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Quality Evaluation of Diffusion Bonded Joints by Electrical Resistance Measuring and Microscopic Fatigue Testing

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Chinese Journal of Mechanical Engineering 2011年第2期24卷 187-194页

作者： li Yujia XUAN Fuzhen li shuxin TU Shandong Key Laboratory of Pressure System and Safety of Ministry of Education East China University of Science and Technology Shanghai 20023 7 China School of Petrochemical Engineering Lanzhou University of Technology Lanzhou 730050 China

Micro-structure related behavior of diffusion bonding joints is a crucial issue in device and reactor fabrication of Micro Chemo Mechanical ***,the previous studies have been focused on the macro mechanical performance of diffusion bonded joint,especially diffusion bonding conditions effects on tensile strength,shearing strength and fatigue *** research of interfacial micro-voids and microstructures evolution for failure mechanism has not been carried out for diffusion-bonded *** interfacial electrical resistance measuring method is proposed to evaluate the quality of bonded joints and verified by using two-dimensional finite-element *** influences of micro void geometry on increments of resistance are analyzed and the relationship between bonded area fraction and resistance increment is established by theoretical analysis combined with simulated *** inspections and micro-hardness testing are conducted near the interface of diffusion bonded *** the purpose of identifying the failure mechanisms of the joints,both microscopic tensile and fatigue tests are conducted on the self-developed in-situ microscopic fatigue testing *** on the microscopic observations,the mechanism of interfacial failure is *** observation result shows that for 316LSS diffusion-bonded joints,microstructure evolution and effect of micro-voids play a key role in interfacial failure ***,a new life prediction model in terms of the increment of electrical resistance is developed and confirmed by the experimental *** proposed study is initiated that constituted a primary interfacial failure mechanism on micron scale and provide the life prediction for reliability of components sealed by diffusion bonding.

关键词： diffusion bonded joints interfacial failure electrical resistance microscopic fatigue testing

Metabolic reprogramming of glial cells as a new target for central nervous system axon regeneration

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Neural Regeneration Research 2022年第5期17卷 997-998页

作者： Erin L.Walden shuxin li Shriners Hospitals Pediatric Research Center Department of Neural SciencesLewis Katz School of Medicine at Temple UniversityPhiladelphiaPAUSA

After central nervous system(CNS)injury,severed axons fail to regenerate and their disconnections to the original targets result in permanent functional deficits in patients(Mahar and Cavalli,2018).Both the diminished intrinsic regenerative capacity of mature neurons and the inhibitory CNS milieu contribute to the regenerative failure following CNS injury.

关键词： programming system permanent

Environmental cues determine the fate of astrocytes after spinal cord injury

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Neural Regeneration Research 2017年第12期12卷 1964-1970页

作者： Fatima M.Nathan shuxin li Shriners Hospitals Pediatric Research Center Department of Anatomy and Cell Biology Lewis Katz School of Medicine at Temple UniversityPhiladelphia PA USA

Reactive astrogliosis occurs after central nervous system（CNS） injuries whereby resident astrocytes form rapid responses along a graded continuum. Following CNS lesions, na？ve astrocytes are converted into reactive astrocytes and eventually into scar-forming astrocytes that block axon regeneration and neural repair. It has been known for decades that scarring development and its related extracellular matrix molecules interfere with regeneration of injured axons after CNS injury, but the cellular and molecular mechanisms for controlling astrocytic scar formation and maintenance are not well known. Recent use of various genetic tools has made tremendous progress in better understanding genesis of reactive astrogliosis. Especially, the latest experiments demonstrate environment-dependent plasticity of reactive astrogliosis because reactive astrocytes isolated from injured spinal cord form scarring astrocytes when transplanted into injured spinal cord, but revert in retrograde to naive astrocytes when transplanted into naive spinal cord. The interactions between upregulated type I collagen and its receptor integrin β1 and the N-cadherin-mediated cell adhesion appear to play major roles for local astrogliosis around the lesion. This review centers on the environment-dependent plasticity of reactive astrogliosis after spinal cord injury and its potential as a therapeutic target.

