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Isoflurane preconditioning protects against ischemia-reperfusion injury partly by attenuating cytochrome c release from subsarcolemmal mitochondria in isolated rat hearts

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Acta Pharmacologica Sinica 2005年第7期26卷 813-820页

作者： li-ping QIAN shan-shan ZHU~2 Jun-li CAO Yin-ming ZENG Jiangsu Provincial Key Lab of Anesthesiology,Jiangsu Institute of Anesthesiology,Xuzhou Medical College,Xuzhou 221002,China Jiangsu Provincial Key Lab of Anesthesiology Jiangsu Institute of Anesthesiology Xuzhou Medical College Xuzhou China

Aim:To examine if isoflurane preconditioning can attenuate ischemia/reperfusioninjury by reducing cytochrome c release from inner mitochondrial ***:Isolated hearts of Sprague-Dawley rats were perfused on *** were randomly assigned to a non-treated group(CON group,n=12)or three isoflurane preconditioning groups(0.5% ISC group,1.0% ISC group,and 2.0% ISC group;n=12).In the latter three groups,isoflurane was given atconcentrations of 0.5%,1.0%,and 2.0% for 15 min with 15-rain washout before30-min *** mitochondria of the myocardium were isolatedafter 60-min *** of the each heart was recorded,infarctsize of the hearts and contents of cytosolic cytochrome or mitochondrial cyto-chrome c were measured at the end of *** of isolated mito-chondria in the four groups was evaluated,***:Compared withthe CON group,cytosolic cytochrome c in 0.5% ISC group,1.0% ISC group,and2.0% ISC group were significantly decreased along with a significant increase ofmitochondrial cytochrome *** size of the hearts in the four groups were56%±12%,41%±12%,32%±7% and 33 %±11%,*** values of thethree isoflurane preconditioning groups were significantly lower than that of theCON group(P<0.05).Isoflurane exposure before ischemia can attenuate the changeof morphology of mitochondria after *** effects of 2.0% isofluraneon reducing cytochrome c release were more remarkable than 0.5% and 1.0%concentrations of ***:Myocardioprotective effects ofisofluranc preconditioning were associated with attenuation of cytochrome c lossfrom the inner membrane of subsarcolemmal mitochondria.

关键词： isoflurane reperfusion injury cytochromec mitochondria

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Cluster planting impact on cotton growth, yield and biomass accumulation in an arid region oasis

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Research in Cold and Arid Regions 2018年第3期10卷 271-278页

作者： Ting Ting Xie Pei Xi Su Wen Zhi Zhao li shan shan College of Forestry Gansu Agricultural University linze Inland River Basin Research Station/Key Laboratory of Ecohydrology of Inland River Basin Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences linze Inland River Basin Research Station/Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences

The cluster planting pattern （3 plants per hole） for cotton （Gossypium hirsutum L.） may increase economic yield over those of the traditional planting pattern （1 plant per hole） in arid regions of China. This increase in yield depends on either increased biomass production or greater partitioning to fruit. This study was conducted to determine whether differences in biomass accumulation or partitioning to reproductive growth contributed to higher yield in the cluster planting pattern compared with the traditional one. Growth parameters, biomass accumulation, crop growth rate and partitioning between cluster planting pattern and traditional planting pattern was compared in northwest of China. The biomass production and partitioning in cluster planting plot was higher than in traditional planting one. Biomass accumulation was faster early in the clustered treatment, and it was also higher at harvest time. Total dry matter production per unit area was significantly higher than in the traditional planting. On a per plant basis, dry matter accumulation was faster and total biomass production was significantly higher in the cluster planting pattern. Numbers of sympodia and boll sizes were also larger, indicating that facilitation among plants was promoting crop yield. The increase in yield in the cluster planting treatment occurred through increased partitioning of dry matter to fruits than in the traditional planting pattern, resulting in more bolls and increased lint yield in arid regions.

