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Grape Seed Extract Attenuates demyelination in Experimental Autoimmune Encephalomyelitis Mice by Inhibiting Inflammatory Response of Immune Cells

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Chinese Journal of Integrative Medicine 2023年第5期29卷 394-404页

作者： WANG Qing chen yang-yang yang Zhi-chao YUAN Hai-jun DONG Yi-wei MIAO Qiang li Yan-qing WANG Jing YU Jie-zhong XIAO Bao-guo ma Cun-gen Research Center of Neurobiology the Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese MedicineShanxi University of Chinese MedicineJinzhongShanxi Province(030619)China department of Neurology the First Affiliated HospitalShanxi Medical UniversityTaiyuan(030001)China Institute of Brain Science Shanxi Key Laboratory of Inflammatory Neurodegenerative DiseasesShanxi Datong UniversityDatongShanxi Province(037009)China department of Neurology Datong Fifth People's HospitalDatongShanxi Province(037009)China Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai(200000)China

Objective: To examine the anti-inflammatory effect of grape seed extract(GSE) in animal and cellular models and explore its mechanism of action. Methods: This study determined the inhibitory effect of GSE on macrophage inflammation and Th1 and Th17 polarization in vitro. Based on the in vitro results, the effects and mechanisms of GSE on multiple sclerosis(MS)-experimental autoimmune encephalomyelitis(EAE) mice model were further explored. The C57BL/6 mice were intragastrically administered with 50 mg/kg of GSE once a day from the 3rd day to the 27th day after immunization. The activation of microglia, the polarization of Th1 and Th17and the inflammatory factors such as tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), IL-6, IL-12, IL-17and interferon-γ(IFN-γ) secreted by them were detected in vitro and in vivo by flow cytometry, enzyme linked immunosorbent assay(EliSA), immunofluorescence staining and Western blot, respectively. Results: GSE reduced the secretion of TNF-α, IL-1β and IL-6 in bone marrow-derived macrophages stimulated by lipopolysaccharide(Plinical symptoms of EAE mice, and inhibited spinal cord demyelination and inflammatory cell infiltration. Peripherally, GSE downregulated the expression of toll-like-receptor 4(TLR4) and Rho-associated kinase(ROCKⅡ, Pmatory factors(Pmatory factors(Plia(P<0.05). Conclusion: GSE had a beneficial effect on the pathogenesis and progression

关键词： grape seed extract experimental autoimmune encephalomyelitis demyelination inﬂammatory cell inﬂammatory factor

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A mussel-induced approach to secondary functional cross-linking 3-aminopropytriethoxysilane to modify the graphene oxide membrane for wastewater purification

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Chinese Chemical Letters 2023年第1期34卷 426-434页

作者： Wenwen Tu Yucheng liu Mingyan chen lili ma lingli li Bing yang College of Chemistry and Chemical Engineering Southwest Petroleum UniversityChengdu 610500China Research Institute of Industrial Hazardous Waste Disposal and Resource Utilization Southwest Petroleum UniversityChengdu 610500China

Graphene oxide(GO)with one-atom-thick exhibit remarkable molecule sieving properties,but its low permeance flux renders it difficult to be applied in practice as a high-permeance separation *** this study,we design complex membrane from covalently crosslinked GO,polydopamine(PDA),and 3-aminopropytriethoxysilane(APTES)as building blocks to fabricate the high-permeance GO-based membrane via the vacuum filtration method.A branched crosslinking product(PDA/APTES)working as a clamp grasped the hydrophilic functional groups(hydroxyl,epoxy,carboxyl)on GO for improving the GO membrane *** interlayer structure of the GO membrane was optimized according to the crosslinker concentration,reaction time,initial p H,and temperature for RGO/PDA/APTES(RGPA)in this *** the optimized reaction conditions including the crosslinker concentration of 1.4 m L/L,the temperature of 80°C,the time of 16 h,and the initial p H of 8.5 for RGPA mixture,the interlayer gallery of RGPA membrane was effectively tunes,endowing high flux ranging from 11.98 L m^(-2)h^(-1)to 1823.97 L m^(-2)h^(-1).Besides,the RGPA membrane ensured the high rejections to dye solutions such as methylene blue(MB)(>99%)and congo red(CR)(>90%).Meanwhile,the superior reusable performance of the RGPA membrane was achieved,together with the rejections for MB and CR to 96.32%and 93.1%after 4 cycles,***,the RGPA membrane possessed superior anti-fouling performances for bovine serum albumin(BSA)aqueous solution and excellent stabilities in harsh conditions(p H 3,7 and 11).Grafting the crosslinker onto GO nanosheets exhibits the distinct advantages of achieving the high flux,high rejections to dyes,and superior reusable performance of membranes,posing a great application potential for membrane separation technology in wastewater treatment.

