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USP2a positively regulates TCR-induced NF-κB activation by bridging MALT1-TRAF6

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Protein & Cell 2013年第1期4卷 62-70页

作者： Yi li Xiao he Shuai Wang Hong-Bing Shu Yu liu College of life Sciences Wuhan UniversityWuhan 430072China

The paracaspase MALT1 is essential for the activation of NF-κB in response to T cell receptor(TCR)*** recruits downstream TRAF6 and activates the E3 ligase activity of TRAF6 to polyubiquitinate several targets,which ultimately leads to NF-κB *** we identified ubiquitin-specific protease 2a(USP2a)as a MALT1-associated protein by biochemical affinity *** USP2a constitutively interacted with TRAF6,but dynamically interacted with MALT1 and CARMA1 in a stimulation-dependent *** interference(RNAi)-mediated silencing of USP2a attenuated TCR-induced NF-κB activation and production of interleukin-2(IL-2).In addition,the ubiq-uitination of MALT1 and TRAF6 were both suppressed by USP2a *** knockdown and reconstitu-tion assays,we found that USP2a mediated the interac-tion between MALT1 and TRAF6 in a catalytic activ-ity-dependent ***,USP2a deSUMOy-lated *** findings implicate that USP2a plays an important role in TCR signaling by deSUMOylating TRAF6 and mediating TRAF6-MALT1 interaction.

关键词： USP2a MALT1 TRAF6 T cell activation NF-κB

Dendrite-free sandwiched ultrathin lithium metal anode with even lithium plating and stripping behavior

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Nano Research 2019年第9期12卷 2224-2229页

作者： Tao li Peng Shi Rui Zhang he liu Xin-Bing Cheng Qiang Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

Thin artificial solid electrolyte coatings are effective to enhance the electrochemical performances and safety issues of lithium (li) metal ***,massive and efficient fabrication of artificial protection layers on li metal anode surface remains ***,we describe a sandwiched li metal anode fabricated through a continuous roll to roll calendering method to implant a thin and large-area carbon layer on li metal anode surface at room ***,a carbon layer (~ 3 μm in thickness) can be entirely grafted from Cu substrate to 50 pm li belt surface due to the stickiness of metallic *** carbon layer not only plays a critical role in providing rich nucleation sites for li plating,but more importantly diminishes the metallurgical nonuniformity effects (slip lines) on ***,even li plating/stripping morphologies are achieved and the as-obtained sandwiched li/C composite anodes exhibit improved cycling stability both in li | liFePO4 and li | S coin cells and pouch *** continuous roll to roll calendering strategy opens a new avenue for grafting various thin artificial protection layers on li metal surface for safe rechargeable batteries.

关键词： lithium metal anodes artificial solid electrolyte in terphases carb on nano materials li strippi ng/plating rechargeable batteries

The Variation of Microbial(Methanotroph)Communities in Marine Sediments Due to Aerobic Oxidation of Hydrocarbons

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Journal of Ocean University of China 2021年第3期20卷 553-561页

作者： li Jing liU Changling WU Nengyou he Xingliang HAO Xiluo li Feng CheN Ye MENG Qingguo Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyQingdao 266071China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China College of Marine life Science Ocean University of ChinaQingdao 266100China

Methanotrophs in marine sediments and overlying water attenuate the emissions of methane into the atmosphere and thus play an important role for the global cycle of this greenhouse ***,gas released from natural hydrocarbon seeps are not pure methane but commonly mixed ***,how methanotrophic bacteria behave in the co-presence of methane and heavier hydrocarbons remains *** this paper,the bacteria were cultured aerobically in fresh sediment samples(collected from Bohai Bay in eastern China)at 28℃under the atmospheres of pure methane and methane+ethane+propane mixed gas,*** prevailing terrigenous n-alkanes and fatty acids in the original sediment samples varied consistently after incubations,confirming the proceeding of aerobic bacterial *** real-time quantitative PCR assay and sequencing of the 16S rRNA and particulate methane monooxygenase(pmoA)genes revealed the changes of microbe communities to a methanotroph-dominating structure after ***,after incubations the family Methylococcaceae(typeⅠmethanotrophs)became dominant with proportions higher than 40%,whereas Methylocystaceae(typeⅡmethanotrophs)nearly disappeared in all incubated ***-over,the species of methanotrophs from the samples treated with pure methane were dominated by Methylobacter luteus,whereas Methylobacter whittenburyi took the predominant proportion in the samples treated with mixed *** phenomenon suggests that some methanotrophs may also utilize ethane and ***,this study may help to gain a better understanding of the ef-fects and contributions of microbial activities in marine hydrocarbon seep ecosystems.

