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In-flight energy Calibration of the GeCAM Gamma-ray Detectors

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Research in Astronomy and Astrophysics 2024年第10期24卷 48-57页

作者： Rui Qiao Dong-Ya Guo Wen-Xi Peng Yan-qiu Zhang Shuo Xiao Shao-lin Xiong Chao Zheng Chao-Yang li Jia-Cong liu wang-Chen Xue Jian-Jian he Zheng-Hua An Da-li Zhang Xin-Qiao li li-Ming Song Shi-Jie Zheng Ke Gong Ya-Qing liu Xin-Ying Song Xiao-Yun Zhao Xiang-Yang Wen Yan-Bing Xu Xiang Ma Xiao-Bo li Ping wang Yue huang Ce Cai Qi-Bin Yi Yi Zhao Chen-Wei wang institute of High energy Physics Chinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Beijing 100049China china West Normal University Nanchong 637002China Xiangtan University Xiangtan 411105China beijing Normal University Beijing 100875China

The Gravitational wave high-energy electromagnetic Counterpart All-sky Monitor(GeCAM)mission is designed to monitor the Gamma-Ray Bursts(GRBs)associated with gravitational waves and other high-energy transient *** mission consists of two microsatellites which are planned to operate at the opposite sides of the *** GeCAM satellite could detect and localize GRBs in about 8 keV-5 MeV with its 25 Gamma-Ray Detectors(GRDs).In this work,we report the in-flight energy calibration of GRDs using the characteristic gamma-ray lines in the background spectra,and show their performance evolution during the commissioning ***,a preliminary cross-calibration of energy response with Fermi GBM data is also presented,validating the energy response of GRDs.

关键词： (stars:)gamma-ray burst:general instrumentation:detectors methods:data analysis

virtual reality-based cognitive-behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction:a randomised clinical trial

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General Psychiatry 2024年第2期37卷 189-196页

作者： Yuanyuan li Juan Peng Pingyuan Yang Jiajun Weng Yan'e Lu Jiajia liu Shikun Xu lihua Guan Dong huang Qibing wang Juying Qian Zexin Zhao Yabin Wei Junbo Ge Xiao huang Department of Psychological Medicine Zhongshan Hospital Fudan UniversityShanghaiChina Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesNational Clinical Research Center for Interventional MedicineShanghaiChina Department of Psychological Medicine Shanghai Geriatric Medical CenterShanghaiChina School of Nursing Peking UniversityBeijingChina beijing Key laboratory of Drug Dependence Research National Institute on Drug DependencePeking UniversityBeijingChina

Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction(AMI),significantly disrupting their *** timely and easily accessible psychological interventions using virtual reality-based cognitive-behavioural therapy(VR-CBT)could potentially improve both acute and long-term symptoms affecting their mental *** We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit(ICU)during the acute stage of their *** In this single-blind randomised clinical trial,participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February *** who were Han chinese aged 18-75 years were randomly assigned(1:1)via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support,or the control group to receive standard mental health support ***-CBT consisted of four modules and was delivered at the bedside over a 1-week *** were done at baseline,immediately after treatment and at 3-month *** intention-to-treat analysis began in June *** primary outcome measure was the changes in anxiety symptoms as assessed by the Hamilton Anxiety Rating Scale(HAM-A).Results Among 148 randomised participants,70 were assigned to the VR-CBT group and 78 to the control *** 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of HAM-A scores at both post intervention(Cohen’s d=−1.27(95%confidence interval(CI):−1.64 to−0.90,phen’s d=−0.37(95%CI:−0.72 to−0.01,p=0.024).Of the 70 participants who received VR-CBT,62(88.6%)completed the entire *** was the main reported adverse event(n=5).Conclusions Our results indicate that VR-CB

