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Calculation model for water influx and controlled reserves for CBM wells with high water yield

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Petroleum Research 2018年第3期3卷 288-292页

作者： Qing Feng Han Jia Zijun Huang Miao Tian jingsong li Xiaonan li Oilfield Production Optimization Institution China Oilfield Services LimitedTianjin300450China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580China

Compared with conventional gas reservoir,percolation mechanism of coalbed methane(CBM)is completely different,it is remarkably affected by adsorption/desorption performance,pressure variation and coalbed *** it is difficult to calculate the controlled reserves of CBM ***,the connection of edge-bottom water or interbedded water by fractures or faults may largely increase the water yield and drainage period,leading to obvious water invasion in some CBM *** are few literature about the predicted production for CBM wells with high water *** on the unconventional CBM reservoir,methods of pseudo geological reserves and production index curves are adopted to establish the calculation model of water influx and controlled *** further confirms that the calculation model is successfully applicated on the CBM wells at the middle part of Qinshui Basin in China.

关键词： CBM well High water yield Water influx Controlled reserves Calculation model

Glucocorticoid receptor–IRS-1 axis controls EMT and the metastasis of breast cancers

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Journal of Molecular Cell Biology 2019年第12期11卷 1042-1055页

作者： Weiwei Shi Dongmei Wang Xinwang Yuan Yi liu Xiaojie Guo jingsong li Jianguo Song State Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesShanghai 200031China

Glucocorticoid receptor (GR) is involved in the transcriptional regulation of genes that are important for various biological functions, including tumor growth and metastatic progression. However, the cellular and biological effects of GR remain poorly understood. Here, we investigated the role of GR and its underlying mechanism in mediating breast cancer cell survival and metastasis. We observed that the GR levels were increased in drug-resistant breast cancer cells and in metastatic breast cancer samples. GR promoted tumor cell invasion and lung metastasis in vivo. The GR expression levels were negatively correlated with the survival rates of breast cancer patients. Both ectopic expression and knockdown of GR revealed that GR is a strong inducer of epithelial-to-mesenchymal transition (EMT), which is consistent with its effects on cell survival and metastasis. GR suppressed the expression of insulin receptor substrate 1 (IRS-1) by acting as an IRS-1 transcriptional repressor. In addition, GR has an opposite effect on the expression levels of IRS-2, indicating that GR is able to differentially regulate the IRS-1 and IRS-2 expression. The cellular and biological effects elicited by GR were consistent with the reduced levels of IRS-1 observed in cancer cells, and GR-mediated IRS-1 suppression activated the ERK2 MAP kinase pathway, which is required for GR-mediated EMT. Taken together, our results indicate that GR–IRS-1 signaling axis plays an essential role in regulating the survival, invasion, and metastasis of breast cancer cells.

关键词： metastasis breast invasion

Thin-bed thickness calculation formula and its approximation using peak frequency

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Applied Geophysics 2009年第3期6卷 234-240,299页

作者： Sun Luping Zheng Xiaodong li jingsong Shou Hao Research Institute of Petroleum Exploration and Development Beijing 100083

Quantitative thickness estimation below tuning thickness is a great challenge in seismic exploration. Most studies focus on the thin-beds whose top and bottom reflection coefficients are of equal magnitude and opposite polarity. There is no systematic research on the other thin-bed types. In this article, all of the thin-beds are classified into four types： thin-beds with equal magnitude and opposite polarity, thin-beds with unequal magnitude and opposite polarity, thin-beds with equal magnitude and identical polarity, and thin-beds with unequal magnitude and identical polarity. By analytical study, an equation describing the general relationship between seismic peak frequency and thin-bed thickness was derived which shows there is a Complex implicit non-linear relationship between them and which is difficult to use in practice. In order to solve this problem, we simplify the relationship by Taylor expansion and discuss the precision of the approximation formulae with different orders for the four types of thin-beds. Compared with the traditional amplitude method for thin-bed thickness calculation, the method we present has a higher precision and isn＇t influenced by the absolute value of top or bottom reflection coefficient, so it is convenient for use in practice.