关键词： methanotroph aerobic oxidation of hydrocarbons sediment incubation lipid biomarker microbial community

Formation of Struvite Crystals in a Simulated Food Waste Aerobic Composting Process

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Chemical Research in Chinese Universities 2010年第2期26卷 210-216页

作者： DU Xian-yuan liU Jian-lin HUANG Guo-he li YU Energy and Environmental Research Centre North China Electric Power University Beo＇ing 102206 P. R. China College of Environment and Resources Jilin University Changchun 130012 P. R. China Environmental Systems Engineering Program Faculty of Engineering University of Regina Regina SK S4S OA2 Canada

Bench-scale treatments with three mixtures of Mg and P salts, including K3PO4＋MgSO4, K2HPO4＋MgSO4, and KH2PO4＋MgSO4 as additives in a simulated food waste aerobic composting process, were conducted to test the magnesium ammonium phosphate（MAP） formation, and the compost products were analyzed by X-ray diffraction（XRD）, Scanning electron microscopy（SEM）, and Energy dispersive X-ray spectroscopy（EDS） analyses. The comparison results between XRD, SEM, and EDS analyses of MAPs in the dried compost and synthesized MAPs confirm the formation of MAP crystals in the simulated food waste aerobic composting process. The analysis of the compost also indicates that the addition of all the three mixtures of Mg and P salts in the aerobic composting process can increase nitrogen conservation and decrease nitrogen loss because of the formation of MAPs. The mechanism of MAP formation was verified as the reaction of ammonium（NH4＋） with magnesium（Mg^2＋） and phosphate[HnPO4^（3-n） , n=0, 1, and 2）.

关键词： Phosphate Magnesium sulphate Magnesium ammonium phosphate Food waste treatment Aerobic composting

Enhancement of red emission by co-dopant Ln^(3+) ions in Eu^(3+) :LaOF nanoparticles

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Science China(Physics,Mechanics & Astronomy) 2013年第5期56卷 928-932页

作者： FU ZhenXing ZheNG HaiRong he EnJie GAO Wei li GuiAn College of Physics and Information Technology Shaanxi Normal University College of Physics and Information Technology Ningxia Normal University

Fluoride nanoparticles of Ln3＋（Ln3＋=Pr3＋, Nd3＋, Sm3＋, Cod3＋,Tb3＋ Dy3＋, I-I03＋, Er3＋, Tm3＋, yb3＋）/Eu3＋：LaOF and Eu3＋：LaOF with rhombohedral crystal structure were prepared by a hydrothermal-sintering method. The red fluorescence emission of Eu3＋ ions was found to be enhanced with most of the co-dopant Ln3. ions. Compared with strong fluorescence emission at 610 nm of Eu3＋：LaOF nanoparticles, the enhancement factors was up to ten times in Ln3~ （Ln3＋=Gd3＋, Dy3＋, Tm3＋）FEu3＋：LaOF co-doped nanoparticles. The results show that the asymmetry of the local environment of Eu3＋ ion was reduced by co-doping Ln3＋ ion into the nanoparticles, and that energy transfer might occur between Eu3_ and codopant Ln3＋ ions, which is suggested as the source of the observed fluorescence enhancement.

关键词： fluorescence enhancement Ln3+/Eu3+:LaOF nanoparticles asymmetry ratio

Overexpression of a Broccoli Defensin Gene BoDFN Enhances Downy Mildew Resistance

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Journal of Integrative Agriculture 2012年第7期11卷 1137-1144页

作者： JIANG Ming he Cai-ming MIAO li-xiang ZHANG Yu-chao College of life Science Taizhou University Linhai 317000 P.R.China Institute of Horticulture Zhejiang Academy of Agricultural Science Hangzhou 310021 P.R. China

Plant defensins are small, basic cysteine-rich peptides that play important roles in disease resistance. A gene, designated BoDFN, was isolated from Brassica oleracea var. italica. Gene sequence has been submitted to NCBI with an accession no. of HQ436486. Complete coding sequence of BoDFN is 243 bp in length encoding 80 amino acids. Sequence comparison results showed that BoDFN shared high homology with those of crucifer plants and there were only few DNA base differences. RT-PCR results indicated an increase of gene expression in Hyaloperonospora parasitica infected leaves and revealed a significant increase at 24 and 36 h of treatment. A recombinant plasmid, named pBI121-BoDFN, was constructed and introduced into Agrobacterium tumefacien LBA4404. PCR screening for 65 regenerated plantlets, 17 positive plantlets were obtained, PCR screening results revealed that 17 out of 65 regenerated plantlets were positive. Disease resistant identification results indicated that all positive plants showed an increase in resistance to H. parasitica.