关键词： admitted behaviour treatment

The In-Flight Realtime Trigger and Localization Software of GeCAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-lin Xiong Xiang-Yang Wen Xin-Qiao li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan liao Yan-qiu Zhang Yue huang Lu li Xing Wen Fei Zhang Jing Duan Chen-Wei wang Dong-li Shi Peng Zhang Qi-Bin Yi Chao-Yang li Yan-Bing Xu Xiao-Hua liang Ya-Qing liu Da-li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu wang Sheng Yang Xiao-Jing liu Min Gao Mao-Shun li Jin-Zhou wang Xing Zhou Yi Zhao wang-Chen Xue Chao Zheng Jia-Cong liu Xing-Bo Han Jin-ling Qi Jia huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa wang Rui Qiao Xiang Ma Xiao-Bo li Ping wang Xin-Ying Song li-Ming Song Shi-Jie Zheng Bing li Hong-Mei Zhang Yue Zhu Wei Chen Jian-Jian he Zhen Zhang Jin Hou Hong-Jun wang Yan-Chao Hao Xiang-Yu wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-Fei Lan Yan-Guo li Gang li Xu-Fang li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui wang Hui-Zhen wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese academy of sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and technology Southwest Jiaotong UniversityChengdu 611756China Key laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation academy for Microsatellites of CAS Shanghai 201203China Changchun University of Science and technology Changchun 130022China chinese academy of sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GeCAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GeCAM electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

川芎嗪联合神经干细胞移植干预脑缺血再灌注大鼠的作用机制研究

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中国中药杂志 2024年第9期49卷 2316-2325页

作者：戚明珠王艳秋王栋李卓航黄荷兰林娜苏晓慧孔祥英中国中医科学院中药研究所北京100700

该文旨在研究川芎嗪(tetramethylpyrazine,TMP)联合神经干细胞(neural stem cells,NSCs)移植对大脑中动脉阻塞(middle cerebral artery occlusion,MCAO)模型大鼠的干预作用,并基于干细胞生物学行为调控探讨TMP联合NSCs移植对缺血性脑卒中的作用机制。将MCAO大鼠按神经功能评分随机分为模型组、TMP组、神经干细胞移植(NSCs)组和TMP联合神经干细胞移植(TMP+NSCs)组,同时设立假手术组。以神经功能评分来评价TMP联合NSCs移植对MCAO大鼠神经功能的改善情况;分别以BrdU、BrdU/DCX、BrdU/NeuN和BrdU/GFAP免疫荧光标记法评价NSCs的增殖、迁移、分化情况;蛋白免疫印迹检测基质细胞衍生因子1(SDF-1)、趋化因子C-X-C-基元受体4(CXCR4)的蛋白表达及氧化应激通路核因子e2相关因子2(Nrf2)、胞浆蛋白伴侣分子1(KeAP1)、血红素加氧酶1(HO-1)、醌氧化还原酶1(NQO1)的蛋白表达,研究TMP联合NSCs发生迁移的作用机制。结果发现,TMP联合NSCs移植可以显著改善MCAO大鼠神经功能评分;免疫荧光染色结果显示TMP组、NSCs组、TMP+NSCs组的BrdU^(+)、BrdU^(+)/DCX^(+)、BrdU^(+)/NeuN^(+)、BrdU^(+)/GFAP^(+)细胞数均明显升高,且以联合治疗组最明显;进一步的蛋白免疫印迹结果分析发现TMP组、NSCs组、TMP+NSCs组的CXCR4蛋白表达均显著升高,Nrf2、HO-1、NQO1的蛋白表达上调,KeAP1蛋白表达降低。该研究表明TMP以及NSCs移植均可促进NSCs增殖、迁移和分化,进而促进神经功能恢复,两者联合作用更佳,其作用机制可能与激活Nrf2/HO-1/CXCR4通路有关。

关键词：川芎嗪神经干细胞移植氧化应激迁移

川芎嗪激活Nrf2/HO-1/CXCR4通路调控神经干细胞迁移干预缺血再灌注大鼠的作用机制

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中国中药杂志 2024年第9期49卷 2308-2315页

