检索结果-南通市图书馆

Food Science and Human Wellness 2024年

作者： huizhen li Yang Chen Huiting Fang Xinmei Guo Xuecong liu Jianxin Zhao Wei Chen Bo Yang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University Jinqiao Biotechnology Co.， Ltd. Huai'an， Jiangsu， China National Engineering Research Center for Functional Food， Jiangnan University International Joint Research Center for Probiotics & Gut Health， Jiangnan University

Ulcerative colitis (UC) is a long-term inflammatory disorder that has evolved into a worldwide challenge. The development of new therapies against UC is imperative as all current therapies for UC are flawed in some way. Thus， the present study aimed to assess the palliative effects of Lactobacillus rhamnosus MP108 on UC in mice and to explore its potential mechanisms. The results showed that L. rhamnosus MP108 ameliorated the symptoms of UC， including preventing body weight loss， DAI elevation， and colon shortening， and attenuated colonic pathological damage. L. rhamnosus MP108 dramatically increased the number of goblet cells， MUC2 level， and tight junction protein level in the colon and remarkably inhibited epithelial cell apoptosis， thereby strengthening the intestinal barrier. L. rhamnosus MP108 pronouncedly diminished pro-inflammatory cytokine levels and strikingly augmented anti-inflammatory cytokine levels， in turn suppressing inflammation. Furthermore， L. rhamnosus MP108 conspicuously boosted the proportion of short-chain fatty acids (SCFAs) producers in gut microbiota， contributing to increased levels of acetate and butyrate. Therefore， L. rhamnosus MP108 might alleviate UC via improving the intestinal barrier， inhibiting inflammation， and modulating intestinal microbiota.

关键词：

Lactobacillus acidophilus and Bifidobacterium breve alleviate neonatal maternal separation induced visceral hypersensitivity and non-spatial memory impairment in rats by the NGF/TrkA pathway

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Chi Chen Bowen li Mengfan Ding huizhen li Jianxin Zhao R.Paul Ross Catherine Stanton Wei Chen Bo Yang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University International Joint Research Center for Probiotics & Gut Health， Jiangnan University APC Microbiome Ireland， University College Cork Teagasc Food Research Centre， Moorepark National Engineering Research Center for Functional Food， Jiangnan University

Irritable bowel syndrome-diarrhea （IBS-D） is a prevalent functional bowel disease severely impairs the quality of life of patients. Visceral hypersensitivity （VH） is the main symptom of IBS-D. Probiotics have been found to effectively alleviate VH. In this study， neonatal maternal separation （NMS） was used to induce VH in 72 rats and investigated the effects of daily gavage of 3*109CFU of Lactobacillus and Bifidobacterium on alleviating the symptoms of IBS-D and behavioral interventions， as well as exploring potential mechanisms. The results demonstrated that Lactobacillus acidophilus and Bifidobacterium breve could alleviate the symptoms of IBS-D such as VH and increased frequency of bowel movements， as well as improving non-spatial memory in NMS rats. These effects were achieved by modulating the composition of gut microbiota and metabolites （including short-chain fatty acids， deoxycholic acid and adenosine）， and by regulating the expression of genes and proteins associated with the NGF/TrkA signaling pathway， tryptophan metabolism， and inflammatory factors in the hippocampus. This finding suggests that Lactobacillus acidophilus and Bifidobacterium breve have promising potential for the alleviation of IBS.

关键词：

幼年特发性关节炎相关葡萄膜炎临床实践相关指南解读

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华实用儿科临床杂志 2024年第8期39卷 576-578页

作者：曹兰芳李会珍上海交通大学医学院附属仁济医院儿科上海200001

幼年特发性关节炎相关葡萄膜炎(JIA-U)是幼年特发性关节炎重要的关节外并发症,可造成眼红、眼痛、畏光、眼前黑影飘动或视力下降等症状,严重者可引起失明,对儿童及其家庭造成巨大伤害。美国风湿病学会、儿童葡萄膜炎跨学科工作组、欧洲... 详细信息

幼年特发性关节炎相关葡萄膜炎(JIA-U)是幼年特发性关节炎重要的关节外并发症,可造成眼红、眼痛、畏光、眼前黑影飘动或视力下降等症状,严重者可引起失明,对儿童及其家庭造成巨大伤害。美国风湿病学会、儿童葡萄膜炎跨学科工作组、欧洲儿科风湿病学会、加拿大风湿病协会针对这一疾病发布了相关的临床指南及专家共识。现重点针对上述临床指南及专家共识涉及对该疾病的诊断、治疗及长期管理进行解读,以期提高临床诊治JIA-U的效能和管理质量。

关键词：幼年特发性关节炎葡萄膜炎指南解读

带二阶位势四阶Schrödinger算子的反散射问题

在线全文

学校读者我要写书评

暂无评论

应用数学 2024年第4期37卷 971-981页

作者：黄华李会珍武汉学院信息工程学院湖北武汉430212 武汉纺织大学数理科学学院湖北武汉430200 武汉纺织大学应用数学与交叉科学研究中心湖北武汉430200

本文研究带二阶位势的四阶Schrödinger算子的反散射问题,利用复几何光学解构造的方法,证明四阶Schrödinger算子的散射矩阵可以唯一确定二阶位势、一阶位势和零阶位势,将四阶Schrödinger算子反散射问题的结果从带一阶位势推广到了带二阶... 详细信息

本文研究带二阶位势的四阶Schrödinger算子的反散射问题,利用复几何光学解构造的方法,证明四阶Schrödinger算子的散射矩阵可以唯一确定二阶位势、一阶位势和零阶位势,将四阶Schrödinger算子反散射问题的结果从带一阶位势推广到了带二阶位势.

