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Cardioprotective effects of simvastatin on reversing electrical remodeling induced by myocardial ischemia-reperfusion in normocholesterolemic rabbits

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Chinese Medical Journal 2008年第6期121卷 551-556页

作者： DING Chao FU Xiang-hua HE Zhen-shan CHEN Hui-xiao XUE ling li Jun-xia Department of Cardiology Second Hospital of Hebei MedicalUniversity Institute of Cardiocerebrovascular Disease of HebeiProvince Shijiazhuang Hebei 050000 China Department of Cardiology Bethune International Peace Hospital ofPeople's Liberation Army Shijiazhuang Hebei 050082 China

Background Recent studies have revealed that pretreatment with statin is effective in preventing arrhythmia, but its electrophysiological mechanism is unclear. This study was conducted to investigate the cardioprotective effects of simvastatin on reversing electrical remodeling in left ventricular myocytes of rabbit heart undergoing ischemia-reperfusion, so as to explore the ionic mechanism responsible for the anti-arrhythmic effect of statin. Methods Forty-five rabbits were randomly divided into three groups： ischemic-reperfusion group （I-R）, simvastatin intervention group （Statin） and sham-operated control group （CON）. Anesthetized rabbits were subjected to 30-minute ischemia by ligation of the left anterior descending coronary artery and a 60-minute reperfusion after a 3-day administration of oral simvastatin of 5 mg-kg^-1.d^-1 in the Statin group or a placebo in the I-R group. Single ventricular myocytes were isolated enzymatically from the epicardial zone of the infracted region dedved from the hearts in the I-R and Statin group and the same anatomical region in the CON animals. The whole cell patch-clamp technique was used to record membrane ionic currents, including sodium current （IRa）, L-type calcium current （Ica-L） and transient outward potassium current （Ito）. Simultaneously, the level of serum cholesterol was examined. Results There was no significant difference in the serum cholesterol concentration among the three groups. The peak IRa current density （at -30 mV） was significantly decreased in I-R （（22.46±5.32） pA/pF, n=12） compared with CON （（42.78±5.48） pA/pF, n=16, P〈0.01） and Statin （（40.66±5.89） pA/pF, n=15, P〈0.01）, while the peak IRa current density in the Statin group was not different from CON （P〉0.05）. The peak ICa-L current density （at 0 mV） was significantly increased in I-R （（4.34±0.92） pA/pF, n=15） compared with CON （（3.13±1.22） pA/pF, n=13, P〈0.05） and Statin （（3.46±0.85） pNpF, n=16, P〈0.05）, while the Peak ICa-L current density in Statin

关键词： simvastatin ischemia reperfusion patch-clamp techniques ionic channel

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高压输电监测无线传感网功率控制算法

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电力系统保护与控制 2013年第23期41卷 91-96页

作者：孙毅柯珊珊李敏崔灿华北电力大学电气与电子工程学院北京102206

为了延长网络生命周期,解决高压输电监测的无线传感器网络中节点能量受限问题,结合应用背景的实际特点,提出一种基于节点动态聚类的功率控制算法。该算法以高压输电监测的网络架构为基础,分析传感器节点间的空间几何位置关系,综合考虑... 详细信息

为了延长网络生命周期,解决高压输电监测的无线传感器网络中节点能量受限问题,结合应用背景的实际特点,提出一种基于节点动态聚类的功率控制算法。该算法以高压输电监测的网络架构为基础,分析传感器节点间的空间几何位置关系,综合考虑空间几何信息与节点剩余能量,利用聚类分析方法对网络内具有相似性的节点进行动态聚类,使数据转发在类区域代表节点之间传递。同时,采用可变的功率调制技术进行数据传输。仿真结果表明,该算法能够有效地降低网络能量消耗,并延长网络的生命周期。

关键词：高压输电监测无线传感器网络功率控制剩余能量聚类

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Whole Lung Lavage Treatment of Chinese Patients with Autoimmune Pulmonary Alveolar Proteinosis： A Retrospective Long-term Follow-up Study

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Chinese Medical Journal 2015年第20期128卷 2714-2719页

