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Primary clear cell carcinoma in the liver: CT and MRI findings

World Journal of Gastroenterology 2011年第7期17卷 946-952页

作者： qing-Yu liu Hai-Gang li Ming Gao Xiao-Feng lin Yong li Jian-Yu Chen Department of Radiology The Second Affiliated Hospitalof Sun Yat-sen University Guangzhou 510120 Guangdong Prov-ince China Department of Pathology The Second Affiliated Hospital of Sun Yat-sen University Guangzhou 510120Guangdong Province China

AIM: To retrospectively analyze the computed tomography (CT) and magnetic resonance imaging (MRI) appearances of primary clear cell carcinoma of the liver (PCCCL) and compare the imaging appearances of PCCCL and common type hepatocellular carcinoma (CHCC) to determine whether any differences exist between the two groups. METHODS: Twenty cases with pathologically proven PCCCL and 127 cases with CHCC in the Second Affiliated Hospital of Sun Yat-sen University were included in this study. CT or MRI images from these patients were retrospectively analyzed. The following imaging findings were reviewed: the presence of liver cirrhosis, tumor size, the enhancement pattern on dynamic contrast scanning, the presence of pseudo capsules, tumor rupture, portal vein thrombosis and lymph node metastasis. RESULTS: Both PCCCL and CHCC were prone to occur in patients with liver cirrhosis, the association rate of liver cirrhosis was 80.0% and 78.7%, respectively (P > 0.05). The mean sizes of PCCCL and CHCC tumors were (7.28 ± 4.25) cm and (6.96 ± 3.98) cm, respectively. Small HCCs were found in 25.0% (5/20) of PCCCL and 19.7% (25/127) of CHCC cases. No significant differences in mean size and ratio of small HCCs were found between the two groups (P = 0.658 and 0.803, respectively). Compared with CHCC patients, PCCCL patients were more prone to form pseudo capsules (49.6% vs 75.0%, P = 0.034). Tumor rupture, typical HCC enhancement patterns and portal vein tumor thrombosis were detected in 15.0% (3/20), 72.2% (13/18) and 20.0% (4/20) of patients with PCCCL and 3.1% (4/127), 83.6% (97/116) and 17.3% (22/127) of patients with CHCC, respectively. There were no significant differences between the two groups (all P > 0.05). No patients with PCCCL and 2.4% (3/127) of patients with CHCC showed signs of lymph node metastasis (P > 0.05). CONCLUSION: The imaging characteristics of PCCCL are similar to those of CHCC and could be useful for differentiating these from other liver tumors (such as h

关键词： Clear cell carcinoma Hepatocellular carcinoma Pathology Magnetic resonance imaging Computed Tomography X-ray

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A reinvestigation of low molecular weight components in SOA produced by cyclohexene ozonolysis

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Nuclear Science and Techniques 2018年第11期29卷 238-246页

作者： jun Chen Zhao-Hui li Ye-Peng Yu Xuan lin Hang Zhang Yan-Bo li Huan-Huan Wang Rui-Rui Sun qing-Hui Meng Chao-Qun Huang Xiao-Bin Shan Fu-Yi liu Chang-Jin Hu Wei-jun Zhang liu-Si Sheng National Synchrotron Radiation Laboratory School of Nuclear Science and TechnologyUniversity of Science and Technology of China Laboratory Medical Optical and Mass Spectrometry Center of Medical Physics and TechnologyHefei Institutes of Physical ScienceChinese Academy of Sciences Laboratory of Atmospheric Physico-Chemistry Anhui Institute of Optics and Fine MechanicsChinese Academy of Sciences School of Environmental Science and Optoelectronic Technology University of Science and Technology of China

The ozonolysis of cyclohexene is an important model system for understanding the more complex reaction of O_3 with monoterpenes; however, many previous studies have come to qualitatively different conclusions about the composition of the secondary organic aerosol(SOA)formed in this system. In the present study, the composition of the SOA produced by cyclohexene ozonolysis in the absence of seed aerosols has been investigated online and off-line using synchrotron-based thermal desorption/tunable vacuum ultraviolet photoionization time-of-flight aerosol mass spectrometry(TD-VUV-TOF-PIAMS) in conjunction with a custom-built smog chamber. On the basis of the molecular ions observed by mass spectrometry at 11.5 e V, it was found that dicarboxylic acids, dialdehydes, and cyclic anhydrides are the predominant low molecular weight components in the particle phase. The results also indicated that TD-VUV-TOF-PIAMS coupled with filter sampling is a potentially useful tool for the investigation of SOA composition both in the field and in the laboratory.

