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Genes & Diseases 2018年第4期5卷 349-357页

作者： Yalan yang Zhaohui zhong Yubin Ding Wanfeng Zhang yang ma li Zhou School of Public Health and management Chongqing Medical UniversityChongqing400016China Research Center for Medicine and Social development Chongqing400016China Innovation Center for Social Risk Governance in Health Chongqing400016China department of Bioinformatics Chongqing Medical UniversityChongqing400016China

In order to explore the molecular mechanisms behind the pathogenesis of acute liver failure(ALF)associated with hepatitis B virus(HBV)infection,the present study aimed to identify potential key genes and pathways involved using samples from patients with HBV-associated *** GSE38941 array dataset was downloaded from the Gene Expression Omnibus database,and differentially expressed genes(deGs)between 10 liver samples from 10 healthy donors and 17 liver specimens from 4 patients with HBV-associated ALF were analyzed using the linear Models for Microarray Data *** Ontology and KEGG pathway enrichment analyses of the deGs were performed,followed by functional annotation of the genes and construction of a proteineprotein interaction(PPI)*** modules were subsequently identified and *** total,3142 deGs were identified,of which 1755 were upregulated and 1387 were *** extracellular exosome,immune response,and inflammatory response pathways may potentially be used as biomarkers of ALF *** total,17 genes(including CCR5,CXCR4,ALB,C3,VGEFA,and IGF1)were identified as hub genes in the PPI network and may therefore be potential marker genes for HBV-associated ALF.

关键词： Differentially expressed genes Function enrichment analysis HBV-associated ALF Module analysis Proteineprotein interaction network

A Network Pharmacology Study to Uncover the Multiple Molecular Mechanism of the Chinese Patent Medicine Toujiequwen Granules in the Treatment of Corona Virus Disease 2019(COVID-19)

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Current Medical Science 2021年第2期41卷 297-305页

作者： Bao-yu yang Hao-zhen WANG Zhen zhong ma chen LU yang li Zi-yin LU Xiu-li LU Bing GAO department of Biochemistry and Molecular Biology Life Science SchoolLiaoning UniversityShenyang 110036China department of Cell biology and Genetics Shenyang Medical CollegeShenyang 110034China

Since the outbreak of the novel corona virus disease 2019(COVID-19)at the end of 2019,specific antiviral drugs have been lacking.A Chinese patent medicine Toujiequwen granules has been promoted in the treatment of *** present study was designed to reveal the molecular mechanism of Toujiequwen granules against COVID-19.A network pharmacological method was applied to screen the main active ingredients of Toujiequwen *** analysis of 149 active ingredients and 330 drug targets showed the most active ingredient interacting with many drug targets is *** targets most ffected by the active ingredients were PTGS2,PTGS1,and *** target disease enrichment analysis showed drug targets were significantly enriched in cardiovascular diseases and digestive tract ***"active ingredient-target-disease"network showed that 57 active ingredients from Toujiequwen granules interacted with 15 key targets of *** were 53 ingredients that could act on DPP4,suggesting that DPP4 may become a potential new key target for the treatment of *** analysis results showed that key targets were mainly enriched in the cellular response to lipopolysaccharide,cytokine activity and other *** analysis showed they were mainly concentrated in viral protein interaction with cytokine and cytokine receptors and endocrine resistance *** evidence suggests that Toujiequwen granules might play an effective role by improving the symptoms of underlying diseases in patients with COVID-19 and multi-target interventions against mutiple signaling pathways related to the pathogenesis of COVID-19.