关键词：四阶Schrödinger算子反散射问题二阶位势复几何光学解

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

智慧教学背景下英语口语教学改革探究

科教导刊 2024年第12期 59-61页

作者：李会真郑州西亚斯学院河南郑州451100

随着人工智能的发展,教育也发生了巨大变革,构建智慧化教育体系成为教学改革的方向。目前我国仍需要熟练使用外语进行谈判和沟通的国际化人才,而提升大学生英语口语水平将有助于国际化人才的培养。文章基于智慧教学背景,从教学目标、教... 详细信息

随着人工智能的发展,教育也发生了巨大变革,构建智慧化教育体系成为教学改革的方向。目前我国仍需要熟练使用外语进行谈判和沟通的国际化人才,而提升大学生英语口语水平将有助于国际化人才的培养。文章基于智慧教学背景,从教学目标、教学内容、学生自主学习能力的培养、评价标准和评价方式等方面探讨了在英语口语教学中如何使用FiF智慧教学平台,助力学生英语口语水平的提升。

关键词：智慧教学 FiF智慧教学平台英语口语教学改革

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

儿童反应性关节炎的诊治进展

中华实用儿科临床杂志 2024年第6期39卷 469-472页

作者：李会珍徐金苹曹兰芳上海交通大学医学院附属仁济医院儿科上海200001

反应性关节炎(ReA)泛指远离关节部位的微生物感染后发生的无菌性、非化脓性关节炎。本病的疾病谱很广,依据临床发病特点,可分为人类白细胞抗原B27(HLA-B27)相关性ReA、急性风湿热(ARF)、链球菌感染后反应性关节炎(PSRA)三类。除关节炎外... 详细信息

反应性关节炎(ReA)泛指远离关节部位的微生物感染后发生的无菌性、非化脓性关节炎。本病的疾病谱很广,依据临床发病特点,可分为人类白细胞抗原B27(HLA-B27)相关性ReA、急性风湿热(ARF)、链球菌感染后反应性关节炎(PSRA)三类。除关节炎外,可伴有胃肠道、皮肤、眼、心脏病变等关节外表现。与成人不同,儿童ReA的发病过程更加复杂。HLA-B27相关性ReA更多见于胃肠道及呼吸系统感染后发生,中轴和骶髂关节累及少见,髋关节及外周关节受累和附着点炎更为常见。ARF最常见于5~15岁的儿童及青少年,以游走性、多发性关节炎为主要特点。儿童PSRA的发病持续时间较成人短,现就儿童ReA的流行病学特点、临床表现、诊治进展及预后进行综述,以提高临床医师对儿童ReA的认识。

关键词：儿童反应性关节炎诊断治疗

基于体外实验和网络药理学探讨紫苏粕多肽抗氧化应激的作用机制

在线全文

学校读者我要写书评

暂无评论

食品与发酵工业 2024年第10期50卷 149-159页

作者：张红玉李会珍张志军赵亚娜侯天宇李河陈林中北大学化学与化工学院山西太原030051 中北大学晋中产业技术创新研究院山西晋中030600

利用体外实验和网络药理学的方法对紫苏粕多肽抗氧化应激的物质基础和作用机制进行研究。首先对紫苏粕碱性蛋白酶酶解液进行超滤分级,以得率和抗氧化活性为指标,筛选出级分UF-4(<1 kDa),考察其对H_(2)O_(2)诱导的4T1细胞氧化应激模型的... 详细信息

利用体外实验和网络药理学的方法对紫苏粕多肽抗氧化应激的物质基础和作用机制进行研究。首先对紫苏粕碱性蛋白酶酶解液进行超滤分级,以得率和抗氧化活性为指标,筛选出级分UF-4(<1 kDa),考察其对H_(2)O_(2)诱导的4T1细胞氧化应激模型的保护作用,发现UF-4可剂量性显著降低胞外乳酸脱氢酶活性和胞内丙二醛含量,显著提高胞内谷胱甘肽的含量及超氧化物歧化酶、过氧化氢酶活性,说明UF-4具有一定的抗氧化作用。在此基础上,运用网络药理学的方法,从UF-4中筛选出潜在活性物质18种,其对应靶点中与抗氧化作用相关的有176个,通过蛋白互作分析得到6个核心靶点,GO和KEGG富集分析表明UF-4通过多靶点、多途径的方式发挥抗氧化应激作用,主要涉及细胞凋亡、脂质与动脉粥样硬化、钙调节、炎症等生物学过程。分子对接进一步验证了18种潜在活性成分与核心靶点间存在较强的相互作用。总之,该研究初步表明UF-4抗氧化应激过程中多组分、多靶点、多通路的作用特点,为后期紫苏粕多肽抗氧化作用的研究与应用提供理论依据及参考。

