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Chinese Chemical Letters 2006年第6期17卷 723-726页

作者： li ping zhang yi qun li mei yun zhou Department of Chemistry Jinan University Guangzhou 510632

Efficient electrophilic substitution reaction of indoles with various aromatic aldehydes were carried out with a catalytic amount of sodium hydrogensulfate monohydrate （NaHSO4·H20） in ionic liquid n-butylpyridinium tetrafluoroborate （[Bpy]BF4） to afford the corresponding bi（indolyl）methanes in excellent yields. The notable advantages of this protocol in terms of low cost of catalyst and ionic liquid, mild conditions, simple operation, short reaction time, high yields and recycling of the ionic liquid.

关键词： Bi(indolyl)methane ionic liquid sodium hydrogen sulfate.

Endoscopic submucosal dissection for foregut neuroendocrine tumors:An initial study

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World Journal of Gastroenterology 2012年第40期18卷 5799-5806页

作者： Quan-lin li yi-qun zhang Wei-Feng Chen mei-Dong Xu yun-Shi Zhong li-li Ma Wen-Zheng Qin Jian-Wei Hu Ming-Yan Cai li-Qing Yao ping-Hong zhou Endoscopy Center and Endoscopy Research Institute Zhongshan HospitalFudan UniversityShanghai 200032China

AIM： To evaluate the feasibility and efficacy of endo- scopic submucosal dissection （ESD） for foregut neuro- endocrine tumors （NETs）. METHODS： From April 2008 to December 2010, pa- tients with confirmed histological diagnosis of foregut NETs were included. None had regional lymph node enlargement or distant metastases to the liver or lung on preoperative computerized tomography scanning or endoscopic ultrasonography （EUS）. ESD was attempted under general anesthesia. After making several mark-ing dots around the lesion, a mixture solution was injected into the submucosa. The mucosa was incised outside the marking dots. Dissection of the submu- cosal layer beneath the tumor was performed under direct vision to achieve complete en bloc resection of the specimen. Tumor features, clinicopathological char- acteristics, complete resection rate, and complications were evaluated. Foregut NETs were graded as G1, G2, or G3 on the basis of proliferative activity by mitotic count or Ki-67 index. All patients underwent regular follow-up to evaluate for any local recurrence or dis- tant metastasis. RESULTS： Those treated by ESD included 24 patients with 29 foregut NETs. The locations of the 29 lesions are as follows： esophagus （n = 1）, cardia （n = 1）, stomach （n = 23）, and duodenal bulb （n = 4）. All le- sions were found incidentally during routine upper gastrointestinal endoscopy for other indications, and none had symptoms of carcinoid syndrome. Preop- erative EUS showed that all tumors were confined to the submucosa. Among the 24 gastric lesions, 16 le- sions in 11 patients were type I gastric NETs arising in chronic atrophic gastritis with hypergastrinemia, while the other 8 solitary lesions were type Ⅲ because of absence of atrophic gastritis in these cases. All of the tumors were removed in an en bloc fashion. The av- erage maximum diameter of the lesions was 9.4 mm （range： 2-30 ram）, and the procedure time was 20.3 rain （range： 10-45 rain）. According to the World Health Orga

关键词： Endoscopic submucosal dissection Neuro-endocrine tumor Foregut

MPFFT：An Auto-Tuning FFT library for OpenCL GPUs

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Journal of Computer Science & Technology 2013年第1期28卷 90-105页

作者： Yan li yun-Quan zhang yi-qun liu Guo-ping Long Hai-Peng Jia Institute of Software Chinese Academy of Sciences Beijing 100190 China Graduate University of Chinese Academy of Sciences Beijing 100049 China School of Information Science and Engineering Ocean University of China Qingdao 266000 China

Fourier methods have revolutionized many fields of science and engineering, such as astronomy, medical imaging, seismology and spectroscopy, and the fast Fourier transform （FFT） is a computationally efficient method of generating a Fourier transform. The emerging class of high performance computing architectures, such as GPU, seeks to achieve much higher performance and efficiency by exposing a hierarchy of distinct memories to software. However, the complexity of GPU programming poses a significant challenge to developers. In this paper, we propose an automatic performance tuning framework for FFT on various OpenCL GPUs, and implement a high performance library named MPFFT based on this framework. For power-of-two length FFTs, our library substantially outperforms the cIAmdFft library on AMD GPUs and achieves comparable performance as the CUFFT library on NVIDIA GPUs. Furthermore, our library also supports non-power-of-two size. For 3D non-power-of-two FFTs, our library delivers 1.5x to 28x faster than FFTYV with 4 threads and 20.01x average speedup over CUFFT 4.0 on Tesla C2050.