作者：李卓航王栋王艳秋戚明珠黄荷兰林娜苏晓慧孔祥英中国中医科学院中药研究所北京100700

以核因子e2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)/血红素加氧酶1(heme oxygenase 1,HO-1)/趋化因子C-X-C-基元受体4(C-X-C motif chemokine receptor 4,CXCR4)通路为切入点,探讨川芎嗪(tetramethylpyrazine,TMP)干预大脑中动脉阻塞(middle cerebral artery occlusion,MCAO)模型大鼠脑内神经干细胞(neural stem cells,NSCs)迁移的作用机制。SD大鼠分为假手术组、模型组、TMP 20 mg·kg^(-1)组和TMP 40 mg·kg^(-1)组;通过神经功能缺失评分评价神经功能损伤;免疫荧光法检测脑组织5-溴脱氧尿苷(5-bromodeoxyuridine,BrdU)/双皮质素(doublecortin,DCX)双标细胞;观察TMP对C17.2细胞迁移的影响;蛋白免疫印迹法检测脑组织和C17.2细胞中Nrf2、HO-1、p62、醌氧化还原酶1[NAD(P)H quinone oxidoreductase 1,NQO1]、基质细胞衍生因子1(stromal cell-derived factor 1,SDF-1)、CXCR4蛋白表达。结果显示,大鼠脑缺血7、21 d后,神经功能损伤评分及BrdU+/DCX+细胞显著升高,脑组织中Nrf2及CXCR4表达均显著升高;与模型组相比,TMP 40 mg·kg-1可显著降低神经功能评分,进一步升高BrdU+/DCX+细胞数量及Nrf2、CXCR4及SDF-1表达;此外TMP可以显著促进C17.2细胞迁移,且时间以及剂量依赖性提高p62、Nrf2、HO-1、NQO1表达,TMP 50μg·mL^(-1)给药12 h表达量最高(P1)。综上,TMP可通过活化Nrf2/HO-1/CXCR4通路,促进NSCs迁移从而发挥抗缺血再灌注损伤作用。该研究为TMP在缺血性脑卒中疾病中的应用提供了实验支持。

关键词：大脑中动脉阻塞川芎嗪神经干细胞迁移 Nrf2/HO-1/CXCR4通路

STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.he S.Q.he X.G.he Y.L.he Z.B.he Z.X.heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.huang J.S.huang M.huang Q.Y.huang W.Q.huang X.T.huang X.J.huang Y.B.huang Y.S.huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop e.Kravchenko A.Kuzmin Y.Lei e.Levichev C.H.li C.li D.Y.li F.li G.li G.li H.B.li H.li H.N.li H.J.li H.L.li J.M.li J.li L.li L.li L.Y.li N.li P.R.li R.H.li S.li T.li W.J.li X.li X.H.li X.Q.li X.H.li Y.li Y.Y.li Z.J.li H.liang J.H.liang Y.T.liang G.R.liao L.Z.liao Y.liao C.X.lin D.X.lin X.S.lin B.J.liu C.W.liu D.liu F.liu G.M.liu H.B.liu J.liu J.J.liu J.B.liu K.liu K.Y.liu K.liu L.liu Q.liu S.B.liu T.liu X.liu Y.W.liu Y.liu Y.L.liu Z.Q.liu Z.Y.liu Z.W.liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan e.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov e.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker institute of Nuclear Physics Novosibirsk 630090Russia CAS Key laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central china Normal University Wuhan 430079China Central South University Changsha 410083China china University of Geosciences Wuhan 430074China china University of Mining and technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(ePFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou institute for Advanced Study UCASHangzhou 310024China hebei Normal University Shijiazhuang 050024China hebei University Baoding 071002China hefei University of technology Hefei 230601China helmholtz institute Mainz Staudinger Weg 18D-55099 MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China High energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of economy 11 Pokrovsky Bulvar Moscow 109028Russia huangshan University Huangshan 245000China Hubei University of Automotive technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China institute of Advanced Science Facilities Shenzhen 518107China institute of High energy Physics Chinese Academy of SciencesBeijing 100049China institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China institute of Physics Academia SinicaTaipeiTaiwan 11529China institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BePCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

Amplification effect of near-field ground motion around deep tunnels based on finite fracturing seismic source model

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Journal of Rock Mechanics and Geotechnical engineering 2022年第6期14卷 1761-1781页

作者： Qiankuan wang Shili qiu Yao Cheng Shaojun li Ping li Yong huang Shirui Zhang State Key laboratory of Geomechanics and Geotechnical engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Faculty of engineering China University of GeosciencesWuhan430074China University of chinese academy of sciences Beijing100049China South-Central University for Nationalities Wuhan430074China china Railway First Survey and Design institute Group Ltd. Xi’an710000China