关键词： Cyclohexene Ozonolysis SOA Smog chamber Aerosol mass spectrometry

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A hybrid model for dissolved oxygen prediction in aquaculture based on multi-scale features

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Information Processing in Agriculture 2018年第1期5卷 11-20页

作者： Chen li Zhenbo li Jing Wu ling Zhu jun Yue College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China College of Information and Electrical Engineering Ludong UniversityYantaiShandong 264025China

To increase prediction accuracy of dissolved oxygen(DO)in aquaculture,a hybrid model based on multi-scale features using ensemble empirical mode decomposition(EEMD)is ***,original DO datasets are decomposed by EEMD and we get several ***,these components are used to reconstruct four terms including high frequency term,intermediate frequency term,low frequency term and trend ***,according to the characteristics of high and intermediate frequency terms,which fluctuate violently,the least squares support vector machine(LSSVR)is used to predict the two *** fluctuation of low frequency term is gentle and periodic,so it can be modeled by BP neural network with an optimal mind evolutionary computation(MEC-BP).Then,the trend term is predicted using grey model(GM)because it is nearly ***,the prediction values of DO datasets are calculated by the sum of the forecasting values of all *** experimental results demonstrate that our hybrid model outperforms EEMD-ELM(extreme learning machine based on EEMD),EEMD-BP and MEC-BP models based on the mean absolute error(MAE),mean absolute percentage error(MAPE),mean square error(MSE)and root mean square error(RMSE).Our hybrid model is proven to be an effective approach to predict aquaculture DO.

关键词： DO prediction Aquaculture Hybrid model

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Development of an enzyme-linked immunosorbent assay using specific monoclonal antibodies against theacrine and its application

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Chinese Chemical Letters 2016年第12期27卷 1771-1775页

作者： Zhuang li jun He Yue Zhang qing-Guo Wang Yah Zhao Hui-Hua Qu Xue-Qian Wang Hui Kong Wei-Ku Zhang Jie-Kun Xu School of Basic Medical Sciences Beijing University of Chinese Medicine Beijing 100029 China Department of Pharmacology Institute of Clinical Medical Sciences China-Japan Friendship Hospital Beijing 100029 China Department of Pharmacy China-Japan Friendship Hospital Beijing 100029 China Classical Prescription Application Foundation Research Innovation Team Beijing University of Chinese Medicine 8eijing 100029 China

Tbeacrine （1,3,7,9-tetramethyluric acid）, a purine alkaloid similar to caffeine in its chemical structure, is isolated from edible Camellia assamica vat. kucha and has various pharmacological activities including hypnotic effects, anti-depressant effects, anti-inflammatory and analgesic effects, and a protective effect against stress-provoked liver damage. A rapid and simple assay is required to quantify theacrine in biological samples for pharmacokinetic studies in small animals. This study aimed to establish an enzyme-linked immunosorbent assay （EliSA） for theacrine quantification in blood. Herein, we successfully obtained monoclonal antibodies （MAbs） against theacrine, MAbs C11B5, and developed an EliSA method for the fast determination of theacrine in mouse blood. The range for calibration of theacrine by EliSA was 0.156-100 μg mL-1. The half maximum inhibitory concentration （IC50） value was 1.55 μg mL-1. The EliSA method lays a good foundation for the further research.

关键词： Theacrine Theophylline-7-acetic acid EliSA Monoclonal antibody

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Aboveground biomass of the alpine shrub ecosystems in Three-River Source Region of the Tibetan Plateau

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Journal of Mountain Science 2018年第2期15卷 357-363页

作者： NIE Xiu-qing YANG Lu-cun XIONG Feng li Chang-bin li FAN ZHOU Guo-ying Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology Chinese Academy of Science Xining 810008 China qinghai Key Laboratory of qing-Tibet Plateau Biological Resources Xining 81008 China University of Chinese Academy of Sciences Beijing 100049 China Institute of qinghai Meteorological Science Research Xining 810001 China

