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Development and validation of a prediction model for early screening of people at high risk for colorectal cancer

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World Journal of Gastroenterology 2024年第5期30卷 450-461页

作者： ling-li Xu Yi lin li-Yuan Han Yue Wang Jian-jiong li Xiao-Yu Dai Department of General Surgery Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina Center for Health Economics Faculty of Humanities and Social SciencesUniversity of NottinghamNingbo 315100Zhejiang ProvinceChina Department of Global Health Ningbo Institute of Life and Health IndustryUniversity of Chinese Academy of SciencesNingbo 315000Zhejiang ProvinceChina School of Public Health Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a serious threat worldwide.Although early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still not optimistic.In China,the incidence of CRC in the Yangtze River Delta region is increasing dramatically,but few studies have been conducted.Therefore,it is necessary to develop a simple and efficient early screening model for CRC.AIM To develop and validate an early-screening nomogram model to identify individuals at high risk of CRC.METHODS Data of 64448 participants obtained from Ningbo Hospital,China between 2014 and 2017 were retrospectively analyzed.The cohort comprised 64448 individuals,of which,530 were excluded due to missing or incorrect data.Of 63918,7607(11.9%)individuals were considered to be high risk for CRC,and 56311(88.1%)were not.The participants were randomly allocated to a training set(44743)or validation set(19175).The discriminatory ability,predictive accuracy,and clinical utility of the model were evaluated by constructing and analyzing receiver operating characteristic(ROC)curves and calibration curves and by decision curve analysis.Finally,the model was validated internally using a bootstrap resampling technique.RESULTS Seven variables,including demographic,lifestyle,and family history information,were examined.Multifactorial logistic regression analysis revealed that age[odds ratio(OR):1.03,95%confidence interval(CI):1.02-1.03,Plifestyle(OR:0.45,95%CI:0.42-0.48,Plifestyle was a protective factor,whereas family history was the most significant risk factor.The area under the curve was 0.734(95%CI:0.723-0.745)for the final validation set ROC curve and 0.735(95%CI:0.728-0.742)for the training set ROC curve.The calibration curve demonstrated

关键词： Colorectal cancer Early screening model High-risk population Nomogram model Questionnaire survey Dietary habit living habit

Discussion on neighborhood optimal trajectory online correction algorithm and its application range

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Journal of Systems Engineering and Electronics 2023年第4期34卷 1053-1062页

作者： li Wanli li jiong LEI Humin Graduate School Air Force Engineering UniversityXi’an 710051China Air and Missile Defense College Air Force Engineering UniversityXi’an 710051China

This paper presents a neighborhood optimal trajectory online correction algorithm considering terminal time variation,and investigates its application range.Firstly,the motion model of midcourse guidance is established,and the online trajectory correction-regenerating strategy is introduced.Secondly,based on the neighborhood optimal control theory,a neighborhood optimal trajectory online correction algorithm considering the terminal time variation is proposed by adding the consideration of terminal time variation to the traditional neighborhood optimal trajectory correction method.Thirdly,the Monte Carlo simulation method is used to analyze the application range of the algorithm,which provides a basis for the division of application domain of the online correction algorithm and the online regeneration algorithm of midcourse guidance trajectory.Finally,the simulation results show that the algorithm has high real-time performance,and the online correction trajectory can meet the requirements of terminal constraint change.The application range of the algorithm is obtained through Monte Carlo simulation.

关键词： midcourse guidance online correction neighborhood optimal control application range

Nickel-modified In_(2)O_(3) with inherent oxygen vacancies for CO_(2) hydrogenation to methanol

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Science China Chemistry 2024年第5期67卷 1715-1728页

作者： Zixuan Zhou Yuchen Wang Yuanjie Bao Haiyan Yang jiong li Chunran Chang Shenggang li Peng Gao CAS Key Laboratory of Low-Carbon Conversion Science and Engineering Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization School of Chemistry and Chemical EngineeringYulin UniversityYulin 719000China

