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Crystal Structure and Thermal Property of 4-(3-Chlorophenyl)-3-isopropyl-1-methyl-3,4-dihydroquinolin-2(1H)-one

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Chinese Journal of Structural Chemistry 2020年第5期39卷 913-917页

作者： li hui-juan LUO Zai-Gang WANG Xiu-Xiu Department of Pharmaceutical Engineering Bengbu Medical CollegeBengbu 233030China College of Chemical Engineering Anhui University of Science and TechnologyHuainan 232001China

The target compound(C19H20ClNO)was structurally determined by single-crystal X-ray *** crystal is in monoclinic system,space group P21/n with a=9.2365(2),b=12.1241(3),c=14.9960(4)?,β=106.589(3)°,C19H20ClNO,Mr=313.81,Dc=1.295 g/cm^3,V=1609.42(7)?3,Z=4,F(000)=664,μ(MoKa)=2.097 mm-1,T=200(10)K,2813 independent reflections with 2533 observed ones(I>2σ(I)),R=0.0389 and wR=0.1057 with GOF=1.043(R=0.0423 and wR=0.1083 for all data).The 3,4-dihydroquinolin-2(1 H)-one moiety maintains thermodynamically stable trans *** decomposition mechanism of compound 3 is complex by thermal analysis.

关键词： 3 4-dihydroquinolin-2(1H)-one crystal structure thermal property

“活血散风,调和肝脾”针刺法对高血压合并腹泻型肠易激综合征症状改善的临床观察

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中华中医药杂志 2022年第11期37卷 6859-6863页

作者：李会娟高鹤申鹏飞天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津300111 天津中医药大学第二附属医院天津300150

目的:观察“活血散风,调和肝脾”针刺法对于高血压合并腹泻型肠易激综合征(IBS)患者血压、症状严重程度、临床疗效、生活质量的影响。方法:将68例高血压合并腹泻型IBS患者随机分为观察组34例,采用“活血散风,调和肝脾”针刺法治疗,每日1... 详细信息

目的:观察“活血散风,调和肝脾”针刺法对于高血压合并腹泻型肠易激综合征(IBS)患者血压、症状严重程度、临床疗效、生活质量的影响。方法:将68例高血压合并腹泻型IBS患者随机分为观察组34例,采用“活血散风,调和肝脾”针刺法治疗,每日1次,每周5次,共治疗8周;对照组34例,采用药物治疗,观察两组患者治疗前和治疗后4、8周白天、夜间及24 h血压、症状严重度评分(IBS-SSS)、临床疗效改善、生活质量量表疗效评价(IBS-QOL)变化。结果:治疗4、8周后,两组患者白天、夜间及24 h平均收缩压、舒张压均较治疗前显著降低(P<0.05),治疗8周时观察组较对照组血压下降更为显著(P<0.05)。治疗4周后,观察组患者腹痛程度、频率、腹胀程度、排便满意度、生活干扰度及总积分均较治疗前显著改善(P<0.05),对照组患者除腹胀程度外,其余较治疗前均显著改善(P<0.05),治疗8周时观察组较治疗组在腹痛程度、腹痛频率、排便满意度、总积分和腹胀程度、生活干扰度改善方面效果更显著(P<0.05);观察组总有效率(85.29%,29/34)显著高于对照组(61.76%,21/34)(P<0.05)。治疗4周后,两组患者IBS-QOL量表积分均较治疗前显著增高(P<0.05);治疗8周后,两组患者IBS-QOL量表积分均较治疗前增高(P<0.05),且观察组较对照组改善更为显著(P<0.05)。结论:“活血散风,调和肝脾”针刺法可显著改善高血压合并腹泻型IBS患者血压水平及临床症状,提高患者生活质量,总体疗效优于药物。

关键词：针刺高血压腹泻型肠易激综合征活血散风调和肝脾临床观察

Spatial data modeling for coalfield geological environment

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Journal of Coal Science & Engineering(China) 2010年第3期16卷 300-305页

作者： JIA Bei SU Qiao-mei liU Chen li hui-juan College of Mining Engineering Taiyuan University of Technology Taiyuan 030024 China

