboxylate ligand 1,1＇-（1,4-phenylene-bis（methylene））-bis（pyridine-3-carboxylic acid）（L）, whose formulas are {[Cd4（L）（SO4）]· （C1）6}n （1）, [Zn（L）C12], （2）, and [Co（L）C12], （3）, respectively. Complexes 1-3 have been characterized by elemental analyses, IR spectroscopy, XRD, thermal analyses and single crystal X-ray （powder） diffraction. 1 crystallizes in monoclinic space group C2/m, displaying a 2-D layer structure with three unique Cd^2＋ centers. 2 and 3 are iso- morphic structures with the orthorhombic Cmca space group. They exhibit a 1-D zigzag chain, which can be linked to generate a 2-D layer via hydrogen bonding interactions （C--H＇＂O）. Moreover, electrochemical behavior reveals that the redox reaction of 3-CPE is a surface-controlled reaction. And the luminescent properties of the title comlexes have been investigated at room temperature.

关键词： zwitterionic dicarboxylate ligand tetranuclear complex electrochemial property luminescent property