关键词： fast Fourier transform GPU OpenCL auto-tuning

Synergistic Effect of Triple Ion Beams on Radiation Damage in CLAM Steel

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Chinese Physics Letters 2014年第4期31卷 93-95页

作者： YUAN Da-Qing ZHENG Yong-Nan ZUO yi FAN ping zhou Dong-mei zhang Qiao-li MA Xiao-Qiang CUI Bao-qun CHEN li-Hua JIANG Wei-Sheng WU yi-Can ttUANG qun-ying PENG Lei CAO Xing-Zhong WANG Bao-yi WEI Long ZHU Sheng-yun China Institute of Atomic Energy Beijing 102413 Institute of Nuclear Energy Safety Technology Chinese Academy of Sciences Hefei 230031 Institute of High Energy Physics Chinese Academy of Sciences Beijing 100039

The synergistic effect of triple ion beams is investigated by simultaneous and scquential irradiations of gold, hydrogen and helium ions on the low activation martensitie steel （CLAM） developed in China. The depth profile measurements of the positron annihilation Doppler broadening S parameter are carried out as a function of slow- positron beam energy to examine the produced radiation damage. The synergistic effect of displacement damage and hydrogen and helium on the formation of radiation damage is clearly observed. In the preset case ,this effect suppresses the radiation damage in the CLAM steel due to the helium and/or hydrogen filling of vacancy clusters.

关键词： Steel Synergistic low

Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity

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Chinese Journal of Natural Medicines 2021年第7期19卷 528-535页

作者： YAN Chen LONG qun zhang yun-Dong BABU Gajendran KRISHNAPRIYA Madhu Varier QIU Jian-Fei SONG Jing-Rui RAO Qing yi ping SUN Mao li Yan-mei Department of Pharmacy An Shun City People’s HospitalAnshun 561000China Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences Guiyang 550014China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Department of Medical Biochemistry Dr.ALM PGIBMSUniversity of MadrasTaramani CampusChennaiIndia

In this study,three new germacranolide sesquiterpenes(1–3),together with six related known analogues(4–9)were isolated from the whole plant of Carpesium *** structures were established by a combination of extensive NMR spectroscopic analysis,HR-ESIMS data,and ECD *** anti-leukemia activities of all compounds towards three cell lines(HEL,KG-1a,and K562)were evaluated in *** 1–3 exhibited moderate cytotoxicity with IC50 values ranging from 1.59 to 5.47μmol·L^(−1).Mechanistic studies indicated that 2 induced apoptosis by decreasing anti-apoptotic protein Bcl-2 and activating the caspase family in K562 *** results suggest that compound 2 is a potential anti-leukemia agent.

关键词： Carpesium cernuum Germacranolides Anti-leukemia K562 MAPK

Long-term outcomes of endoscopic submucosal dissection for high-grade dysplasia and early-stage carcinoma in the colorectum

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Cancer Communications 2018年第1期38卷 42-49页

作者： Tao Chen Wen-Zheng Qin li-Qing Yao yun-Shi Zhong yi-qun zhang Wei-Feng Chen Jian-Wei Hu Marie Ooi ling-li Chen ying-Yong Hou mei-Dong Xu ping-Hong zhou Endoscopy Center Zhongshan Hospital and Endoscopy Research InstituteFudan University180 Fenglin RoadShanghai 200032P.R.China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032P.R.China

Background:Colorectal carcinomas(CRCs)arise from premalignant precursors in an adenoma-carcinoma sequence,in which adenoma with high-grade dysplasia(HGD)and early-stage carcinoma are defined as advanced neoplasia.A limited number of studies have evaluated the long-term outcomes of endoscopic submucosal dissection(ESD)for advanced colorectal *** study aimed to assess the efficacy and safety of ESD for advanced colorectal neoplasia as well as the long-term outcomes,including local recurrence and ***:We analyzed data collected from 610 consecutive patients with 616 advanced colorectal neoplasia lesions treated with ESD between January 2007 and December ***,endoscopic,and histological data were col-lected over a median follow-up period of 58 months to determine tumor stage and type,resection status,complica-tions,tumor recurrence,and distant ***:The overall rates of en bloc resection,histological complete resection,and major complications were 94.3%,89.4%,and 2.3%,*** ESD was an independent factor of piecemeal *** location in the colon was associated with increased risk of ESD-related *** the follow-up period,all patients remained free of ***,local recurrence occurred in 4 patients(0.8%);piecemeal resection was a risk ***:ESD is effective and safe for resection of advanced colorectal neoplasia,with a high en bloc resection rate and favorable long-term *** is indicated for the treatment of HGD and early-stage CRC to obtain cura-tive resection and reduce local recurrence rate.

