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Impact of environmental factors on gastric cancer:A review of the scientific evidence,human prevention and adaptation

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Journal of Environmental Sciences 2020年第3期32卷 65-79页

作者： Jie Yin Xiaoxu Wu suping li Chenlu li Zhiyi Guo State Key Laboratory of Remote Sensing Science College of Global Change and Earth System ScienceBeijing Normal UniversityBeijing 100875China The Second People’s Hospital of Lanzhou City Lanzhou 730046China

Globally,gastric cancer(GC) ranks fifth in prevalence and third in fatalities,and shows a distinct geographical distribution in morbidity and *** a spatial pattern indicates that environmental factors could be an important contributor to *** reviewed a total of 135 relevant peer-reviewed articles and other literature published 1936-2019 to investigate the scientific evidence concerning the effects of environmental factors on GC *** factors affect GC from the aspects of water,soil,air,radiation,and *** factors identified include water type,water pollution,water hardness,soil type,soil pollution,soil element content,climate change,air pollution,radiation,altitude,latitude,topography,and lithology;and most of them have an adverse impact on ***,we found that their effects followed five common rules:(1) the leading environmental factors that affect GC incidence and mortality vary by region,(2) the same environmental factors may have different effects on GC in different regions,(3) some different environmental factors have similar effects on GC in essence,(4) different environmental factors often interact to have combined or synergistic effects on GC,and(5)environmental factors can affect human factors to have an impact on *** factors have a great impact on *** beings may prevent GC by controlling carcinogenic factors,screening high-risk populations and providing symptomatic and rehabilitative ***,adaptation measures are recommended to reduce GC risk on private and public *** studies should transcend existing empirical studies to develop causal relationship models and focus on vulnerable population analysis.

关键词： Gastric cancer Environmental factor Review Impact Human prevention Human adaptation

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Chemiluminescence and electrochemiluminescence applications of metal nanoclusters

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Science China Chemistry 2016年第7期59卷 794-801页

作者： Shuang Han Zhichao Zhang suping li liming Qi Guobao Xu College of Applied Chemistry Shenyang University of Chemical Technology State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences University of the Chinese Academy of Sciences Chinese Academy of Sciences

Due to strong photoluminescence,extraordinary photostability,excellent biocompatibility,and good water-solubility,metal nanoclusters have attracted enormous attention since *** are found to be novel fluorescence labels for biological applications and environmental *** the chemiluminescence(CL) or electrochemiluminescence(ECL) of metal nanoclusters has received increasing *** review covers recent vibrant developments in this field of the past 5 years,and highlights different functions of metal nanoclusters in various CL and ECL systems,such as luminophores,catalysts,and *** synthetic methods of metal nanoclusters used in CL or ECL are also ***,we discuss some perspectives and critical challenges of this field in the near future.

关键词： nanoclusters chemiluminescence electrochemiluminescence fluorescence sensors

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Climate Reconstruction based on Pollen Analysis in Inner Mongolia, North China from 51.9 to 30.6 kaBP

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Acta Geologica Sinica(English Edition) 2013年第5期87卷 1444-1459页

作者： li suping David K.FERGUSON WANG Yong li Jinfeng YAO Jianxin Key Laboratory of Stratigraphy and Palaeontology Institute of Geology Chinese Academy of Geological Sciences Institute of Palaeontology University of Vienna State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of Sciences

The palynomorph assemblage of lake sediments younger than 51.9 kaBP from Wulagai Gobi in Inner Mongolia was analyzed to reconstruct the vegetation and climate. From 51.9 to 30.6 kaBP, the vegetation was arid to semi-arid grassland with only slight changes. According to the palynomorphs, trees and shrubs were very rare. The large number and diversity of algae indicate the presence of a lake. Quantitative climatic conditions were reconstructed using the Best Analogues Method. The results indicate that the annual mean temperature was higher than that at present. The combination of temperature and annual precipitation suggests a change in the climate from cool dry to warm dry and then cool humid. Our results show that the annual precipitation values were mostly higher than that at present but were lower than 400 mm. It infers that the study area was already within the arid to semi-arid regions but with a stronger influence of the summer monsoon during 51.9 to 30.6 kaBP than at present. With slight differences mainly in time scale, the changing trend of the annual temperature curve is consistent with the other climatic records from Antarctica, Greenland, Hulu Cave （East China）, and the Tibetan Plateau during the last glacial period. From 30.6 kaBP to present, very few palynomorphs were detected in the samples. Hence, no information about the vegetation and climate could be extracted. Combined with other studies during Late Pleistocene, we presume that the reason for the lack of pollen during this period was caused by an abrupt temperature fall after 30.6 kaBP or that the lacustrine conditions were unsuitable for pollen deposition. It was probably incurred by the oxidation on land prior to deposition. But for those samples only with algae, it might be caused by the fact that algae could finish their life history in a very short time in a seasonal lake.

