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China Ocean Engineering 2019年第2期33卷 198-206页

作者： li Da-yong li shan-shan ZHANG Yu-kun CHEN Fu-quan College of Civil Engineering Fuzhou University Key Laboratory of Civil Engineering Disaster Prevention and Mitigation Shandong University of Science and Technology

The modified suction caisson(MSC) is a novel type of foundation for ocean engineering, consisting of a short external closed-top cylinder-shaped structure surrounding the upper part of the regular suction caisson(RSC). The MSC can provide larger lateral bearing capacity and limit the deflection compared with the RSC. Therefore, the MSC can be much more appropriate to use as an offshore wind turbine foundation. Model tests on the MSC in saturated sand subjected to monotonic lateral loading were carried out to investigate the effects of external structure sizes on the sand surface deformation and the earth pressure distribution along the embedded depth. Test results show that the deformation range of the sand surface increases with the increasing width and length of the external structure. The magnitude of sand upheaval around the MSC is smaller than that of the RSC and the sand upheaval value around the MSC in the loading direction decreases with the increasing external structure dimensions. The net earth pressure in the loading direction acting on the internal compartment of the MSC is smaller than that of the RSC at the same embedded depth. The maximum net earth pressure acting on the external structure outer wall in the loading direction is larger than that of the internal compartment, indicating that a considerable amount of the lateral load and moment is resisted by the external skirt structure.

关键词： MSC (modified suction caisson) RSC (regular suction caisson) model tests monotonic lateral loading deformation of sand surface earth pressure distribution

Studies on Suction-Assisted Installation Behavior of Suction Caissons in Clay Under Various Undrained Shear Strengths

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China Ocean Engineering 2023年第6期37卷 989-999页

作者： li Da-yong HOU Xin-yu ZHANG Yu-kun MA Shi-li li shan-shan Key Laboratory of Civil Engineering Disaster Prevention and Mitigation Shandong University of Science and TechnologyQingdao 266590China College of Pipeline and Civil Engineering China University of Petroleum(East China)Qingdao 266580China College of Civil Engineering Weifang UniversityWeifang 261061China

Suction caissons are widely used for anchoring floating platform and offshore wind *** of the suction caisson into the desired position under the combination of its self-weight and applied suction resulted from pumping out the encased water is integral to practical *** tests were carried out to investigate the suctionassisted installation of suction caissons in clay under various undrained shear *** was found that there exists a critical penetration depth *** the penetration depth is smaller than the critical value,the soil plug undrained shear strength is higher than intact clay(i.e.,clay prior to installation).However,when the penetration depth is greater than the critical penetration depth,the undrained shear strength of soil plug is lower than intact *** critical value decreases with the increasing consolidation time and undrained shear strength of *** suction-assisted installation,cracks occur around suction *** installation way has little effect on the crack *** influence range(i.e.,the maximum distance between the crack and the suction caisson edge)was found to increase with the increasing friction coefficient of interface between the suction caisson wall and soil and decreases with the increasing soil undrained shear *** addition,the drained condition of the clay during installation is dominated by the caisson aspect ratio,the undrained shear strength and the friction coefficient between the caisson wall and *** to estimate the penetration resistance and the required suction to install the suction caisson are summarized.

关键词： suction caisson suction-assisted installation model tests undrained shear strength of clay soil deformation

Resistance Factor of Caisson-Tip with Internal Fillet for Suction Caissons Penetrating into Clay

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China Ocean Engineering 2023年第3期37卷 525-532页

作者： WU Yu-qi li Da-yong ZHANG Yu-kun ZHANG Yu li shan-shan College of Pipeline and Civil Engineering China University of Petroleum(East China)Qingdao 266580China College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China Weifang Key Laboratory of Coastal and Offshore Engineering Weifang UniversityWeifang 261061China

This paper presents failure mechanisms of the soil at the caisson-tip with fillet during suction-assisted penetration of suction caissons in undrained *** solutions of resistance factor N_c of the caisson-tip are obtained in terms of the caisson-tip geometry ratio of the flat section of the caisson-tip to the caisson wall thickness m/t and adhesion factorsα_i along inside of caisson wall andα_b at the base of the *** is indicated that the factor N_c increases with the increase of m/t,α_i and a_*** resistance factors N_c for the rough base(α_b=1)are larger by 0.57than that for the smooth base(α_b=0).Besides,the factors N_c of caisson-tip with flat base(m=t)are larger by 1.14 than that with full internal fillet(m=0).The required suction to penetrate suction caissons with various fillets is obtained in terms of the force equilibrium in vertical *** finite element limit analysis and centrifuge model test results are used to verify the rationality of the presented failure mechanisms and theoretical predictions.

