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Cadherin-18 loss in prospermatogonia and spermatogonial stem cells enhances cell adhesion through a compensatory mechanism

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Zoological Research 2024年第5期45卷 1048-1060页

作者： Xiao-Xiao li Dan-Chen Zhang Yan Wang Jian wen Xing-Ju Wang Yu-Lu Cao Ru jiang Jia-Rui li Yi-Nuo li He-He liu wen-Hai Xie Zheng-Feng Xu Ping Hu Kang Zou Germline Stem Cells and Microenvironment Lab College of Animal Science and TechnologyNanjing Agricultural UniversityNanjingJiangsu 210095China Stem Cell Research and Translation Center Nanjing Agricultural UniversityNanjingJiangsu 210095China School of life Sciences and Medicine Shandong University of TechnologyZiboShandong 255000China Department of Prenatal Diagnosis Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China

Extracellular membrane proteins are crucial for mediating cell attachment,recognition,and signal transduction in the testicular microenvironment,particularly germline stem *** 18(CDH18),a type Ⅱ classical cadherin,is primarily expressed in the nervous and reproductive ***,we investigated the expression of CDH18in neonatal porcine prospermatogonia(ProSGs)and murine spermatogonial stem cells(SSCs).Disruption of CDH18 expression did not adversely affect cell morphology,proliferation,self-renewal,or differentiation in cultured porcine ProSGs,but enhanced cell adhesion and prolonged cell *** analysis indicated that the down-regulation of CDH18 in ProSGs significantly up-regulated genes and signaling pathways associated with cell *** further elucidate the function of CDH18 in germ cells,Cdh18 knockout mice were generated,which exhibited normal testicular morphology,histology,*** analysis showed increased expression of genes associated with adhesion,consistent with the observations in porcine *** interaction of CDH18withβ-catenin and JAK2 in both porcine ProSGs and murine SSCs suggested an inhibitory effect on the canonical Wnt and JAK-STAT signaling pathways during CDH18 ***,these findings highlight the crucial role of CDH18 in regulating cell adhesion in porcine ProSGs and mouse *** this regulatory mechanism provides significant insights into the testicular niche.

关键词： Extracellular signal Fertility Quiescency Wnt signaling pathway

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基于溶胶-凝胶技术的磷钨杂多酸化学修饰电极的组装及其电催化

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高等学校化学学报 2000年第6期21卷 865-869页

作者：李丽东李文江孙长青吉林大学化学系长春130023

将 Dawson型磷钨杂多酸盐 K6 P2 W1 8O6 2 · 1 0 H2 O( P2 W1 8)掺杂到溶胶 -凝胶中 ,滴涂在碳糊电极表面 ,制备成化学修饰电极 .并对该化学修饰电极的电化学行为 ,包括溶液 p H值的影响和电极稳定性等进行了详细的研究 .结果表明 ,此... 详细信息

将 Dawson型磷钨杂多酸盐 K6 P2 W1 8O6 2 · 1 0 H2 O( P2 W1 8)掺杂到溶胶 -凝胶中 ,滴涂在碳糊电极表面 ,制备成化学修饰电极 .并对该化学修饰电极的电化学行为 ,包括溶液 p H值的影响和电极稳定性等进行了详细的研究 .结果表明 ,此电极既保持了该杂多酸的电化学活性和电催化性能 ,又具有良好的稳定性和灵敏度 .实验发现 ,在 0 .5mol/L H2 SO4溶液中 ,掺杂在溶胶 -凝胶膜中的 P2 W1 8的第 3、第 4个还原峰对 NO- 2 离子具有很好的电催化活性 ,且催化电流同 NO- 2 浓度呈线性关系 .同时 ,P2 W1 8的第 3、第 4个还原峰对分子氧也具有很好的电催化活性 .

