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Dynamic Response of Sea-Crossing Rail-cum-Road Cable-Stayed Bridge Influenced by random Wind–Wave–Undercurrent Coupling

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China Ocean Engineering 2023年第1期37卷 85-100页

作者： BIAN Chen-jie DU li-ming WANG Ga-ping li Xin li wei-ran School of Civil Engineering Dalian Jiaotong UniversityDalian 116028China School of Locomotive and Rolling stock Engineering Dalian Jiaotong UniversityDalian 116028China School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China

Sea-crossing bridges are affected by random wind–wave–undercurrent coupling loads, due to the complex marine environment. The dynamic response of long-span Rail-cum-Road cable-stayed bridges is particularly severe under their influence, potentially leading to safety problems. In this paper, a fluid–structure separation solution method is implemented using Ansys–Midas co-simulation, in order to solve the above issues effectively while using less computational resources. The feasibility of the method is verified by comparing the tower top displacement response with relevant experimental data. From time and frequency domain perspectives, the displacement and acceleration responses of the sea-crossing Rail-cum-Road cable-stayed bridge influenced by wave-only, wind–wave, and wind–wave–undercurrent coupling are comparatively studied. The results indicate that the displacement and acceleration of the front bearing platform top are more significant than those of the rear bearing platform. The dominant frequency under wind–wave–undercurrent coupling is close to the natural vibration frequencies of several bridge modes,such that wind–wave–undercurrent coupling is more likely to cause a resonance effect in the bridge. Compared with the wave-only and wind–wave coupling, wind–wave–undercurrent coupling can excite bridges to produce larger displacement and acceleration responses: at the middle of the main girder span, compared with the wave-only case, the maximum displacement in the transverse bridge direction increases by 23.58% and 46.95% in the wind–wave and wind–wave–undercurrent coupling cases, respectively;at the tower top, the variation in the amplitude of the displacement and acceleration responses of wind–wave and wind–wave–undercurrent coupling are larger than those in the wave-only case, where the acceleration change amplitude of the tower top is from-0.93 to 0.86 m/s^(2) in the waveonly case, from-2.2 to 2.1 m/s^(2) under wind–wave coupling effect, and from-2.6 to 2.6

关键词： random wind wave undercurrent coupling effect Rail-cum-Road cable-stayed bridge dynamic response

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Effect of RNA Interference Targeting STAT3 Gene Combined with Ultrasonic Irradiation and SonoVue Microbubbles on Proliferation and Apoptosis in Keratinocytes of Psoriatic Lesions

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Chinese Medical Journal 2018年第17期131卷 2097-2104页

作者： li-wei ran Hao Wang Dong Lan Hong-Xia Jia Si-Si Yu Department of DermatolocIy Jinqxi Campus Beijing Chaoyang Hospital Capital Medical University Beijing 100043 China Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710004 China

Background： Signal transducer and activator of transcription 3 （STAT3） was strongly expressed and activated in psoriatic keratinocytes （KCs） and correlated with the severity of psoriasis. The study aimed to investigate the effects of STAT3 small interfering RNA （siRNA） combined with ultrasonic irradiation and SonoVue microbubbles on the proliferation and apoptosis in KCs of psoriatic lesions and the relative mechanisms. Methods： Psoriatic KCs were transfected under four experimental conditions：（1） STA T3 siRNA carried by lipofectamine 3000 combined with ultrasonic irradiation and SonoVue microbubbles （LUS group）; （2） STA T3 siRNA only carried by lipofectamine 3000 （L group）; （3） the negative control ofsiRNA carried by lipofectamine 3000 combined with ultrasonic irradiation and SonoVue microbubbles （siRNA-NC）; （4） not treated as Blank. Cell Counting Kit-8 assay was used to evaluate the cell proliferation. Cell cycle analysis was detected with cycle test Plus DNA reagent kit associated with flow cytometer. FITC Annexin V apoptosis detection kit associated with flow cytometer was applied for apoptosis analysis. Fluo calcium indicator associated with flow cytometer was used to analyze intracellular free calcium concentration （[Ca^2＋）. The expressions of cyclin D1 and Bcl-xL were detected both at the mRNA level by real-time reverse transcription-polymerase chain reaction （RT-PCR） and at the protein level by Western blotting. The obtained data were statistically evaluated by two-way analysis of variance. Results： STAT3 siRNA inhibited the growth of KCs in a time-dependent manner showing the highest proliferation inhibition in LUS group with proliferation ratio of 45.38% ± 5.85% at 72h （P 〈 0.05 vs. L group, siRNA-NC, or Blank）. STAT3 siRNA induced an altered cell cycle distribution of KCs showing the highest increases in G2/M-phase population up to 18.06% ± 0.36% in LUS group （P 〈 0.05 vs. L group, siRNA-NC, or Blank）. ST,4 T3 siRNA induced late apoptosis of KCs with the