关键词： astrogliosis astrocyte fate scar formation spinal cord injury axon regeneration environmentcue collagen I integrin β1

Birds and plastic pollution:recent advances

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Avian Research 2021年第4期12卷 591-599页

作者： limin Wang Ghulam Nabi liyun Yin Yanqin Wang shuxin li Zhuang Hao Dongming li Ministry of Education Key Laboratory of Molecular and Cellular Biology Key Laboratory of Animal PhysiologyBiochemistry and Molecular Biology of Hebei ProvinceCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China

Plastic waste and debris have caused substantial environmental pollution globally in the past decades,and they have been accumulated in hundreds of terrestrial and aquatic avian *** are susceptible and vulnerable to external environments;therefore,they could be used to estimate the negative effects of environmental *** this review,we summarize the effects of macroplastics,microplastics,and plastic-derived additives and plastic-absorbed chemicals on ***,macroplastics and microplastics accumulate in different tissues of various aquatic and terrestrial birds,suggesting that birds could suffer from the macroplastics and microplastics-associated contaminants in the aquatic and terrestrial ***,the detrimental effects of macroplastics and microplastics,and their derived additives and absorbed chemicals on the individual survival,growth and development,reproductive output,and physiology,are summarized in different birds,as well as the known toxicological mechanisms of plastics in laboratory model ***,we identify that human commensal birds,long-life-span birds,and model bird species could be utilized to different research objectives to evaluate plastic pollution burden and toxicological effects of chronic plastic exposure.

关键词： Birds Microplastics pollution Plastics pollution Toxicological effects

Flexible Si/PEDOT：PSS hybrid solar cells

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Nano Research 2015年第10期8卷 3141-3149页

作者： shuxin li Zhibin Pei Fei Zhou Ying liu Haibo Hu Shulin Ji Changhui Ye AnhuiKeyLaboratoryofNanomaterials andTechnologyandKeyLaboratoryofMaterialsPhysicsInstituteofSolidStatePhysicsChineseAcademyofSciencesHefei230031China

Si hybrid solar cells have attracted tremendous research attention in recent years because of their low production costs and high performance. However, flexible Si hybrid solar cells have rarely been reported owing to the difficulty of fabricating single-crystalline Si with good flexibility. In this study, we fabricated flexible Si/PEDOT：PSS hybrid solar cells with micro-pyramid-structured Si light absorbers using a facile approach. Compared with planar flexible hybrid solar cells with a power-conversion efficiency of 4%, solar cells with micro-pyramid-structured Si light absorbers have a higher efficiency of 6.3%. External quantum efficiency and electrochemical impedance spectroscopy measurements revealed that the solar cells with micro-pyramid-structured Si light absorbers exhibited a pronounced light-harvesting enhancement in the spectra region of 400-1,000 nm and had a smaller series resistance and larger recombination resistance compared with the planar cells, yielding a higher efficiency. Additionally, in mechanical-bending tests, the flexible solar cells with micro-pyramid-structured Si light absorbers exhibited an excellent performance stability after bending for 600 cycles. Our findings lay the foundation for the real-world applications of flexible Si/PEDOT：PSS hybrid solar cells in next-generation portable electronics.

关键词： flexible devices hybrid solar cells micro-pyramid flexing test

A pretargeting nanoplatform for imaging and enhancing anti-inflammatory drug delivery

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Bioactive Materials 2020年第4期5卷 1102-1112页

作者： Min Kyung Khang Jun Zhou Cynthia M.Co shuxin li liping Tang Department of Chemistry and Biochemistry University of Texas at Arlington700 Planetarium PlaceChemistry Physics Building Room 130ArlingtonTX76019-0065USA Department of Bioengineering University of Texas at ArlingtonEngineering Research BuildingRoom 226Box 19138ArlingtonTX76010USA

This work details a newly developed“sandwich”nanoplatform via neutravidin-biotin system for the detection and treatment of ***,biotinylated-and folate-conjugated optical imaging micelles targeted activated macrophages via folate/folate receptor ***,multivalent neutravidin proteins in an optimal concentration accumulated on the biotinylated ***,biotinylated anti-inflammatory drug-loaded micelles delivered drugs effectively at the inflammatory sites via a highly specific neutravidin-biotin *** in vitro and in vivo studies have shown that the“sandwich”pretargeting platform was able to diagnose inflammation by targeting activated macrophages as well as improve the therapeutic efficacy by amplifying the drug delivery to the inflamed *** overall results support that our new pretargeting platform has the potential for inflammatory disease diagnosis and treatment.