关键词：溶胶-凝胶技术磷钨杂多酸化学修饰电极组装

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时间触发以太网的多域同步方法改进

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电子科技大学学报 2019年第4期48卷 504-510页

作者：李文江刘强张文向渝中国电子科技集团公司第五十四研究所(通信网信息传输与分发技术重点实验室) 石家庄050081 成都阳辰物联天下科技有限公司成都611731 电子科技大学计算机科学与工程学院成都611731

时间触发以太网(TTE)是一种保证以太网实时性的解决方案。该文首先分析了在大规模确定性网络中引入同步域和同步优先级的原因,并针对TTE网络中3种常见的集群情况,设计了多同步域下多同步优先级的具体通信规则,满足更为复杂的TTE网络需... 详细信息

时间触发以太网(TTE)是一种保证以太网实时性的解决方案。该文首先分析了在大规模确定性网络中引入同步域和同步优先级的原因,并针对TTE网络中3种常见的集群情况,设计了多同步域下多同步优先级的具体通信规则,满足更为复杂的TTE网络需求。通过仿真验证了同步域和同步优先级对确定性网络的影响。实验结果说明同步域和同步优先级能够提高TTE中时钟同步服务的精确性和安全性,在满足TTE网络实时性要求的前提下增加网络的灵活性。

关键词：确定性网络多同步域多同步优先级时间触发以太网

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Effect of miR-124 Overexpression under Wnt/β-catenin Signaling Pathway on Inflammatory Factor and Epidermal Growth Factor in Rats with Precancerous Gastric Lesions

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Chinese Journal of Biomedical Engineering 2024年第01期33卷 17-26页

作者： ZHOU li-jiang Zhejiang Chinese Medical University Shangyu People's Hospital of Shaoxing

Objective: To investigate the effects of miR-124 overexpression on inflammatory factors and epidermal growth factor in rats with gastric precancerous lesions by modulating the Wnt/β-catenin signaling pathway. Methods: Eighty SPF-grade Wistar rats were selected as the research subjects. After adaptive feeding,they were divided into 4 groups using a random number table method. The control group was fed a regular diet, while the model group, low expression group, and overexpression group of rats were treated with N-methyl-N'-nitro-N-nitrosoguanidine to establish a model of gastric cancer precancerous lesions. After successful modeling, the control group and model group rats were injected intraperitoneally with 0.9% sodium chloride solution, the low-expression group rats were injected intraperitoneally with miR-124-5p inhibitor, and the over-expression group rats were injected intraperitoneally with miR-124-5p mimic. After 8 weeks of continuous injection, the levels of miR-124,Wnt/β-catenin signaling pathway-related proteins, inflammatory factors, and epidermal growth factor were observed and compared among the four groups of rats. Results: The differences in the relative expression of miR-124 among the four groups of rats were statistically significant(P<0.05); the differences in the expression of Wnt protein andβ-catenin protein among the four groups of rats were statistically significant(P<0.05),and the expression of Wnt protein and β-catenin protein in the overexpression group was significantly higher than that of the control group, and significantly lower than that in the model group and the low-expression group; the levels of IL-1β, IL-6, and TNF-αof rats in the four groups of rats IL-1β, IL-6 and TNF-α levels were statistically different(P<0.05), and the levels of IL-1β, IL-6 and TNF-α in rats in the overexpression group were higher than those in the model group and significantly lower than those in the model group and the low-expression group(P<0.05); the differ

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Multifunctional carbon materials from rugose rose for energy storage and water purification

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 1-13页

作者： Peng-Hui li Hui Zhou wen-Juan Wu jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China College of light Industry and Food Engineering Nanjing Forestry UniversityNanjing 210037China College of Chemical Engineering East China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering Shanghai 200237China

