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Mo_(3)(C_(6)X_(6))_(2)(X=NH,S,O)monolayers:two-dimensional conductive metal-organic frameworks as effective electrocatalysts for the nitrogen reduction reaction

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Journal of Energy Chemistry 2021年第10期30卷 71-76,I0003页

作者： Juan Zhang Xinyue Zhu Weixiang Geng Tianchun li manman li Chubo Fang Xiaocao Shan Yafei li Yu Jing Jiangsu Co-Innovation Centre of Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037JiangsuChina Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023JiangsuChina

As a constituent element of amino acids,nitrogen plays an important role in nourishing plants,animals and other forms of *** the atmosphere is rich in nitrogen gas(N_(2)),the highly inert N≡N bond makes it difficult for most organisms to directly utilize N_(2).The supply of nitrogen in the biological chain mainly depends on the slow conversion of N_(2) to ammonia(NH3)by biological nitrogen fixation[1].

关键词： Nitrogen reduction reaction Electrocatalysis Two-dimensional metal–organic frameworks First principles calculations

Multi-omics analysis reveals the pivotal role of phytohormone homeostasis in regulating maize grain water content

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The Crop Journal 2024年第4期12卷 1081-1092页

作者： Yuanliang liu manman li Jianju liu Suining Deng Yan Zhang Yuanfeng Xia Baoshen liu Mingliang Xu State Key Laboratory of Plant Environmental Resilience/College of Agronomy and Biotechnology/National Maize Improvement Center/Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China College of Agronomy/State Key Laboratory of Crop Biology Shandong Agricultural UniversityTai’an 271018ShandongChina Institute of Agricultural Biotechnology Jilin Academy of Agricultural SciencesGongzhuling 136100JilinChina Maize Research Institute Jilin Academy of Agricultural SciencesGongzhuling 136100JilinChina

Grain water content(GWC)is a key determinant for mechanical harvesting of maize(Zea mays).In our previous research,we identified a quantitative trait locus,qGWC1,associated with GWC in ***,we examined near-isogenic lines(NILs)NILL and NILH that differed at the qGWC1 *** GWC in NILL was primarily attributed to reduced grain water weight(GWW)and smaller fresh grain size,rather than the accumulation of dry *** difference in GWC between the NILs became more pronounced approximately 35 d after pollination(DAP),arising from a faster dehydration rate in *** an integrated analysis of the transcriptome,proteome,and metabolome,coupled with an examination of hormones and their derivatives,we detected a marked decrease in JA,along with an increase in cytokinin,storage forms of IAA(IAA-Glu,IAA-ASP),and IAA precursor IPA in immature NILL *** kernel development,genes associated with sucrose synthases,starch biosynthesis,and zein production in NILL,exhibited an initial up-regulation followed by a gradual down-regulation,compared to those in *** discovery highlights the crucial role of phytohormone homeostasis and genes related to kernel development in balancing GWC and dry matter accumulation in maize kernels.

关键词： Grain water content Maize kernel Phytohormone homeostasis

Mechanisms of traditional Chinese medicines in the treatment of allergic rhinitis using a network biology approach

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Journal of Traditional Chinese Medical Sciences 2021年第1期8卷 82-89页

作者： li Du Xiaotong Ye manman li Huihui Wang Baixia Zhang Rao Zheng Yun Wang Information Engineering Research Center for Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 102488China