关键词： Early-stage carcinoma High-grade dysplasia Colorectum Endoscopic submucosal resection

Mapping and Quantitative Trait Loci Analysis of Verticillium Wilt Resistance Genes in Cotton

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Journal of Integrative Plant Biology 2008年第2期50卷 174-182页

作者： Hong-mei Wang Zhong-Xu lin Xian-Long zhang Wei Chen Xiao-ping Guo yi-Chun Nie yun-Hai li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China Key Laboratory of Cotton Genetic Improvement of the Ministry of Agriculture Cotton Research Institute Chinese Academy of Agricultural Sciences Anyang 455112 China

Verticillium wilt is one of the most serious constraints to cotton production in almost all of the cotton-growing countries. In this study, ＂XinLuZaol＂（XLZl）, a susceptible cultivar Gossypium hirsutum L. and ＂Hai7124＂（H7124）, a resistant line G. barbadense, and their F2：3 families were used to map and study the disease index induced by verticillium wilt. A total of 430 SSR loci were mapped into 41 linkage groups; the map spanned 3 745.9 cM and the average distance between adjacent loci was 8.71 cM. Four and five quantitative trait loci （QTLs） were detected based on the disease index investigated on July 22 and August 24 in 2004, respectively. These nine QTLs explained 10.63-28.83% of the phenotypic variance, six of them were located on the D sub-genome. Two QTLs located in the same marker intervals may partly explain the significant correlation of the two traits. QTLs explaining large phenotypic variation were identified in this study, which may be quite useful in cotton anti-disease breeding.

关键词： cotton molecular marker quantitative trait locus Verticillium wilt.

Effects of nerve growth factor on the action potential duration and repolarizing currents in a rabbit model of myocardial infarction

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Journal of Geriatric Cardiology 2013年第1期10卷 39-51页

作者： yun-Feng Lan Jian-Cheng zhang Jin-Lao Gao Xue-ping Wang zhou Fang yi-Cheng Fu mei-Yan Chen Min lin Qiao Xue Yang li Institute of Geriatric Cardiology of Chinese PLA General Hospital 28 Fuxing Road 100853 Beijing China Provincial Clinical Medicine College of Fujian Medical University Fujian 350001 China

Objectives To investigate the effect of nerve growth factor (NGF) on the action potential and potassium currents of non-infarcted myocardium in the myocardial infarcted rabbit *** Rabbitswith occlusion of the left anterior descending coronary arterywere prepared and allowed to recover for eight weeks (healed myocardial infarction, HMI). During ligation surgery of the left coronary artery, a polyethylene tube was placed near the left stellate ganglion in the subcutis of the neck for the purpose of administering NGF 400 U/d for eight weeks (HMI + NGF group). Cardiomyocytes were isolated from regions of the non-infarcted left ventricular wall and the action potentials and ion currents in these cellswere recorded using whole-cell patch clamps. Results Comparedwith HMI and control cardiomyocytes, significant prolongation of APD50 or APD90 (Action potential duration (APD) measured at 50% and 90% of repolarization) in HMI + NGF cardiomyocytes was found. The results showed that the 4-aminopyridine sensitive transient outward potassium current (Ito), the rapidly activated omponent of delayed rectifier potassium current (IKr), the slowly activated component of delayed rectifier potassium current (IKs), and the L-type calcium current (ICaL) were significantly altered in NGF + HMI cardiomyocytes compared with HMI and control cells. Conclusions Our results suggest thatNGF treatment significantly prolongsAPDinHMI cardiomyocytes and that a decrease in outward potassium currents and an increase of inward Ca2+ current are likely the underlying mechanism of action.

关键词： Action potential Cardiomyocytes Myocardial infarction Nervous growth factor

Blocking postsynaptic density-93 binding to C-X3-C motif chemokine ligand 1 promotes microglial phenotypic transformation during acute ischemic stroke

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Neural Regeneration Research 2023年第5期18卷 1033-1039页