With the advancement of social process,the resource problem is becoming more prominent,biomass materials come into being,and it is becoming more and more important to explore and prepare efficient and multifunctional biomass materials to alleviate the problems of energy storage and water *** this paper,nitrogen-doped hierarchical porous carbon materials(NRRC)were produced by one-step carbonization of withered rose as raw material and melamine as nitrogen source with KOH-activated *** resulting nitrogen-doped porous carbon material had the most abundant pores and the best microspherical graded pore structure,with a specific surface area of up to 1393 m2·g^(-1),a pore volume of 0.68 cm3·g^(-1),and a nitrogen-doped content of 5.52%.Electrochemical tests showed that the maximum specific capacitance of NRRC in the three-electrode system was 346.4 F·g^(-1)(0.5 A·g^(-1)),which was combined with favorable capacitance retention performance and cycling *** NRRC//NRRC symmetric supercapacitors were further assembled,and the maximum energy density of a single device was 23.88 Wh·kg^(-1),which still maintains excellent capacitance retention and cyclic charging/discharging *** example,the capacitance retention rate was always close to 96.27%with almost negligible capacitance loss after 10000 consecutive charge/discharge cycles(current density:10 A·g^(-1)).Regardless of the three-electrode or two-electrode system,the super capacitive performance of NRRC porous carbon materials was comparable to the electrochemical performance of many reported biomass porous carbon materials,which showed better energy storage advantages and practical application *** addition,NRRC porous carbon materials had excellent water purification *** dye adsorption test confirmed that NRRC had a high adsorption capacity(491.47 mg·g^(-1))for methylene *** undoubtedly also showed a potential and promising avenue for high value-added utilization

关键词： rose carbon adsorption electrode material electrochemical performance

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MXenes/CNTs-based hybrids:Fabrications,mechanisms,and modification strategies for energy and environmental applications

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Nano Research 2024年第5期17卷 3429-3454页

作者： Jizhou jiang Fangyi li Lei Ding Chengxun Zhang Arramel Xin li School of Environmental Ecology and Biological Engineering School of Chemistry and Environmental EngineeringKey Laboratory of Green Chemical Engineering Process of Ministry of EducationEngineering Research Center of Phosphorus Resources Development and Utilization of Ministry of EducationNovel Catalytic Materials of Hubei Engineering Research CenterWuhan Institute of TechnologyWuhan 430205China Nano Center Indonesia Jl.PUSPIPTEK Tangerang SelatanBanten 15314Indonesia Institute of Biomass Engineering Key Laboratory of Energy Plants Resource and UtilizationMinistry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou 510642China

Emerging two-dimensional(2D)layered metal carbide and nitride materials,commonly termed MXenes,are increasingly recognized for their applications across diverse fields such as energy,environment,and *** the past few years,MXenes/carbon nanotubes(CNTs)-based hybrids have attracted extensive attention as an important catalyst in energy and environmental fields,due to their superior multifunctions and mechanical *** review aims to address the fabrication strategies,the identification of the enhancement mechanisms,and recent progress regarding the design and modification of MXenes/CNTs-based hybrids.A myriad of fabrication techniques have been systematically summarized,including mechanical mixing,spray drying,three-dimensional(3D)printing,self-assembly/in-situ growth,freeze drying,templating,hydrothermal methods,chemical vapor deposition(CVD),and ***,the identification of the enhancement mechanisms was thoroughly discussed from the two dimensions of theoretical simulations and in-situ ***,the recent advancements in profound applications of MXenes/CNTs-based hybrids have also been carefully revealed,including energy storage devices,sensors,water purification systems,and microwave *** also underscore anticipated challenges related to their fabrication,structure,underlying mechanisms,modification approaches,and emergent ***,this review offers insights into prospective directions and the future trajectory for these promising *** is expected that this review can inspire new ideas or provide new research methods for future studies.

关键词： MXenes/carbon nanotubes(CNTs)-based hybrids fabrication applications modification strategies

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Spatially Coupled Codes via Bidirectional Block Markov Superposition Transmission

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Tsinghua Science and Technology 2024年第3期29卷 656-670页

作者： Gaoyan li Shancheng Zhao Haiqiang Chen Jinming wen College of Information Science and Technology Jinan UniversityGuangzhou 510632China Guangxi Key Laboratory of Multimedia Communications and Network Technology Guangxi UniversityNanning 530004China