Presented a study on the design and implementation of spatial data modelingand application in the spatial data organization and management of a coalfield geologicalenvironment *** on analysis of a number of existing data models and takinginto account the unique data structure and characteristic, methodology and key techniquesin the object-oriented spatial data modeling were proposed for the coalfield geological *** model building process was developed using object-oriented technologyand the Unified Modeling Language (UML) on the platform of ESRI geodatabase datamodels.A case study of spatial data modeling in UML was presented with successful implementationin the spatial database of the coalfield geological *** modelbuilding and implementation provided an effective way of representing the complexity andspecificity of coalfield geological environment spatial data and an integrated managementof spatial and property data.

关键词： spatial data model object-oriented Unified Modeling Language (UML) coal- field geological environment

Heredity and gene mapping of a novel white stripe leaf mutant in wheat

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Journal of Integrative Agriculture 2021年第7期20卷 1743-1752页

作者： li hui-juan JIAO Zhi-xin Nl Yong-jing JIANG Yu-mei li Jun-chang PAN Chao ZHANG Jing SUN Yu-long AN Jun-hang liU Hong-jie li Qiao-yun NIU Ji-shan National Centre of Engineering and Technological Research for Wheat/National Key Laboratory of Wheat and Maize Crop Science/Henart Agricultural University Zhengzhou 450046P.R.China Shangqiu Academy of Agricultural and Forestry Sciences Shangqiu 476000P.R.China

Spotted leaf(spl)mutant is a type of leaf lesion mimic mutants in *** obtained some lesion mimic mutants from ethyl methane sulfonate(EMS)-mutagenized wheat(Triticum aestivum L.)cultivar Guomai 301(wild type,WT),and one of them was named as white stripe leaf(wsl)mutant because of the white stripes on its *** we report the heredity and gene mapping of this novel wheat mutant *** are many small scattered white stripes on the leaves of wsl throughout its whole growth *** the plants grew,the white stripes became more severe and the necrotic area *** mutant wsl grew only weakly before the jointing stage and gradually recovered after *** length and width of the flag leaf,spike number per plant and thousand-grain weight of wsl were significantly lower than those of the *** analysis indicated that the trait of white stripe leaf was controlled by a recessive gene locus,named as wsl,which was mapped on the short arm of chromosome 6 B by SSR marker *** SSR markers in the F2 population of wsl×CS were linked to wsl in the order of Xgpw1079–Xwmc104–Xgwm508-wsl–Xgpw7651 at 7.1,5.2,8.7,and 4.4 c M,respectively and three SSR markers in the F2 population of wsl×Jimai 22 were linked to wsl in the order of Xgwm508–Xwmc494–Xgwm518-wsl at 3.5,1.6 and 8.2 c M,*** comparison to the reference genome sequence of Chinese Spring(CS),wsl is located in a 91-Mb region from 88 Mb(Xgwm518)to 179 Mb(Xgpw7651)on chromosome 6 *** wsl is a novel germplasm for studying the molecular mechanism of wheat leaf development.

关键词： wheat(Triticum aestivum L.) mutant white stripe leaf(wsl) heredity gene mapping

Ds-echinoside A,a new triterpene glycoside derived from sea cucumber,exhibits antimetastatic activity via the inhibition of NF-κB-dependent MMP-9 and VEGF expressions

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第7期12卷 534-544页

作者： Qin ZHAO Zhi-dong liU Yong XUE Jing-feng WANG hui li Qing-juan TANG Yu-ming WANG Ping DONG Chang-hu XUE College of Food Science and Engineering Ocean University of China Qingdao 266003 China