关键词： suction caissons suction-assisted penetration internal fillet resistance factor undrained clay

Effect of Interaction of Non-residual Fractions on Adsorption of Atrazine onto Surficial Sediments and Natural Surface Coating Samples

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Chemical Research in Chinese Universities 2011年第2期27卷 212-216页

作者： li Yu li shan-shan GAO Qian WANG Ao Sino-Canada Research Academy of Energy and Environmental Studies North China Electric Power University Beijing 102206 P. R. China Jilin Provincial Center for Sanitary Inspection and Test Changchun 130062 P. R. China College of Environment and Resources Jilin University Changchun 130012 P. R. China

To quantify the effect of the interaction of non-residual fractions[Fe oxides（Fe）, Mn oxide（Mn）, organic materials（OMs）] in the surficial sediments and the natural surface coating samples on the adsorption of atrazine（AT）, an AT multiple regression adsorption model（AT-MRAM） was developed. The AT-MRAM improves upon the previous AT additional adsorption model（AT-AAM） with superior goodness-of-fit test（adjusted R2=ca.1.000）, F-test and t-test（P〈0.01）, and reveals the effect of the interaction among the components in the surficial sediments（SSs） and na- tural surface coatings samples（NSCSs） on the adsorption of AT, which was neglected by the AT-AAM. Meanwhile, the AT-MRAM was also verified through adsorption experiments of AT and the relative deviation between predicted maximum adsorption of AT and the experimental one is less than 15%. The resulted information shows that Mn is prone to interact with other non-residual components, the total maximum adsorption of AT is inversly proportional to the level of Mn, and Fe and OMs facilitate the adsorption of AT. The results also indicate that the adsorption of AT is not only dominated by Fe, OMs, Fe/OMs, but also restrained by Fe/Mn, Fe/Mn/OMs, with lesser roles attributed to Mn, and the estimated AT distributions among the components do not agree with that previously predicted by the AT-AAM, especially with the relative contribution of Mn to the adsorption of AT, revealing significant contribution of the interactions among non-residual components in controlling the behavior of AT in aquatic environments.

关键词： Atrazine Interaction adsorption Mn oxide Surficial sediment Multiple linear regression

Artificial Neural Network and Full Factorial Design Assisted AT-MRAM on Fe Oxides, Organic Materials, and Fe/Mn Oxides in Surficial Sediments

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Chemical Research in Chinese Universities 2011年第6期27卷 944-948页

作者： GAO Qian WANG Zhi-zeng WANG Qian li shan-shan li Yu Research Academy of Energy and Environmental Studies North China Electric Power University Beijing 102206 P. R. China

Artificial neural network（ANN） and full factorial design assisted atrazine（AT） multiple regression adsorption model（AT-MRAM） were developed to analyze the adsorption capability of the main components in the surficial sediments（SSs）. Artificial neural network was used to build a model（the determination coefficient square r2 is 0.9977） to describe the process of atrazine adsorption onto SSs, and then to predict responses of the full factorial design. Based on the results of the full factorial design, the interactions of the main components in SSs on AT adsorption were investigated through the analysis of variance（ANOVA）, F-test and t-test. The adsorption capability of the main components in SSs for AT was calculated via a multiple regression adsorption model（MRAM）. The results show that the greatest contribution to the adsorption of AT on a molar basis was attributed to Fe/Mn（–1.993 μmol/mol）. Organic materials（OMs） and Fe oxides in SSs are the important adsorption sites for AT, and the adsorption capabilities are 1.944 and 0.418 μmol/mol, respectively. The interaction among the non-residual components（Fe, Mn oxides and OMs） in SSs interferes in the adsorption of AT that shouldn’t be neglected, revealing the significant contribution of the interaction among non-residual components to controlling the behavior of AT in aquatic environments.

