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H2A.Z Represses Gene Expression by Modulating Promoter Nucleosome Structure and Enhancer Histone Modifications in Arabidopsis

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Molecular Plant 2017年第10期10卷 1274-1292页

作者： Xiaozhuan Dai Youhuang Bai lihua Zhao Xianying DOU Yanhui liu Lulu Wang Yi li weimin li Yanan Hui Xinyu Huang Zonghua Wang Yuan Qin Fujian Provincial Key Laboratory of Haixia Applied Plant Systems Biology State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops Center for Genomics and Biotechnology College of Life Science Fujian Agriculture and Forestry University Fuzhou 350002 China College of Plant Protection Fujian Agriculture and Forestry University Fuzhou 350002 China Institute of Ocean Science Minjiang University Fuzhou 350108 China

Deposition of the histone variant H2A.Z at gene bodies regulates transcription by modifying chromatin accessibility in plants. However, the role of H2A.Z enrichment at the promoter and enhancer regions is unclear, and how H2A.Z interacts with other mechanisms of chromatin modification to regulate gene expression remains obscure. Here, we mapped genome-wide H2A.Z, H3K4me3, H3K27me3, Pol II, and nucleosome occupancy in Arabidopsis inflorescence. We showed that H2A.Z preferentially associated with H3K4me3 at promoters, while it was found with H3K27me3 at enhancers, and that H2A.Z deposition negatively correlated with gene expression. In addition, we demonstrated that H2A.Z represses gene expression by establishing low gene accessibility at ＋1 nucleosome and maintaining high gene accessibility at -1 nucleosome. We further showed that the high measures of gene responsiveness correlate with the H2A.Z-associated closed ＋1 nucleosome structure. Moreover, we found that H2A.Z represses enhancer activity by promoting H3K27me3 and preventing H3K4me3 histone modifications. This study provides a framework for future studies of H2A.Z functions and opens up new aspects for decoding the interplay between chromatin modification and histone variants in transcrip- tional control.

关键词： ChlP-seq RNA-seq H2A.Z histone modification nucleosome occupancy gene expression

Biosorption of Cu(Ⅱ) on extracellular polymers from Bacillus sp.F19

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Journal of Environmental Sciences 2008年第11期20卷 1288-1293页

作者： ZHENG Yan,FANG Xuliang,YE Zhilong,li Yahong,CAI weimin School of Environmental Science and Engineering,Shanghai Jiao Tong University,Shanghai 200240,China. School of Environmental Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

Biosorption can be an effective process for the removal of heavy metals from aqueous *** adsorption of Cu(Ⅱ) from aqueous solution on the extracellular polymers (EPS) from Bacillus sp.(named MBFF19) with respect to pH,incubation time,concentration of initial Cu(Ⅱ),and biosorbent dose was *** of Cu(Ⅱ) is highly pH *** maximum uptake of Cu(Ⅱ) (89.62 mg/g) was obtained at pH *** equilibrium was established in approximately 10 *** correlation coeffcient of mor...

关键词： Bacillus sp. biosorption extracellular polymers isotherms

Developing Learner＇s Integrated Skills in College English Multimedia Classroom

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Sino-US English Teaching 2004年第10期1卷 66-69,81页

作者： weimin li li liu Hebei Universiy

Based on critical thinking of the relevant literature, the study has been carried out to investigate to what extent Whole Language Approach contributes to better results and motivates students to acquire the English language faster and more naturally in the multimedia language lab. A tentative model of whole language teaching comes into view, and an eighteen-month experimental project is designed and implemented in Hebei University, China. Research evaluation in both the qualitative and quantitative approaches is conducted and analyzed to ensure validity and reliability of the research.

关键词： whole language approach multimedia computer-assisted language learning

Sino-U.S. Military Transparency in a New Security Concept

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Contemporary International Relations 2005年第11期15卷 27-42页

作者： li Yihu Zhao weimin the School of International Studies Peking University

Military transparency is a complicated the Sino-U. S. relations and also a degree of their interest coincidence. and sensitive issue in touchstone testing the One can hardly gain a full and profound insight into the essential implication of military transparency if he is dominated by the realist logic and putting undue emphasis on the importance of it in the bilateral military relation. Given the fact that China and the United States are two important powers shouldering critical responsibilities for maintaining global peace and security, this article argues that only by adopting a new security concept toward military transparency could the two countries forge a consensus on the international security situation and remove misunderstanding, misgivings and distrust in their military contacts and cooperation. Only by actively seeking and constructing a new security regime could the two sides strengthen the institutional base for their military cooperation.