作者： Xiao-Wei Cao Hui Yang Xiao-mei liu Shi-ying Lou li-ping Kong liang-qun Rong Jun-Jun Shan yun Xu Qing-Xiu zhang Department of Neurology of Drum Tower Hospital Medical School and the State Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjingJiangsu ProvinceChina Nanjing Drum Tower Clinical College of Xuzhou Medical University NanjingJiangsu ProvinceChina Institute of Brain Sciences Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Province Stroke Center for Diagnosis and Therapy NanjingJiangsu ProvinceChina Nanjing Neurology Clinic Medical Center NanjingJiangsu ProvinceChina Department of Neurology Lianyungang Municipal HospitalAffiliated Hospital of Xuzhou Medical UniversityLianyungangJiangsu ProvinceChina Department of Neurosurgery of Drum Tower Hospital Medical School and the State Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjingJiangsu ProvinceChina Department of Neurosurgery Affiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogen Biology and Immunology and Laboratory of Infection and ImmunityXuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology Second Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina

We previously reported that postsynaptic density-93 mediates neuron-microglia crosstalk by interacting with amino acids 357–395 of C-X3-C motif chemokine ligand 1(CX3 CL1) to induce microglia polarization. More importantly, the peptide Tat-CX3 CL1(comprising amino acids 357–395 of CX3 CL1) disrupts the interaction between postsynaptic density-93 and CX3 CL1, reducing neurological impairment and exerting a protective effect in the context of acute ischemic stroke. However, the mechanism underlying these effects remains unclear. In the current study, we found that the pro-inflammatory M1 phenotype increased and the anti-inflammatory M2 phenotype decreased at different time points. The M1 phenotype increased at 6 hours after stroke and peaked at 24 hours after perfusion, whereas the M2 phenotype decreased at 6 and 24 hours following reperfusion. We found that the peptide Tat-CX3 CL1(357–395 aa) facilitates microglial polarization from M1 to M2 by reducing the production of soluble CX3 CL1. Furthermore, the a disintegrin and metalloprotease domain 17(ADAM17) inhibitor GW280264 x, which inhibits metalloprotease activity and prevents CX3 CL1 from being sheared into its soluble form, facilitated microglial polarization from M1 to M2 by inhibiting soluble CX3 CL1 formation. Additionally, Tat-CX3 CL1(357–395 aa) attenuated long-term cognitive deficits and improved white matter integrity as determined by the Morris water maze test at 31–34 days following surgery and immunofluorescence staining at 35 days after stroke, respectively. In conclusion, Tat-CX3 CL1(357–395 aa) facilitates functional recovery after ischemic stroke by promoting microglial polarization from M1 to M2. Therefore, the Tat-CX3 CL1(357–395 aa) is a potential therapeutic agent for ischemic stroke.

关键词： a disintegrin and metalloprotease domain 17 cerebral ischemia/reperfusion C-X3-C motif chemokine ligand 1 GW280264x microglia neuroinflammation postsynaptic density-93 Tat-CX3CL1(357–395aa)

Establishment of HIV-1 model cell line GHOST（3） with stable DRiP78 and NHERF1 knockdown

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Zoological Research 2015年第3期36卷 161-166页

作者： lin zhang Xu-He HUANG ping-ping zhou Guo-Long YU Jin YAN Bing QIN Xin-Ge YAN li-mei DIAO Peng liN yi-qun KUANG Center for Translational Medicine Huaihe Clinical Institute Henan University Keifeng 475000 China Guangdong Institute of Public Health and Institute of AIDS Control and Prevention Guangdong Center for Disease Control andPrevention Guangzhou 510433 China

Chemokine receptors CXCR4 and CCR5 are indispensable co-receptors for HIV-1 entry into host cells. In our previous study, we identified that dopamine receptor-interacting protein 78（DRi P78） and Na＋-H＋ exchanger regulatory factor 1（NHERF1） are the CXCR4 and CCR5 homo- or hetero-dimerinteracting proteins. DRi P78 and NHERF1 are able to influence the co-receptor internalization and intracellular trafficking. Over-expression of NHERF1 affects the ligands or HIV-1 gp120-induced CCR5 internalization and HIV-1 production. It is reasonable to speculate that DRi P78 and NHERF1, as well as the signaling pathways involved in viral replication, would probably affect HIV-1 replication through regulating the co-receptors. In this present study, we designed two short hairpin RNAs（sh RNAs） targeting the DRi P78 and NHERF1, respectively, and constructed the p Lenti6/BLOCK-i T-DEST lentiviral plasmids expressing DRi P78 or NHERF1 sh RNA. The packaged lentiviruses were used to transduce the widely-applied HIV-1 model cell line GHOST（3）. Then, cells with stable knockdown were established through selecting transduced cells with Blasticidin. This study, for the first time, reported the establishment of the GHOST（3） with DRi P78 and NHERF1 knockdown, which is the first stable cell line with HIV-1 co-receptor-interacting molecular defects.

关键词： HIV-1 DRi P78 NHERF1 sh RNA GHOST(3) cells