关键词： Back propagation(BP) artificial neural network Full factorial design Fe/Mn oxide Organic material Atrazine Interaction

Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against H2O2-induced myocardial cell injury

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Chinese Journal of Natural Medicines 2017年第2期15卷 115-120页

作者： li shan-shan liU Yan-li XU Qiong-Ming MAO Chen-Mei YANG Shi-lin Children's Hospital of Soochow University Suzhou 215003China College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China

In the present study, three new triterpenoids, 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-α-L-arabinopyranoside(1), 23-hydroxyurs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester(2), and urs-12, 18-dien-28-oic acid 3β-O-β-D-glucuronopyranoside-6-O-methyl ester(3), and a known triterpenoid, 3β-hydroxy-urs-2, 18-dien-28-oic acid(4, randialic acid B), were isolated from the aerial parts of Ilex cornuta. Their structures were identified by the spectroscopic analyses(IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR) and chemical reactions. Compound 4 showed significant cell-protective effects against H_2O_2-induced H9c2 cardiomyocyte injury. Compounds 1-4 did not show any significant DPPH radical scavenging activity.

关键词： Ilex cornuta Aquifoliaceae Triterpenoids Cardiomyocytes Oxidative injury

A microarray analysis of early activated pathways in concanavalin A-induced hepatitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 366-377页

作者： Qing-yi CAO Feng CHEN Jie li shan-shan WU Jing WANG Zhi CHEN State Key Laboratory for Diagnosis and Treatment of Infectious Diseases the First Affiliated Hospital School ofl Medicine Zhejiang University Hangzhou 310003 China

Objective:To explore the mechanisms of fulminant hepatitis(FH) in the early stages,and to determine the critical pathways in its initiation and ***:Twelve BALB/c mice were divided into four groups:one group left as negative control and sacrificed immediately after injection of phosphate-buffered saline(PBS),and another three groups with concanavalin A(Con A) administration sacrificed at 1,3,and 6 h after *** GeneChip Mouse 430 2.0 Array was employed to evaluate the expression profile of each of the 12 *** analysis was done on the microarray data to extract the genes that were differentially *** analysis was carried out to determine relevant pathways within which regulated genes were significantly ***:A total of 393,8354 and 11 344 differentially expressed genes were found,respectively,at three time *** 0-1 h and 1-3 h,most of the pathways enriched with regulated genes were related to immune response and inflammation,among which Toll-like receptor(TLR) signaling and mitogen-activated protein kinase(MAPK) signaling appeared during both phases,while cytokine-cytokine receptor interaction,apoptosis,T cell receptor signaling,and natural killer(NK) cell-mediated cytotoxicity pathways emerged during the second *** found to be significant during 3-6 h were mostly related to metabolic ***:The TLR signaling pathway dominates the early responses of Con A-induced FH in *** stimulates the production of type I cytokines,therefore recruiting and activating T/NK *** T/NK cells exert their cytotoxicity on hepatocytes through inducing death receptorintermediated apoptosis,resulting in liver injury.

关键词： Concanavalin A Fulminant hepatitis Microarray Expression profile Pathway analysis

Overview on current criteria for heavy metals and its hint for the revision of soil environmental quality standards in China

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Journal of Integrative Agriculture 2018年第4期17卷 765-774页

作者： CHEN Shi-bao WANG Meng li shan-shan ZHAO Zhong-qiu E Wen-di Key Laboratory of Plant Nutrition and Fertilizer Ministry of Agriculture/Institute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural Sciences School of Land Science and Technology China University of Geosciences National Agricultural Technology Extension and Service Center Ministry of Agriculture

Following rapid social and economic development over the past several decades, soil pollution by heavy metals(HMs) has been both serious and widespread in China. The Soil Environmental Quality Standards(SEQSs) in China(GB 15618-1995) have been introduced to encourage and enforce sustainable soil HM management. However, in recent years, HM contents in soils have frequently been found to exceed their associated standard values, while the crops growing on them might still meet regulatory standards, and vice versa. There is thus growing awareness that GB 15618-1995 does not effectively regulate current soil HM pollution, as it has encountered bottlenecks, and disappointing outcomes caused by poor execution along with deficiencies and gaps in the policies. However, due to the deficiency of scientific research about relationships between soil HM concentrations and their ecological or human health effects, the development of SEQSs in China is still greatly restricted. This paper discusses international SEQSs of HMs as well their development in China over time, then examines current Chinese SEQSs to demonstrate their potential regulatory deficiencies by referring to international SEQSs. The corresponding legislative policies are described, and scientific information or responses are outlined for maintaining soil environmental quality. China’s experience has shown that policy and science can be linked to work in tandem to better understand and manage soil quality issues.