关键词： cluster planting growth parameter biomass crop growth rate distribution ratio

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Total Fractionation and Analysis of Polysaccharides from Leaves of Panax ginseng C.A. Meyer

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Chemical Research in Chinese Universities 2010年第2期26卷 230-234页

作者： NI Xiu-zhen WANG Bing-qing ZHI Yuan WEI Ning-ning ZHANG Xu li shan-shan TAI Gui-hua ZHOU Yi-fa ZHAO Ji-ming School of life Sciences Northeast Normal University Changchun 130024 P. R. China School of life Sciences Changchun Normal University Changchun 130032 P. R. China

The water-soluble polysaccharides isolated from the leaves of Panax ginseng C. A. Meyer were totally fractionated into one neutral fraction（GLPN-1）, six acidic fractions（GLPN-2, GLPA-1a, GLPA-1b, GLPA-1c, GLPA-2 and GLPA-3） by a combination of ethanol precipitation, ion-exchange and gel permeation chromatography. All the fractions were analyzed by determining monosaccharide composition, molecular weight distribution. The resuits show that GLPN-1 was mainly composed of Gal（38.1%） and Ara（33.6%） and presumed to be an arabinogalactan. GLPA-1a, GLPA-1b and GLPA-2 mainly contained Gal, Ara, Rha and GalA. The amount of Gal and Ara acounted for over 50% of total sugar and the amount of Rha was more than 10%. The molar ratios of Rha/GalA in GLPA-1a, GLPA-1b and GLPA-2 were 1：1, 1：2 and 1：2.7, respectively, indicating that they belong to type-1 rhamnogalacturonan （RG-1）-rich pectin. GLPA-1c was mainly composed of GalA（78%）, belonging to homogalacturonan（HG）-rich pectin. GLPA-3 might be a glycoprotein.

关键词： Ginseng leave Polysaccharide Fractionation RG-I domain

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Can Na+/K+ATPase be a novel target to treat anxiety?A hint from its regulatory effect on neuroinflammation

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中国药理学与毒理学杂志 2021年第9期35卷 664-665页

作者： HUANG Song-qiang ZHU Meng-yuan li shan-shan NIE Xiao-wei BIAN Jin-song Department of Pharmacology School of Medi-cineSouthern University of Science and TechnologyShenzhen 518055China Department of Phar-macology Yong Loo Lin School of MedicineNational University of Singapore117600Singapore Shenzhen Institute of Respiratory Diseases the First Affiliated Hospital(Shenzhen People′s Hospi-tal)Southern University of Science and Technolo-gyShenzhen 518020China

OBJECTIVE Na+/K+-ATPase(NKA)is large membrane protein expressed uni⁃versally which is indispensable for the mainte⁃nance of ionic gradient as well as neuronal excit⁃*** role of NKA in inflammatory regula⁃tion is still *** responses are initiated upon the activation of *** order to investigate the crosslink between NKA and inflammasome,NKAα1 knockout(KO)N2a cells were generated using CRISPR/Cas9 *** AND RESULTS qPCR results showed that NLRP1 and NLRP3 were upregulated in response to NKAα1 loss while both NLRC4 and AIM2 remained ***,consistent with the change in NLRP1 and NLRP3,both the mRNA level of ASC and IL-1βwere significantly increased in NKAα1 KO *** data indicated that NKAα1 interfer⁃ence might influence the level of NLRP1 and NLRP3 inflammasomes in neuronal *** evidence indicating the potential link between NKA and inflammasome pathway were provided using cytokine array assay where all the differen⁃tiated protein detected were closely linked to NLRP1 and *** confirm this effect,we also observed the transcriptional levels of inflam⁃masome proteins in the brain cortex from both NKAα1+/+and NKAα1+/-*** line with the observation gained in NKAα1 KO cells,the mRNA level of NLRP1,NLRP3 and IL-1βwere significantly upregulated in NKAα1+/-mice ***,in the primary cultured astrocytes,treatment with LPS/ATP significantly reduced the mRNA and protein levels of NKAα1 *** data imply that a negative regulation loop between NKAα1 and inflammation may exist in the central nervous *** neuroinflam⁃matory mechanism is currently considered the most potential of interventions to target anxiety,we therefore perform behavioural experiments to investigate the role of NKAα1 in *** restraint stress(CRS)for 10 d significantly reduced the time and frequency of entering the open arm and prolonged the retention time in the closed arm in the elevated p

关键词： Na+/K+ATPase anxiety inflamma⁃some neuroinflammation

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基于小波改进阈值去噪和HHT的滚动轴承故障诊断

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振动与冲击 2013年第14期32卷 204-208,214页

作者：孟宗李姗姗燕山大学河北省测试计量技术及仪器重点实验室秦皇岛066004

利用Hilbert-Huang变换(Hilbert-Huang Transformation,简称HHT)对滚动轴承进行故障诊断时,发现振动信号中包含的噪声对诊断结果影响较大。为克服此不足,提出了一种小波改进阈值法与HHT相结合的信号分析方法。该方法首先应用小波改进阈... 详细信息