作者： Yu-Yue Zhao Hui Huang Yong-Zhe liu Xin-Yu Song shan li Zuo-Jun Xu Department of Respiratory Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Pulmonary alveolar proteinosis （PAP） is a rare lung disease, the most common type of which is autoimmune PAP. The gold standard therapy for PAP is whole lung lavage （WLL）. Few studies have reported the optimal technique with which to evaluate the response to WLL. In this study, we aimed to identify parameters with which to assess the need for repeat WLL during a long-term 8-year follow-up. Methods： We conducted a retrospective analysis of 120 patients with autoimmune PAP with 80 of whom underwent WLL. Physiologic, serologic, and radiologic features of the patients were analyzed during an 8-year follow-up after the first WLL treatment. Results： Of the 40 patients without any intervention, 39 patients either achieved remission or remained stable and only one died of pulmonary infection. Of the 56 patients who underwent WLL for 1 time, 55 remained free from a second WLL and 1 patient died of cancer. Twenty-four required additional treatments after their first WLL. The baseline PaO2, （P = 0.000）, PA-aO2 （P = 0.000）, shunt fraction rate （P = 0.001）, percent of predicted normal diffusing capacity of the lung for carbon monoxide （DLCO%Pred）（P = 0.016）, 6-rain walk test （P = 0.013）, carcinoembryonic antigen （CEA）（P = 0.007）, and neuron-specific enolase （NSE）（P = 0.003） showed significant differences among the three groups. The need for a second WLL was significantly associated with PaO2 （P = 0.000）, CEA （P= 0.050）, the 6-minute walk test （P= 0.026）, and DLCO%Pred （P = 0.041 ）. The DLCO%Pred on admission with a cut-off value of42.1% （P = 0.001） may help to distinguish whether patients with PAP require a second WLL. Conclusions： WLL is the optimal treatment method for PAP and provides remarkable improvements for affected patients. The DLCO%Pred on admission with a cut-offvalue of 42.1% may distinguish whether patients with PAP require a second WLL.

关键词： Diffusing Capacity of the Lung fbr Carbon Monoxide Prognosis Pulmonary Alveolar Proteinosis Treatment:Whole Lung Lavage

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广西8市HIV抗体阳性母亲使用预防艾滋病母婴传播药物后对18月龄幼儿身体发育不良的9年回顾性研究

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实用预防医学 2022年第1期29卷 37-41页

作者：葛宪民蓝光华朱金辉蒋武梁旭邓鑫晖林兆森覃熙茂韦宁农爱丹郭伟贵陈欢欢李彬温平镜李江恒林倩覃允孟琴罗柳红邓月琴李珊珊刘帅凤吴秀玲黄精华广西壮族自治区疾病预防控制中心南宁530028 南宁市妇幼保健院南宁530011 百色市疾病预防控制中心百色533000 来宾市疾病预防控制中心来宾546100 钦州市疾病预防控制中心钦州535099 玉林市疾病预防控制中心玉林537000 河池市妇幼保健院河池530011 崇左市疾病预防控制中心崇左532200 北海市疾病预防控制中心北海536000 南宁市疾病预防控制中心南宁530023

目的回顾性研究广西8市2010—2018年HIV抗体阳性母亲使用预防艾滋病母婴传播(prevention of mother-to-child transmission of HIV,PMTCT)的抗逆转录病毒药物后对18月龄幼儿身体发育不良的影响,为国家改进PMTCT的用药方案提供依据。方... 详细信息

目的回顾性研究广西8市2010—2018年HIV抗体阳性母亲使用预防艾滋病母婴传播(prevention of mother-to-child transmission of HIV,PMTCT)的抗逆转录病毒药物后对18月龄幼儿身体发育不良的影响,为国家改进PMTCT的用药方案提供依据。方法选取广西8市作为研究现场,按照回顾性病例对照研究设计,病例组为广西8市2010年1月—2018年12月"全国母婴阻断系统数据库"中使用PMTCT药物的HIV抗体阳性母亲及所分娩婴儿,收集分析其使用PMTCT药物的历史卡片和母婴阻断资料及18月龄幼儿体检资料。对照组为相同8市妇幼保健院2018年健康母亲及所分娩婴儿,收集分析其18月龄幼儿体检资料。幼儿身体发育不良定义为身高、体重和头围3项指标中至少1项指标低于正常值范围。结果病例组的HIV抗体阳性母亲及所分娩婴儿使用PMTCT药物率分别为91.38%(2811/3076)和96.41(2954/3064),病例组18月龄幼儿的HIV抗体阳性率为1.21%(37/3064)、死亡率为2.28%(70/3064)、HIV母婴传播率为2.21%。病例组满18月龄健康体检时发现幼儿身体发育不良率为14.57%(301/2066);对照组满18月龄幼儿身体发育不良率为10.39%(563/5419),病例组与对照组差异有统计学意义(P=0.000)。结论广西8市近9年HIV抗体阳性母亲及所分娩婴儿使用PMTCT药物率高,可能导致满18月龄幼儿身体发育不良率较高,应进一步深入研究影响因素。