关键词： Cross-linked graphene oxide Polydopamine APTES High flux membranes Dye separation

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Prognostic factors influencing outcome in adult liver transplantation using hypernatremic organ donation after brain death

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 371-377页

作者： Zheng-Jun Zhou Guang-Shun chen zhong-Zhou Si Qiang li yang-yang Bin Hai-Zhi Qi Jie-Qun li Center of Organ Transplantation The Second Xiangya Hospital of Central South UniversityChangsha 410011China

Background:Hypernatremic donors was regarded as the expanded criteria donors in liver *** study was to investigate the effects of donor hypernatremia on the outcomes of liver transplantation and identify the prognostic factors possibly contributing to the poor ***:Donor serum sodium levels before procurement were categorized as normal sodium(derate high sodium(155–170 mmol/L),and severe high sodium(≥170 mmol/L).Furthermore,we subdivided the 142 hypernatremic donors(≥155 mmol/L)into two subgroups:subgroup A,the exposure time of liver grafts from hypernatremia to reperfusion wasded initial graft function,survival rates of grafts and recipients,graft loss and early events within the first year following liver ***:There were no significant differences in the 1-year survival rates of grafts and recipients,1-year graft loss rates and early events among the normal,moderate high and severe high sodium ***,the overall survival rates of grafts and recipients in subgroup A were significantly higher than those in subgroup *** model showed that the exposure time(HR=1.117;95%CI:1.053–1.186;Pliver *** hypernatremia liver donors,minimization of the exposure time from hypernatremia to reperfusion is critical to prevent graft loss.

关键词： liver transplantation Hypernatremia Expanded criteria donors

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High activity of hot electrons from bulk 3D graphene materials for efficient photocatalytic hydrogen production

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Nano Research 2017年第5期10卷 1662-1672页

作者： Yanhong Lu Bo ma yang yang Erwei Huang Zhen Ge Tengfei Zhang Suling Zhang Landong li Naijia Guan Yanfeng ma Yongsheng chen State Key Laboratory and Institute of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Key Laboratory of Functional Polymer Materials and the Centre of Nanoscale Science and Technology Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China School of material Science and Engineering & National Institute for Advanced materials Nankai University Tianjin 300350 China School of Chemistry & material Science Langfang Teachers University Langfang 065000 China

design and synthesis of efficient photocatalysts for hydrogen production via water splitting are of great importance from both theoretical and practical viewpoints. many metal-based semiconductors have been explored for this purpose in recent decades. Here, for the first time, an entirely carbon-based material, bulk three-dimensionally cross-linked graphene （3DG）, has been developed as a photocatalyst for hydrogen production. It exhibits a remarkable hydrogen production rate of 270 μmol-h-l.g-t under full-spectrum light via a hot/free electron emission mechanism. Furthermore, when combined with the widely used semiconductor TiO2 to form a TiO2/3DG composite, it appears to become a more efficient hydrogen production photocatalyst. The composite achieves a production rate of 1,205 bimol-h μg-t under ultraviolet-visible （UV-vis） light and a 7.2% apparent quantum efficiency at 350 nm due to the strong synergetic effects between TiO2 and 3DG.

关键词： graphene hot electron hydrogen production water splitting Ti02

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The local density of H3K9me3 dictates the stability of HP1α condensates-mediated genomic interactions

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Journal of Genetics and Genomics 2023年第10期50卷 776-785页

作者： Ying Feng li Guo chen yang Hui Zheng Xiao Xiao Hanhui ma School of Biotechnology East China University of Science and TechnologyShanghai 200237China Gene Editing Center School of Life Science and TechnologyShanghaiTech UniversityShanghai 201210China School of life Science and Technology ShanghaiTech UniversityShanghai 201210China

The human genome can be demarcated into domains based on distinct epigenetic *** trimethylation of histone H3 lysine 9(H3K9me3)is essential for the formation of constitutive heterochromatin ***,the extent to which genomic regions require specific densities or degrees of H3K9me3 for stable interactions remains ***,we utilize CRISPR-based DNA imaging to investigate the role of endogenous or ectopic H3K9me3 in chromatin dynamics and genomic *** select three loci(IDR3,TCF3,and PR1)with distinct levels of H3K9me3 to examine the genomic interactions and association with endogenous Heterochromatin Protein 1(HP1α)*** results demonstrate a positive correlation between the levels of H3K9me3 at the loci and their association with HP1α*** dual-color labeling and long-term tracking of IDR3 and PR1 loci,we find a periodical association between the two ranging from one to three *** perturbation-induced Genome organization(EpiGo)-KRAB introduces∼20 kilobases of H3K9me3 at the TCF3 locus,which is sufficient to establish a stable association between TCF3 and HP1α*** addition,EpiGo-mediated H3K9me3 also leads to stable genomic interaction between IDR3 and ***,these data suggest that the density of H3K9me3 could dictate the stability of interactions between genomic loci and HP1αcondensates.