Ds-echinoside A (DSEA),a non-sulfated triterpene glycoside,was isolated from the sea cucumber Pearsonothuria *** vitro and in vivo investigations were conducted on the effects of DSEA on tumor cell adhesion,migration,invasion,and *** this study,we found that DSEA inhibited the proliferation of human hepatocellular liver carcinoma cells Hep G2,with a half-maximal inhibitory concentration (IC50) of 2.65 μmol/L,and suppressed Hep G2 cell adhesion,migration,and invasion in a dose-dependent *** also reduced tube formation of human endothelial cells ECV-304 on matrigel in vitro and attenuated neovascularization in the chick embryo chorioallantoic membrane (CAM) assay in *** analysis revealed that DSEA significantly decreased the expression of matrix metalloproteinase-9 (MMP-9),which plays an important role in the degradation of basement membrane in tumor metastasis and *** also increased the protein expression level of tissue inhibitor of metalloproteinase-1 (TIMP-1),an important regulator of MMP-9 *** the results of Western blotting,the expressions of nuclear factor-kappa B (NF-κB) and vascular endothelial growth factor (VEGF) were found to be remarkably reduced by *** findings suggest that DSEA exhibits a significant antimetastatic activity through the specific inhibition of NF-κB-dependent MMP-9 and VEGF expressions.

关键词： Triterpene glycoside Ds-echinoside A (DSEA) Metastasis Angiogenesis Nuclear factor-κB (NF-κB) Matrix metalloproteinase-9 (MMP-9) Vascular endothelial growth factor (VEGF)

Dexamethasone increases susceptibility of Aspergillus fumigatus to hydrogen peroxide via down-regulation of Afyapl gene expression in vitro

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Chinese Medical Journal 2011年第22期124卷 3773-3777页

作者： XU hui li li-juan WAN Zhe li Ruo-yu liU Wei Department of Dermatology Peking University First Hospital and Research Center for Medical Mycology Peking University Beijing 100034 China

Background Glucocorticoid is speculated to be able to have Aspergillus fumigatus （A. tum/gatus） I^e~ng more susceptible to reactive oxygen species （ROS） by inhibiting Afyapl, the transcription factor activating protein-1 （AP-1） homologue in A. fumigatus, which may provide a clue to expand the clinical use of glucocorticoid in patients with fungal infections. In this study, we used dexamethasone to determine the direct effect on oxidative killing susceptibility of A. fumigatus in vitro, as well as the expression level of Afyapl gene and its target genes （catalase and superoxide dismutase （SOD） genes）. Methods A. fumigatus spores were treated with different concentrations （0, 0.02, 0.2 mg/ml） of glucocorticoids and assigned to four groups （A： 0.5 hour, B： 2 hours, C： 7 hours, D： 16 hours） according to the time of treatment. The H202 oxidative killing assay was done, using the standard method-spot test, in each group of A. fumigatus. We measured the oxidative killing susceptibility as well as the expression level of the gene Afyapl, CATA, SOD1 and SOD2 in A. fumigatus at each group. The antifungal susceptibility to itraconazole and amphotericin B in each group of A. fumigatus was also measured with M38-A2 method. Results The oxidative killing susceptibility of A. fumigatus was increased, consistent with the reduction of Afyapl, CATA, SOD1 and SOD2 gene expression level after being treated with dexamethasone for 0.5 hours. However, these observations were disappeared along with being treated for longer time. The antifungal susceptibility to itraconazole and amphotericin B in the A. fumigatus strains treated with dexamethasone indicated no change, compared with those without dexamethasone treatment. Conclusion Dexamethasone can have A. fumigatus being more susceptible to ROS when treated for shorter period （0.5 to 2 hours） via the reduction of Afyapl gene expression as well as the down-stream enzyme-coding gene expression.

关键词： Aspergillus fumigatus Afyapl dexamethasone oxidative killing

Successful management of an intra-operative pulmonary tumor embolism during resection of a retroperitoneal leiomyosarcoma

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Chinese Medical Journal 2013年第5期126卷 980-981页

作者： ZHU Sheng-mei GUO Shao-hui li li-juan LUO li-hui YAO Yong-xing Department of Anesthesiology First Affiliated Hospital ZhejiangUniversity School of Medicine Hangzhou Zhejiang 310003China

Pulmonary tumor embolisms due to renal cell carcinoma are common. In contrast, intra-operative puhnonary artery embolisms due to the release of large tumor fragments during surgery for retroperitoneal leiomyosarcoma have not been reported. When a massive tumor embolus does occur, a patient＇s survival depends on prompt surgical intervention.2 In this report, a patient experienced a pulmonary tumor embolism during resection of a retroperitoneal leiomyosarcoma, and the condition was successfully treated. However, for the hemodynamic collapse that occurred, a puhnonary arteriography was followed by an emergency puhnonary embolectomy with cardiopulmonary bypass.