关键词：艾滋病病毒预防艾滋病母婴传播抗逆转录病毒药物 18月龄幼儿身体发育

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物种定殖和丧失驱动近70年森林演替进程中的群落结构动态

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Journal of Plant Ecology 2023年第5期16卷 1-12页

作者： shan Rao Xin-Yu Miao Shu-Ya Fan Yu-Hao Zhao Chi Xu Shao-Peng li Zhejiang Tiantong Forest Ecosystem National Observation and Research Station School of Ecological and Environmental SciencesEast China Normal UniversityShanghai 20024lChina School of life Sciences Nanjing UniversityNanjing 210023China Breeding Base for State Key Lab.of Land Degradation and Ecological Restoration in northwestern China Key Lab of Restoration and Reconstruction of Degraded Ecosystems in northwestern China of Ministry of EducationNingxia UniversityYinchuan 750021China

在过去的几十年中,揭示群落谱系和功能性状结构如何随着演替变化引起了广泛关注。但长期动态数据的缺乏限制了我们对于群落格局和构建机制的理解,这一问题在森林群落中尤为突出。本研究基于南京灵谷寺森林1951、1981、2002和2019年的定... 详细信息

在过去的几十年中,揭示群落谱系和功能性状结构如何随着演替变化引起了广泛关注。但长期动态数据的缺乏限制了我们对于群落格局和构建机制的理解,这一问题在森林群落中尤为突出。本研究基于南京灵谷寺森林1951、1981、2002和2019年的定点样带调查数据,分析了这一中国东南部亚热带森林68年的次生演替动态。研究发现,随着演替的深入,群落谱系和性状结构呈现相反的变化趋势。尽管近缘物种间的谱系距离在下降,物种间的平均谱系距离却在增加,群落谱系结构整体上趋于发散。相反,无论用平均还是最近距离作为度量,物种间的性状距离均随着演替逐渐下降,群落功能性状结构趋于聚集。我们进一步拆分了物种定殖和丧失对群落谱系和性状结构动态的相对贡献。结果表明:谱系结构趋于发散主要是由于定殖的物种本身亲缘关系较远,也和群落中原有的物种有着较远的亲缘距离;性状结构趋于聚集主要是因为那些与群落中原有的物种性状相似的物种具有更高的定殖机会但从群落中丧失的概率却更低。这一研究结果表明,拆分物种定殖和丧失过程是解开长期演替进程中群落动态和构建机制的关键。

关键词：群落构建竞争环境过滤森林演替谱系结构功能性状

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Controlled synthesis of one-dimensional Au-Ag porous nanostructures

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Transactions of Nonferrous Metals Society of China 2014年第6期24卷 1807-1812页

作者：杨立山谷小虎湖南师范大学化学与化工学院化学生物学及中药分析教育部重点实验室资源精细化与先进材料湖南省高校重点实验室石化新材料与资源精细利用国家地方联合工程实验室长沙410081 山东大学材料科学与工程学院济南250061

The fabrication of a new type of one-dimensional Au-Ag porous nanotube（NPT） structure was presented based on a facile combination of nanocrystal growth and surface *** nanowires with various diameters were firstly served as the chemical plating templates via a ***,one-dimensional（1D） Au-Ag porous nanostructures with tailored structural features could be prepared by controlling the individual steps involved in this process,such as nanowire growth,surface modification,thermal diffusion,and *** characterizations reveal these Au-Ag porous nanotubes,non-porous nanotubes and porous nanowires possess novel nano-architectures with multimodal open porosity and excellent structural continuity and integrity,which make them particularly desirable as novel 1D nanocarriers for biomedical,drug delivery and sensing applications.