关键词： Polymeric micelles Neutravidin/biotin system Pretargeting Macrophages Dexamethasone Inflammatory responses

Two-Stage Solar Flare Forecasting Based on Convolutional Neural Networks

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Space(Science & Technology) 2022年第1期2022卷 36-45页

作者： Jun Chen Weifu li shuxin li Hong Chen Xuebin Zhao Jiangtao Peng Yanhong Chen Hao Deng College of Science Huazhong Agricultural UniversityWuhan 430070China Hubei Key Laboratory of Applied Mathematics Hubei UniversityWuhan 430062China Nation Space Science Center Chinese Academy of ScienceBeijing 100190China Key Laboratory of Science and Technology on Environment Space Situation Awareness Beijing 100190China University of Chinese Academy of Science Beijing 100049China

Solar flares are solar storm events driven by the magnetic field in the solar activity *** flare,often associated with solar proton event or CME,has a negative impact on ratio communication,aviation,and ***,its forecasting has attracted much attention from the academic *** to the limitation of the unbalanced distribution of the observation data,most techniques failed to effectively learn complex magnetic field characteristics,leading to poor forecasting *** the statistical analysis of solar flare magnetic map data observed by SDO/HMI from 2010 to 2019,we find that unsupervised clustering algorithms have high accuracy in identifying the sunspot group in which the positive samples account for the ***,for these identified sunspot groups,the ensemble model that integrates the capability of boosting and convolutional neural network(CNN)achieves high-precision prediction of whether the solar flares will occur in the next 48 *** on the above findings,a two-stage solar flare early warning system is established in this *** F1 score of our method is 0.5639,which shows that it is superior to the traditional methods such as logistic regression and support vector machine(SVM).

关键词： Solar forecasting storm

PTEN inhibition and axon regeneration and neural repair

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Neural Regeneration Research 2015年第9期10卷 1363-1368页

作者： Yosuke Ohtake Umar Hayat shuxin li Shriners Hospitals Pediatric Research Center Department of Anatomy and Cell Biology Temple University School of Medicine

The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for controlling axon elongation. As a negative regulator of this pathway, the tumor suppressor phosphatase and tensin homolog （PTEN） appears critical to con- trol the regenerative ability of young and adult neurons. This review will focus on recent research progress in axon regeneration and neural repair by PTEN inhibition and therapeutic potential of blocking this phosphatase for neurological disorders. Inhibition of PTEN by deletion in con- ditional knockout mice, knockdown by short-hairpin RNA, or blockade by pharmacological approaches, including administration of selective PTEN antagonist peptides, stimulates various degrees of axon regrowth in juvenile or adult rodents with central nervous system injuries. Im- portantly, post-injury PTEN suppression could enhance axonal growth and functional recovery in adult central nervous system after injury.

关键词： PTEN inhibition antagonist peptide spinal cord injury intrinsic growth capacity axonregeneration functional recovery

Annealing effect on optical and electronic properties of silicon rich amorphous silicon-carbide films

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Frontiers of Optoelectronics 2012年第1期5卷 107-111页

作者： shuxin li Yunjun RUI Yunqing CAO Jun XU Kunji CHEN Nanjing National Laboratory of Microstructures School of Electronic Science and EngineeringSchool of PhysicsNanjing UniversityNanjing 210093China Department of Applied Physics Nanjing University of TechnologyNanjing 210009China

A series of Si-rich amorphous silicon carbide （a-SiC：H） thin films were deposited in conventional plasma enhanced chemical vapor deposition system with various gas ratio R = [CH4]/[SiH4]. The microstructural, optical and electronic properties of as-deposited films were investigated in this study. It was found that optical band gap was linearly proportional to carbon content in the films and it could be controlled in a range of 1.8-2.4 eV by changing the gas ratio, R. Both dark and photo conductivities in room temperature were decreased with the increasing of carbon content in the films, and the photosensitivity reached as high as 104 for the film with the optical band gap of 1.96 eV. The as-deposited samples were subsequently annealed at the temperatures of 900℃ and 1000℃. The formation of nanocrystalline silicon （nc- Si） dots in amorphous silicon carbide （a-SiC） host matrix was shown. The dark conductivity was enhanced by five orders of magnitude after annealing compared with that of as-deposited films. The result of temperature-dependent conductivity suggested that the property of carrier transport was dominated by conduction process between the extended states. Furthermore, room temperature electroluminescence （EL） was achieved from nc-Si/SiC system and the possible mechanism of radiative recombination mechanism was discussed.

关键词： amorphous silicon carbide (a-SiC) opticalband gap photo-conductivity dark conductivity electro-luminescence (EL)