Methanol synthesis is one of the most important industrially-viable approaches for carbon dioxide(CO_(2)) utilization, as the produced methanol can be used as a platform chemical for manufacturing green fuels and chemicals. The In_(2)O_(3) catalysts are ideal for sustainable methanol synthesis and have received considerable attention. Herein, Co-, Ni-and Cu-modified In_(2)O_(3) catalysts were fabricated with high dispersion and high stability to improve the hydrogenation performance. The Ni-promoted In_(2)O_(3) catalyst in the form of high dispersion possessed the largest amount of oxygen vacancies and the strongest ability for H_(2) activation, leading to the highest CO_(2) conversion and space time yield of methanol of 0.390 g_(Me OH)g_(cat)^(-1)h^(-1) with CH_(3)OH selectivity of 68.7%. In addition, the catalyst exhibits very stable performance over 120 h on stream, which suggests the promising prospect for industrial applications. Further experimental and theoretical studies demonstrate that surface Ni doping promotes the formation of oxygen defects on the In_(2)O_(3) catalyst, although it also results in lower methanol selectivity. Surprisingly, subsurface Ni dopants are found to be more beneficial for methanol formation than surface Ni dopants, so the Nipromoted In_(2)O_(3)catalyst with a lower surface Ni content at the similar Ni loading can reach higher methanol selectivity and productivity. This work thus provides theoretical guidance for significantly improving the CO_(2) reactivity of In_(2)O_(3)-based catalysts while maintaining high methanol selectivity.

关键词： carbon dioxide hydrogenation methanol synthesis indium oxides Ni doping sites transition metal promoters

Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-li Zhang Xi Zhang Wang Hua Zheng-De Xie Han-Min liu Hai-lin Zhang Bi-Quan Chen Yuan Chen Xin Sun Yi Xu Sai-Nan Shu Shun-Ying Zhao Yun-Xiao Shang ling Cao Yan-Hui Jia Luo-Na lin jiong li Chuang-li Hao Xiao-Yan Dong Dao-jiong lin Hong-Mei Xu De-Yu Zhao Mei Zeng Zhi-Min Chen li-Su Huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare burden.There is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in children.Data sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of consensus.Although supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled out.Conclusions This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV infections.Further improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

Nickel-modified InOwith inherent oxygen vacancies for COhydrogenation to methanol

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Science China Chemistry 2024年

作者： Zixuan Zhou Yuchen Wang Yuanjie Bao Haiyan Yang jiong li Chunran Chang Shenggang li Peng Gao University of Chinese Academy of Sciences School of Physical Science and Technology ShanghaiTech University Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Shaanxi Key Laboratory of Low Metamorphic Coal Clean Utilization School of Chemistry and Chemical Engineering Yulin University CAS Key Laboratory of Low-Carbon Conversion Science and Engineering Shanghai Advanced Research Institute Chinese Academy of Sciences

Methanol synthesis is one of the most important industrially-viable approaches for carbon dioxide (CO2) utilization,as the produced methanol can be used as a platform chemical for manufacturing green fuels and chemicals.The In2O3catalysts are ideal for sustainable methanol synthesis and have received considerable attention.Herein,Co-,Ni-and Cu-modified In2O3catalysts were fabricated with high dispersion and high stability to improve the hydrogenation performance.The Ni-promoted In2O3catalyst in the form of high dispersion possessed the largest amount of oxygen vacancies and the strongest ability for H2activation,leading to the highest CO2conversion and space time yield of methanol of 0.390 gMeOHg-1cath-1with CH3OH selectivity of 68.7%.In addition,the catalyst exhibits very stable performance over 120 h on stream,which suggests the promising prospect for industrial applications.Further experimental and theoretical studies demonstrate that surface Ni doping promotes the formation of oxygen defects on the In2O3catalyst,although it also results in lower methanol selectivity.Surprisingly,subsurface Ni dopants are found to be more beneficial for methanol formation than surface Ni dopants,so the Nipromoted In2O3catalyst with a lower surface Ni content at the similar Ni loading can reach higher methanol selectivity and productivity.This work thus provides theoretical guidance for significantly improving the CO2reactivity of In2O3-based catalysts while maintaining high methanol selectivity.

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Prescribed performance neural control to guarantee tracking quality for near space kinetic kill vehicle

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Journal of Systems Engineering and Electronics 2019年第3期30卷 573-586页

作者： ZHANG Tao li jiong li Weimin WANG Huaji LEI Humin Air and Missile Defense College Air Force Engineering University

A prescribed performance neural controller to guarantee tracking quality is addressed for the near space kinetic kill vehicle (NSKKV) to meet the state constraints caused by side window detection. Different from the traditional prescribed performance control in which the shape of the performance function is constant, this paper exploits new performance functions which can change the shape of their function according to different symbols of initial errors and can ensure the error convergence with a small overshoot. The neural backstepping control and the minimal learning parameters (MLP) technology are employed for exploring a prescribed performance controller (PPC) that provides robust tracking attitude reference trajectories. The highlight is that the transient performance of tracking errors is satisfactory and the computational load of neural approximation is low. The pseudo rate (PSR) modulator is used to shape the continuous control command to pulse or on-off signals to meet the requirements of the thruster. Numerical simulations show that the proposed method can achieve state constraints, pseudo-linear operation and high accuracy.