关键词： Toujiequwen granules COVID-19 network pharmacology target molecular mechanism

DuaI-Functionalized Hollow Polymer Particle as a pH-Responsive Adsorbent for Selective Removal of Basic Dye

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Chinese Journal of Chemistry 2017年第5期35卷 596-604页

作者： Dong chen yang liu Yan Qin li Wang Yuhong ma Wantai yang State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China Key Laboratory of Carbon Fiber and Functional Polymers Ministry of Education Beijing University of Chemical Technology Beijing 190029 China

In the present work,novel dual-functionalized hollow polymer particles （DF-HPP） with high density of carboxylate and amino dual functional groups have been specially designed and fabricated to serve as high-performance adsorbent for selective removal of basic dye （methylene blue,b-MB,as a model dye）.Due to both the high surface area and the extremely high density of carboxylate and amino groups,the DF-HPPs exhibited excellent adsorption property for methylene blue （b-MB）,including high adsorption capacity,fast adsorption/desorption rates,unique pH-sensitivity and easy *** equilibrium adsorption data of b-MB on the DF-HPPs were evaluated using Freundlich and Langmuir isotherm models,and the equilibrium isotherm was better fit with Langmuir model with a maximum adsorption capacity of 538.8 mg/g at pH *** interestingly,the DF-HPPs showed a significant pH-dependent equilibrium adsorption capacity,which decreased dramatically from 516.1 mg/g to 24 mg/g as the solution pH decreased from 12 to *** dye-adsorbed DF-HPPs can be facilely and rapidly regenerated under mild condition （under weak acidic solution,pH 3,in 30 min） to recover both b-MB and the DF-HPPs,and the regenerated DF-HPPs can be reused for dye removal with high efficiency,indicating the exceptional recyclability of the DF-HPPs.

关键词： dual-functional hollow polymer particles adsorbent adsorption basic dye

Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： Jiandong Pang Wentao Jiang Xue-Wen Zhang Hao-Long Zhou Yuxiu Sun Wei Gong Bin Wang Fuyin ma linwei He Long chen Qiang chen He-Qi Zheng Yuanjing Cui Wen-Jie Shi Chao Zhang Mei Wang Yue-Biao Zhang Jie-Peng Zhang Chongli zhong Yong Cui Shuao Wang Jian-Rong li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

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Effect of magnesium on microstructure and properties of 440C stainless bearing steel melted under pressurized conditions

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Journal of Iron and Steel Research International 2023年第4期30卷 808-824页

作者： yang li Chang-yong chen Qi Wang Hao yang Shuai ma Meng Sun Zhou-hua Jiang School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

The effects of magnesium(Mg)on the microstructure and properties of 440C stainless bearing steel melted under pressurized conditions were *** Mg improved the cleanliness of molten steel,modified the inclusions in steel,enhanced the distribution of carbides,and improved the mechanical properties and corrosion resistance of experimental *** detail,the contents of TO,S,and N in steel decreased from 0.0013 to 0.0003 wt.%,from 0.0032 to 0.0018 wt.%and from 0.0088 to 0.0049 wt.%,*** addition,the transformation order of oxide inclusions in steel is Al_(2)O_(3)→MgO∙Al_(2)O_(3)→MgO,where the content of Mg in steel sharply increased from 0.00 to 29×10^(-4),81×10^(-4),and 160×10^(-4)wt.%,and the transformation order of S-containing inclusions in steel is MnS→Mg–S–Mn(–MgO)→Mg–O–***,the number and size of inclusions and the proportion of large-size inclusions in steel decreased ***,the network structure of carbides in steel collapsed,the size of carbides was reduced,and the distribution was more ***,the tensile strength,impact toughness,and pitting corrosion resistance of the experimental steel were significantly improved.

关键词： magnesium Bearing steel Inclusion Carbide Corrosion resistance

Microwave-hydrothermal preparation of a graphene/hierarchy structure MnO_2 composite for a supercapacitor

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Particuology 2014年第4期12卷 27-33页

作者： zhong chen Jianling li Yu chen Yakun Zhang Guofeng Xu Jun yang Ye Feng State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing30 College Road State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of Sciences