利用Hilbert-Huang变换(Hilbert-Huang Transformation,简称HHT)对滚动轴承进行故障诊断时,发现振动信号中包含的噪声对诊断结果影响较大。为克服此不足,提出了一种小波改进阈值法与HHT相结合的信号分析方法。该方法首先应用小波改进阈值方法对滚动轴承故障信号进行预处理,然后对去噪后的信号进行经验模态分解(EmpiricalMode Decomposition,简称EMD),接着选取含有故障信息的本征模函数(Intrinsic Mode Function,简称IMF)分量进行边际谱分析,从而提取出故障特征频率,并判断故障类型。仿真和实验结果验证了该方法的有效性。

关键词：改进阈值去噪 Hilbert-Huang变换滚动轴承故障诊断

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Study on Immunotherapy-related Biomarkers of Small-cell Lung Cancer

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Chinese Journal of Biomedical Engineering(English Edition) 2022年第1期31卷 27-32页

作者： li Yu-yan li shan-shan FAN li ZHANG Bin Jilin Kingmed for Clinical Laboratory Co. Ltd.Changchun Jilin 130000China

The prognosis of small cell lung cancer is *** all patients have a tendency for tumor spreading to the whole body when they are ***,the combination of radiotherapy and chemotherapy is the main treatment,and surgical treatment is only implemented in a small number of limited *** recent years,there has been no obvious breakthrough in the treatment of small cell lung cancer,and the overall poor prognosis has not *** the development of medical technology,immune checkpoint inhibitors are gradually applied to the treatment of small-cell lung cancer,but the overall effect is *** to screen the beneficiary population to further improve the effect of immunotherapy is the key issue in the treatment of small-cell lung cancer.

关键词： immunosuppression biomarkers lung tumor

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碳纳米管预处理及CuO/CNTs燃烧催化剂的制备

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火炸药学报 2022年第5期45卷 735-743页

作者：李珊珊门爽魏莉沈阳理工大学材料科学与工程学院辽宁沈阳110159

采用N-酰化法制备了氯化1-十二烷基-3-甲基咪唑鎓盐([C_(12)C_(1)Im]Cl),与十二烷基硫酸钠(SDS)和混酸(浓硫酸与浓硝酸体积比为3∶1)在碳纳米管(CNTs)预处理和纳米氧化铜(CuO)负载两方面效果进行了对比。采用ATR-FTIR研究了[C_(12)C_(1)... 详细信息

采用N-酰化法制备了氯化1-十二烷基-3-甲基咪唑鎓盐([C_(12)C_(1)Im]Cl),与十二烷基硫酸钠(SDS)和混酸(浓硫酸与浓硝酸体积比为3∶1)在碳纳米管(CNTs)预处理和纳米氧化铜(CuO)负载两方面效果进行了对比。采用ATR-FTIR研究了[C_(12)C_(1)Im]Cl的分子结构;采用SEM研究了不同预处理后的CNTs的微观形貌;采用XPS分析了CNTs负载CuO的反应机理。结果表明,成功合成了[C_(12)C_(1)Im]Cl,其分子中含有一个带正电荷的咪唑鎓亲水基团,SDS含有一个带负电荷的硫酸酯基亲水基团,可分别作为阳离子表面活性剂和阴离子表面活性剂对CNTs进行表面预处理;经[C_(12)C_(1)Im]Cl预处理后的CNTs管状清晰,管壁光滑,无团聚状态,具有优异的分散程度;CuO锚定在CNTs的缺陷位点上使得CuO稳定在CNTs表面。经[C_(12)C_(1)Im]Cl表面预处理后,可获得CuO质量分数为46.40%、分布状态均匀、高结合强度的CuO/CNTs燃烧催化剂。

关键词：固体推进剂 CNTs 碳纳米管负载CuO CuO/CNTs 燃烧催化剂

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基于多核并行计算技术的混合交通微观仿真

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中南大学学报（自然科学版） 2012年第12期43卷 4931-4938页

作者：李珊珊钱大琳北京交通大学交通运输学院北京100044 北京交通大学城市交通复杂系统理论与技术教育部重点实验室北京100044

为提高混合交通微观仿真的运行速度,将多核并行计算技术应用于混合交通微观仿真中。提出混合交通微观仿真的并行化方法,包括基于对串行混合交通微观仿真中各个模块CPU运算时间的百分比分析,确定基于数据并行的任务分解方法,及结合多内核... 详细信息