关键词： paleoclimate paleovegetation pollen analysis Late Pleistocene Inner Mongolia

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Stigmasterol protects human brain microvessel endothelial cells against ischemia-reperfusion injury through suppressing EPHA2 phosphorylation

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Chinese Journal of Natural Medicines 2023年第2期21卷 127-135页

作者： li suping XU Fei YU liang YU Qian YU Nengwei FU Jing Department of Neurology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China Department of Rehabilitation Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengdu 610072China

Stigmasterol is a plant sterol with anti-apoptotic,anti-oxidative and anti-inflammatory effect through multiple *** this study,we further assessed whether it exerts protective effect on human brain microvessel endothelial cells(HBMECs)against ischemia-reperfusion injury and explored the underlying *** were used to establish an in vitro oxygen and glucose deprivation/reperfusion(OGD/R)model,while a middle cerebral artery occlusion(MCAO)model of rats were *** interaction between stigmasterol and EPHA2 was detected by surface plasmon resonance(SPR)and cellular thermal shift assay(CETSA).The results showed that 10μmol·L−1 stigmasterol significantly protected cell viability,alleviated the loss of tight junction proteins and attenuated the blood-brain barrier(BBB)damage induced by OGD/R in the in vitro *** molecular docking showed that stigmasterol might interact with EPHA2 at multiple sites,including T692,a critical gatekeep residue of this *** ephrin-A1(an EPHA2 ligand)exacerbated OGD/R-induced EPHA2 phosphorylation at S897,facilitated ZO-1/claudin-5 loss,and promoted BBB leakage in vitro,which were significantly attenuated after stigmasterol *** rat MCAO model confirmed these protective effects in *** summary,these findings suggest that stigmasterol protects HBMECs against ischemia-reperfusion injury by maintaining cell viability,reducing the loss of tight junction proteins,and attenuating the BBB *** protective effects are at least meditated by its interaction with EPHA2 and inhibitory effect on EPHA2 phosphorylation.

关键词： Stigmasterol Oxygen and glucose deprivation/reperfusion EPHA2 Blood-brain barrier

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Time budget and activity rhythm of wild Great Bustard in winter

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Frontiers in Biology 2006年第4期1卷 443-447页

作者： SUN Yanfeng li suping li Juyong WU Yuefeng li Jianping College of life Science Hebei Normal UniversityShijiazhuang 050016China Foreign Language Middle School Pingshan CountyPingshan 050400China

Instantaneous scanning and focal animal sampling methods were used to record the behaviors of nine wild Great Bustards(Otis tarda)and their time budget from November 2004 to January *** results indicated that foraging and resting time accounted for as high as 46.40%and 39.12%,respectively,while the rest of the behaviors,such as walking,alerting,preening and flying,only shared 6.83%,2.03%,2.64%and 1.84%,*** were significant differences in foraging time,alert time and walking time between males and females(P−5 and℃≤−5)℃was significantly different.