Graphene/hierarchy structure manganese dioxide （GN/MnO2） composites were synthesized using a simple microwave-hydrothermal method. The properties of the prepared composites were analyzed using field emission scanning electron microscopy （FE-SEM）, X-ray diffraction （XRD）, transmission electron microscopy （TEM）, and X-ray photoelectron spectroscopy （XPS） measurements. The electrochemical performances of the composites were analyzed using cyclic voltammetry, electrochemical impedance spectrometry （EIS）, and chronopotentiometry. The results showed that GN/MnO2 （10 wt% graphene） displayed a specific capacitance of 244 F/g at a current density of 100 ma/g. An excellent cyclic stability was obtained with a capacity retention of approximately 94.3% after 500 cycles in a 1 mol/L li2SO4 solution. The improved electrochemical performance is attributed to the hierarchy structure of the manganese dioxide, which can enlarge the interface between the active materials and the electrolyte. The prepa- ration route provides a new approach for hierarchy structure graphene composites; this work could be readily extended to the preparation of other graphene-based composites with different structures for use in energy storage devices.

关键词： Graphene MnO2 Hierarchy structure Supercapacitor

Numerical simulation and experimental study of gas cyclone–liquid jet separator for fine particle separation

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Chinese Journal of Chemical Engineering 2022年第11期51卷 43-52页

作者： liwang Wang Erwen chen liang ma Zhanghuang yang Zongzhe li Weihui yang Hualin Wang Yulong Chang School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China College of Architecture and Environment Sichuan UniversityChengdu 610065China

To address the shortcomings of existing particulate matter trapping technology,especially the low separation efficiency of fine particles,herein,a novel gas cyclone-liquid jet separator was developed to research fine particle ***,numerical simulation methods were used to investigate the flow field characteristics and dust removal efficiency of the separator under different working conditions,and to determined suitable experimental conditions for subsequent dust removal ***,the separation efficiency of the separator against five kinds of common particles,including g-C_(3)N_(4),TiO_(2),SiC,talc,and SiO_(2),was experimentally studied.A maximum separation efficiency of 99.48%was achieved for particles larger than 13.1μm,and 96.55%efficiency was achieved for particles larger than 2μ*** best crushing atomization effect was achieved for the separator when uGwas 10 m·s^(-1)and uLwas 3 m·s^(-1),while the best separation effect was achieved when uGwas 10 m·s^(-1)and uLwas 3.75 m·s^(-1).Studies have shown that the gas cyclone-liquid jet separator has excellent applicability in the separation of fine particles.

关键词： Gas cyclone-liquid jet Dust removal Fine particles Numerical simulation

Vote-Based Feature Selection Method for Stratigraphic Recognition in Tunnelling Process of Shield machine

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Chinese Journal of Mechanical Engineering 2023年第5期36卷 141-155页

作者： liman yang Xuze Guo Jianfu chen Yixuan Wang Huaixiang ma Yunhua li Zhiguo yang Yan Shi School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China China Railway 14th Bureau Group Mega Shield Construction Engineering Co. Ltd.Nanjing 211800China School of Mechanical Engineering Shijiazhuang Tiedao UniversityShijiazhuang 050043China

Shield machines are currently the main tool for underground tunnel construction. Due to the complexity and variability of the underground construction environment, it is necessary to accurately identify the ground in real-time during the tunnel construction process to match and adjust the tunnel parameters according to the geological conditions to ensure construction safety. Compared with the traditional method of stratum identifcation based on staged drilling sampling, the real-time stratum identifcation method based on construction data has the advantages of low cost and high precision. Due to the huge amount of sensor data of the ultra-large diameter mud-water balance shield machine, in order to balance the identifcation time and recognition accuracy of the formation, it is necessary to screen the multivariate data features collected by hundreds of sensors. In response to this problem, this paper proposes a voting-based feature extraction method (VFS), which integrates multiple feature extraction algorithms FSM, and the frequency of each feature in all feature extraction algorithms is the basis for voting. At the same time, in order to verify the wide applicability of the method, several commonly used classifcation models are used to train and test the obtained efective feature data, and the model accuracy and recognition time are used as evaluation indicators, and the classifcation with the best combination with VFS is obtained. The experimental results of shield machine data of 6 diferent geological structures show that the average accuracy of 13 features obtained by VFS combined with diferent classifcation algorithms is 91%;among them, the random forest model takes less time and has the highest recognition accuracy, reaching 93%, showing best compatibility with VFS. Therefore, the VFS algorithm proposed in this paper has high reliability and wide applicability for stratum identifcation in the process of tunnel construction, and can be matched with a variety of

