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Mitochondrial phylogenomics provides insights into the phylogeny and evolution of spiders(Arthropoda:Araneae)

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Zoological Research 2022年第4期43卷 566-584页

作者： min li Wen-Ting chen Qi-lin Zhang min liu cheng-wei Xing Ya Cao fang-zhen Luo ming-Long Yuan State Key Laboratory of Grassland Agro-Ecosystems Lanzhou UniversityLanzhouGansu 730020China College of Pastoral Agriculture Science and Technology Lanzhou UniversityLanzhouGansu 730020China National Demonstration Center for Experimental Grassland Science Education Lanzhou UniversityLanzhouGansu 730020China Faculty of life Science and Technology Kunming University of Science and TechnologyKunmingYunnan 650500China Lanzhou University Second Hospital Lanzhou UniversityLanzhouGansu 730030China

Spiders are among the most varied terrestrial predators,with highly diverse morphology,ecology,and *** and molecular data have greatly contributed to advances in the phylogeny and evolutionary dynamics of ***,we performed comprehensive mitochondrial phylogenomics analysis on 78 mitochondrial genomes(mitogenomes)representing 29 families;of these,23 species from eight families were newly *** retained the same gene arrangement as the arthropod ancestor(limulus polyphemus),while Opisthothelae showed extensive rearrangement,with 12 rearrangement types in transfer RNAs(tRNAs)and control *** spider tRNAs were extremely truncated and lacked typical dihydrouridine or TΨC arms,showing high tRNA structural diversity;in particular,trnS1 exhibited anticodon diversity across the *** evolutionary rates of mitochondrial genes were potentially associated with gene rearrangement or truncated *** mitogenomic sequences and rearrangements possessed phylogenetic characteristics,providing a robust backbone for spider phylogeny,as previously *** monophyly of suborder,infraorder,retrolateral tibial apophysis clade,and families(except for Pisauridae)was separately supported,and high-level relationships were resolved as(Mesothelae,(Mygalomorphae,(Entelegynae,(Synspermiata,Hypochilidae)))).The phylogenetic positions of several families were also resolved(e.g.,Eresidae,Oecobiidae and Titanoecidae).Two reconstructions of ancestral web type obtained almost identical results,indicating that the common ancestor of spiders likely foraged using a silk-lined *** study,the largest mitochondrial phylogenomics analysis of spiders to date,highlights the usefulness of mitogenomic data not only for providing efficient phylogenetic signals for spider phylogeny,but also for characterizing trait diversification in spider evolution.

关键词： Spiders Mitochondrial genome Gene rearrangement Truncated tRNAs Trait evolution Phylogenomics

Superconducting and structural properties of the phosphorus-rich Nb_(2)P_(5) superconductor under high pressure

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Tungsten 2023年第3期5卷 364-369页

作者： lei-ming chen fang-Huang wei Yan-Hong chen Hang-Qi liu Yang Xu Bo-Yu chen Can-li Dai Yu-Bo Zhang zhen-Hai Yu School of Materials Science and Engineering Henan Key Laboratory of Aeronautic Materials and Application TechnologyZhengzhou University of AeronauticsZhengzhou 450046China Henan Key Laboratory of Aeronautical Material and Application Technology Zhengzhou University of AeronauticsZhengzhou 450046China Yongcheng City Vocational Education Center Shangqiu 476600China Kaixue Cold Chain Logistics Co. LtdZhengzhou 451450China minjiang Collaborative Center for Theoretical Physics College of Physics and Electronic Information EngineeringMinjiang UniversityFuzhou 350108China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

Nb_(2)P_(5) is a recently discovered Bardeen,Cooper,Schrieffer theory s-wave superconductor hosting nontrivial topological nodal-line structure,which could serve as an excellent platform for studying the interplay between the superconductivity and nontrivial topological *** report herein the superconducting and structural properties of Nb2P5studied by measuring the electrical resistivity and structure under high pressure up to ~28 GPa and performing first principles *** superconducting transition temperature TCdecreases with applied pressure,and reaches a minimum of 1.9 K at ~20.0 GPa,followed by a continuous enhancement up to 50.0 GPa without ***,at pressures above ~8.2 GPa,it is likely that a second superconducting transition appears and coexists with the initial one even up to~28 *** calculations rule out the correlation between the second superconducting-like transition and ***,the Nb2P5showed remarkable axial anisotropic compressibility,in which the b-axis is more compressible than the a-and *** variation of TCis discussed via considering the evolution of density of states around the Fermi level and the phonon spectrum.