关键词： Apoptosis Cell Proliferation Keratinocytes Microbubbles Psoriasis RNA Interference Small Interfering RNA STAT3 Transcription Factor

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Novel Mutation of Cleidocranial Dysplasia-related Frameshift Runt-related Transcription Factor 2 in a Sporadic Chinese Case

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Chinese Medical Journal 2017年第2期130卷 165-170页

作者： Xue-Yan Qin Pei-Zeng Jia Hua-Xiang Zhao wei-ran li Feng Chen Jiu-Xiang lin Department of Orthodontics Peking University School and Hospital of Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology Beijing 100081 China Central Laboratory Peking University School and Hospital of Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology Beijing 100081 China

Background： Cleidocranial dysplasia （CCD） is an autosomal dominant disease that affects the skeletal system. Common symptoms of CCD include hypoplasia or aplasia of the clavicles, delayed or even absent closure of the fontanels, midface hypoplasia, short stature, and delayed eruption of permanent and supernumerary teeth. Previous studies reported a connection between CCD and the haploinsufficiency of runt-related transcription factor 2 （RUNX2）. Here, we report a sporadic Chinese case presenting typical symptoms of CCD. Methods： We made genetic testing on this sporadic Chinese case and identified a novel RUNX2 ffameshift mutation： c.1111 dupT. In situ immunofluorescence microscopy and osteocalcin promoter luciferase assay were performed to compare the functions of the RUNX2 mutation with those of wild-type RUNX2. Results： RUNX2 mutation was observed in the perinuclear region, cytoplasm, and nuclei. In contrast, wild-type RUNX2 was confined in the nuclei, which indicated that the subcellular compartmentalization of RUNX2 mutation was partially perturbed. The transactivation function on osteocalcin promoter of the RUNX2 mutation was obviously abrogated. Conclusions： We identified a sporadic CCD patient carrying a novel insertion/frameshift mutation of RUNX2. This finding expanded our understanding of CCD-related phenotypes.

关键词： Cleidocranial Dysplasia Frameshift Mutation Runt-related Transcription Factor 2

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生态资本主义的“反生态性”——基于马克思主义政治经济学批判视角

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毛泽东邓小平理论研究 2023年第4期 84-90,109页

作者：李蔚然吉林大学马克思主义学院

资本主义制度的反生态性,导致在资本主义制度框架下任何生态理论都无济于事,无论是生态市场主义,还是生态凯恩斯主义,其具体主张、策略并未触及生态问题的实质根源。因此,必须从生态问题产生根源——资本主义生产方式和资本主义制度入手... 详细信息

资本主义制度的反生态性,导致在资本主义制度框架下任何生态理论都无济于事,无论是生态市场主义,还是生态凯恩斯主义,其具体主张、策略并未触及生态问题的实质根源。因此,必须从生态问题产生根源——资本主义生产方式和资本主义制度入手,生态问题只有在以公有制为基础的社会主义制度框架下才能彻底解决。相较于资本主义,社会主义在解决生态问题上具有价值立场、制度基础和经济体制等多重优势。当前,我国正处于社会主义初级阶段,更要立足生产资料公有制,认识到资本对于生态文明建设的积极意义,在党的坚强领导下走出一条区别于西方资本主义国家的中国特色社会主义生态文明道路。

关键词：生态资本主义反生态性社会主义公有制

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锥形束CT在评价双颌前突患者前牙区牙槽骨缺损中的应用

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北京大学学报（医学版） 2015年第3期47卷 514-520页

作者：周琳李巍然北京大学口腔医学院·15腔医院第五门诊部北京100020 北京大学口腔医学院·口腔医院正畸科北京100081

目的:应用锥形束CT(cone-beam computed tomography,CBCT)评价治疗前双颌前突患者前牙区牙槽骨缺损情况。方法:选取50名未经正畸治疗的患者,根据年龄分为成人组[30例,平均(22.9±4.2)岁]与青少年组[20例,平均(13.1±1.0)岁],其中成人组... 详细信息

