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Association between big endothelin-1 and CHADS2/CHA2DS2-VASc scores in non-valvular atrial fibrillation

Journal of Geriatric Cardiology 2019年第11期16卷 812-817页

作者： li-hui zheng Shang-Yu liU Feng HU Er-Peng liANG ling-Min WU Hong-Lei WANG Ammar M Killu Yan YAO Clinical EP Lab&Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangChina Department of Cardiovascular Medicine Mayo ClinicRochesterMNUSA

Background Endothelial function,as measured by big endothelin-1(ET-1),has been demonstrated to be useful in predicting adverse long-term events in patients with cardiovascular ***,there are little data about the association between big ET-1 and thromboembolism risk in atrial fibrillation(AF).We aimed to investigate the relationship between big ET-1 and CHADS2/CHA2DS2-VASc scores used for evaluating thromboembolic risk in patients with non-valvular *** The study population consisted of 238 consecutive AF patients(67.6%with paroxysmal AF and 32.4%with persistent AF).The patients were divided into two groups(high-or low-intermediate risk group)based on CHADS2 and CHA2 DS2-VASc scores(score≥2 orlinical,laboratory,and echocardiographic parameters were evaluated,and the CHADS2/CHA2DS2-VASc scores were compared between *** association between big ET-1 levels and CHADS2/CHA2DS2-VASc score was *** logistic regression analysis was performed to identify independent predictors of CHADS2/CHA2DS2-VASc *** The high CHADS2/CHA2DS2-VASc score group had older age,higher big ET-1 levels,and enlarged left atrial diameter than the low CHADS2/CHA2DS2-VASc score group(P<0.05).Multiple logistic regression analysis revealed that big ET-1 level was an independent determinant of high CHADS2/CHA2DS2-VASc scores[odds ratio(OR)=2.545 and OR=3.816;both P<0.05].Conclusions Our study indicates that in non-valvular AF,big ET-1 was significantly correlated with CHADS2/CHA2DS2-VASc scores and an independent predictor of high CHADS2/CHA2DS2-VASc *** ET-1 may serve as a useful marker for risk stratification in this setting.

关键词： Atrial fibrillation Cardiac risk factors Prevention Stroke

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THE PREPARATION OF 5-HYDROXYMETHYLFURFURALDEHYDE FROM FRUCTOSE OR SUCROSE CATALYZED BY ZrCl_4

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Chinese Chemical Letters 1993年第6期4卷 495-496页

作者： Biao YU Chuan li Yong zheng hui Shanghai Institute of Organic Chemistry,Shanghai,300032

5-Hydroxymethylfurfuraldehyde(HMF)was prepared from fructose or sucrose in high yield by using ZrCl_4 or Cp_2ZrCl_2 as the catalyst under mild conditions.

关键词： HMF THE PREPARATION OF 5-HYDROXYMETHYLFURFURALDEHYDE FROM FRUCTOSE OR SUCROSE CATALYZED BY ZrCl4

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A new menthane-type monoterpene from Pleurotus eryngii

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中国天然药物 2013年第1期11卷 71-73页

作者： liU liang-Yan li zheng-hui liU Ji-Kai State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of SciencesKunming 650201 China Graduate University of Chinese Academy of Sciences Beifing 100049 China

新menthane类型 monoterpene ， pleurolactone ( 1 )，从真菌 Pleurotus eryngii 的文化肉汤被孤立，与五已知的混合物一起 1 ， 2-dihydroxymintlactone ( 2 )，( 22E ， 24R )-ergosta-5, 7 ， 22-trien-3-ol ( 3 )，( 22E ， 24R )-ergosta-7, 22-dien-3 ， 5 ， 6-triol ( 4 )，( 22E ， 24R )-ergosta-7, 22-dien-3-ol ( 5 )，和 cerebroside B ( 6 )。他们的结构被广泛的分光镜的分析识别。

关键词：杏鲍菇薄荷烷型单萜侧耳内酯

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Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

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Relationships of High-sensitive C-reactive Protein ant P-wave Dispersion in Lone Atrial Fibrillation

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Chinese Medical Journal 2015年第11期128卷 1450-1454页

