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An approach to synthesis of(Z)-2-chloro-1,3-diarylpropen-1-ones by Vilsmeier reagent(bis-(trichloromethyl)carbonate/DMF)

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Chinese Chemical Letters 2011年第12期22卷 1395-1398页

作者： Yi Yi Weng Jian jun li wei Ke Su Key Laboratory of Pharmaceutical Engineering of Ministry of Education College of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou 310014 China

A series of（Z）-2-chloro-1,3-diarylpropen-1-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2,3-epoxy-1,3-diarylpropan-1-ones with Vilsmeier reagent,which was derived from bis（trichloromethyl） carbonate（BTC, triphosgene） and DMF.A possible mechanism was also proposed,where sequential ring-opening,halogenation and elimination reactions were involved.

关键词： Ring-opening Halogenation Vilsmeier reagent Bis-(trichloromethyl)carbonate (Z)-2-Chloro-1 3-diaryl-2-enones

Effect of strain rate and temperature on the serration behavior of SA508-Ⅲ RPV steel in the dynamic strain aging process

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Journal of Iron and Steel Research International 2018年第7期25卷 767-775页

作者： Xue Bai Su-jun Wu li-jun wei Shuai Luo Xie Xie Peter K. liaw School of Materials Science and Engineering Beihang University Beijing 100191 China Department of Materials Science and Engineering The University of Tennessee Knoxville TN 37996 USA Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang University Beijing 100191 China

Dynamic strain aging （DSA） effect on SA508-III reactor pressure vessel （RPV） steel was investigated. The SA508-III RPV steel was subjected to tension tests at different strain rates （1.1× 10-5 s-1 and 6.6× 10-5 s-1） and different temperatures （500 and 550 ℃） to evaluate the influence of strain rate and temperature on the serrated flow behavior, which is the repetitive and discontinuous yielding phenomenon on the stress-strain curves. The higher temperature leads to the higher density of precipitates, M23C6 carbides and needle-like Mo2C carbides. It was found that the samples under tension test of 6.6 × 10-5 s-1 and 500 ℃ possess superior mechanical properties and mainly show A-type serrations on the tension test curves. Then, the local regress method was used to filter the DSA curves, thus to show the real trend of the curves. It has been found that the less time of interaction between dislocations and precipitates under higher strain rates leads to a higher strength of the sample. The more tiny-stress drops on the 550 ℃ serration curve can be attributed to the hardening phase, M23C6 carbides and needle-like Mo2C carbides. The higher percentage of the small stress drops on the serration curves represents the higher mechanical strength.

关键词： Reactor pressure vessel steel SA508-Ⅲ steel Dynamic strain aging Serration behavior

Design of violet InGaN light-emitting diode with staggered quantum well structure

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Optoelectronics Letters 2008年第6期4卷 399-402页

作者： li wei-jun ZHANG Bo XU Wen-Lan LU wei State key Laboratory for Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai 200083 China Department of Electronic Engineering East China Normal University Shanghai 200062 China

The staggered InGaN quantum well (QW) structure and the conventional InGaN QW structure for the emission at a particu-lar wavelength of 400 nm are designed and theoretically investigated,including the distribution of the carriers’ concentration,the radiative recombination rate,the Shockley-Read-Hall (SRH) recombination rate as well as the output performance and the internal quantum efficiency. The theoretical result indicates that the staggered QW structure offers significant improve-ment of carriers’ concentration in the QW,especially the hole concentration. The output power and the internal quantum efficiency also show 32.6 % and 32.5 % enhancement,respectively,in comparison with that of the conventional InGaN QW structure. The reduction of the electron overflow can be the main factor for the improvement of the optical perfor-mance for novel staggered InGaN QW structure.