关键词： Great Bustard wintering period behaviors time budget rhythm

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Extracellular ATP-activated hybridization chain reaction for accurate and sensitive detection of cancer cells

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Chinese Chemical Letters 2023年第12期34卷 495-498页

作者： lie li suping li Jie Wang Xiaohong Wen Mei Yang Haiyan Chen Qiuping Guo Kemin Wang State Key Laboratory of Chemo/Biosensing and Chemometrics College of BiologyCollege of Chemistry and Chemical EngineeringHunan UniversityState Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceChangsha 410082China

Accurate and sensitive detection of caner cells is of significant importance for early diagnosis and treat-ment of ***,we developed an extracellular ATP-dctivated hybridization chain reaction(HCR)amplification strategy to meet this *** strategy relies on three DNA probes,Apt-trigger,H1-AТP aptamer duplex and hairpin *** Apt-trigger probe consists of two com sequence for specific recognition of the target *** a trigger sequence for the HCR ***роnents:an aptamer duplex structure of H1-ATP aptamer causes the tochold in hairpin H1 to be hidden,preventing the strand-ent displacement reaction between haipin H1 and *** activation with ATP the ATP aptamer will blnd to ATP to dissoci iate from hairpin H1,thus leading to an Apt-trigger-induced strand-displacement reaction and subsequent HCR with hairpin H2 on the target cell *** from aptamer recogni-tion and ATP-activated HCR amplification,this strategy can not only perform sensitive quantitative anal-ysis with a detection limit of 25 cells in 200 *** binding buffer,but also show desirable specificity and accuracy for identifylng target cells from control cells and mixed cell samples,Imporantly,this method retains stable and good perfor mance for target cell detection in 10%fetal bovine ser rum,den onstrating great potential for clinical diagnosis in complex biological ***,this strategy can be adapted to detect various types of cancer cells by changing the corresponding aptamer sequence.

关键词： Cancer cells ATP Aptamer Hybridization chain reaction Fluorescence

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DNA tetrahedron-based split aptamer probes for reliable imaging of ATP in living cells

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Chinese Chemical Letters 2023年第3期34卷 153-156页

作者： lie li Jie Wang Huishan Jiang Xiaohong Wen Mei Yang suping li Qiuping Guo Kemin Wang State Key Laboratory of Chemo/Biosensing and Chemometrics College of BiologyCollege of Chemistry and Chemical EngineeringHunan UniversityState Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceChangsha 410082China

Accurate detection and imaging of adenosine triphosphate(ATP)expression levels in living cells is of great value for understanding cell metabolism,physiological activities,and pathologic ***,we developed a DNA tetrahedron-based split aptamer probe(TD probe)for ratiometric fluorescence imaging of ATP in living *** TD probe is constructed by hybridizing two split ATP aptamer probes(Apt-a and Apt-b)to a DNA tetrahedron assembled by four DNA oligonucleotides(T1,T2,T3 and T4).In the presence of ATP,the TD probe will alter its structure from the open to closed state,thus bringing the separated donor and acceptor fluorophores into close proximity for high fluorescence resonance energy transfer(FRET)*** TD probe exhibits low cytotoxicity,efficient cell internalization and good biological ***,based on the FRET“off”to“on”signal output mode,the TD probe can effectively avoid false-positive signals from complex biological matrices,which is significant for long-term reliable imaging in living *** addition,by changing the split aptamers attached to DNA tetrahedron,the proposed strategy may be extended for detecting various intracellular ***,this strategy provides a valuable sensing platform for biomarkers analysis in living cells,thus having great potential for early clinical diagnosis and therapeutic evaluation.

关键词： Adenosine triphosphate DNA tetrahedron Split aptamer Fluorescence resonance energy transfer living cell imaging

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Palynological constraints on the age of the Mississippi Valley-type Changdong Pb-Zn deposit,Sanjiang belt,West China

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Science China Earth Sciences 2022年第1期65卷 167-181页

作者： Yingchao liU Yucai SONG Zengqian HOU Dangpeng XI suping li Longlong YUE Wang MA Bolang TANG Key Laboratory of Deep-Earth Dynamics of Ministry of Natural Resources Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China School of Earth Science and Resources China University of Geosciences(Beijing)Beijing 100083China Jiangsu Nanjing Institute of Geo-Engineering Investigation Nanjing 210041China