Though aboveground biomass(AGB) has an important contribution to the global carbon cycle,the information about storage and climatic effects of AGB is scare in Three-River Source Region(TRSR)shrub ecosystems. This study investigated AGB storage and its climatic controls in the TRSR alpine shrub ecosystems using data collected from 23 sites on the Tibetan Plateau from 2011 to 2013. We estimated the AGB storage(both shrub layer biomass and grass layer biomass) in the alpine shrubs as 37.49 Tg, with an average density of 1447.31 g m^(-2). Biomass was primarily accumulated in the shrub layer, which accounted for 92% of AGB, while the grass layer accounted for only 8%. AGB significantly increased with the mean annual temperature(P < 0.05). The effects of the mean annual precipitation on AGB were not significant. These results suggest that temperature,rather than precipitation, has significantly effects on of aboveground vegetation growth in the TRSR alpine shrub ecosystems. The actual and potential increase in AGB density was different due to global warming varies among different regions of the TRSR. We conclude that long-term monitoring of dynamic changes is necessary to improve the accuracy estimations of potential AGB carbon sequestration across the TRSR alpine shrub ecosystems.

关键词： Alpine shrub ecosystem Abovegroundbiomass Temperature Precipitation Sanjiangyuan Three-River Source Region

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Development of an integrated dynamic model for supply security and resilience analysis of natural gas pipeline network systems

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Petroleum Science 2022年第2期19卷 761-773页

作者： Huai Su Enrico Zio Zong-Jie Zhang Chang-Zheng Xiong Qian-Sheng Dai qing-Wei Wu Jin-jun Zhang National Engineering Laboratory for Pipeline Safety/MOE Key Laboratory of Petroleum Engineering/Beijing Key Laboratory of Urban Oil and Gas Distribution Technology China University of Petroleum-Beijing102249BeijingChina Dipartimento di Energia Politecnico di MilanoVia La Masa 3420156MilanoItaly MINES ParisTech PSL Research UniversityCRCSophiaAntipolisFrance PipeChina West East Gas Pipeline Company Dongfushan Road 458Pudong District200122ShanghaiChina China Special Equipment Inspection and Research Institute Heping Street 2Chaoyang District100013BeijingChina

An integrated dynamic model of natural gas pipeline networks is developed in this *** for gas supply,e.g.,pipelines,junctions,compressor stations,LNG terminals,regulation stations and gas storage facilities are included in the *** components are firstly modeled with respect to their properties and functions and,then,integrated at the system level by Graph *** model can be used for simulating the system response in different scenarios of operation,and evaluate the consequences from the perspectives of supply security and resilience.A case study is considered to evaluate the accuracy of the model by benchmarking its results against those from literature and the software Pipeline ***,the model is applied on a relatively complex natural gas pipeline network and the results are analyzed in detail from the supply security and resilience points of *** main contributions of the paper are:firstly,a novel model of a complex gas pipeline network is proposed as a dynamic state-space model at system level;a method,based on the dynamic model,is proposed to analyze the security and resilience of supply from a system perspective.

关键词： Natural gas pipeline networks Dynamic modeling State space model Graph theory Resilience of natural gas supply

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Discovery of a Novel 5-HT_(2A) Inhibitor by Pharmacophore-based Virtual Screening

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Chemical Research in Chinese Universities 2011年第4期27卷 655-660页

作者： XIONG Zi-jun DU Peng li Bian XU li-li ZHEN Xue-chu FU Wei Key Laboratory of Smart Drug Delivery Ministry of Education ＆ PLA Department of Medicinal Chemistry School of Pharmacy Fudan University Shanghai 201203 P. R. China State Key Laboratory for Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 P. R. China Department of Pharmacology College of Pharmacy Soochow University Suzhou 215123 P. R. China

The serotonin 2A（5-HT2A） receptor has been implicated in several neurological conditions and potent 5-HT2A antagonists have therapeutic effects in the treatment of schizo phrenia and *** this study,a potent novel 5-HT2A inhibitor 05245768 with a Ki value of （593.89±34.10） nmol/L was discovered by integrating a set of computational approaches and experiments（protein structure prediction,pharmacophore-based virtual screening,automated molecular docking and pharmacological bioassay）.The 5-HT2A receptor showed a negatively charged bin-ding *** binding mode of compound 05245768 with 5-HT2A was obtained by GOLD docking procedure,which revealed the conserved interaction between protonated nitrogen in compound 05245768 and carboxylate group of D3.32 at the active site of 5-HT2A.

