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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang li jia Xiu-Jun Zhan Charity Ngina Qing-Rui Zhang Xiao-Ge li Qi-Bao jiang Shi Bai Miao-Miao jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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Global trends and hotspots of type 2 diabetes in children and adolescents:A bibliometric study and visualization analysis

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World Journal of Diabetes 2025年第1期16卷 140-168页

作者： Fang-Shuo Zhang Hai-Jing li Xue Yu Yi-Ping Song Yan-Feng Ren Xuan-Zhu Qian jia-li liu Wen-Xun li Yi-Ran Huang Kuo Gao School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus(T2DM)among children and adolescents *** to rapid disease progression,severe long-term cardiorenal complications,a lack of effective treatment strategies,and substantial socioeconomic burdens,it has become an urgent public health issue that requires management and *** T2DM differs from adult *** a significant increase in our understanding of youth-onset T2DM over the past two decades,the related review and evidence-based content remain *** To visualize the hotspots and trends in pediatric and adolescent T2DM research and to forecast their future research *** This study utilized the terms“children”,“adolescents”,and“type 2 diabetes”,retrieving relevant articles published between 1983 and 2023 from three citation databases within the Web of Science Core Collection(SCI,SSCI,ESCI).Utilizing CiteSpace and VoSviewer software,we analyze and visually represent the annual output of literature,countries involved,and participating *** allows us to predict trends in this research *** analysis encompasses co-cited authors,journal overlays,citation overlays,time-zone views,keyword analysis,and reference analysis,*** A total of 9210 articles were included,and the annual publication volume in this field showed a steady growth *** United States had the highest number of publications and the highest *** United States also had the most research institutions and the strongest research *** global hot journals were primarily diabetes professional journals but also included journals related to nutrition,endocrinology,and *** analysis showed that research related to endothelial dysfunction,exposure risk,cardiac metabolic risk,changes in gut microbiota,the impact on comorbidities and outcomes,etc.,were emerging *** have maintained their popularity in this field,sugges

关键词： Child Adolescent Type 2 diabetes mellitus Bibliometrics Knowledge mapping Visualization CiteSpace VOSviewer

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Joint Bayesian and Greedy Recovery for Compressive Sensing

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Chinese Journal of Electronics 2020年第5期29卷 945-951页

作者： li jia China Electronics Technology Group Corporation 54th Research Institute Hebei Key Laboratory of Electromagnetic Spectrum Cognition and Control

Greedy algorithms are widely used for sparse recovery in compressive sensing. Conventional greedy algorithms employ the inner product vector of signal residual and sensing matrix to determine the support, which is based on the assumption that the indexes of the larger-magnitude entries of the inner product vector are more likely to be contained in the correct ***, this assumption may be not valid when the number of measurements is not sufficient, leading to the selection of an incorrect support. To improve the accuracy of greedy recovery, we propose a novel greedy algorithm to recover sparse signals from incomplete *** entries of a sparse signal are modelled by the type-II Laplacian prior, such that the k indexes of the correct support are indicated by the largest k variance hyperparameters of the entries. Based on the proposed model, the supports can be recovered by approximately estimating the hyperparameters via the maximum a posteriori process. Simulation results demonstrate that the proposed algorithm outperforms the conventional greedy algorithms in terms of recovery accuracy, and it exhibits satisfactory recovery speed.

关键词： Sparse recovery Compressive sensing Greedy algorithm Laplacian prior

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基于建构主义的“信息素养与检索实践”课程思政元素挖掘与实践

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大学图书情报学刊 2025年第1期43卷 79-85页

作者：袁帆李佳上海第二工业大学图书馆 201209 华东师范大学课程与教学研究所上海200062

文章基于建构主义理论探讨在“信息素养与检索实践”课程中如何融入思政元素,以期提升新时代高校学生信息素养及思想政治素养。通过案例教学与项目教学法挖掘课程思政元素,以能力和知识目标为抓手,构建思政元素融入信息素养教育的研究... 详细信息

文章基于建构主义理论探讨在“信息素养与检索实践”课程中如何融入思政元素,以期提升新时代高校学生信息素养及思想政治素养。通过案例教学与项目教学法挖掘课程思政元素,以能力和知识目标为抓手,构建思政元素融入信息素养教育的研究体系。研究表明,政治认同、家国情怀、科学精神及信息道德是培育课程思政的关键要素,是促进高校信息素养教学质量发展的核心指标。建立以创设问题情境、引导自主探究为主的课程思政实践机制,有助于增强独立思考与批判分析能力,提升学生的信息处理能力。研究为高校图书馆信息素养教育实现立德树人目标提供了教学策略和研究启示。

关键词：信息素养文献检索课程思政建构主义

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Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第01期 653-664页

作者： Rahul Navik Eryu Wang Xiao Ding Huang Yunyi Yiyu liu jia li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

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The Investigation on Flow Boiling Heat Transfer of R134a in Micro-channels

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Journal of Thermal Science 2015年第5期24卷 452-462页

作者： li Xuejiao jia li Institute of Thermal Engineering School of Mechanical Electronic and Control Engineering Beijing Jiaotong University Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale

The present study reports an experimental evaluation of heat transfer characteristic of R134a flow boiling in mi- cro-channel heat sink. The heat sink is composed of 30 parallel rectangular micro-channels with cross-sectional dimensions of 500μm width and depth, as well as total length 30ram. Experiments were conducted with heat flux up to 80.212 W/cm2, mass velocity ranging from 373.33 to 1244.44 kg/m2s, vapor quality ranging from 0.06 to 0.9. The wall temperature of heat sink heated could be controlled at around 50℃. Heat transfer coefficient could be up to 180 kW/mZK. Two dominating flow patterns were observed by analyzing boiling curves. The heat trans- fer characteristics of nucleate boiling and convective boiling were presented in the study. Revised correlations of R134a flow boiling in micro-channel heat sink were carded out with the consideration of nucleate boiling and convective boiling mechanisms.