关键词：发光二级管量子阱波长 SRH

Effects of seed aerosols on the growth of secondary organic aerosols from the photooxidation of toluene

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Journal of Environmental Sciences 2007年第6期19卷 704-708页

作者： HAO li-qing WANG Zhen-ya HUANG Ming-qiang FANG li ZHANG wei-jun Laboratory of Environmental Spectroscopy Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 230031 China

Hydroxyl radical （.OH）-initiated photooxidation reaction of toluene was carried out in a self-made smog chamber. Four individual seed aerosols such as ammonium sulfate, ammonium nitrate, sodium silicate and calcium chloride, were introduced into the chamber to assess their influence on the growth of secondary organic aerosols （SOA）. It was found that the low concentration of seed aerosols might lead to high concentration of SOA particles. Seed aerosols would promote rates of SOA formation at the start of the reaction and inhibit its formation rate with prolonging the reaction time. In the case of ca. 9000 pt/cm^3 seed aerosol load, the addition of sodium silicate induced a same effect on the SOA formation as ammonium nitrate. The influence of the four individual seed aerosols on the generation of SOA decreased in the order of calcium chloride〉sodium silicate and ammonium nitrate〉ammonium sulfate.

关键词： toluene photooxidation secondary organic aerosol seed aerosol

Ureteral-artificial iliac artery fistula:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12711-12716页

作者： Tao Feng Xing Zhao Lei Zhu wei Chen Yan-lin Gao jun-li wei Department of Urology Xingtai People's HospitalXingtai 054000Hebei ProvinceChina Department of Emergency Xingtai Pepole's HospitalXingtai 054000Hebei ProvinceChina Department of Radiology Xingtai People's HospitalXingtai 054000Hebei ProvinceChina

BACKGROUND Ureteral-iliac artery fistula is a rare disease resulting from the pathological connection between the ureter and iliac artery,with artificial iliac artery-ureteral fistula being *** artery ureteral fistula is challenging to diagnose,and the misdiagnosis and mortality rates are *** SUMMARY A case of artificial iliac artery ureteral fistula was reported in this *** patient was a 69-year-old male with paroxysmal painless *** artificial iliac artery ureteral fistula was diagnosed by *** hematuria was stopped after intravascular embolization,and no bleeding occurred after 6 months of *** Ureteral arterial fistula should be considered when inconspicuous hematuria with previous iliac vessels is encountered in addition to local ureteral surgery history.A rapid endovascular approach is recommended for fistula identification.

关键词： Artificial iliac artery Ureteral fistula Case report

Flow Uniformity of Roller-Type Quenching Machine

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Journal of Iron and Steel Research International 2010年第7期17卷 24-27页

作者： ZHU Dong-mei liU Guo-yong ZHANG Shao-jun li Mou-wei School of Mechanical Engineering University of Science and Technology Beijing Beijing 100083 China

Three-dimensional finite element flow field model of spraying pipe of roller-type quenching machine is *** flow field with different structural parameters is *** grouping the nozzles,the spraying uniformity is analyzed under the conditions of different water inlet pipe diameter,different water inlet pipe distance,nozzle diameter and nozzle *** the spraying intensity absolute deviation and relative deviation are computed under different *** effect of different structural parameters on cooling uniformity is *** results provide theoretical basis for improving production quality and optimizing cooling device design.

关键词： roller-type quenching machine uniform cooling structural parameter

Data Mining and Systems Pharmacology to Elucidate Effectiveness and Mechanisms of Chinese Medicine in Treating Primary liver Cancer

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Chinese Journal of Integrative Medicine 2022年第7期28卷 636-643页

作者： ZHANG Zhen li jun-wei ZENG Pu-hua GAO Wen-hui TIAN Xue-fei Department of Internal Medicine College of Integrated Chinese and Western Medicine of Hunan University of Chinese MedicineChangsha 410208China Hunan Key Laboratory of TCM Prescription and Syndromes Translational Medicine Hunan University of Chinese MedicineChangsha 410208China Department of Pharmacy Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina the First Affiliated Hospital Southern University of Science and Technology)5.Department of OncologyAffiliated Hospital of Hunan Academy of Traditional Chinese MedicineChangsha 410006China

Objective: To identify specific Chinese medicines(CM) that may benefit patients with primary liver cancer(PLC), and to explore the mechanism of action of these medicines. Methods: In this retrospective, singlecenter study, prescription information from PLC patients was used in combination with Traditional Chinese Medicine Inheritance Supports System to identify the specific core drugs. A system pharmacology approach was employed to explore the mechanism of action of these medicines. Results: Taking CM more than 6 months was significantly associated with improved survival outcomes. In total, 77 putative targets and 116 bioactive ingredients of the core drugs were identified and included in the analysis(Pling, signaling between advanced glycan end products and their receptors, cellular senescence, tumor necrosis factor signaling, p53 signaling, cell cycle signaling,steroid hormone biosynthesis, T-helper 17 cell differentiation, and metabolism of xenobiotics by cytochrome. Docking studies suggested that the ingredients in the core drugs exert therapeutic effects in PLC by modulating c-jun and interleukin-6. Conclusions: Receiving CM for 6 months or more improves survival for the patients with PLC. The core drugs that really benefit for PLC patients likely regulates the tumor microenvironment and tumor itself.