关键词： Phosphorus-rich superconductor Superconducting transition temperature High-pressure measurement First principles calculations

Silencing MYH9 blocks HBx-induced GSK3βubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2361-2372页

作者： Xian lin Ai-min li Yong-Hao li Rong-cheng Luo Yu-Jiao Zou Yi-Yi liu chen liu Ying-Ying Xie Shi Zuo Zhan liu zhen liu wei-Yi fang Cancer Center Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhouGuangdongPeople’s Republic of China510310 Department of Hepatobiliary Surgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhouPeople’s Republic of China550004 Department of Gastroenterology and Clinical Nutrition The First Affiliated Hospital(People’s Hospital of Hunan Province)Hunan Normal UniversityChangshaHunanPeople’s Republic of China410002 Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory DiseaseSchool of Basic Medical SciencesGuangzhou Medical UniversityAffiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouGuangdongPeople’s Republic of China510095 Cancer Institute School of Basic Medical ScienceSouthern Medical UniversityGuangzhouGuangdongPeople’s Republic of China510515

MYH9 has dual functions in ***,its role in inducing tumor stemness in hepatocellular carcinoma(HCC)is not yet ***,we found that MYH9 is an effective promoter of tumor stemness that facilitates hepatocellular carcinoma ***,targeting MYH9 remarkably improved the survival of hepatocellular carcinoma-bearing mice and promoted sorafenib sensitivity of hepatocellular carcinoma cells in *** analysis suggested that MYH9 interacted with GSK3βand reduced its protein expression by ubiquitin-mediated degradation,which therefore dysregulated theβ-catenin destruction complex and induced the downstream tumor stemness phenotype,epithelial–mesenchymal transition,and c-Jun signaling in HCC.C-Jun transcriptionally stimulated MYH9 expression and formed an MYH9/GSK3β/β-catenin/c-Jun feedback loop.X protein is a hepatitis B virus(HBV)-encoded key oncogenic protein that promotes HCC ***,we observed that HBV X protein(HBX)interacted with MYH9 and induced its expression by modulating GSK3β/β-catenin/c-Jun *** MYH9 blocked HBX-induced GSK3βubiquitination to activate theβ-catenin destruction complex and suppressed cancer stemness and *** on TCGA database analysis,MYH9 was found to be elevated and conferred poor prognosis for hepatocellular carcinoma *** clinical samples,high MYH9 expression levels predicted poor prognosis of hepatocellular carcinoma *** findings identify the suppression of MYH9 as an alternative approach for the effective eradication of CSC properties to inhibit cancer migration,invasion,growth,and sorafenib resistance in HCC *** study demonstrated that MYH9 is a crucial therapeutic target in HCC.

关键词： GSK3β hepatocellular MYH9

Tetrandrine suppresses proliferation, induces apoptosis, and inhibits migration and invasion in human prostate cancer cells

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Asian Journal of Andrology 2015年第5期17卷 850-853,I0011页

作者： wei liu Bo KOU zhen-Kun Ma Xiao-Shuang Tang Chuan Lv min Ye Jia-Qi chen lei li Xin-Yang Wang Da-lin He Department of Urology First Affiliated Hospital of Medical School Xi'an Jiaotong University Xi'an 710061 China Oncology Research Lab Key Laboratory of Environment and Genes Related to Diseases Ministry of Education of the People's Republic of China Xi'an 710061 China Department of Urology First People's Hospital of Jining Jining 272100 China Ophthalmology department The First Affiliated Hospital of Medical School Xi'an Jiaotong University Xi'an 710061 China

Tetrandrine （TET）, a traditional Chinese medicine, exerts remarkable anticancer activity on various cancer cells. However, little is known about the effect of TET on human prostate cancer cells, and the mechanism of function of TET on prostate cancer has not yet been elucidated. To investigate the effects of TET on the suppression of proliferation, induction of apoptosis, and inhibition of migration and invasion in human prostate cancer cell lines, DU145 and PC-3. Inhibition of growth was determined by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide assay and clone formation assay, and flow cytometry analysis was performed to detect the induction of apoptosis. Activation of poly （ADP-ribose） polymerase, caspase-3, Akt, phospho-Akt, Bcl-2, and Bax was analyzed by Western blotting. Wound healing assay and transwell migration assay were used to evaluate the effect of TET on migration and invasion of cancer cells. TET inhibited the growth of DU145 and PC-3 cells in a dose- and time-dependent manner. Cell cloning was inhibited in the presence of TET in DU145 and PC-3 cells. TET suppressed the migration of DU145 and PC-3 cells. Transwell invasion assay showed that TET significantly weakened invasion capacity of DU 145 and PC-3 cells. TET exhibited strong inhibitory effect on proliferation, migration, and invasion of prostate cancer cells. In addition, TET induced apoptosis in a dose-dependent manner by activating the caspase cascade and inhibiting phosphoinositide 3-kinase-Akt signal pathway. The accumulating evidence suggests that TET could be a potential therapeutic candidate against prostate cancer in a clinical setting.