关键词： one-dimension Ag alloy thermal diffusion dealloying porous nanostructure nanotube

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Structural evolution of layered oxide cathodes for spent li-ion batteries:Degradation mechanism and repair strategy

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SusMat 2023年第3期3卷 362-378页

作者： shan Jin Jianquan liang Deying Mu Tianning lin Yuyang Tian Jian Zhang YueWang Meng Chen Qingmo Shi Changsong Dai MIIT Key Laboratory of CriticalMaterials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbinChina State Grid Heilongjiang Electric Power Co. Ltd.Electric Power Research InstituteHarbinChina Dongying Cospower Technology Co. Ltd.DongyingChina

Sustainable development has long been recognized as one of the most critical issues in today’s energy and environment-conscious *** has never been more urgent to recycle and reuse the end-of-life cathode ***,this work systematically investigates the structure-critical degradation mechanism of polycrystalline liNi_(x)Co_(y)Mn_(1−x−y)O_(2)(NCM),combining experimental characterization and DFT *** the key degradation factors,a synergistic repair strategy based on deep mechanochemical activation and heat treatment was successfully proposed to direct regenerate the *** indicate the induction and promotion of synergistic repair technique on the reconstruction of particlemorphology,the recovery of the chemical composition and crystal structure,and the favorable transformation of the impurities phase in the failed *** particular,the synergistic repair process induces a gradient distribution of liF and further enables partial fluorine doping into the NCM surface,forming abundant oxygen vacancies and increasing the content of highly reactive Ni2+.Benefiting from the comprehensive treatment for the multi-scale and multi-form degradation behaviors,the repaired material exhibits a capacity of 176.8 mA h g^(-1)at 0.1 C,which is comparable to the corresponding commercial material(172.8 mA h g^(-1)).The satisfactory capacity of the recovered cathode proves that it is an effective direct renovating strategy.

关键词： cathode material degradation mechanism impurity phase transformation spent lithium-ion batteries synergistic repair strategy

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微电网群频率调整的分层协调控制策略

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电力系统保护与控制 2020年第21期48卷 1-14页

作者：李咸善董鑫程杉陈铁湖北省新能源微电网协同创新中心(三峡大学) 湖北宜昌443002 梯级水电站运行与控制湖北省重点实验室(三峡大学) 湖北宜昌443002

针对分属于不同经营主体的微电网组成的微电网群,各微电网的经营目标、调频资源或调频能力等存在差异。为了使微电网群的频率调整达到调频任务的有序分担、调频费用的有序分摊以及调频经济性的有序达成等要求,分析了孤岛微电网群调频备... 详细信息

针对分属于不同经营主体的微电网组成的微电网群,各微电网的经营目标、调频资源或调频能力等存在差异。为了使微电网群的频率调整达到调频任务的有序分担、调频费用的有序分摊以及调频经济性的有序达成等要求,分析了孤岛微电网群调频备用容量配备应遵循的规则,提出了微电网群频率调整的双层协调控制策略。第一层,各微电网中央控制器MGCC在微电网内部实施基于联络线功率偏差TBC的经济性调频控制,承担微电网自身有功变化所引发的调频任务,恢复系统频率和消除联络线交换功率偏差。当受扰微电网调频能力不足时,向上层微电网群中央控制器MGGCC申请微电网群互济频率调整辅助服务。第二层,MGGCC在微电网群层面实施基于恒频FFC的经济性调频控制,恢复系统频率。该策略可实现分属于不同经营主体的微电网群的频率调整控制的有序性和经济性。在频率分层调整过程中,各微电网承担自身扰动所引发的频率调整所产生的费用,包括自我调整和互济调整费用。算例结果验证了所提控制策略的有效性。该策略思想可为微电网群的设计、组网、运行与控制等工作提供参考借鉴。

关键词：微电网群频率调整微电网控制偏差分层协调控制调频辅助服务

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Feasibility Analysis of Oxygen-Glucose Deprivation-Nutrition Resumption on H9c2 Cells In vitro Models of Myocardial Ischemia-Reperfusion Injury

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Chinese Medical Journal 2018年第19期131卷 2277-2286页

作者： Gui-Zhen Yang Fu-shan Xue Ya-Yang liu Hui-Xian li Qing liu Xu liao Department of Anesthesiology Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100144 China