作者： li-hui zheng Yan Yao ling-Min Wu Kui-Jun Zhang Shu Zhang State Key Laboratory of Cardiovascular Disease Clinical EP Laboratory and Arrhythmia Center Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： Current evidence links atrial fibrillation （AF） to the inflammation. Inflammatory indexes such as high-sensitive C-reactive protein （hs-CRP） have been related to the development and persistence of AF. However, the role of inflammation in the atrial electrophysiological remodeling indexed by P-wave dispersion （Pa） remains unclear. Methods： The study consisted of 71 patients with lone paroxysmal AF （AF group） and 71 age- and gender-matched controls of paroxysmal supraventricular tachycardia without history of AF （control group）. Electrocardiography, P hs-CRP, and other clinical characteristics were compared between the two groups. Results： There was no significant difference between the two groups regarding age, gender, hyperlipidemia, etc. Compared to controls, left atrial diameter （44 ± 7 vs 39 ± 7 mm）, Pd （49 ± 13 vs 26 ± 8 ms）, and hs-CRP （2.17 [1.46-2.89] vs 1.12 [0.74-1.41] rag/L） were increased （P 〈 0.05）, respectively. linear regression identified hs-CRP as an independent correlation ofPd level both in the total population and the AF group （r = 0.464 and 0.313; P 〈 0.001, respectively）. Multiple logistic regression revealed hs-C RP as an independent determinant of AF （odds ratio [OR] =l 5.430, 95% confidence interval： 6.031-39.476： P 〈0.001）. Further adjusted tbr Pd, both Pd and hs-CRP were independent predictors for AF, but the OR for hs-CRP in predicting AF has been attenuated from 15.430 to 6.246. Conclusions： In lone AF, P and plasma hs-CRP concentration are inter-associated and related to AF. The interaction between hs-CRP and AF may be mediated by Pe, suggesting an important role of inflammation in the atrial electrophysiological remodeling predisposing to AF.

关键词： Atrial Fibrillation High-sensitive C-reactive Protein Inflammation P-wave Dispersion

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Associations of big endothelin-1 and C-reactive protein in atrial fibrillation

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Journal of Geriatric Cardiology 2016年第5期13卷 465-470页

作者： li-hui zheng Wei SUN Yan YAO Bing-Bo HOU Yu QIAO Shu ZHANG State Key Laboratory of Cardiovascular Disease Clinical EP Lab & Arrhythmia Center Fuwai Hospital Beijing China

Background Atrial fibrillation （AF） is associated with inflammation and endothelial dysfunction. However, the association between inflammation （as indexed by high-sensitivity C-reactive protein, hs-CRP） and endothelial function [as indexed by big endothelin-1 （ET-1）] in AF patients remains unclear. Methods We enrolled 128 patients with lone AF, among which 83 had paroxysmal AF, and 45 had persistent AF. Eighty-two age- and gender-matched controls of paroxysmal supraventricular tachycardia without AF history were evaluated. Plasma hs-CRP, big ET-1 levels and other clinical characteristics were compared among the groups. Results Patients with persistent AF had higher hs-CRP concentrations than those with paroxysmal AF （P 〈 0.05）, both groups had higher hs-CRP level than controls （P 〈 0.05）. Patients with persistent AF had higher big ET-1 level than those with paroxysmal AF, although the difference did not reach the statistical significance （P 〉 0.05）, and both groups had higher big ET-1 levels than controls （P 〈 0.05）. Multiple regression analyses revealed hs-CRP as an inde- pendent determinant of AF （P 〈 0.001）. Further adjusted for big ET-1, both big ET-1 and hs-CRP were independent predictors for AF （P 〈 0.001）, but the odds ratio for hs-CRP in predicting AF attenuated from 8.043 to 3.241. There was a positive relation between hs-CRP level and big ET-1 level in paroxysmal AF patients （r = 0.563, P 〈 0.05）, however, the relationship in persistent AF patients was poor （r = 0.094, P 〈 0.05）. Conclusions Both plasma hs-CRP and big ET-1 levels are elevated in lone AF patients, and are associated with AF. In paroxysmal lone AF patients, there were significant positive correlations between plasma hs-CRP level and big ET- 1 level.

关键词： Atrial fibrillation C-reactive protein Endothelin Inflammation

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0Optimized Fluoroscopy Setting and Appropriate Project Position Can Reduce X-ray Radiation Doses Rates during Electrophysiology Procedures

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Chinese Medical Journal 2015年第9期128卷 1151-1153页

作者： Bing-Bo Hou Yan Yao ling-Min Wu Yu Qiao li-hui zheng li-Gang Ding Gang Chen State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background：Nonfluoroscopic three-dimensional electroanatomical system is widely used nowadays,but X-ray remains indispensable for complex electrophysiology *** study aimed to evaluate the value of optimized parameter setting and different projection position to reduce X-ray radiation dose ***：From June 2013 to October 2013,105 consecutive patients who underwent complex ablation were enrolled in the *** the ablation,the radiation dose rates were measured by two different settings （default setting and optimized setting） with three projection positions （posteroanterior [PA] projection;left anterior oblique [LAO] 30° projection;and LAO 45° projection）.The parameter of preset voltage,pulse width,critical voltage,peak voltage,noise reduction,edge enhancement,pulse rate,and dose per frame was modified in the optimized ***：The optimized setting reduced radiation dose rates by 87.5％（1.7 Gy/min vs.13.6 Gy/min,P ＜ 0.001） in PA,87.3％（2.5 Gy/min vs.19.7 Gy/min,P＜0.001） in LAO 30°,85.9％（3.1 Gy/min vs.22.1 Gy/min,P ＜ 0.001） in LAO 45°.Increase the angle of projection position will increase the radiation dose ***：We can reduce X-ray radiation dose rates by adjusting the parameter setting of X-ray *** oblique projection of large angle is another way to reduce X-ray radiation dose rates.