关键词： H3K9me3 HP1α Chromatin dynamics Genomic interaction Epigenetic perturbation

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Potato yield gaps across the rainfed Yin-mountain Hilly Area of China

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Journal of Integrative Agriculture 2018年第11期17卷 2418-2425页

作者： JIA li-guo chen yang QIN Yong-lin liANG Rui-fang CUl Shi-xin ma zhong FAN Ming-shou College of Agronomy Inner Mongolia Agricultural University Hohhot 010018 P.R.China College of Ecology & Environmental Science Inner Mongolia Agricultural University Hohhot 010019 P.R.China department of Biology Truman State University Kirksville MO 63501 USA

Yin-mountain Hilly Area is one of the ideal regions for potato （Solanum tuberosum） production in China. However, potato yield is severely limited as a result of rain-fed crop mode due to water deficiency, as well as an inadequate farming practices. In this study, yield gaps were determined by using attainable yield （Ya） as a benchmark under optimized management practices, i.e., micro-ridge and side planting with plastic-mulching （MS）, and flat planting with plastic-mulching （PM）. The yields under MS and PM modes are defined as Yal and Ya2, respectively. Under the same field with MS and PM modes but different densities and fertilizer usages and so on, it was defined as simulated farmers＇ practices. The yield of simulated farmers＇ practices （Yfl） reached 57.3 and 69.6% of Yal and Ya2, respectively, while the average yield of 298 randomly surveyed farmers （Yf2） reached only 37.0 and 47.8% of Yal and Ya2 for rain-fed potato, respectively. The gaps of water use efficiency exhibited similar pattern. Further analysis shows that improper measures in rainwater conservation and accumulation, and other management practices contributed to 18.5, 18.2, and 42.6% of yield gap between Yal and Yf2. Improper nutrition management, including overuse of nitrogen and the deficiency of phosphorus andpotassium supplication, was one of the important reasons of yield gap. The results indicate the possibilities of increasing rain-fed potato yields by optimized water and fertilizermanagements in the Yin-mountain Hilly Area.

关键词： rain-fed potato yield gap water management Yin-mountain Hilly Area

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Cryoablation for liver metastasis from solid pseudopapillary tumor of the pancreas: A case report

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World Journal of Clinical Cases 2020年第2期8卷 398-403页

作者： yang-yang ma Ji-Bing chen Juan-Juan Shi li-Zhi Niu Ke-chen Xu Central Laboratory Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina department of Oncology Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina

BACKGROUND Solid pseudopapillary tumor(SPT) of the pancreas is a rare pancreatic tumor and 10% to 15% of cases are associated with metastasis. Cryoablation is a new method that can induce tumor necrosis, and treatment of tumors by cryoablation can cause anti-tumor immune *** SUMmaRY A 16-year-old woman with SPT of the pancreas developed liver metastases 5.3 years after complete resection of the primary pancreatic tumor. She was admitted with chief complaints of abdominal pain in the upper abdomen and a weight loss of approximately 5 kg over 4 mo. Carbohydrate antigen(CA) 125,carcinoembryonic antigen, and CA 199 were normal. An abdominal computed tomography scan found multiple nodules in the right lobe of the liver that measured approximately 13.5 cm × 10.8 cm × 21.4 cm. Immunohistochemical staining results showed that CD10 and CD56 were positive, and the patient was diagnosed with SPT of the pancreas with liver metastasis. The patient underwent percutaneous cryoablation and interventional embolization. During the 5-year follow-up, the patient remained disease-free after cryoablation, with relatively normal immune *** Herein, we for the first time report the treatment of liver metastasis from SPT of the pancreas using cryoablation plus interventional embolization, which could be a promising alternative therapy for pancreatic SPT liver metastasis.

关键词： Solid pseudopapillary tumor Pancreas liver metastasis Cryoablation Interventional embolization Case report

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Reasonable design a high-entropy garnet-type solid electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2024年第9期96卷 414-423页

作者： Shiyu Yu Yandi li Jiaxin Luo Daming chen liang yang Yaqing Wei de li Yuanxun li Yong chen State Key Laboratory of marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti ResourcesHainan UniversityHaikou 570228HainanChina State Key Laboratory of Electronic Thin Films1nd Integrated devices University of Electronic Science and Technology of ChinaChengdu 610054SichuanChina Guangdong Key Laboratory for Hydrogen Energy Technologies School of Materials Science and Hydrogen EnergyFoshan UniversityFoshan 528000GuangdongChina