Background： Oxygen-glucose deprivation-nutrition resumption （OGD-NR） models on H9c2 cells are commonly used in vitro models of simulated myocardial ischemia-reperfusion injury （M1RI）, but no study has assessed whether these methods for establishing in vitro models can effectively imitate the characteristics of MIRI in vivo. This experiment was designed to analyze the feasibility of six OGD-NR models of MIRI. Methods： By searching the PubMed database using the keywords ＂myocardial reperfusion injury H9c2 cells,＂ we obtained six commonly used OGD-NR in vitro models of MIRI performed on H9c2 cells from more than 400 published papers before January 30, 2017. For each model, control （C）, simulated ischemia （SI）, and simulated ischemia-reperfusion （SIR） groups were assigned, and cell morphology, lactate dehydrogenase （LDH） release, adenosine triphosphate （ATP） levels, reactive oxygen species （ROS）, mitochondrial membrane potential （MMP）, and inflammatory cytokines were examined to evaluate the characteristics of cell injury. Subsequently, a coculture system of cardiomyocyte-endothelial-macrophage was constructed. The coeulture system was dealt with SI and SIR treatments to test the effect on cardiomyocytes survival. Results： For models l, 2, 3, 4, 5, and 6, SI treatment caused morphological damage to cells, and subsequent SIR treatment did not cause further morphological damage. In the models 1, 2, 3, 4, 5 and 6, LDH release was significantly higher in the SI groups than that in the C group （P 〈 0.05）, and was significantly lower in the SIR groups than that in the SI groups （P 〈 0.05）, except tbr no significant differences in the LDH release between C, SI and SIR groups in model 6 receiving a 3-h SI treatment. In models 1, 2, 3, 4, 5, and 6, compared with the C group, ATP levels of the S1 groups significantly decreased （P 〈 0.05）, ROS levels increased （P 〈 0.05）, and MMP levels decreased （P 〈 0.05）. Compared with the SI group, ATP level of the SIR groups was significantly

关键词： Feasibility In vitro Models Myocardial Ischemia-Reperfusion Injury

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Bidirectional associations among gallstone disease,non-alcoholic fatty liver disease,kidney stone disease

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World Journal of Gastroenterology 2024年第46期30卷 4914-4928页

作者： Guo-Heng Jiang Sheng li Hong-Yu li lin-Jun Xie Shi-Yi li Zi-Tong Yan Wen-Qian Yu Jing Luo Xuan Bai ling-Xi Kong Yan-Mei Lou Chi Zhang Guang-Can li Xue-Feng shan Min Mao Xin Wang Department of Epidemiology and Biostatistics West China School of Public Health and West China Fourth HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Health Management Beijing Xiaotangshan HospitalBeijing 102211China Department of Prevention Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Pharmacy The People’s Hospital of Kaizhou DistrictChongqing 405400China Department of Pharmacy Bishan Hospital of Chongqing Medical UniversityChongqing 402760China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND A body of evidence has suggested bidirectional relationships among gallstone disease(GSD),non-alcoholic fatty liver disease(NAFLD),and kidney stone disease(KSD).However,the results are inconsistent,and studies on this topic in China are relatively *** goal is to explore the bidirectional associations among these three diseases through a multicenter study,systematic review,and *** To explore the bidirectional associations among these three diseases through a multicenter study,systematic review,and *** results may help to investigate the etiology of these diseases and shed light on the individualized prevention of these three *** Subjects who participated in physical examinations in Beijing,Tianjin,Chongqing in China were *** logistic regression was employed to explore the bidirectional relationships among GSD,KSD,and *** review and meta-analysis were initiated to confirm the epidemiologic evidence from previous observational ***,trial sequential analysis(TSA)was conducted to evaluate whether the evidence was sufficient and *** Significant bidirectional associations were detected among the three diseases,independent of potential confounding *** pooled results of the systematic review and meta-analysis also corroborated the aforementioned *** combined evidence from the multicenter study and meta-analysis was significant[pooled odds ratio(OR)=1.42,95%CI:1.16-1.75,KSD→GSD;pooled OR=1.48,95%CI:1.31-1.67,GSD→KSD;pooled OR=1.31,95%CI:1.17-1.47,GSD→NAFLD;pooled OR=1.37,95%CI:1.26-1.50,NAFLD→GSD;pooled OR=1.28,95%CI:1.08-1.51,NAFLD→KSD;pooled OR=1.21,95%CI:1.16-1.25,KSD→NAFLD].TSA indicated that the evidence was sufficient and *** The present study presents relatively sufficient evidence for the positive bidirectional associations among GSD,KSD,and *** results may provide clues for investigating the etiology of these t

关键词： Gallstones Non-alcoholic fatty liver disease Kidney calculi Cross-sectional study Meta-analysis

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