Dynamic failure of rock masses around deep tunnels,such as fault-slip rockburst and seismic-induced collapse,can pose a significant threat to tunnel construction *** of the most significant factors that control the accuracy of its risk assessment is the estimation of the ground motion around a tunnel caused by seismicity *** general,the characteristic parameters of ground motion are estimated in terms of empirical scaling ***,these scaling laws make it difficult to accurately estimate the near-field ground motion parameters because the roles of control factors,such as tunnel geometry,damage zone distribution,and seismic source parameters,are not *** this,the finite fracturing seismic source model(FFSSM)proposed in this study is used to simulate the near-field ground motion characteristics around deep ***,the amplification effects of ground motion caused by the interaction between seismic waves and deep tunnels and corresponding control factors are *** control effects of four factors on the near-field ground motion amplification effect are analyzed,including the main seismic source wavelength,tunnel span,tunnel shape,and range of damage *** empirical formula for the maximum amplification factor(a_(m))of the near-field ground motion around deep tunnels is proposed,which consists of four control factors,*** wavelength control factor(F_(λ)),tunnel span factor(F_(D)),tunnel shape factor(F_(s))and excavation damage factor(F_(d)).This empirical formula provides an easy approach for accurately estimating the ground motion parameters in seismicityprone regimes and the rock support design of deep tunnels under dynamic loads.

关键词： Near-field ground motion Amplification effect Seismic waves Deep tunnel Rockburst

emerging contaminants:A One health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang wang Leilei Xiang Kelvin Sze-Yin Leung Martin elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian ehelbling Jianqiang Sun Hao qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu wang Ali el-Naggar Yiming Yao Yanran huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao li Tong Zhang Natàlia Corcoll Min liu Daniel SAlessi Hui li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan he Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo lizhong Zhu Xiangdong li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of chinese academy of sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU institute of Research and Continuing education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of environmental Science&engineering Kunming University of Science&TechnologyKunming 650500China Ministry of education Key laboratory of Pollution Processes and environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key laboratory of environmental Catalysis and health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of education Key laboratory of environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of environment Tsinghua UniversityBeijing 100084China School of Civil and environmental engineering Cornell UniversityIthacaNY 14853USA Key laboratory of Microbial technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of environmental Science and engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

Consensus on the digestive endoscopic tunnel technique

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World Journal of Gastroenterology 2019年第7期25卷 744-776页

作者： Ning-li Chai Hui-Kai li en-Qiang linghu Zhao-Shen li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang he Bing Hu1 Bing Hu2 Xiao-Jun huang Yong-Hui huang Zhen-Dong Jin Mouen A Khashab James Lau Peng li Rui li De-liang liu Hai-Feng liu Jun liu Xiao-Gang liu Zhi-Guo liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi wang Wen wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai Department of Gastroenterology and hepatology Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Gastroenterology the First Affiliated Hospital of Xi’an Jiao Tong UniversityXi’an 710000Shaanxi ProvinceChina Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of endoscopy Eastern Hepatobiliary Surgical Hospital Affiliated to Naval Medical UniversityShanghai 200438China Department of Gastroenterology the Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Gastroenterology Peking University Third HospitalBeijing 100191China Division of Gastroenterology and hepatology the Johns Hopkins University School of MedicineBaltimoreMD 21218United States Department of Gastrointestinal endoscopy Prince of Wales Hospitalthe Chinese University of Hong KongHong KongChina Department of Gastroenterology the First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Gastroenterology Second Xiangya Hospital of Central South UniversityChangsha 410000Hunan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Gastroenterology General Hospital of Chinese People’s Armed Police ForcesBeijing 100039China Division of Gastroenterology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Gastroenterology Sichuan Provincial People’s HospitalChengdu 610072Sichuan ProvinceChina Department of Gastroenterology Xijing HospitalAir Force Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Digestion Qinghai Provincial People’s HospitalXining 810007Qinghai ProvinceChina Department of Gastroenterology Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Gastroenterology Peking Univ

With the digestive endoscopic tunnel technique(DeTT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) *** present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DeTTs performed worldwide, endoscopic tunnel therapeutics, which is based on DeTT, has been gradually developed and optimized. However, there is not yet an expert consensus on DeTT to regulate its indications, contraindications, surgical procedure, and postoperative *** International DeTT Alliance signed up this consensus to standardize the procedures of DeTT. In this consensus, we describe the definition, mechanism,and significance of DeTT, prevention of infection and concepts of DeTTassociated complications, methods to establish a submucosal tunnel, and application of DeTT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DeTT and other operations).

关键词： Digestive endoscopic tunnel technique endoscopic submucosal tunnel dissection Per-oral endoscopic myotomy Submucosal tunnelling endoscopic resection Gastrointestinal tract