关键词： Shield machine Tunneling parameters Feature selection Stratigraphic recognition

Mechanical response and microscopic damage mechanism of pre-flawed sandstone subjected to monotonic and multilevel cyclic loading:A laboratory-scale investigation

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International Journal of Mining Science and Technology 2023年第12期33卷 1487-1510页

作者： Kesheng li Shengqi yang Chuanxiao liu Yun chen Guanglei Zhang Qing ma State Key Laboratory of Intelligent Construction and Healthy Operation and maintenance of deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China College of Water Conservancy and Civil Engineering Shandong Agricultural UniversityTai’an 271018China School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing 100084China

This study aims to investigate the mechanical response and acoustic emission(AE)characteristic of pre-flawed sandstone under both monotonic and multilevel constant-amplitude cyclic ***,we explored how coplanar flaw angle and load type impact the strength and deformation behavior and microscopic damage *** indicated that being fluctuated before rising with increasing fissure angle under monotonic loading,the peak strength of the specimen first increased slowly and then steeply under cyclic *** effect of multilevel cyclic loading on the mechanical parameters was more *** a single fatigue stage,the specimen underwent greater deformation in early cycles,which subsequently *** variation pattern was also reflected by AE count/energy/*** behaviors were dominated by the fissure angle and load type and medium-scale crack accounted for 74.83%–86.44%of total *** with monotonic loading,crack distribution of specimen under cyclic loading was more ***,a simple model was proposed to describe the damage evolution of sandstone under cyclic ***,SEM images revealed that the microstructures at the fracture were mainly composed of intergranular fracture,and percentage of transgranular fracture jumped under cyclic loading due to the rapid release of elastic energy caused by high loading rate.

关键词： Sandstone Pre-existing coplanar flaws Multilevel constant-amplitude cyclic loading Mechanical behavior Microscopic damage mechanism

Garcinia xanthochymus extract protects PC12 cells from H2O2-induced apoptosis through modulation of PI3K/AKT and NRF2/HO-1 pathways

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Chinese Journal of Natural Medicines 2017年第11期15卷 825-833页

作者： XU Jing GAN Sheng li Jun WAND de-Bing chen Yu HU Xin yang Guang-zhong Laboratory for Natural Products Chemistry School of Pharmaceutical Sciences South-Central University for NationalitiesWuhan 430074 China College of Chemistry and material Sciences South Central University for Nationalities Wuhan 430074 China

The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2 O2-induced oxidative damage in rat pheochromacytoma PC12 cells. Preincubation of PC12 cells with fruit Et OAc fraction(fruit-EFr., 12.5–50 μmol·L^(-1)) of G. xanthochymus for 24 h prior to H_2O_2 exposure markedly improved cell viability and increased the activities of antioxidant enzymes(superoxide dismutase, catalase, and heme oxygenase-1 [HO-1]), prevented lactate dehydrogenase release and lipid peroxidation malondialdehyde production, attenuated the decrease of matrix metalloproteinases(MMP), and scavenged reactive oxygen species(ROS). Fruit-EFr. also reduced BAX and cytochrome C expression and improved BCL-2 expression, thereby decreasing the ratio of BAX to BCL-2. Fruit-EFr. activated the nuclear translocation of NRF2 to increase HO-1 and induced the phosphorylation of AKT. Its cytoprotective effect was abolished by LY294002, a specific inhibitor of PI3 K. Taken together, the above findings suggested that *** G. xanthochymus could enhance cellular antioxidant defense capacity, at least in part, through upregulating HO-1 expression and activating the PI3 K/AKT pathway and that it could suppress H_2O_2-induced oxidative damage via PI3 K/AKT and NRF2/HO-1 signaling pathways.

关键词： Garcinia xanthochymus Oxidative stress PC12 PI3K/Akt pathway Nrf2/HO-1 signaling pathways