目的:应用锥形束CT(cone-beam computed tomography,CBCT)评价治疗前双颌前突患者前牙区牙槽骨缺损情况。方法:选取50名未经正畸治疗的患者,根据年龄分为成人组[30例,平均(22.9±4.2)岁]与青少年组[20例,平均(13.1±1.0)岁],其中成人组根据垂直骨面型分为低角组(9例)、均角组(11例)与高角组(10例),所有患者在相同参数条件下进行CBCT扫描,在其CBCT图像上诊断牙槽骨开窗与开裂的情况并分析其分布特征。结果:双颌前突患者发生牙槽骨缺损的人数比为94.00%。所有接受检验的牙齿牙槽骨缺损发生率为38.60%。牙槽骨缺损绝大多数发生在唇侧(98.66%);牙槽骨开窗主要发生在上颌,而骨开裂主要发生在下颌。青少年组牙槽骨开裂(3.06%)及骨缺损(30.13%)发生率明显低于成人组的骨开裂(11.73%)及骨缺损(42.46%)发生率,P0.05)。低角组骨开窗(22.22%)的发生率低于均角组(33.84%)和高角组(37.50%),P<0.05。牙槽骨缺损发生率最低的牙位为上颌中切牙。结论:双颌前突患者在正畸治疗前即存在广泛的牙槽骨缺损,缺损的发生率受年龄、垂直骨面型等因素影响。

关键词：锥束计算机体层摄影术错牙合牙槽骨质丢失双颌前突

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习近平关于榜样教育重要论述的科学内涵、精神实质与原创性贡献

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中国地质大学学报（社会科学版） 2023年第6期23卷 12-19页

作者：李蔚然李霞中国地质大学(武汉)马克思主义学院湖北武汉430074

习近平关于榜样教育的重要论述立意高远、思想深刻,以崇德向善、砥砺奋斗为价值目标,遵循宣传推广、学习认同、内化于心、外化于行的榜样教育过程,深刻阐释弘扬先进、见贤思齐、知行合一等丰富内涵。其精神实质主要体现为爱党报国为民... 详细信息

习近平关于榜样教育的重要论述立意高远、思想深刻,以崇德向善、砥砺奋斗为价值目标,遵循宣传推广、学习认同、内化于心、外化于行的榜样教育过程,深刻阐释弘扬先进、见贤思齐、知行合一等丰富内涵。其精神实质主要体现为爱党报国为民的爱国主义精神,坚守拼搏求精的敬业精神,无私无畏忘我的奉献精神,有梦追梦圆梦的奋斗精神以及攻坚克难闯关的创造精神。习近平关于榜样教育重要论述创造性提出若干新论断,在榜样教育选树的人民性、榜样教育目的的引领性、榜样教育意义的精神性及榜样教育表彰的系统性等方面作出重大原创性贡献。

关键词：习近平党的二十大精神思想政治教育榜样教育

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Micro-strain regulation strategy to stabilize perovskite lattice based on the categories and impact of strain on perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 578-604页

作者： Caixia li Wenwu liu Shiji Da lingbin Kong Fen ran State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology

Photovoltaic metal halide perovskite solar cells(PSCs) convert light to electricity more efficiently than crystalline silicon cells, and the cost of materials used to make them is lower than that of silicon *** efficiency is not a core issue affecting the application of perovskite solar cells in special *** present, stability is the major technical encounters that hinders its further commercial development. Microstrain in PSCs is currently a significant factor responsible for the device's instability. Strain-induced ion migration is widely believed to accelerate perovskite degradation even when external stimuli are ***, it is imperative to study strain to enhance the stability of PSCs. This paper reviews recent developments to understand strain's origin and effect mechanisms on performance of PSCs, including ion migration,failure behavior, defect formation, and its effect on photoelectric properties, stability, and ***, several well-known strain management strategies are systematically introduced based on the strain effect mechanism and strain engineering on the film, providing more clues for further preparation with increased stability. The manipulation of external physical strain applied from films to entire devices has been extensively studied. Furthermore, recommendations for future research directions and chemical approaches have been provided. It is emphasized that strain engineering plays a crucial role in improving the efficiency and longevity of PSCs. Tensile strain causes rapid degradation, while moderate compressive strain and external strain control could improve properties and stability. Efforts should focus on controlling compressive strain to mitigate residual tensile strain and introducing it in a controlled manner. Future research endeavors may focus on exploring these pathways to improve the efficiency and lifespan of PSCs.