关键词： broccoli downy mildew defensin overexpression

Orientation and strain rate dependent tensile behavior of single crystal titanium nanowires by molecular dynamics simulations

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Journal of Materials Science & Technology 2018年第5期34卷 864-877页

作者： Le Chang Chang-Yu Zhou Hong-Xi liu Jian li Xiao-Hua he School of Mechanical and Power Engineering Nanjing Tech University Nanjing 211816 China School of Mechanical Engineering Jiangsu University of Science and Technology Zhenjiang 212000 China

Molecular dynamics simulation was employed to study the tensile behavior of single crystal titanium nanowires（NWs）with[112^-0],[1^-100] and[0001]orientations at different strain rates from 10^8s^-1 to 10^11s^-*** strain rates are above 10^10s^-1,the state transformation from HCP structure to amorphous state leads to super plasticity of Ti NWs,which is similar to FCC *** strain rates are below 10^10s^-1,deformation mechanisms of Ti NWs show strong dependence on *** [112^-0] orientated NW.{101^-1} compression twins（CTs）and the frequently activated transformation between CTs and deformation faults lead to higher plasticity than the other two orientated ***,tensile deformation process along [112^-0] orientation is insensitive to strain *** [1^-100] orientated NW,prismaticslip is the main deformation mode at 10^8s^-*** the strain rate increases,more types of dislocations are activated during plastic deformation ***[0001]orientated NW,{101^-2} extension twinning is the main deformation mechanism,inducing the yield stress of [0001] orientated NW,which has the highest strain rate *** number of initial nucleated twins increases while the saturation twin volume fraction decreases nonlinearly with increasing strain rate.

关键词： Molecular dynamics Single crystal titanium nanowires Strain rate Orientation Plastic deformation mechanisms

Multi-parameter optimization of machining impeller surface based on the on-machine measuring technique

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Chinese Journal of Aeronautics 2019年第8期32卷 2000-2008页

作者： Gang WANG Wen-long li Fan RAO Zheng-rong he Zhou-ping YIN State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China China National South Aviation Industry Co. LtdZhuzhou 412002China

Selecting the optimal machining parameters for impeller surface is a challenging task in the automatic manufacturing industry, due to its free-form surface and deep-crooked flow *** experimental methods require lots of machining experiments and off-line tests, which may lead to high machining cost and low efficiency. This paper proposes a novel method of machining parameters optimization for an impeller based on the on-machine measuring technique. The absolute average error and standard deviation of the measured points are used to define the grey relational grade for reconstructing the objective function, and the complex problem of multi-objective optimization is simplified into a problem of single-objective optimization. Then, by comparing the values of the defined grey relational grade in a designed orthogonal experiment, the optimal combination of the machining parameters is obtained. The experiment-solving process of the objective function corresponds to the minimization of the used errors, which is advantageous to reducing the machining error. The proposed method is efficient and low-cost, since it does not require re-clamping the workpiece for off-line tests. Its effectiveness is verified by an on-machine inspection experiment of the impeller blade.

关键词： Grey relational grade Impeller surface Multi-parameters optimization On-machine measuring Orthogonal experiment

Effect of Solution Annealing Temperature on Pitting Behavior of Duplex Stainless Steel 2204 in Chloride Solutions

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Journal of Iron and Steel Research International 2016年第4期23卷 357-363页

作者： liang he Yan-jun GUO Xia-yu WU Yi-ming JIANG Jin li Department of Materials Science Fudan University School of Materials Engineering Shanghai University of Engineering Science

The effect of solution annealing temperature ranging from 950 to 1 200 ℃ on the microstructure and corrosion performance of duplex stainless steel （DSS） 2204 were investigated. The proportion of the ferrite phase increased while the austenite phase decreased and the ferrite stabilizing elements diluted in the ferrite phase with the increase of annealing temperature. The critical pitting temperature （CPT） of specimens annealed at 1000℃ was higher than those annealed at 950℃, whereas further increasing the annealing temperature to 1200℃ decreased the CPT. The pitting initiation sites were observed in the austenite phase, at the boundary of ferrite/austenite phase and inside the ferrite phase for specimens annealed at 950, 1000℃ and exceeding 1 100℃, respectively. The evolution trend of the CPT and the pit initiation site were analyzed by the pitting resistance equivalent number.

关键词： duplex stainless steel pitting corrosion solution annealing treatment critical pitting temperature