为提高混合交通微观仿真的运行速度,将多核并行计算技术应用于混合交通微观仿真中。提出混合交通微观仿真的并行化方法,包括基于对串行混合交通微观仿真中各个模块CPU运算时间的百分比分析,确定基于数据并行的任务分解方法,及结合多内核CPU架构特点确定Fork/Join的并行模式。提出基于多核技术的混合交通微观仿真的关键并行算法,包括初始路网分割算法、车辆穿越边界算法及动态负载平衡算法。通过仿真实验验证多核并行计算技术能够提高混合交通微观仿真的运行效率。

关键词：交通运输系统工程多核并行计算混合交通微观仿真

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Quantify work load and muscle functional activation patterns in neck-shoulder muscles of female sewing machine operators using surface electromyogram

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Chinese Medical Journal 2011年第22期124卷 3731-3737页

作者： ZHANG Fei-ruo HE li-hua WU shan-shan li Jing-yun YE Kang-pin WANG Sheng Department of Occupational ＆ Environmental Health School of Public Health Peking University Beijing 100191 China

Background Work-related musculoskeletal disorders （WMSDs） have high prevalence in sewing machine operators employed in the garment industry. Long work duration, sustained low level work and precise hand work are the main risk factors of neck-shoulder disorders for sewing machine operators. Surface electromyogram （sEMG） offers a valuable tool to determine muscle activity （internal exposure） and quantify muscular load （external exposure）. During sustained and/or repetitive muscle contractions, typical changes of muscle fatigue in sEMG, as an increase in amplitude or a decrease as a shift in spectrum towards lower frequencies, can be observed. In this paper, we measured and quantified the muscle load and muscular activity patterns of neck-shoulder muscles in female sewing machine operators during sustained sewing machine operating tasks using sEMG. Methods A total of 18 healthy women sewing machine operators volunteered to participate in this study. Before their daily sewing machine operating task, we measured the maximal voluntary contractions （MVC） and 20%MVC of bilateral cervical erector spinae （CES） and upper trapezius （UT） respectively, then the sEMG signals of bilateral UT and CES were monitored and recorded continuously during 200 minutes of sustained sewing machine operating simultaneously which equals to 20 time windows with 10 minutes as one time window. After 200 minutes＇ work, we retest 20%MVC of four neck-shoulder muscles and recorded the sEMG signals. linear analysis, including amplitude probability distribution frequency （APDF）, amplitude analysis parameters such as roof mean square （RMS） and spectrum analysis parameter as median frequency （MF）, were used to calculate and indicate muscle load and muscular activity of bilateral CES and UT. Results During 200 minutes of sewing machine operating, the median load for the left cervical erector spinae （LCES）, right cervical erector spinae （RCES）, left upper trapezius （LUT） and right upper trapezius （RUT） were

关键词： neck-shoulder pain muscle activity pattern surface electromyogram occupational health

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基于Geoeye-1影像光谱特性的红树林冠层种类识别

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光谱学与光谱分析 2013年第1期33卷 136-141页

作者：李姗姗田庆久南京大学国际地球系统科学研究所江苏南京210093

基于Geoeye-1高空间分辨率影像与冠层实测高光谱数据,以广西北部湾五种红树群落为研究对象,分析影像光谱用于冠层种类识别的能力。首先研究红树林冠层光谱响应特征,再针对影像采用高光谱分析方法提取端元,结合实测训练样本进行不同方法... 详细信息

基于Geoeye-1高空间分辨率影像与冠层实测高光谱数据,以广西北部湾五种红树群落为研究对象,分析影像光谱用于冠层种类识别的能力。首先研究红树林冠层光谱响应特征,再针对影像采用高光谱分析方法提取端元,结合实测训练样本进行不同方法的识别对比。结果表明:350～1 100nm谱段内以435,469,523,677,751和761nm为中心波段的红树群落冠层光谱表现最佳;木榄端元应用识别精度高于实测训练样本应用结果;光谱角制图法能够克服多光谱波段对全色波段分辨率的影响,并有效获取冠层轮廓。利用Geoeye-1影像光谱信息可有效识别三种红树植被,种类最高识别精度达93.03%。研究证实高空间分辨率影像光谱信息的重要性,从机理和应用角度为面向对象红树林种类识别提供了依据和参考。

关键词：光谱 Geoeye-1 红树林种类识别

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