关键词： Halide perovskite solar cells Strain origins Strain effects Strain management

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转录介导融合基因RBM6-RBM5在肿瘤细胞及组织中的表达

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吉林大学学报（医学版） 2009年第6期35卷 1068-1073页

作者：王珂张捷李然伟吉林大学第二医院呼吸内科吉林长春130041 吉林大学第二医院泌尿外科吉林长春130041

目的:鉴定RBM6-RBM5融合基因的存在,研究其与肿瘤发生的关系。方法:采用GLC20、MDA、MB、231、Jurkat、TF-1、MCF-7、Hela、BT-474、A431、K562及Raji10种肿瘤细胞株,肺、卵巢、骨骼肌、皮肤、脾脏、子宫、心脏、骨、脑、淋巴结、胰腺... 详细信息

目的:鉴定RBM6-RBM5融合基因的存在,研究其与肿瘤发生的关系。方法:采用GLC20、MDA、MB、231、Jurkat、TF-1、MCF-7、Hela、BT-474、A431、K562及Raji10种肿瘤细胞株,肺、卵巢、骨骼肌、皮肤、脾脏、子宫、心脏、骨、脑、淋巴结、胰腺、前列腺及睾丸等肿瘤组织及其相应正常对照组织的cDNA,5例乳腺癌组织,以巢式PCR方法检测融合基因的存在,并通过QPCR方法研究融合基因的产生与RBM6、RBM5基因表达水平之间的关系。结果:RBM6-RBM5融合基因首次在MDA、MB、231细胞株中获得鉴定,序列分析发现该基因为RBM6和RBM5的融合体,该融合体不包括RBM6的外显子20、21以及RBM5的外显子1。该融合基因在10种肿瘤细胞株及部分肿瘤组织中表达,但在正常组织中却未见表达。融合基因的表达与RBM6和RBM5 mRNA的表达有关;RBM6和RBM5 mRNA的表达水平在融合基因阳性的肿瘤组织中明显高于融合基因阴性的肿瘤组织。结论:融合基因的表达与肿瘤发生有关,高水平的RBM6和RBM5 mRNA水平可能是融合基因产生的原因之一。

关键词： RNA结合基序蛋白转录介导融合基因肿瘤细胞,培养的

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基于水稻生产水足迹的盘锦市水资源利用效率评价及水土资源测算与评价

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节水灌溉 2023年第7期 60-66页

作者：申祺李蔚然辽宁省盐碱地利用研究所辽宁盘锦124010

水足迹是评价人类活动对水资源开采和水环境污染程度的重要方法。为缓解盘锦市水资源问题,结合水稻生产水足迹评估水资源利用效率,探究水稻生产中水土资源配置及短缺压力。结果表明:①2009-2021年,盘锦市水稻生产单位质量水足迹年均值为... 详细信息

水足迹是评价人类活动对水资源开采和水环境污染程度的重要方法。为缓解盘锦市水资源问题,结合水稻生产水足迹评估水资源利用效率,探究水稻生产中水土资源配置及短缺压力。结果表明:①2009-2021年,盘锦市水稻生产单位质量水足迹年均值为1.26 m^(3)/kg。从用水来源来看,绿水足迹和蓝水足迹占水足迹总量的比重较大。②盘锦市水资源利用程度较高,表现为大多数年份基本不存在水资源压力;水资源开发程度较高;消耗等量水资源所带来的经济价值逐渐增加。③考虑资源数量的水土资源匹配系数均值为0.375万m^(3)/hm^(2),考虑资源质量的匹配系数均值为0.273万m^(3)/hm^(2),盘锦农业生产所产生的资源数量影响大于质量产生的影响。④整体上,水资源短缺压力高于土地资源短缺压力,基于生产视角的水资源短缺压力受社会、经济、生产环境发展因素的影响较小,经济环境因素对土地资源短缺压力影响显著。研究结果可在推动农业用水的高效利用、提高水资源利用率、促进农业水土资源合理配置方面,实现区域水资源的可持续利用。

关键词：盘锦市水足迹水资源利用效率评价水土资源短缺压力

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人工神经网络在柚皮总黄酮提取中的应用

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湖北农业科学 2011年第10期50卷 2088-2091页

作者：黄华黎未然贺州学院化学与生物工程系广西贺州542800 贺州学院教育技术中心广西贺州542800

为获得柚皮总黄酮提取的优化工艺,以乙醇体积分数、溶剂用量、提取温度和提取时间作为影响因素,进行了柚皮总黄酮提取的单因素试验和正交试验。以获得的20个单因素试验结果和9个正交试验结果作为训练样本,设计和训练了4-5-1结构的三层B... 详细信息

为获得柚皮总黄酮提取的优化工艺,以乙醇体积分数、溶剂用量、提取温度和提取时间作为影响因素,进行了柚皮总黄酮提取的单因素试验和正交试验。以获得的20个单因素试验结果和9个正交试验结果作为训练样本,设计和训练了4-5-1结构的三层BP人工神经网络。运用训练好的网络对设计的625种工艺组合进行预测,获得了3组总黄酮得率较高的提取工艺。结果表明,通过人工神经网络获得的提取工艺总黄酮得率比正交试验提高了5.7%。

关键词：人工神经网络柚皮总黄酮提取

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