关键词：紫苏粕多肽氧化应激网络药理学作用机制分子对接

Influence of dissolved organic carbon on multimedia distribution and toxicity of fipronil and its transformation products in lotic waterways

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2023年第8期130卷 52-64页

作者： Weizong li Hao Hu Fen liu huizhen li Jing You School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health Jinan UniversityGuangzhou 511443China

Environmental fate and ecological impacts of fipronil and its transformation products(FIPs)in aquatic environment have caused worldwide attention,however,the influence of dissolved organic carbon(DOC)on multimedia distribution,bioavailability,and toxicity of FIPs in field waterways was largely ***,we collected 11 companion water and sediment samples along a lotic stream in Guangzhou,South *** were ubiquitous with total water concentrations ranging from 1.22 to 43.2 ng/L(14.8±12.9 ng/L)and fipronil sulfone was predominant in both water and *** than 70%of FIPs in aqueous phase were bound to DOC and the KDOC values of FIPs were approximately 1–2 orders of magnitude higher than K_(d-s)/K_(OC),emphasizing the significance of DOC in phase partitioning and transport of FIPs in aquatic *** and sediment samples were more toxic to Chironomus dilutus than Hyallela azteca,and FIPs(especially fipronil sulfone)pronouncedly contributed toxicity to *** units(TU)based on freely dissolved concentrations in water determined by solid phase microextraction significantly improved toxicity estimation of FIPs to the invertebrates compared to TUs based on aqueous *** present study highlights the significance of DOC association on fate and ecological risk of hydrophobic insecticides in lotic ecosystem.

关键词： Hydrophobic organic contaminant Bioavailability Partitioning Aquatic toxicity Passive sampler

在线全文

学校读者我要写书评

暂无评论

紫苏籽壳提取物纳米银颗粒的制备及性能表征

食品工业科技 2024年第6期45卷 49-58页

作者：韩婉毓李会珍张志军郭誉嵘张红玉王丹中北大学化学与化工学院山西太原030051 中北大学晋中产业技术创新研究院山西晋中030600

为进一步提高紫苏资源的利用价值,本研究以紫苏籽壳提取物(PSHE)为原料,通过单因素实验,分别考察硝酸银浓度、提取液浓度、超声波功率、超声温度和超声时间对紫苏籽壳提取物纳米银(PSHE@AgNPs)银离子还原率的影响,并在单因素实验基础上... 详细信息

为进一步提高紫苏资源的利用价值,本研究以紫苏籽壳提取物(PSHE)为原料,通过单因素实验,分别考察硝酸银浓度、提取液浓度、超声波功率、超声温度和超声时间对紫苏籽壳提取物纳米银(PSHE@AgNPs)银离子还原率的影响,并在单因素实验基础上,采用响应面法对超声波辅助制备PSHE@AgNPs的工艺进行优化,并采用X射线衍射、傅里叶变换红外光谱、热重分析及透射电子显微镜对PSHE@AgNPs的结构及性能进行表征。结果表明,PSHE@AgNPs制备最佳工艺为:硝酸银浓度15 mmol/L,提取液浓度0.4 g/mL,超声波功率480 W,超声温度80℃,超声时间7 h,在此工艺条件下制备的PSHE@AgNPs银离子还原率达92.37%。X射线衍射分析表明PSHE@AgNPs具有面心立方结构;傅里叶变换红外光谱表明PSHE@AgNPs表面存在植物化学物质,酚类化合物参与纳米银的合成;热重分析显示了PSHE@AgNPs的热稳定性,在276.7~420.3℃范围内存在主要的质量损失,质量减少46.74%;透射电子显微镜显示PSHE@AgNPs是粒径均值为27.97 nm的近球形分散颗粒。研究结果可为超声波辅助绿色合成粒径小、分散性高、具有热稳定性的面心立方结构的PSHE@AgNPs提供理论指导,并推动其在生物材料和医学领域的应用。

关键词：紫苏籽壳纳米银颗粒生物还原法结构性能

Quantum-inspired ant algorithm for knapsack problems

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2009年第5期20卷 1012-1016页

作者： Wang Honggang Ma liang Zhang huizhen li Gaoya Business School Univ. of Shanghai for Science and Technology Shanghai 200093 P. R. China

The knapsack problem is a well-known combinatorial optimization problem which has been proved to be NP-hard. This paper proposes a new algorithm called quantum-inspired ant algorithm （QAA） to solve the knapsack problem. QAA takes the advantage of the principles in quantum computing, such as qubit, quantum gate, and quantum superposition of states, to get more probabilistic-based status with small colonies. By updating the pheromone in the ant algorithm and rotating the quantum gate, the algorithm can finally reach the optimal solution. The detailed steps to use QAA are presented, and by solving series of test cases of classical knapsack problems, the effectiveness and generality of the new algorithm are validated.

关键词： knapsack problem, quantum computing ant algorithm, quantum-inspired ant algorithm.