关键词： flow boiling micro-channel R134a correlation IGBT

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Investigation on Combustion Characteristics and NO Formation of Methane with Swirling and Non-Swirling High Temperature Air

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Journal of Thermal Science 2014年第5期23卷 472-479页

作者： li Xing jia li Institute of Thermal Engineering School of MechanicalElectronic and Control EngineeringBeijing Jiaotong University

Combustion characteristics of methane jet flames in an industrial burner working in high temperature combustion regime were investigated experimentally and numerically to clarify the effects of swirling high temperature air on ***-Sarkar-Gatski(SSG) Reynolds stress model,Eddy-Dissipation Model(EDM),Discrete Ordinates Method(DTM) combined with Weighted-Sum-of-Grey Gases Model(WSGG) were employed for the numerical *** Thermal-NO and Prompt-NO mechanism were considered to evaluate the NO *** distribution,NO emissions by experiment and computation in swirling and non-swirling patterns show combustion characteristics of methane jet flames are totally ***-swirling high temperature air made high NO formation while significant NO prohibition were achieved by swirling high temperature ***,velocity fields,dimensionless major species mole fraction distributions and Thermal-NO molar reaction rate profiles by computation interpret an inner exhaust gas recirculation formed in the combustion zone in swirling case.

关键词： swirling non-swirling high temperature air combustion methane NO experiment numerical simulation

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An Experimental Investigation on Heat Transfer Performance of Nanofluid Pulsating Heat Pipe

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Journal of Thermal Science 2013年第5期22卷 484-490页

作者： Hongwei jia li jia Zetao Tan Institute of Thermal Energy Engineering School of Mechanical Electronic and Control EngineeringBeijing Jiaotong University jiangsu Key Laboratory of Process Enhancement & New Energy Equipment Technology Nanjing University of Technology

The effect of SiO2 particles on heat transfer performance of a pulsating heat pipe （PHP） was investigated experi- mentally. DI water was used as the base fluid and contrast medium for the PHP. In order to study and measure the character, there are SiO2/H20 nanofluids with different concentration and applying with various heating powers during the experiment investigation. According to the experimental result, the high fraction of SiO2/H20 will de- teriorate the performance of PHP compared with DI water, i.e. the thermal resistance and the temperature of evaporation section increases. It is in contrary in the case of low fraction of SiO2/H20. Finally, the comparison of the thermal performances between the normal operation system and the static settlement system is given. It is found that both the thermal resistance of nanofluid PHP and the temperature of the evaporation section increase after standing for a period, and it is the same trend for the temperature fluctuation at the identical heating power for PHP.

关键词： Nanofluid Pulsating heat pipe Heat transfer characteristics Suspension characteristics

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The Module-Phase Synchronization of Complex-Valued Neural Networks with Time-Varying Delay and Stochastic Perturbations

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Journal of Systems Science & Complexity 2021年第6期34卷 2139-2154页

作者： NIAN Fuzhong li jia School of Computer Sz Communication Lanzhou University of TechnologyLanzhou 730050China

The problem of exponential module-phase synchronization of complex-valued neural networks(CVNNs)with time-varying delay and stochastic perturbations was *** model of CVNNs with time-varying delay and stochastic perturbations was *** error system was deduced and the module-phase synchronization was *** on the principle of Lyapunov stability theory,the appropriate controller was designed to control the ***,the effectiveness and reliability of the method were verified by the numerical simulations.

关键词： Complex-valued neural networks exponential module-phase synchronization Lyapunov function time-varying delay

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The Experimental Study on Regenerative Heat Transfer in High Temperature Air Combustion

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Journal of Thermal Science 2004年第4期13卷 366-370页

作者： li jia jianshu li Department of Power Engineering School of MechanicalElectronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Beijing Institute of Civil Engineering&Architecture Beijing 100044China

For the purpose of decomposing the processing gases CF4 from semiconductor manufacturers, ceramic honeycomb regenerative burner system is suggested by using the principle of HTAC. A simulated high temperature air combustion furnace has been used to determine the features of HTAC flames and the results of the decomposition of CF4. The preheat air temperature of it is above 900℃. The exhaust gas released into the atmosphere is lower than 150℃. Moreover, the efficiency of recovery of waste heat is higher than 80%, the NOx level in exhaust gas is less than 198 mg/m3 and the distribution of temperature in the furnace is nearly uniform. The factors influencing on heat transfer, temperature profile in chamber and NOX emission were discussed. Also some CF4 can be decomposed in this system.

关键词： generator heat transfer high temperature air combustion NOX emission.

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