关键词：中国美国军事策略国家安全

The Application of Laparoscopic B-Ultrasound Microwave Ablation Technology in liver Metastasis of Colorectal Cancer

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International Journal of Clinical Medicine 2020年第2期11卷 62-69页

作者： Wenfu Zhou weimin li Department of Hepatological Surgery Xiaogan Hospital of Wuhan University of Science and Technology Xiaogan China

liver is the most common metastasis target organ in the late stage of colorectal cancer. More than 50% of colorectal cancer patients will have simultaneous or heterochronous liver metastasis. The survival time of patients with colorectal cancer and liver metastasis (CRLM) is short;not all patients can get radical resection of liver metastasis. For this part of patients, microwave ablation technology has been proved to be one of the effective methods for the treatment of liver metastasis. Laparoscopic B-ultrasound ablation also highlights a lot of minimally invasive advantages;this paper reviews the relevant literature of PubMed database, Wanfang database and CNKI database, in order to provide the treatment basis for clinical application of microwave ablation technology under laparoscopic B-ultrasound in the treatment of CRLM. The results showed that the safety and effectiveness of microwave ablation for liver metastases under the location of B-ultrasonic laparoscopy were confirmed, and patients with liver metastases of colorectal cancer who could not be resected could choose this treatment.

关键词： Laparoscopic Technique Microwave Ablation Colorectal Cancer liver Metastases Review

Analysis of the Causes of Chronic Pain after Inguinal Hernia Repair without Tension and Its Prevention and Treatment

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International Journal of Clinical Medicine 2019年第3期10卷 122-127页

作者： Hao Wu weimin li School of Medicine Wuhan University of Science and Technology Wuhan China Xiaogan Hospital Affiliated to Wuhan University of Science and Technology Wuhan University of Science and Technology Xiaogan China

Purpose: Analyzing the causes of pain after tension-free repair in the inguinal hernia, and propose corresponding treatment strategies. Results: The patients in this group were followed up for 3 - 12 months. A total of 5 patients still had pain relief within 3 months after surgery. Further treatment was needed, and the incidence rate was 5%. Conclusion: Skilled surgical procedures are performed in patients with local anesthesia, and some of the absorbable repair materials can be used. The improved patch fixation and extra peritoneal repair can reduce the pain after inguinal hernia repair without tension.

关键词： Inguinal Hernia Tension-Free Hernia Repair Chronic Pain The Reason Treatment

Early Permian A-type Granites in the Zhangdaqi Area, Inner Mongolia, China and Their Tectonic Implications

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Acta Geologica Sinica(English Edition) 2019年第5期93卷 1300-1316页

作者： ZHANG li liU Yongjiang SHAO Jun li weimin liANG Chenyue CHANG Ruihong YANG Hongzhi FENG Zhiqiang ZHANG Chao XU Jia SHI Yi YANG Fan HE Pengfei College of Earth Sciences Jilin UniversityChangchun 130061China Shenyang Institute of Geology and Mineral Resources China Geological SurveyShenyang 110034China Key Lab of Submarine Geoscience and Prospecting Techniques MOEInstitute for Advanced Ocean StudyCollege of Marine GeosciencesOcean University of ChinaQingdao 266100China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266100China College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China

There is a controversy regarding the amalgamation of Xing’an and Songnen Blocks along the Hegenshan-Heihe Suture(HHS)in the eastern Central Asian Orogenic Belt(CAOB).To solve this problem,we performed detailed study on the granites from the Zhangdaqi area,adjacent to the north of the HHS in the northern part of the Great Xing’an Range,NE ***,the granites in the study area are metaluminous-weak peraluminous and high-K calc-alkaline *** elements of the granites show that LREEs are relatively enriched,while HREEs are relatively deficient and obvious REE *** granites are characterized by obvious negative Eu anomalies,meanwhile,they are relatively enriched in Rb,K,Th and depleted in Ba,Nb,Sr,P,*** the geochemical features suggest that the granites in the Zhangdaqi area are aluminum A-type *** zircon LA-ICP-MS U-Pb ages of these granites are 294-298 Ma,indicating that they formed in the Early *** granites also have positiveεHf(t)values(8.4-14.2)and a relatively young two-stage model age between 449 Ma and 977 Ma,implying that the magma was derived from the re-melting of the Early Paleozoic-Neoproterozoic juvenile *** with geochemical characteristics(Nb/Ta ratios of 9.0-22.2,and Zr/Hf ratios of 52.3-152.0),we believe that the magmatic source area is a mixture of partial melting of the lower crust and depleted mantle.A-type granites and bimodal volcanic rocks along the Hegenshan-Heihe Suture formed during the Late Carboniferous-Early Permian,indicating that the HHS between Xing’an and Songnen Blocks closed in the late ***,the Zhangdaqi area was in a post-orogenic extensional environment from Late Carboniferous to Early Permian and resulted in the formation of the A-type granites.