Objective:To systematically explore the effect and mechanism of traditional Chinese herbs in the treatment of allergic ***:Magnolia flower,xanthium fruit,astragalus root,paniculate cynanchum,scutellaria root,cicada molting,stephania root,small centipeda herb,and licorice root as traditional Chinese herbs are widely used to treat allergic *** multiple database integration and entity grammar systems,a molecular interaction network of traditional Chinese herbs for treating allergic rhinitis was *** approaches were adopted to integrate relevant data and biological information by multiple *** interaction network of Chinese herbs for treating allergic rhinitis was constructed based on entity grammar systems *** network was then used for elucidating the antiallergic rhinitis mechanism of the Chinese herbs on the molecular *** subnetworks were also extracted to explicitly display the pathway and targets where effective components acted ***:Traditional Chinese herbs could influence various pathological aspects in allergic rhinitis including the production of pro-inflammatory substances,such as histamine and cytokine interleukin-4(IL-4),interleukin-13(IL-13),lowering immunoglobulin E(IgE)level or blocking antigen binding,altering the biological processes of IgE,modulating the balance of T helper(Th)or other cells by cell proliferation and differentiation,mediating cellecell signaling and second-messenger-mediated signaling,stabilizing the cell membrane,and affecting regulation of cellular defense ***:The research theoretically confirms the mechanism of anti-allergic rhinitis by traditional Chinese herbs,provides important fundamental research information for treatment of allergic rhinitis,and may serve as a reference for new drug development and effective ingredients of compatibility.

关键词： Traditional Chinese medicine Allergic rhinitis Entity grammar systems Mechanisms

Tea Polyphenols Reducing lipopolysaccharide-induced Inflammatory Responses in RAW264.7 Macrophages via NF-κB Pathway

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Chemical Research in Chinese Universities 2019年第6期35卷 1105-1110页

作者： SU Siyi li Xiaoyu GUO Xu ZHOU Ruiming li manman MING Pengfei HUANG Yingying Sajid Ur RAHMAN DING Hongyan FENG Shibin li Jinchun WANG Xichun li Yu WU linjie College of Animal Science and Techmology Anhui Agricultural UniversityHefei 230036P.R.China

The anti-inflammatory activity of tea polyphenols(TPs)in RAW264.7 macrophages stimulated by lipopolysaccharide(LPS)was investigated in this ***264.7 macrophages were treated with different concentrations of TP(0,12.5,25,50,100,and 200μg/mL)and then stimulated by *** blank control group was set *** expression of pro-inflammatory cytokines associated with the nuclear factor-kappa B(NF-κB)signaling pathway was investigated before and after TP *** of RAW264.7 cells with TP decreased the expression of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin 1 beta(IL-1β)pro-inflammatory *** addition,TP inhibited the phosphorylation of p65 and IκB by blocking the phosphorylation and the degradation of NF-κB inhibitor *** conclusion,TP exerts anti-inflammatory effects by regulating the release of inflammatory mediators via the NF-κB signaling pathway.

关键词： Tea polyphenol Inflammatory response,RAW264.7 Nuclear factor-kappa B pathway

Research on Establish an Efficient Log Analysis System with Kafka and Elastic Search

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Journal of Software Engineering and Applications 2017年第11期10卷 843-853页

作者： Yuanzhou Wei manman li Binsen Xu Beihang University Beijing China Henan University of Economics and Law Zhengzhou China

Search logs in a timely and efficient manner are an important part of SRE (Site Reliability Engineer). Logs help us solve the problems during our development work. In this paper, we will introduce you a way how to build an efficient logs analysis system based on kafka and Elastic Search. We hope you can learn something through the iteration of the Version and get some inspiration with your own log analysis system.

关键词： Log Analysis System Kafka Elastic Search Software Applications Site Reliability Engineer

改进的减轮Kiasu-BC算法的中间相遇攻击

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通信学报 2022年第7期43卷 41-48页

作者：李曼曼陈少真信息工程大学网络空间安全学院河南郑州450001 密码科学技术国家重点实验室北京100878 河南省网络密码技术重点实验室河南郑州450001

Kiasu-BC算法是加密认证竞赛CAESAR第一轮入选方案Kiasu的内置可调分组密码。Kiasu-BC算法是基于AES-128轮函数构造的可调分组密码算法,通过对Kiasu-BC算法的结构特征进行研究,利用调柄自由度以及内部密钥间的制约关系,降低预计算的复... 详细信息