Mississippi Valley-type(MVT)Pb-Zn deposits serve as the world’s major supply of Pb-Zn ***,the age constraint of MVT Pb-Zn deposits has long been a big challenge,due to the lack of minerals that are unequivocally related to ore deposition and that can be used for radioisotopic *** we show sporopollens can provide useful chronological information on the Changdong MVT Pb-Zn deposit in the Simao basin,Sanjiang belt,West *** Pb-Zn ores in the Changdong deposit are hosted by internal sediments in paleo-karst caves of meteoric *** and galena occur as replacements of carbonate minerals and void infillings in the internal *** relations suggest that the Pb-Zn mineralization occurred after the deposition of the internal sediments.A palynological assemblage mainly composed of angiosperm pollen dominated by Castanea,Quercus,and Carya and fern spores dominated by Polypodiaceae,Pteris,and Athyriaceae was *** pollen and spores place the ore-hosting internal sediments and the Changdong paleo-karst at early to middle ***,the Changdong Pb-Zn deposit must have formed after the early Oligocene(~34 Ma).These age constraints,together with the geological characteristics,indicate that the Changdong Pb-Zn deposit is a paleo-karst-controlled MVT deposit related to fold-thrust systems in the Sanjiang *** Changdong deposit is similar to other MVT Pb-Zn deposits in the northern part of the Sanjiang belt,making it possible to extend this Pb-Zn belt 500 km further to the *** presented here highlights the potential of sporopollens in dating the age of MVT deposits related to paleo-karst formation in young orogenic belts.

关键词： Mississippi Valley-type(MVT)Pb-Zn deposits Age constraint Palynomorphs Internal sediments Paleo-karst Changdong deposit Sanjiang fold-thrust belt

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Molecularly engineered truncated tissue factor with therapeutic aptamers for tumor-targeted delivery and vascular infarction

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Acta Pharmaceutica Sinica B 2021年第7期11卷 2059-2069页

作者： Bozhao li Jingyan Wei Chunzhi Di Zefang Lu Feilong Qi Yinlong Zhang Wei Sun Leong Lele li Guangjun Nie suping li College of Pharmaceutical Science Jilin UniversityChangchun 130021China CAS Key Laboratory for Biomedical Effects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Materials Science and Engineering National University of Singapore117575Singapore

Selective occlusion of tumor vasculature has proven to be an effective strategy for cancer *** vascular coagulation agents,the extracellular domain of coagulation-inducing protein tissue factor,truncated tissue factor(tTF),is the most widely *** the truncated protein exhibits no coagulation activity and is rapidly cleared in the circulation,free tTF cannot be used for cancer treatment on its own but must be combined with other *** here developed a novel,tumor-specific tTF delivery system through coupling tTF with the DNA aptamer,AS1411,which selectively binds to nucleolin receptors overexpressing on the surface of tumor vascular endothelial cells and is specifically cytotoxic to target *** administration of the tTF-AS1411 conjugates into tumor-bearing animals induced intravascular thrombosis solely in tumors,thus reducing tumor blood supply and inducing tumor necrosis without apparent side *** conjugate represents a uniquely attractive candidate for the clinical translation of vessel occlusion agent for cancer therapy.

关键词： Tumor targeted delivery Truncated tissue factor(tTF) AS1411 aptamer Thrombosis Tumor infarction

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Enzymatically controlled DNA tetrahedron nanoprobes for specific imaging of ATP in tumor

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Chinese Chemical Letters 2024年第8期35卷 221-224页

作者： Xiaohong Wen Mei Yang lie li Mingmin Huang Wei Cui suping li Haiyan Chen Chen li Qiuping Guo College of Biology State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringKey Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan ProvinceHunan UniversityChangsha 410082China

Intracellular ATP is an emerging biomarker for cancer early diagnosis because it is a key messenger for regulating the proliferation and migration of cancer ***,the conventional ATP biosensing strat-egy is often limited by the undesired on-target off-tumor ***,we reported a novel strategy to design enzymatically controlled DNA tetrahedron nanoprobes(En-DT)for biosensing and imaging ATP in tumor *** En-DT was designed via rational engineering of structure-switching aptamers with the incorporation of an enzyme-activatable site and further conjugation on the DNA *** En-DT could be catalytically activated by apurinic/apyrimidinic endonuclease 1(APE1)in cancer cells,but they did not respond to ATP in normal cells,thereby enabling cancer-specific ATP biosensing and imaging in vitro and in vivo with improved tumor *** strategy would facilitate the precise detection of a broad range of biomarker in tumors and may promote the development of smart probes for cancer diagnosis.

关键词： Enzyme-controlled APE1 DNA tetrahedron Cancer-specific ATP biosensing

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