关键词： Ablation Fluoroscopy Projection Position Radiation Dose

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Effects of α-adrenoreceptor antagonists on apoptosis and proliferation of pancreatic cancer cells in vitro

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World Journal of Gastroenterology 2008年第15期14卷 2358-2363页

作者： Su-Gang Shen Dong Zhang Heng-Tong Hu Jun-hui li zheng Wang Qing-Yong Ma Department of Hepatobiliary and Pancreas Surgery The First Affiliated Hospital Medical College Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM: To discuss the expression of α-adrenoreceptors in pancreatic cancer cell lines PC-2 and PC-3 and the effects of α1- and α2-adrenoreceptor antagonists, yohimbine and urapidil hydrochloride, on the cell lines in vitro. METHODS: We cultured the human ductal pancreatic adenocarcinoma cell lines PC-2 and PC-3 and analyzed the mRNA expression of α1- and α2-adrenergic receptors by reverse transcription polymerase chain reaction (RT-PCR). The effects of yohimbine and urapidil hydrochloride on cell proliferation were assessed by 3-(4,5-dimethylthiasol-2-yl)- 2,4,-diphenyltetrazolium bromide (MTT) assay. Apoptosis was detected using the terminal deoxyribonucleotidyl transferase (TdT)-mediated biotin-16-dUTP nick-end labeling (TUNEL) assay and flow cytometry (FCM). RESULTS: PC-2 expressed mRNA in α1- and α2- adrenoreceptors. MTT assays showed that urapidil hydrochloride had no effect on PC-3 cell lines. However, exposure to urapidil hydrochloride increased DNA synthesis in PC-2 cell lines as compared to the control group. PC-2 cell lines were sensitive to both drugs. The proliferation of the 2 cell lines was inhibited by yohimbine. Cell proliferation was inhibited by yohimbine via apoptosis induction. CONCLUSION: The expression of α1- and α2- adrenoreceptors is different in PC-2 and PC-3 cell lines, which might be indicative of their different functions. The α2-adrenoceptor antagonist, yohimbine, can inhibit theproliferation of both cell lines and induce their apoptosis, suggesting that yohimbine can be used as an anticancer drug for apoptosis of PC-2 and PC-3 cells.

关键词： Alpha-adrenoreceptor Pancreatic cancer Yohimbine Urapidil hydrochloride

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Factors influencing adherence to non-vitamin K antagonist oral anticoagulants in the early period after atrial fibrillation catheter ablation in China

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Chinese Medical Journal 2020年第16期133卷 1989-1991页

作者： Zhi-Cheng Hu Shang-Yu liu ling-Min Wu li-Shui Shen li-Min liu Guo-liang li li-hui zheng Yan Yao Cardiac Arrhythmia Center Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China

Anticoagulants are routinely prescribed in the first several weeks after atrial fibrillation(AF)catheter *** K antagonist oral anticoagulants(NOACs)have been recommended over warfarin for their *** warfarin need regular clinical visit to perform blood test,NOACs are more patient *** the lack of routine medical contact may lead to poor *** adherence to anticoagulant treatment is essential for both efficacy and *** NOACs are increasingly commonly used in China,it is therefore necessary to evaluate the adherence of NOACs after AF catheter *** purpose of this research was to investigate the treatment adherence and identify factors that could improve the quality of anticoagulation.

关键词： vitamin routine fibrillation

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Fast rate （≥ 250 beats/min） right ventricular burst stimulation is useful for ventricular tachycardia induction in arrhythmogenic right ventricular cardiomyopathy

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Journal of Geriatric Cardiology 2016年第1期13卷 70-74页

作者： ling-Min WU Jing-Ru BAO Yan YAO Bing-Bo HOU li-hui zheng Shu ZHANG State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Cardiovascular Center PLA Navy General Hospital Beijing China

Background One of the major challenges in arrhythmogenic right ventricular cardiomyopathy （ARVC） ablation is ventricular tachy-cardia （VT） non-inducibility. The study aimed to assess whether fast rate （≥ 250 beats/min） right ventricular burst stimulation was useful for VT induction in patients with *** Ninety-one consecutive ARVC patients with clinical sustained VT that underwent electro-physiological study were enrolled. The stimulation protocol was implemented at both right ventricular apex and outflow tract as follows： Step A, up to double extra-stimuli; Step B, incremental stimulation with low rate （＆lt; 250 beats/min）; Step C, burst stimulation with fast rate （≥ 250 beats/min）; Step D, repeated all steps above with intravenous infusion of *** A total of 76 patients had inducible VT （83.5%）, among which 49 were induced by Step C, 15 were induced by Step B, 8 and 4 by Step A and D, respectively. Clinical VTs were induced in 60 patients （65.9%）. Only two spontaneously ceased ventricular fibrillations were induced by Step C. Multivariate analysis showed that a narrower baseline QRS duration under sinus rhythm was independently associated with VT non-inducibility （OR： 1.1; 95% CI： 1.0-1.1;P = 0.019）.ConclusionFast rate （≥ 250 beats/min） right ventricular burst stimulation provides a useful supplemental method for VT induction in ARVC patients.

关键词： Burst stimulation Cardiomyopathy Right ventricular Ventricular tachycardia

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