关键词： prescribed performance control near space kinetic kill vehicle (NSKKV) neural approximation minimal learning parameter (MLP) pseudo rate (PSR) modulator

Tween-modified suspension array for sensitive biomolecular detection

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Chinese Science Bulletin 2013年第21期58卷 2628-2633页

作者： ZHAO Zhuan li Zong li jiong Division of Nano-biomedicine Suzhou Institute of Nano-tech and Nano-bionics Chinese Academy of Sciences Technical Institute of Physics and Chemistry Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences Institute of Semiconductors Chinese Academy of Sciences

Suspension arrays are attracting increasing interest for detecting and quantifying proteins, nucleic acids and other biomolecules. Among various suspension arrays, sillica-based suspension arrays which benefit from low fluorescence background and material stability have been widely used. Sillica-based suspension arrays are often manufactured with the popular aldehyde-aminosilane chemistry for the attachment of a variety of biomolecules. One drawback of this immobilization strategies is the relatively high array particles lost efficiency when washed by centrifugation. Due to this shortcoming, it is low reproductivity and limited in multiplex assay. Herein we report a novel method to fabricate Tween-coated suspension sillica particles, which could achieve good- reproductivity and the low limit of detection. Tween surfactants, each containing hydrophilic ethylene glycol head groups and a hydrophobic alkyl tail, prevent silica particles from being adsorbed onto the centrifuge tube wall and make beads resuspended well. Also, Tween with low fluorescence background could reduce non-specific protein adsorption. Also Tween surfactants are economic and facile agent. In this study, we demonstrate the preparation of the protein array to substantiate the applicability of our approach. Under the optimized experiment conditions, the limit of detection of our Tween-modified particles is as low as 50 pg/mL, which is sufficiently low for the current methods. We believe that the proposed method could provide a perspective on the improvement of self-encoded silica particle arrays.

关键词：蛋白质阵列分子检测生物分子再悬浮吐温改性二氧化硅粒子特异性蛋白质

南宋地方官咨政与基层治理——以地方民用基础设施建设为例

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南阳理工学院学报 2024年第1期16卷 81-90页

作者：李炯河南大学历史文化学院河南开封475001

南宋地方民用基础建设中存在着地方财政拮据、地方官对基层情况不熟悉等问题,咨政则是地方官应对地方建设中民用基础建设难题的有效途径。地方官对民间人士的咨政活动,不仅可以帮助地方官获取民意,而且有助于应对来自基层建设中的挑战... 详细信息

南宋地方民用基础建设中存在着地方财政拮据、地方官对基层情况不熟悉等问题,咨政则是地方官应对地方建设中民用基础建设难题的有效途径。地方官对民间人士的咨政活动,不仅可以帮助地方官获取民意,而且有助于应对来自基层建设中的挑战。通过对水利、桥梁、学校、祠庙等方面的咨政,地方官进一步拓宽信息渠道,实现了官民之间的良好互动。因此,南宋地方官咨政对基层治理具有积极作用,有助于地方官了解当地突出的政务问题,能在施政的过程中更好地获得民间力量支持,使地方施政更加符合民意,对于社会舆情有积极的引导作用。

关键词：南宋地方官咨政基层治理民用基础设施建设

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拈笔论画

书画世界 2024年第1期263卷 44-49页

作者：李炯中国画院河北省工笔画学会中央美术学院北京师范大学启功书院艺委会李可染画院山东青年政治学院

环境南北画风有异,南画偏润北画略苍,与人与气候皆有关联。我画花鸟工写兼备,不图工细更期苍润气象。个人而言,不喜在北京3月末和11月初两个时段画画,因为总觉室内有一定的湿度,纸张绵软,行笔略感湿腻,不如冬季有暖气或秋季干燥时节行... 详细信息

环境南北画风有异,南画偏润北画略苍,与人与气候皆有关联。我画花鸟工写兼备,不图工细更期苍润气象。个人而言,不喜在北京3月末和11月初两个时段画画,因为总觉室内有一定的湿度,纸张绵软,行笔略感湿腻,不如冬季有暖气或秋季干燥时节行笔那么有沧桑感和力度感。南北画风因地域不同、干湿不同而迥异。我笔下这种风格的花鸟画,湿润实则不如干燥更好些,润则润了,但少了骨感和苍劲感,本就工细的花鸟画再加上湿润便会“腻”得有些脂粉气。我这几年春游江南、秋游大西北亦是“借气”,画可有“女人气”,但绝不能缺乏“大丈夫气”。

关键词：沧桑感花鸟画笔论画风工细苍润南画大丈夫