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Preliminary study of the urinary proteome in li and han ethnic individuals from Hainan

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Science China(life Sciences) 2020年第1期63卷 125-137页

作者： Fanshuang Zhang Xundou li Yanying Ni Guangliang Shan Youhe Gao Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathophysiology Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Epidemiology and Statistics Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China Department of Biochemistry and Molecular Biology Beijing Normal UniversityGene Engineering Drug and Biotechnology Beijing Key LaboratoryBeijing 100875China

Biomarkers indicate changes associated with disease. Blood is relatively stable due to the homeostatic mechanisms of the body;however, urine accumulates metabolites from changes in the body, making it a better source for early biomarker discovery. The li ethnic group is a unique minority ethnic group that has only lived on Hainan Island for approximately 5,000 years. Studies have shown that various specific genetic variations are different between the li and han ethnic groups. However, whether the urinary proteome between these two ethnic groups is significantly different remains unknown. In this study, differential urinary proteins were identified in the li and han ethnic groups using liquid chromatography tandem mass spectrometry(LC-MS/MS).In total, 1,555 urinary proteins were identified. Twenty-five of the urinary proteins were statistically significantly different, 16 of which have been previously reported to be biomarkers of many diseases, and that these significantly different proteins were caused by ethnic differences rather than random differences. Ethnic group differences may be an influencing factor in urine proteome studies and should be considered when human urine samples are used for biomarker discovery.

关键词： proteomics urine biomarker li ethnic group han ethnic group

Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-han li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-han Yao Chun-Wen Pu Xiao-Feng li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,Pline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

Comparison of Hematological Parameters and Critical Value Analysis in the Prevention and Control of Thalassaemia in Hainan li and han Nationalities

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Open Journal of Blood Diseases 2021年第2期11卷 46-56页

作者： Junjie Hu Xinping Chen Xiaojuan li Weihua Xu Shengmiao Fu Department of Central Laboratory Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University Hainan Provincial Key Laboratory for Cell and Molecular Genetic Translational Medicine Haikou China

Objective: To compare the distribution of “mean corpuscular hemoglobin”-MCV, “mean corpuscular volume”-MCH, “hemoglobin”-HGB, “hemoglobin A”-HbA and “hemoglobin A2”-HbA2 in α and β thalassemia hematology screening between Li and Han nationality, and analyze the best diagnostic cut-off value. Methods: Select 7816 middle school students from Li nationality area as the research object, collect peripheral blood for blood cell analysis, hemoglobin electrophoresis and thalassaemia gene detection, and compare the difference in hematological parameters of common thalassemia genotype between Li and Han nationalities. Taking the genetic test results as the gold standard, construct the receiver operator characteristic curve (ROC curve) of relevant hematology parameters, calculate the Youden index and take its maximum diagnostic cut-off point as the best critical value. Results: Comparison of hematological parameters of common thalassemia genotypes showed that the average value of MCH and MCV of -α3.7/-α

A review of the microseismic focal mechanism research

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Science China Earth Sciences 2021年第3期64卷 351-363页

作者： han li Xu ChanG Key Laboratory of Petroleum Resource Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China

Reservoir reconstructions implemented in unconventional oil and gas exploration usually adopt hydraulic fracturing techniques to inject high-pressure fluid into the reservoir and change its pore-fracture connection structure to enhance *** fracturing changes the reservoir stress and causes the rocks to crack,thus generating microseismic *** important component of microseismic research is the source mechanism *** the research on the microseismic focal mechanism,information on the source mechanisms and in-situ stress status variations can be quantitatively revealed to effectively optimize the reservoir reconstruction design for increasing *** paper reviews the recent progress in hydraulic fracturing induced microseismic focal mechanism *** summarize their main principles and provide a detailed introduction of the research advances in source modeling,microseismic data synthesis,and focal mechanism *** also discuss the challenges and limitations in the current microseismic focal mechanism research and propose prospects for future research ideas and directions.

关键词： Unconventional oil and gas Microseismic monitoring Microseismic events Focal mechanism research

Effect of plastic deformation on diffusion-rolling bonding of steel sandwich plates

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Journal of University of Science and Technology Beijing 2006年第6期13卷 532-537页

作者： Hong li Jingtao han Materials Science and Engineering School University of Science and Technology Beijing Beijing 10083 China

Diffusion bonding is one of the most important techniques for composite materials, while bonding temperature, holding time,and rolling reduction are the key parameters that affect the bonding strength of sandwich plates. To study the effect of plastic deformation on the bonding strength, laboratory experiments were carried on a Gleeble Thermal Simulator to imitate the diffusion-rolling bonding under different reductions for steel sandwich plates. The bonding strength and interlayer film thickness were measured, and the element diffusion was analyzed using line scanning. The relationship between the bonding strength and “diffused interlayer” thickness was investigated. It has been found that the bonding strength increases with reduction, whereas the interlayer film thickness decreases gradually as the reduction increases. The diffusion under plastic deformation is obviously enhanced in comparison with that of nil reduction. The mechanism of plastic deformation effect on the diffusion bonding and related models have been discussed.