In this paper,we present a new class of spatially coupled codes obtained by using both non-recursive and recursive block-oriented *** resulting codes are termed as bidirectional block Markov superposition transmission(BiBMST)***,we perform an iterative decoding threshold analysis according to protograph-based extrinsic information transfer(PEXIT)charts for the BiBMST codes over the binary erasure channels(BECs).Secondly,we derive the generator and parity-check matrices of the BiBMST ***,extensive numerical results are presented to show the advantages of the proposed BiBMST ***,our numerical results show that,under the constraint of an equal decoding latency,the BiBMST codes perform better than the recursive BMST(rBMST)***,the simulation results show that,in finite-length regime,negligible performance gain is obtained by increasing the encoding *** solve this limitation by introducing partial superposition,and the resulting codes are termed as partially-connected BiBMST(PC-BiBMST)*** results have confirmed the advantages of the PC-BiBMST codes over the original BiBMST *** also present extensive simulation results to show the performance advantages of the PC-BiBMST codes over the spatially coupled low-density parity-check(SC-LDPC)codes,spatially coupled generalized LDPC(SC-GLDPC)codes,and the original BiBMST codes in the finite-length regime.

关键词： block Markov superposition transmission(BMST) protograph-based extrinsic information transfer(PEXIT) capacity-approaching codes spatial coupling

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DC Traction Power Supply System Based on Modular Multilevel Converter Suitable for Energy Feeding and De-icing

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 649-659页

作者： lingxi Hou Shuqing Zhang Yingdong Wei Xiaoqian li Qirong jiang Mingrui li Weirui li Department of Electrical Engineering Tsinghua UniversityBeijing 100084China

A novel DC traction power supply system suitable for energy feeding and de-icing is proposed in this paper for an urban rail transit catenary on the basis of the full bridge submodule (FBSM) modular multilevel converter (MMC). The FBSM-MMC is a novel type of voltage source converter (VSC) and can directly control the output DC voltage and conduct bipolar currents, thus flexibly controlling the power flow of the urban rail transit catenary. The proposed topology can overcome the inherent disadvantages of the output voltage drop in the diode rectifier units, increase the power supply distance and reduce the number of traction substations. The flexible DC technology can coordinate multiple FBSM-MMCs in a wide area and jointly complete the bidirectional control of catenary power flow during the operation of the electric locomotive, so as to realize the local consumption and optimal utilization of the recovered braking energy of the train. In addition, the FBSM-MMCs can also adjust the output current when the locomotive is out of service to prevent the catenary from icing in winter. The working modes of the proposed topology are illustrated in detail and the control strategy is specially designed for normal locomotive operations and catenary de-icing. Simulation cases conducted by PSCAD/EMTDC validate the proposed topology and its control strategy.

关键词： DC traction power supply system de-icing for catenary energy feeding modular multilevel converter based on full-bridge submodules(FBSM-MMC) urban rail transit

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STDNet: A Spatio-Temporal Decomposition Neural Network for Multivariate Time Series Forecasting

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Tsinghua Science and Technology 2024年第4期29卷 1232-1247页

作者： Zhuolun jiang Zefei Ning Hao Miao li Wang College of Computer Science and Technology(College of Data Science) Taiyuan University of TechnologyJinzhong 030600China

Long-term multivariate time series forecasting is an important task in engineering applications. It helps grasp the future development trend of data in real-time, which is of great significance for a wide variety of fields. Due to the non-linear and unstable characteristics of multivariate time series, the existing methods encounter difficulties in analyzing complex high-dimensional data and capturing latent relationships between multivariates in time series, thus affecting the performance of long-term prediction. In this paper, we propose a novel time series forecasting model based on multilayer perceptron that combines spatio-temporal decomposition and doubly residual stacking, namely Spatio-Temporal Decomposition Neural Network (STDNet). We decompose the originally complex and unstable time series into two parts, temporal term and spatial term. We design temporal module based on auto-correlation mechanism to discover temporal dependencies at the sub-series level, and spatial module based on convolutional neural network and self-attention mechanism to integrate multivariate information from two dimensions, global and local, respectively. Then we integrate the results obtained from the different modules to get the final forecast. Extensive experiments on four real-world datasets show that STDNet significantly outperforms other state-of-the-art methods, which provides an effective solution for long-term time series forecasting.

关键词： time series forecasting multivariate time series spatio-temporal decomposition

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Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

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Rare Metals 2024年第1期43卷 410-412页

作者： Chao-Yue Sun wen li Hai-Qing Wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

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