Kiasu-BC算法是加密认证竞赛CAESAR第一轮入选方案Kiasu的内置可调分组密码。Kiasu-BC算法是基于AES-128轮函数构造的可调分组密码算法,通过对Kiasu-BC算法的结构特征进行研究,利用调柄自由度以及内部密钥间的制约关系,降低预计算的复杂度。结合差分枚举技术,构造新的5轮中间相遇区分器,改进Kiasu-BC算法的8轮中间相遇攻击。改进后攻击的时间复杂度为2^(114),存储复杂度为2^(63),数据复杂度为2^(108)。

关键词：可调分组密码 Kiasu-BC算法中间相遇攻击差分枚举

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Network traffic flow evolution with battery electric vehicles and conventional gasoline vehicles

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Journal of Southeast University(English Edition) 2019年第2期35卷 213-219页

作者： li manman Lu Jian Sun Jiahui Tu Qiang Jiangsu Key Laboratory of Urban ITS Southeast UniversityNanjing 210096China Collaborative Innovation Center of Modern Urban Traffic Technologies Southeast UniversityNanjing 210096China School of Transportation Southeast UniversityNanjing 210096China Xi'an Aerospace Power Test Technology Institute Xi'an 710100China

In order to investigate the effect of the use of battery electric vehicles on traffic dynamics,the valid paths of electric battery vehicles are defined and a check-based method is proposed to obtain ***,assuming that travelers only focus on their past travel experience,a day-to-day traffic assignment model is established based on reinforcement learning and bounded *** the proposed model,the Bush-Mosteller model,a reinforcement learning model,is modified to calculate path choice probability according to bounded *** modified model updates the path choice probability only if the gap between expected travel time and perceived travel time is beyond the cognitive *** experiments validate the effectiveness of the model and show that traffic flows can converge to the equilibrium in any case of cognitive thresholds and penetration rates of battery electric *** cognitive threshold has a positive influence on the variation of traffic flows while it has a negative influence on the differences between traffic *** adaptation of battery electric vehicles leads to the poor performance of the traffic system.

关键词： battery electric vehicles constrained path reinforcement learning bounded rationality traffic dynamics

A highly sensitive and selective fluorescence probe for singlet oxygen based on paeoniflorin

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A highly sensitive and selective fluorescence probe for sing...

An HIV protein suppresses immunity by targeting STING

第十届全国化学生物学学术会议

作者： manman li Chengcheng Song Jintao Zhang Huaixia Yang Yanju liu Pharmacy College Henan University of Chinese Medicine

Creatures produce a lot of reactive oxygen species(ROS) in the metabolic process, and many diseases, deterioration, organism aging and many normal physiological processes are closely related to these free radicals, Singlet oxygen(O) is one of the most important[1]. Singlet oxygen in the body involved in a variety of physiological activities, and in the signal transduction, nerve transmission, muscle tension regulation, peristalsis and platelet healing and so have a very important role. But because O is a strong electrophilic reagent and it can react with some biological molecules such as amino acids, proteins, enzymes and nucleic acids leading to the body’s injury that lead to cell necrosis and cause serious chronic diseases[2]. Detecting singlet oxygen usually use these methods: spectrophotometry, HPLC, fluorescence spectrophotometry,chemiluminescence and electron spin resonance(ESR). The principle of spectrophotometry and fluorescence spectroscopy are to detect the absorbance or fluorescence intensity of the probe changing with the singlet oxygen[3]. Paeoniflorin is an active ingredient of white peony root and belongs to monoterpenoidglucoside compound. It was found that paeoniflorin has the effect of anti-free radical damage and *** has been studied as singlet oxygen probe by fluorescence spectroscopy, the results indicated that paeoniflorin acted as a highly sensitive and selective fluorescent probe for singlet oxygen in aqueous, resulting in 6.25-fold enhancement in neutral medium, and 9.95-fold decrease in alkaline medium, the detection limit is 2.6 and 38.7μM respectively, and the rate constant of the neutral condition was 1.3×10 mol·L·s, Results indicate that paeoniflorin holding great potential to be used as a probe for singlet oxygen in cells with high sensitivity and selectivity.

关键词： singlet oxygen fluorescentprobe paeoniflorin

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An HIV protein suppresses immunity by targeting STING