关键词： Chinese medicine primary liver cancer system pharmacology bioinformatics tumor microenvironment

Evaluating electron induced degradation of triple-junction solar cell by numerical simulation

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Optoelectronics Letters 2021年第5期17卷 276-282页

作者： li jun-wei WANG Zu-jun SHI Cheng-ying XUE Yuan-yuan NING Hao XU Rui Xi’an Research Institute of High-Technology Xi’an710025China Northwest Institute of Nuclear Technology Xi’an710024China School of Materials Science and Engineering Xiangtan UniversityXiangtan411105China

In this paper,the degradation related parameters of GaInP/GaAs/Ge triple-junction solar cell induced by electron irradiation are carried out by numerical *** degradation results of short-circuit current,open-circuit voltage,maximum power have been investigated,and the degradation mechanism is *** the degradation results,the degradation of normalized parameters versus displacement damage dose is *** results show that the degradation increases with the increase of the electron fluence and electron irradiation *** degradation normalized related parameters versus displacement damage dose can be characterized by a special curve that is not affected by the type of irradiated *** calculating the annual displacement damage dose and the on-orbit operation time of special space orbit,the degradation of normalized parameters can be obtained with the fitting curve in the *** study will provide an approach to estimate the radiation damage of triple-junction solar cell induced by space particle irradiation.

关键词： Evaluating electron induced degradation of triple-junction solar cell by numerical simulation

Bis(2-butoxyethyl) Phthalate Delays Puberty Onset by Increasing Oxidative Stress and Apoptosis in Leydig Cells in Rats

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Biomedical and Environmental Sciences 2023年第1期36卷 60-75页

作者： liU Miao Qing CHEN Hai Qiong DAI Hai Peng li Jing Jing TIAN Fu Hong WANG Yi Yan CHEN Cong De li Xiao Heng li jun wei li Zhong Rong GE Ren Shan Department of Pediatric Surgery the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027ZhejiangChina Key Laboratory of Structural Malformations in Children of Zhejiang Province Wenzhou 325000ZhejiangChina

Objective This study investigated the effects of bis(2-butoxyethyl) phthalate(BBOP) on the onset of male puberty by affecting Leydig cell development in *** Thirty 35-day-old male Sprague-Dawley rats were randomly allocated to five groups mg/kg bw per day that were gavaged for 21 days with BBOP at 0, 10, 100, 250, or 500 mg/kg bw per day. The hormone profiles;Leydig cell morphological metrics;mRNA and protein levels;oxidative stress;and AKT,mTOR, ERK1/2, and GSK3β pathways were *** BBOP at 250 and/or 500 mg/kg bw per day decreased serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels mg/kg bw per day(P < 0.05). BBOP at 500 mg/kg bw per day decreased Leydig cell number mg/kg bw per day and downregulated Cyp11a1, Insl3, Hsd11b1,and Dhh in the testes, and Lhb and Fshb mRNAs in the pituitary gland(P < 0.05). The malondialdehyde content in the testis significantly increased, while Sod1 and Sod2 mRNAs were markedly downregulated, by BBOP treatment at 250–500 mg/kg bw per day(P < 0.05). Furthermore, BBOP at 500mg/kg bw per day decreased AKT1/AKT2, mTOR, and ERK1/2 phosphorylation, and GSK3β and SIRT1levels mg/kg bw per day(P < 0.05). Finally, BBOP at 100 or 500 μmol/L induced ROS and apoptosis in Leydig cells after 24 h of treatment in vitro(P < 0.05).Conclusion BBOP delays puberty onset by increasing oxidative stress and apoptosis in Leydig cells in *** graphical abstract is available on the website ***.

关键词： Bis(2-butoxyethyl)phthalate Leydig cells Testosterone Oxidative stress Gonadotropin