关键词： apoptosis invasion migration proliferation prostate cancer tetrandrine

SAPT:a synchrotron-based proton therapy facility in Shanghai

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Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou Zhang De-ming li li-Ren Shen Hai-Rong Zhang Zhi-ling chen Han-Wen Du ming Gu Rui li De-Kang liu Yue-Hu Pu Jun-Feng Yu Jian-Feng chen Chu chen Chun-Long Guo Hao Guo Ge-Yang Jiang Zhi-Qiang Jiang lin Jin Wen-Jing li Xiu-fang li Ye lin ming liu Yong-Hao liu Ya-Juan liu ming Lv Qing-Ru Mi lian-Hua Ouyang wei-Guo Shi Hang Shu Qi-Sheng Tang Kun Wang Zhi-Shan Wang Jun Wu Xiao-Bing Wu Jia-Qiang Xu Wen-zhen Xu Chong-Xian Yin cheng Yu Ren-Xian Yuan Qi-Bing Yuan Hai-Qun Zhang miao Zhang Wen-Zhi Zhang li-Ying Zhao wei-min Zhou Shou-Xian fang Xi-Dong Sun zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

Oral JS-38,a metabolite from Xenorhabdus sp.,has both anti-tumor activity and the ability to elevate peripheral neutrophils

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Chinese Journal of Natural Medicines 2014年第10期12卷 768-776页

作者： liu min-Yu XIAO lin chen Geng-Hui WANG Yong-Xiang XIONG wei-Xia li Fei liu Ying HUANG Xiao-ling DENG Yi-fang ZHANG zhen SUN Hai-Yan liu Quan-Hai YIN ming School of Pharmacy Shanghai Jiao Tong University Department of Pharmacology Shanghai Institute of Pharmaceutical Industry Beijing Wenfeng Tianji Pharmaceuticals Ltd.

AIM: JS-38(mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell(WBC) elevating activities. METHOD: These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo using B16 allograft mouse models and xenograft models of A549 human lung carcinoma and QGY human hepatoma in nude mice. The anti-tumor interactions of JS-38 and cyclophosphamide(CTX) or 5-fluorouracil(5-Fu) were studied in a S180 sarcoma model in ICR mice. Specific stimulatory effects were determined on peripheral neutrophils in normal and CTX- and 5-Fu-induced neutropenic mice. RESULTS: The IC50 values ranged from 0.1 to 2.0 μmol·L-1. JS-38(1 μmol·L-1) caused an increase in A549 tumor cell apoptosis. Multi-daily gavage of JS-38(15, 30, and 60 mg?kg-1?d-1) inhibited in vivo tumor progression without a significant effect on body weight. JS-38 additively enhanced the in vivo anti-tumor effects of CTX or 5-Fu. JS-38 increased peripheral neutrophil counts and neutrophil rates in normal BALB/c mice almost as effectively as granulocyte colony-stimulating factor(G-CSF). In mice with neutropenia induced by CTX or 5-Fu, JS-38 rapidly restored neutrophil counts. CONCLUSION: These results suggest that JS-38 has anti-tumor activity, and also has the ability to increase peripheral blood neutrophils.

关键词： JS-38 (mitothiolore) Xenorhabdus sp. Anti-tumor activity Neutrophils Apoptosis

Macrophage-derived extracellular vesicles regulate skeletal stem/progenitor Cell lineage fate and bone deterioration in obesity

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Bioactive Materials 2024年第6期36卷 508-523页

作者： chen He chen Hu Wen-zhen He Yu-chen Sun Yangzi Jiang ling liu Jing Hou Kai-Xuan chen Yu-Rui Jiao Mei Huang min Huang Mi Yang Qiong Lu Jie wei Chao Zeng Guang-Hua lei Chang-Jun li Department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan410008China School of Biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Center for Neuromusculoskeletal Restorative Medicine(CNRM) The Chinese University of Hong KongHong Kong SARChina Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Department of Pharmacy The Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan410008China Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangshaHunan410008China Hunan Key Laboratory of Joint Degeneration and Injury ChangshaHunan410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan410008China Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina

Obesity-induced chronic inflammation exacerbates multiple types of tissue/organ deterioration and stem cell dysfunction;however,the effects on skeletal tissue and the underlying mechanisms are still ***,we show that obesity triggers changes in the microRNA profile of macrophage-secreted extracellular vesicles,leading to a switch in skeletal stem/progenitor cell(SSPC)differentiation between osteoblasts and adipocytes and bone *** marrow macrophage(BMM)-secreted extracellular vesicles(BMM-EVs)from obese mice induced bone deterioration(decreased bone volume,bone microstructural deterioration,and increased adipocyte numbers)when administered to lean ***,BMM-EVs from lean mice rejuvenated bone deterioration in obese *** further screened the differentially expressed microRNAs in obese BMM-EVs and found that among the candidates,miR-140(with the function of promoting adipogenesis)and miR-378a(with the function of enhancing osteogenesis)coordinately determine SSPC fate of osteogenic and adipogenic differentiation by targeting the Pparα-Abca1 *** miR-140 conditional knockout mice showed resistance to obesity-induced bone deterioration,while miR-140 overexpression in SSPCs led to low bone mass and marrow adiposity in lean *** miR-378a conditional depletion in mice led to obesity-like bone *** importantly,we used an SSPC-specific targeting aptamer to precisely deliver miR-378a-3p-overloaded BMM-EVs to SSPCs via an aptamer-engineered extracellular vesicle delivery system,and this approach rescued bone deterioration in obese ***,our study reveals the critical role of BMMs in mediating obesity-induced bone deterioration by transporting selective extracellular-vesicle microRNAs into SSPCs and controlling SSPC fate.

关键词： Obesity-induced bone deterioration Macrophage-derived extracellular vesicles Skeletal stem/progenitor cells Cell fate Aptamer Cell-specific targeting

Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes

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Nuclear Science and Techniques 2024年第4期35卷 208-220页

作者： Ao-Yan cheng Hao Cai Shi chen Tian-Lu chen Xiang Dong You-liang Feng Qi Gao Quan-Bu Gou Yi-Qing Guo Hong-Bo Hu ming-ming Kang Hai-Jin li chen liu Mao-Yuan liu wei liu fang-Sheng min Chu-cheng Pan Bing-Qiang Qiao Xiang-li Qian Hui-Ying Sun Yu-Chang Sun Ao-Bo Wang Xu Wang zhen Wang Guang-Guang Xin Yu-Hua Yao Qiang Yuan Yi Zhang School of Physics and Technology Wuhan UniversityWuhan 430072China School of Physics and Astronomy Yunnan UniversityKunming 650091China ministry of Education The Key Laboratory of Cosmic Rays(Tibet University)Lhasa 850000China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences 19 A Yuquan RoadShijingshan DistrictBeijing 100049China College of Physics Sichuan UniversityChengdu 610064China School of Intelligent Engineering Shandong Management UniversityJinan 250357China Tsung‑Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Suzhou Aerospace Information Research Institute Suzhou 215123China College of Physics Chongqing UniversityNo.55 Daxuecheng South RoadHigh‑tech DistrictChongqing 401331China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210008China

The High Altitude Detection of Astronomical Radiation(HADAR)experiment,which was constructed in Tibet,China,combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity advantages of focused Cherenkov *** objective is to observe transient sources such as gamma-ray bursts and the counterparts of gravitational *** study aims to utilize the latest AI technology to enhance the sensitivity of HADAR *** datasets and models with distinctive creativity were constructed by incorporating the relevant physical theories for various *** models can determine the type,energy,and direction of the incident particles after careful *** obtained a background identification accuracy of 98.6%,a relative energy reconstruction error of 10.0%,and an angular resolution of 0.22°in a test dataset at 10 *** findings demonstrate the significant potential for enhancing the precision and dependability of detector data analysis in astrophysical *** using deep learning techniques,the HADAR experiment’s observational sensitivity to the Crab Nebula has surpassed that of MAGIC and *** energies below 0.5 TeV and remains competitive with conventional narrow-field Cherenkov telescopes at higher *** addition,our experiment offers a new approach for dealing with strongly connected,scattered data.

关键词： VHE gamma-ray astronomy HADAR Deep learning Convolutional neural networks

The Chinese Hα Solar Explorer(CHASE) mission: An overview

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Science China(Physics,Mechanics & Astronomy) 2022年第8期65卷 2-9页

作者： Chuan li cheng fang zhen li mingDe Ding PengFei chen Ye Qiu wei You Yuan Yuan minJie An HongJiang Tao XianSheng li Zhe chen Qiang liu Gui Mei liang Yang wei Zhang weiQiang cheng JianXin chen ChangYa chen Qiang Gu QingLong Huang mingXing liu chengShan Han Hongwei Xin Changzheng chen Yiwei Ni WenBo Wang ShiHao Rao HaiTang li Xi Lu wei Wang Jun lin YiXian Jiang lingJie Meng Jian Zhao School of Astronomy and Space Science Nanjing University Key Laboratory for Modern Astronomy and Astrophysics (Nanjing University) Ministry of Education Shanghai Institute of Satellite Engineering Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences Shanghai Academy of Spaceflight Technology China Center for Resources Satellite Data and Application China Aerospace Science and Technology Corporation Key and Special Project Center of China National Space Administration (CNSA)

The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations.

关键词： space-based telescope solar physics chromosphere photosphere