Traditional garnet solid electrolyte(li_(7)La_(3)Zr_(2)O_(12))suffers from low room temperature ionic conductivity,poor air stability,high sintering temperature and energy *** the development prospects of high-entropy materials with high structural disorder and strong component controllability in the field of electrochemical energy storage,herein,a novel high-entropy garnet-type oxide solid electrolyte,li_(5.75)Ga_(0.25)La_(3)Zr_(0.5)Ti_(0.5)Sn_(0.5)Nb_(0.5)O_(12)(LGLZTSNO)was constructed by partially replacing the li and Zr sites in li_(7)La_(3)Zr_(2)O_(12)with Ga and Ti/Sn/Nb elements,*** experimental and density functional theory(DFT)calculation results show that the high-entropy LGLZTSNO electrolyte has preferable room temperature ion conductivity,air stability,interface contact performance with lithium anode,and the ability to suppress lithium *** to the improvement of electrolyte performance,the critical current density of li/Ag@LGLZTSNO/li symmetric cell was increased from 0.42 to 1.57 ma cm^(−2),and the interface area specific impedance(IASR)was reduced from 765.2 to 42.3Ωcm^(2).Meanwhile,the li/Ag@LGLZTSNO/LFP full cell also exhibits excellent rate performance and cycling performance(148 ma h g^(−1)at 0.1 C and 124 ma h g^(−1)at 0.5 C,capacity retention up to 84.8%after 100 cycles at 0.1 C),showing the application prospects of high-entropy LGLZTSNO solid electrolyte in high-performance all solid state lithium batteries.

关键词： Garnet solid electrolyte Dual-site substitution High-entropy all solid-state lithium batteries(ASSLBs)

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Glass-forming ability and corrosion performance of Mn-doped Mg-Zn-Ca amorphous alloys for biomedical applications

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Rare Metals 2018年第7期37卷 579-586页

作者： Jian-li Wang Yin Wan Zhi-Jun ma Yong-Chun Guo zhong yang Ping Wang Jian-Ping li School of materials and Chemical Engineering Xi'an Technological University

In the present work, ribbon and 2-mm rod samples of Mg-Zn-Ca-Mn alloys were prepared by meltspinning and copper mold injection methods, respectively. Effects of Mn doping on glass-forming ability and corrosion performance in simulated body fluid of Mg65Zn30Ca5 alloy were studied through X-ray diffraction, scanning electron microscopy, differential scanning calorimeter, and electrochemical and immersion tests. Results show that with the Mn addition increasing, all the ribbon samples are completely in amorphous state. However, the microstructure of 2-mm rod samples transfers from fully amorphous for the Mn-free alloy to almost polycrystalline state with precipitated Mg, Mn, and MgZn phases. Glass-forming ability of Mg65Zn30Ca5 alloy is decreased by Mn addition. Results of electrochemical and immersion tests demon- strate that the Mn-doped samples exhibit more negative corrosion potential and larger corrosion current density, suggesting that the corrosion resistance decreases with doping amount of Mn element increasing.

关键词： Mg-Zn-Ca amorphous alloys Mn doping Glass-forming ability Corrosion performance

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Catalytic oxidation of CO over Pt/Fe3O4 catalysts:Tuning O2 activation and CO adsorption

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Frontiers of Environmental Science & Engineering 2020年第4期14卷 115-123页

作者： Zihao li yang Geng Lei ma Xiaoyin chen Junhua li Huazhen Chang Johannes W.Schwank department of Chemical Engineering University of MichiganAnn ArborMI 48109USA School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Environment Tsinghua UniversityBeijing 100084China School of Environment and Natural Resources Renmin University of ChinaBeijing 100872China

The self-inhibition behavior due to CO poisoning on Pt metal particles strongly impairs the performance of CO *** is an effective method to use reducible metal oxides for supporting Pt metal particles to avoid self-inhibition and to improve catalytic *** this work,we used in situ reductions of chloroplatinic acid on commercial Fe3O4 powder to prepare heterogeneousstructured Pt/Fe3O4 catalysts in the solution of ethylene *** heterogeneous Pt/Fe3O4 catalysts achieved a better catalytic performance of CO oxidation compared with the Fe3O4 *** temperatures of 50%and 90%CO conversion were achieved above 260℃and 290℃at Pt/Fe3O4,***,they are accomplished on Fe3O4 at temperatures higher than 310℃.XRD,XPS,and H2-TPR results confirmed that the metallic Pt atoms have a strong synergistic interaction with the Fe3O4 *** results and transient DRIFTS results proved that the Pt metal particles facilitate the release of lattice oxygen and the formation of oxygen vacancies on *** combined results of O2-TPD and DRIFTS indicated that the activation step of oxygen molecules at surface oxygen vacancies could potentially be the rate-determining step of the catalytic CO oxidation at Pt/Fe3O4 *** reaction pathway involves a Pt-assisted mars-van Krevelen(MvK)mechanism.

关键词： Strong metal-support interaction(SMSI) Surface oxygen vacancy Lattice oxygen magnetite Platinum metals

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