关键词： thin-bed quantitative thickness calculation peak frequency Taylor expansion approximation

Model-based adaptive non-null interferometry for freeform surface metrology

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Chinese Optics Letters 2018年第8期16卷 40-44页

作者： Lei Zhang Sheng Zhou Dong li jingsong li Benli Yu Key Laboratory of Opto-Electronic Information Acquisition and Manipulation Ministry of Education Anhui University Hefei 230601 China Research Center of Laser Fusion China Academy of Engineering Physics Mi~nyang 621900 China

A model-based adaptive non-null interferometry （MANI） is proposed for steep optical freeform surfaces in situ testing. The deformable mirror （DM） affording the flexible compensation is monitored with the beam in the interferometer by a wavefront sensor. The residual wavefront aberration in the non-null interferogram is eliminated by the multi-configuration ray tracing algorithm based on the system model, especially the DM surface model. The final figure error can be extracted together with the surface misalignment aberration correction. Experiments proving the feasibility of the MANI are shown.

关键词： DM Model-based adaptive non-null interferometry for freeform surface metrology

Microsatellite DNA analysis proves nucleus of interspecies reconstructed blastocyst coming from that of donor giant panda

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Chinese Science Bulletin 2000年第20期45卷 1883-1885页

作者： DING Bo SHI Peng XIANGYU Jinggong ZHANG Yaping CHEN Dayuan SUN Qingyuan li Guangpeng WANG Minkang liU Yilong KANG li HAN Zhiming SONG Xiangfen li jingsong CHEN Yuchun Laboratory of Cellular and Molecular Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100080China Fuzhou Panda Institute Center Fuzhou 350001China 不详

A method for DNA isolation from early development of blastocyst and further analysis of nuclear and mitochondrial DNA was developed in present study. Total DNA was prepared from interspecies reconstructed blastocyst and a giant panda specific microsatellite locus g010 was successfully amplified. DNA sequencing of the PCR product showed that two sequences of reconstructed blastocysts are the same as that of positive control giant panda. Our results prove that the nucleus of interspecies reconstructed blastocyst comes from somatic nucleus of donor giant panda.

关键词： giant panda (Ailuropoda melanoleuca) interspecies cloning microsatellite DNA nucleus.

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流变与坚守:中国西南山区农业变迁追踪研究

开放时代 2023年第1期 172-188,M0007页

作者：李静松浙江大学社会学系

农业现代化进程的推进正在使原本以农业生物多样性和生计农业为基本特征的西南山区发生根本性改变。通过生产方式和种植结构两条主线追踪广西、云南和贵州山区农业在1998年—2018年间的变化发现,当地主粮作物品种的商品化程度极大提高,... 详细信息

农业现代化进程的推进正在使原本以农业生物多样性和生计农业为基本特征的西南山区发生根本性改变。通过生产方式和种植结构两条主线追踪广西、云南和贵州山区农业在1998年—2018年间的变化发现,当地主粮作物品种的商品化程度极大提高,农化投入品被广泛使用,机械化水平有所提升,产业发展带动下的农户土地流转普遍存在;同时,种植结构存在“去粮作”和“耕地种树”的趋势。西南山区农业的整体性变迁从总体上降低了农户生产选择的自主性,从食物自给程度和市场依赖程度两个维度可以描述农户在从生计农业向产业农业转变过程中的分化。当前生产对农业体系多样性和农户粮食安全的影响不容忽视,推动西南山区农业的可持续转型需突破来自常规生产体系的限制,生成能够抵抗风险、增强农业抗逆力的替代性方案。

关键词：农业生物多样性粮食安全农业产业抗逆力替代性方案

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超越生产主义——探析全球农业食物体系转型进程中的锁定效应

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浙江大学学报（人文社会科学版） 2020年第6期50卷 55-69页

作者：李静松浙江大学社会学系浙江杭州310058

全球农业食物体系在二战后历经了生产主义、后生产主义及新生产主义的范式演进,在当前呈现的基本特征是:生产方式工业化、生产与供给全球化、治理模式公司化以及面向可持续的转型。来自环境、农业和食物方面的压力和紧张关系是该体系转... 详细信息