关键词： Central Asian Orogenic Belt Hegenshan-Heihe Suture A-type granites zircon U-Pb age Lu-Hf isotopic NE China

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铁死亡与骨质疏松症

中国组织工程研究 2025年第3期29卷 554-562页

作者：杨城李玮民冉栋成许嘉木吴王祥胥家福陈晶晶蒋光福王春庆贵州医科大学临床医学院贵州省贵阳市550004 贵州省人民医院骨科贵州省贵阳市550004 贵州医科大学附属医院急诊外科贵州省贵阳市550004

背景:已证实铁死亡与多种骨骼肌肉疾病密切相关,例如类风湿关节炎、骨肉瘤、骨质疏松症等。而铁死亡和骨质疏松症的病理生理机制有待进一步研究和阐明,以拓宽对铁代谢和骨质疏松症的认识,为今后阐明骨质疏松的新机制、开发治疗骨质疏松... 详细信息

背景:已证实铁死亡与多种骨骼肌肉疾病密切相关,例如类风湿关节炎、骨肉瘤、骨质疏松症等。而铁死亡和骨质疏松症的病理生理机制有待进一步研究和阐明,以拓宽对铁代谢和骨质疏松症的认识,为今后阐明骨质疏松的新机制、开发治疗骨质疏松的新技术和新药提供研究思路。目的:对铁死亡在骨质疏松症中的研究现状展开综述,为未来研究骨质疏松症的具体分子机制提供一条新方向,为骨质疏松症的治疗策略提供更有效、更好的选择。方法:由第一作者应用计算机检索2000-2024年出版的文献,以“铁死亡,铁代谢,骨质疏松,成骨细胞,破骨细胞,骨代谢,信号通路,肌肉骨骼,综述”等为中文检索词检索中国知网、万方和维普数据库;以“ferroptosis,iron metabolism,osteoporosis,osteoblast,osteoclast,bone metabolism,signal pathway,musculoskeletal,review”等为英文检索词检索PubMed数据库,按照入选标准最终共纳入68篇文献。结果与结论:①铁死亡是近年来发现的一种新的细胞死亡类型,通常伴随着细胞死亡过程中的大量铁积累和脂质过氧化,其发生具有铁依赖性,这与目前研究较热的几种细胞死亡方式(例如细胞焦亡、坏死性凋亡、铜死亡、自噬)有明显的区别。②细胞内铁稳态表现为铁的吸收、输出、利用和储存之间的平衡。人体的铁调节系统包括全身调节和细胞内调节,系统调节的主要因子是肝分泌产生的铁调节激素,细胞调节依赖于铁调节蛋白/铁反应元件系统;当然,细胞内铁稳态还可以由其他因素控制,例如缺氧、细胞因子和激素等。③脂质过氧化反应会对生物膜(质膜和内部细胞器膜)、脂蛋白和其他含脂质的分子造成氧化损伤。多不饱和脂肪酸磷脂是脂质过氧化的重要靶点,游离多不饱和脂肪酸是脂质氧化的重要底物,可与磷脂双分子层结合,导致过度氧化,从而引发脂质凋亡。④多项研究表明,通过不同的方式使成骨细胞铁超载,致细胞内不稳定的亚铁不断积累并产生活性氧和脂质过氧化物,造成成骨细胞铁死亡,最终引起骨形成减少影响骨稳态发生骨质疏松。⑤破骨细胞是由单核巨噬细胞系或骨髓间充质干细胞在核因子κB配体受体激活因子诱导下融合形成的大型多核细胞,具有骨吸收功能。铁离子可通过产生细胞内脂质活性氧促进破骨细胞分化和骨吸收,而铁螯合剂在体外可以抑制破骨细胞形成进而影响骨质疏松症的发生发展。

关键词：铁死亡铁代谢骨质疏松成骨细胞破骨细胞骨代谢信号通路综述

Characteristics and significance of peripheral blood T-cell receptor repertoire features in patients with indeterminate lung nodules

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4007-4010页

作者： Huaichao Luo Ruiling Zu Ziru Huang Yingqiang li Yulin liao Wenxin Luo Peng Zhou Dongsheng Wang Shifu Chen weimin li Jian Huang School of life Science and Technology University of Electronic Science and Technology of ChinaChengduSichuanChina Department of Clinical Laboratory&Division of Radiology Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuanChina HaploX Biotechnology Co. LtdShenzhenChina Department of Respiratory and Critical Care Medicine West China HospitalWest China Medical SchoolSichuan UniversityChengdu610041China

Dear Editor,Dear Editor,Lung cancer is one of the most common cancers and a leading cause of cancer-related deaths.T cells are known to play a significant role in the destruction of cancer cells.T cells have therefore become the focus of lung cancer immunotherapy.T-cell receptors(TCRs)can recognize antigenic peptides presented by HLA *** are distinct individually and vary with pathophysiological condition,so T cells can respond to a wide range of *** repertoire diversity reflects the potential for cellular immunity,and several studies have demonstrated that complementarity determining region 3(CDR3β)diversity is important in cancer therapy and prognosis.1 liu et *** reported that the CDR3βdiversity of patients with advanced lung cancer differs significantly from that of healthy individuals.

关键词： CDR3 lung patients