关键词： Pharmacophore model Serotonin 2A receptor Database search Virtual screening Molecular docking

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Natural products that target macrophages in treating non-alcoholic steatohepatitis

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World Journal of Gastroenterology 2020年第18期26卷 2155-2165页

作者： Chun-lin li Wen-jun Zhou Guang Ji li Zhang Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Nonalcoholic steatohepatitis(NASH)is the progressive subtype of non-alcoholic fatty liver disease and potentiates risks for both hepatic and metabolic *** the pathophysiology of NASH is not completely understood,recent studies have revealed that macrophage activation is a major contributing factor for the disease *** integrate the immune response and metabolic process and have become promising targets for NASH *** products are potential candidates for NASH treatment and have multifactorial underlying *** involvement in the development of steatosis and inflammation in NASH has been widely *** this review,we assess the evidence for natural products or their active ingredients in the modulation of macrophage activation,recruitment,and polarization,as well as the metabolic status of *** work may highlight the possible natural products that target macrophages as potential treatment options for NASH.

关键词： Nonalcoholic steatohepatitis Macrophages Natural products Inflammation Metabolism

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Morphological transformation of elongated MnS inclusions in non-quenched and tempered steel during isothermal heating

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Journal of Iron and Steel Research International 2023年第3期30卷 525-536页

作者： jun-yu liu Cheng-song liu Rui-juan Bai Wei Wang qing-bo Wang Hua Zhang Hong-wei Ni The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Henan Jiyuan Iron&Steel(Group)Co. Ltd.Jiyuan 459000HenanChina

Elongated MnS inclusions in rolled non-quenched and tempered steel tend to cause the mechanical anisotropy of steel,deteriorate the mechanical properties and degrade the quality and service life of the steel *** reveal the mechanisms of morphological transformation of strip-shaped MnS inclusions during isothermal heating,the effects of heat treatment time and temperature on the morphology,number density and size distribution of elongated MnS inclusions were systematically studied and discussed.A diffusion couple experiment was also conducted to clarify the diffusion mode of MnS *** experimental results showed that with the increase in isothermal heating time(from 0 to 10 h at 1473 K)and temperature(from 1173 to 1573 K for 3.0 h),the number density and average aspect ratio of MnS inclusions generally showed an increase and decrease trend,respectively,while the area fraction remained stable and only slightly fluctuated around 0.4%.In the diffusion couple,after the isothermal heating at 1473 K for 3.0 h,the elements Mn and S in the steel near the steel-MnS interface were very stable without any concentration *** morphology change sequence of the elongated MnS inclusions in the rolled non-quenched and tempered steel during the isothermal heating was strip→cylinderization→spindle→*** between the diameter of MnS inclusion and the spacing between two MnS inclusions after splitting,and the fitting goodness of different n values under different experimental time and temperature confirmed that the driving force for the transformation of MnS inclusions during the isothermal heating was surface diffusion,instead of volume diffusion.

关键词： Non-quenched and tempered steel MnS inclusion Isothermal heating Surface diffusion Morphological transformation

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Opportunities and challenges of strain engineering for advanced electrocatalyst design

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Nano Research 2023年第7期16卷 8655-8669页

作者： qing-Man liang Xinchang Wang Xin-Wang Wan Long-Xing lin Bi-jun Geng Zhong-Qun Tian Yang Yang Department of Physics Pen-Tung Sah Institute of Micro-Nano Science and TechnologyState Key Laboratory of Physical Chemistry of Solid SurfacesXiamen UniversityXiamen 361005China

Electrocatalysis is becoming more and more important in energy conversion and storage due to rising energy demands,increasing carbon dioxide emissions,and impending climate *** design and synthesis of high-performance electrocatalysts are the spotlights of *** many design methodologies reported,strain engineering has gained growing attention because it can change the atomic arrangement and lattice structure of ***,strain engineering remains to be problematic in regulating the properties of *** review discusses the strain effect tactics to regulate metal and non-metal electrocatalysts,including three sections focusing on strain categorization,strain regulation mechanism,and applications in electrocatalysis,***,the current challenges and an outlook of strain engineering are discussed.

关键词： electrocatalysis electrocatalyst design strain engineering categorization and mechanism applications in electrocatalysis

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