全球农业食物体系在二战后历经了生产主义、后生产主义及新生产主义的范式演进,在当前呈现的基本特征是:生产方式工业化、生产与供给全球化、治理模式公司化以及面向可持续的转型。来自环境、农业和食物方面的压力和紧张关系是该体系转型的重要驱动力。然而,主流制度系统产生的锁定效应却在很大程度上制约了该体系对困境的突破能力,致使转型始终未能超越生产主义。从该体系相关的七个主要问题被制度系统锁定的路径及其结构性根源中能够发现,依靠当前主流制度系统自身的调适难以从根本上解决问题,超越生产主义、化解制度系统锁定效应的关键是在认知反思的基础上确保“实践—制度”的有效对话。

关键词：农业食物体系生产主义锁定效应农业与食物社会学粮食安全食品安全

Large-eddy simulations of the Richtmyer-Meshkov instability of rectangular interfaces accelerated by shock waves

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Science China(Physics,Mechanics & Astronomy) 2010年第12期53卷 905-914页

作者： WANG Tao,BAI jingsong,li Ping & liU Kun Institute of Fluid Physics,China Academy of Engineering Physics,Mianyang 621900,China Institute of Fluid Physics China Academy of Engineering Physics Mianyang China

A parallel algorithm and code MVFT(multi-viscous-fluid and turbulence) of large-eddy simulation(LES) is developed from our MVPPM(multi-viscous-fluid piecewise parabolic method),and performed to solve the multi compressible Navier-Stokes(N-S) *** effect of the unresolved subgrid-scale(SGS) motions on the large scales is represented by different SGS stress models in LES.A Richtmyer-Meshkov instability experiment of the evolution of a rectangular block of SF6,which occupies half of the height of the shock tube test section,following the interaction with a planar shock wave,is numerically and exhaustively simulated by this *** comparison between experimental and simulated images of the evolving SF6 block shows that they are *** numerical simulations reproduce the complex developing process of SF6 block,which grows *** geometric quantities that characterize the extents of SF6 block are also compared in detail between numerical simulations and experiment with good agreements between them,a quantitative demonstration of the developing law of SF6 *** is an evident discrepancy between the three numerical simulations for the maximum position of the right edge of block at the late stage,because the right interface grows complicated and the dissipation is different for different SGS *** SGS turbulent dissipation,molecular viscosity dissipation and SGS turbulent kinetic energy have been studied and *** have a similar distribution to the large eddy *** SGS turbulent dissipation is much greater than the molecular viscosity dissipation;the SGS turbulent dissipation of Vreman model is smaller than the Smagorinsky *** general,the simulated results of Vreman SGS model are better compared with the dynamic viscosity and Smagorinsky SGS *** vorticity and circulation deposition on the block interface have also been investigated.

关键词： large-eddy simulation Navier-Stokes equations subgrid-scale Richtmyer-Meshkov instability turbulent dissipation turbulent kinetic energy circulation deposition

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差分式共振光声光谱技术研究

中国激光 2024年第5期51卷 229-234页

作者：徐靖黄琪李劲松航宇救生装备有限公司湖北襄阳441003 安徽大学物理与光电工程学院安徽合肥230601

针对光声光谱系统本底噪声限制问题,以圆柱形声共振器作为研究对象,开展了双共振腔光声池设计,并将共振光声光谱和差分探测原理相结合,建立了一套基于近红外半导体激光器的高灵敏度激光光谱气体探测系统。以空气中的水汽(H_(2)O)分子作... 详细信息

针对光声光谱系统本底噪声限制问题,以圆柱形声共振器作为研究对象,开展了双共振腔光声池设计,并将共振光声光谱和差分探测原理相结合,建立了一套基于近红外半导体激光器的高灵敏度激光光谱气体探测系统。以空气中的水汽(H_(2)O)分子作为检测对象,结合高灵敏度波长调制二次谐波探测方法,对建立的差分式共振光声光谱系统进行了理论分析和实验评估。艾伦方差分析结果显示,系统可实现几个10^(-6)量级水汽分子浓度的高灵敏度检测。相较于传统单通道光声探测模式,所提出的差分探测式共振光声光谱探测技术可有效提升系统的稳定性和检测灵敏度,最佳信号平均时间可提高2倍。

关键词：光谱学光声光谱差分探测共振效应气体检测