关键词： steel sandwich plate diffusion-bonding plastic deformation bonding strength interlayer film thickness diffusion mechanism models

A modeling study of the impact of heterogeneous reactions on mineral aerosol surfaces on tropospheric chemistry over East Asia

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Particuology 2010年第5期8卷 433-441页

作者： Jiawei li Zhiwei han Key Laboratory of Regional Climate-Environment Research for Temperate East-Asia (RCE-TEA) Institute of Atmospheric Physics Chinese Academy of Sdences Beijing China

Nine heterogeneous reactions （uptake of H2O2, HNO3, HO2, N2O5, NO2, NO3, O3, OH and SO2 on mineral aerosol surfaces） are incorporated into a Regional Air Quality Model System （RAQMS） to investigate their impacts on tropospheric chemistry in East Asia during the dust storm period in March 2006. Comparison with observations shows the model system well represents the behaviors of the gaseous and aerosol species. Most of the reaction probability γvalues used for this study are the best estimation specifically for dust samples from deserts of China, derived from analysis of a number of recent laboratory studies. There are large variations in gas and aerosol concentrations while taking heterogeneous reactions on mineral aerosol surface into account, especially during dust storm events. The domain-averaged monthly mean percentage changes in SO2, NO2, O3, HNO3, NH3, total sulfate, total nitrate and total ammonium concentrations are -4.4%, -3.8%, -2.1%, -22.0%, 12.7%, 6.6%, 26.1%, and -9.5%, respectively below 3 km. These changes indicate the considerable perturbation of heterogeneous reactions on mineral aerosol surface to tropospheric chemical system and components. The strength of heterogeneous reactions is determined by both reaction probability and gas precursor concentration. Among the nine reactions, dust uptakes of HNO3, SO2, and N2O5 exert relatively large influences on the other chemical components, whereas the reactions regarding H2O2, HO2, and OH have little impacts.

关键词： Heterogeneous reactionMineral aerosolTropospheric chemistryNumerical simulationDust storm

Verification of monocular and binocular pose estimation algorithms in vision-based UAVs autonomous aerial refueling system

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Science China(Technological Sciences) 2016年第11期59卷 1730-1738页

作者： li han DUAN HaiBin Bio-inspired Autonomous Flight Systems (BAFS) Research Group Science and Technology on Aircraft Control Laboratory School of Automation Science and Electrical Engineering Beihang University

With the high focus on autonomous aerial refueling(AAR), it becomes increasingly urgent to design efficient methods or algorithms for solving the AAR problems in complicated aerial environments. A vision-based technology for AAR is developed in this paper, and five monocular and binocular visual algorithms for pose estimation of the unmanned aerial vehicles(UAVs) are adopted and verified in this AAR system. The real-time on-board vision system is also designed for precise navigation in the UAVs docking phase. A series of out-door comparative experiments for different pose estimation algorithms are conducted to verify the feasibility and accuracy of the vision algorithms in AAR.

关键词： unmanned aerial vehicles(UAVs) autonomous aerial refueling(AAR) pose estimation monocular vision binocular vision

Magnetocaloric and Colossal Magnetoresistance Effect in Layered Perovskite La_(1.4) Sr_(1.6)Mn_2O_7

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Journal of Materials Science & Technology 2010年第3期26卷 234-236页

作者： li'an han Changle Chen School of science Northwestern Polytechnical University Xi'an 710072 China Department of applied physics Xi'an University of Science and Technology Xi'an 710054 China

Magnetocaloric and colossal magnetoresistance effects of the layered perovskite La 1.4 Sr 1.6 Mn 2 O 7 compound have been studied.A broad peak of magnetic entropy change （-△S M） is found above the Curie temperature （T C =120 K）,which can be associated with the existence of two-dimensional short range ferromagnetic ***,the curvilinear shape of-△S M for layered perovskite is quite different from that of the Ln 1-x A x MnO 3 probably arising from magnetocrystalline *** the same time,a wide peak of colossal magnetoresitance effect near T C is found in the layered provskite La 1.4 Sr 1.6 Mn 2 O 7.

关键词： Magnetocaloric effect Layered perovskite Colossal magnetoresistance

GBO algorithm for seismic source parameters inversion

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Geodesy and Geodynamics 2023年第2期14卷 182-190页

作者： Leyang Wang han li Faculty of Geomatics East China University of TechnologyNanchang 330013China Key Laboratory of Mine Environmental Monitoring and Improving Around Poyang Lake Ministry of Natural ResourcesNanchang 330013China

The use of geodetic observation data for seismic fault parameters inversion is the research hotspot of geodetic inversion, and it is also the focus of studying the mechanism of earthquake occurrence. Seismic fault parameters inversion has nonlinear characteristics, and the gradient-based optimizer(GBO) has the characteristics of fast convergence speed and falling into local optimum hardly. This paper applies GBO algorithm to simulated earthquakes and real LuShan earthquakes in the nonlinear inversion of the Okada model to obtain the source parameters. The simulated earthquake experiment results show that the algorithm is stable, and the seismic source parameters obtained by GBO are slightly closer to the true value than the multi peak particle swarm optimization(MPSO). In the 2013 LuShan earthquake experiment, the root mean square error between the deformation after forwarding of fault parameters obtained by the introduced GBO algorithm and the surface observation deformation was 3.703 mm, slightly better than 3.708 mm calculated by the MPSO. Moreover, the inversion result of GBO algorithm is better than MPSO algorithm in stability. The above results show that the introduced GBO algorithm has a certain practical application value in seismic fault source parameters inversion.

关键词： Fault source parameters inversion Gradient-based optimizer algorithm Nonlinear Multi-peak particle swarm optimization algorithm GPS data