关键词： puhnonary tumori embolismi retroperitoneal leiomyosarcoma

Assessment of personal noise exposure of overhead-traveling crane drivers in steel-rolling mills

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Chinese Medical Journal 2007年第8期120卷 684-689页

作者： ZENG lin CHAI Dong-liang li hui-juan LEI Zhuo ZHAO Yi-ming Research Center of Occupational Medicine Peking University Third Hospital Beijing 100083 China Department of Occupational Health Center for Disease Control and Prevention Taiyuan Iron ＆ Steel （Group） Company LTD. Taiyuan 030003 China

Background Noise is widespread occupational hazard in iron and steel industry. Overhead-traveling cranes are widely used in this industry, but few studies characterized the overhead-traveling crane drivers＇ noise exposure level so far. In this study, we assessed and characterized personal noise exposure levels of overhead-traveling crane drivers in two steel-rolling mills.Methods One hundred and twenty-four overhead-traveling crane drivers, 76 in the cold steel-rolling mill and 48 in the hot steel-rolling mill, were enrolled in the study. Personal noise dosimeters （AIHUA Instruments Model AWA5610e, Hangzhou, China） were used to collect full-shift noise exposure data from all the participants. Crane drivers carried dosimeters with microphones placed near their collars during the work shifts. Work logs had been taken by the drivers simultaneously. Personal noise exposure data were divided into segments based on lines in which they worked. All statistical analyses were done using SPSS 13.0.Results The average personal noise exposure （LAeq.8h） of overhead-traveling crane drivers in the hot steel-rolling mills （（85.03±2.25） dB（A）） was higher than that in the cold one （（83.05±2.93） dB（A）, P〈0.001）. There were 17 overhead traveling cranes in the hot steel-rolling mill and 24 cranes in the cold one, of which carrying capacities varied from 15 tons to 100 tons. The average noise exposure level based on different lines in the hot and cold steel-rolling mills were （85.2±2.61） dB（A） and （83.3±3.10） dB（A） respectively （P=-0.001）, which were similar to the average personal noise exposure in both mills. The noise exposure levels were different among different lines （P=-0.021）. Conclusion Noise exposure levels, depending upon background noise levels and the noise levels on the ground, are inconstant. As the noise exposure levels are above the 85 dB（A） criteria, these drivers should be involved in the Hearing Conservation Program to protect their hearing.

关键词： noise, occupational exposure assessment overhead-traveling crane driver

Suppressing the formation of SRZ in a Ni-based single crystal superalloy by RuNiAl diffusion barrier

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Progress in Natural Science:Materials International 2012年第2期22卷 146-152页

作者： Zhiming Bai,Dongqing li,hui Peng,juan Wang,Hongbo Guo,Shengkai Gong School of Materials Science and Engineering,Beihang University,No.37,Xueyuan Road,Beijing 100191,China School of Materials Science and Engineering Beihang University No. 37 Xueyuan Road Beijing 100191 China

NiAl-based bond coats applied in thermal barrier coating(TBC)systems containing Ru and Pt have been studied in recent *** between the coatings and the underlying superalloy substrates usually results in degradation of the mechanical properties of the *** this paper,a NiAl/Ru coating was deposited onto a single crystal superalloy DD6 by electroplating and electron beam physical vapor deposition(EB-PVD).Interdiffusion behavior of the NiAl/Ru and NiAl coated specimens at 1100 1C was comparatively *** the NiAl coated specimen,after 100 h vacuum annealing,beneath the coating there was a 50 mm thickness secondary reaction zone(SRZ)with some needle-like topologically closed packed(TCP) *** no SRZ was observed in the NiAl/Ru coated *** may be attributed to the RuNiAl that acted as a diffusion barrier to prevent the inward diffusion of Al from the coating and the outward diffusion of refractory elements from the substrate,and hence suppressing the formation of TCP phases and SRZ in the superalloy.

关键词： NiAl RuNiAl Coating Interdiffusion Secondary reaction zone(SRZ)