关键词： soil heavy metals regulatory standards soil science policy

Effect of Quercetin on Atherosclerosis Based on Expressions of ABCA1, LXR-α and PCSK9 in ApoE-/- Mice

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Chinese Journal of Integrative Medicine 2020年第2期26卷 114-121页

作者： li shan-shan CAO Hui SHEN Ding-zhu CHEN Chuan XING San-li DOU Fang-fang JIA Qing-ling shanghai Geriatric Institute of Chinese Medicine Shanghai University of Traditional Chinese Medicine

Objective:To investigate the effect of quercetin on ATP binding cassette transporter A1(ABCA1),liver X receptor(LXR),and proprotein convertase subtilisin/kexin type 9(PCSK9)expressions in apoE-knockout(ApoE-/-)***:The high-fat diet-induced atherosclerosis(AS)in ApoE-/-mice was *** mice were divided into 3 groups using random number table method:model group(n=12),quercetin group(n=12),and atorvastatin group(n=12),with C57BL/6J mice of the same strain and age as the control group(n=12).Quercetin group and atorvastatin group were administrated with quercetin and atorvastatin by oral gavage,with doses of 12.5 and 4 mg/(kg・d),*** in the control and model groups were given an equal volume of distilled water by oral gavage once per day for a total of 12 *** blot and immunohistochemical methods were employed to determine the aortic ABCA1,LXR-a and PCSK9 protein expressi *** zyme linked imm uno sorbent assay method was used to detect the expressi on of serum total cholesterol(TC),triglyceride(TG),high density lipoprotein-cholesterol(HDL-C),low density lipoproteincholesterol(LDL-C),tumor necrosis factor-a(TNF-a),interleukin-6(IL-6),and IL-10,combined with tissue pathological exami ***:ApoE-/-mice fed with a high-fat diet had no table atherosclerosis lesions,with reduced ABCA1,LXR-a and IL-10 levels(all P<0.01),elevated PCSK9,TNF-a and IL-6 expression,and increased TC and LDL-C con tents(all P<0.01).After querceti n in terventi on,the areas of AS plaques and the expressions of PCSK9,TNF-a and IL-6 were significantly reduced(all P<0.01),while the expressions of ABCA1 and LXR-a were increased significantly(all P<0.01).Conclusion:Quercetin effectively interfered with AS development by regulating the expressions of ABCA1,LXR-a and PCSK9 in ApoE,mice.

关键词： quercetin atherosclerosis ATP binding cassette transporter A1 liver X receptor proprotein convertase subtilisin/kexin type 9

Identification of Bovine Casein Phosphorylation Using Titanium Dioxide Enrichment in Combination with Nano Electrospray Ionization Tandem Mass Spectrometry

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Journal of Integrative Agriculture 2012年第3期11卷 439-445页

作者： li shan-shan WANG Jia-qi WEI Hong-yang YANG Yong-xin BU Deng-pan ZHANG Le-ying ZHOU ling-yun State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193P.R.China

Protein phosphorylation is an important post-translational modification that regulates milk protein structure and *** objective of this study was to analyze the presence of phosphorylated *** milk proteins were first separated by SDS polyacrylamide gel *** in gels digestion and extraction,phosphorylated peptides were enriched by titanium dioxide and identified by ultra performance liquid chromatography coupled with nano electrospray ionization tandem mass *** method ensured the identification of 20 phosphorylated peptides,including 7 phosphorylated forms of α_s1-casein,8 α_s2-casein,and 5 β-*** phosphorylated sites derived from 3 α_s1-caseins,3 α_s2-caseins,and 2 β-caseins were also identified,and localized on residues Ser^61,Ser^63 and Ser^130 in α_s1-casein;Thr^145,Ser^146 and Ser^158 in α_s2-casein;and Ser^50 and Thr^56 in β-*** findings provide valuable information for investigating casein phosphorylation of the bovine milk.

关键词： bovine milk casein phosphorylation mass spectrometry titanium dioxide enrichment