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Chinese Chemical Letters 2023年第4期34卷 246-250页

作者： Ning Ding Xueliang liu Aixia Meng Xiuxiu Zhao {2. ma Weina Han Peng Dong Jianchun li Jin Zhou School of Pharmacy School of Medical ImagingSchool of Basic Medical SciencesWeifang Key Laboratory of Pharmaceutical Chemical Biology for CancerWeifang Medical UniversityWeifang 261053China Weifang People’s Hospital Weifang 261000China

Computed tomography(CT) is one of the most commonly used non-invasive clinical imaging modalities to predict, diagnose and treat the disease. Iodinated contrast media(ICM) is a form of intravenous radiocontrast agent containing iodine, which enhances the visibility of hollow tissue structures in medical CT imaging. ICM may cause allergic reactions, contrast-induced nephropathy, hyperthyroidism and possibly metformin accumulation. It is significant to find out the risk factors, pathogenesis, diagnosis, prevention, and treatment of adverse reactions caused by ICM. Revealing the changes of the lipid droplets(LDs)viscosity in pathophysiological processes such as cancer and iodined contrast media induced adverse reaction is not only important for monitoring the occurrence and development of some pathophysiological processes but also vital for the deep insight of the biological effects of LDs in these pathophysiological processes. A lipid droplets targeted fluorescent probe DN-1 was devised to sense cellular viscosity alteration with high selectivity and sensitivity, which was applied to distinguish cancer cells and normal cells and reveal viscosity changes during iodined CT contrast media treatment.

关键词： Fluorescent probe Viscosity lipid droplets Iodined contrast media Distinguishment of cancer and normal cells

Metal-free nucleophilic 7,8-dearomatization of quinolines:Spiroannulation of aminoquinoline protected amino acids

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Chinese Chemical Letters 2023年第2期34卷 219-223页

作者： Zhiguo Zhang Xiyang Cao Xiaoqing Song gang Wang Bingbing Shi Xiang li Nana {2. Lantao liu Guisheng Zhang Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Centre of Henan Province for Green Manufacturing of Fine ChemicalsNMPA Key Laboratory for Research and Evaluation of Innovative DrugSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China The college of Chemistry and Chemical Engineering Shangqiu Normal UniversityShangqiu 476000China

Atom-and step-economy in IBX assisted diversity-oriented synthesis is achieved with a versatile AQ auxiliary α-amino acid analogs offering rapid access to polycyclic spiro-quinolines featuring a quaternary stereocenter in 2.%–91% yields under mild conditions via 7,8-dearomatization of quinolines. Free of a preinstalled activation group is highlight of this intramolecular oxidation spiroannulation tandem reaction. This type of N-heterospirocycles, traditionally difficult to access, may open the door to a potentially interest scaffold for synthetic and medicinal chemistry.

关键词： Dearomatization Spiroannulation Aminoquinoline Amino acids Hypervalent iodine reagents

S型铺管瞬态张力对动力定位控制的影响（英文）

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船舶力学 2019年第9期23卷 1099-1109页

作者：艾尚茂刘德鹏李鹏马刚哈尔滨工程大学船舶工程学院哈尔滨150001 中海油能源发展采油服务公司天津300457

铺管船动力定位能力和张紧器能力通常基于静态管线张力或者采用一定动力放大系数进行评估,忽略了管线张力动态的影响.本文集成PID动力定位控制和卡曼滤波,充分考虑管线-辊筒接触及管线-铺管船耦合,发展了一种S型铺管作业的闭环自动控制... 详细信息

铺管船动力定位能力和张紧器能力通常基于静态管线张力或者采用一定动力放大系数进行评估,忽略了管线张力动态的影响.本文集成PID动力定位控制和卡曼滤波,充分考虑管线-辊筒接触及管线-铺管船耦合,发展了一种S型铺管作业的闭环自动控制数值模型.时域数值结果对比分析表明:动力定位推力动态耦合效应显著,亦证明了管线张力的瞬态效应对深水S型铺管作业动力定位评估影响深远,且基于静态管线张力评估张紧器能力将会高估.

关键词： S型铺管耦合分析瞬态张力动力定位

A Genome-Wide Transcription Analysis Reveals a Close Correlation of Promoter INDEL Polymorphism and Heterotic Gene Expression in Rice Hybrids

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Molecular Plant 2008年第5期1卷 720-731页

作者： Hui-Yong Zhang Hang He liang-Bi Chen Lei li {2.n-Zhong liang Xiang-Feng Wang Xi-gang liu Guang-Ming He Run-Sheng Chen li-Geng {2. Xing Wang Deng National Institute of Biological Sciences Zhongguancun Life Science Park Beijing 102206 China Institute of Biophysics Chinese Academy of Sciences. 15 Oatun Road Beiiing 100101 China Department of Botany College of Life Sciences Hunan Normal University Changsha 410081 China Peking-Yale Joint Research Center of Plant Molecular Genetics and Agrobiotechnology College of Life Sciences Peking University Beijing 100871 China Department of Molecular Cellular and Developmental Biology Yale University New Haven Connecticut 06520 USA

Heterosis, or hybrid vigor, refers to the phenomenon in which hybrid progeny of two inbred varieties exhibits enhanced growth or agronomic performance. Although a century-long history of research has generated several hypotheses regarding the genetic basis of heterosis, the molecular mechanisms underlying heterosis and heterotic gene expression remain elusive. Here, we report a genome-wide gene expression analysis of two heterotic crosses in rice, taking advantage of its fully sequenced genomes. Approximately 7-9% of the genes were differentially expressed in the seedling shoots from two sets of heterotic crosses, including many transcription factor genes, and exhibited multiple modes of gene action. Comparison of the putative promoter regions of the ortholog genes between inbred parents revealed extensive sequence variation, particularly small insertions/deletions （INDELs）, many of which result in the formation/disruption of putative cis-regulatory elements. Together, these results suggest that a combinatorial interplay between expression of transcription factors and polymorphic promoter cis-regulatory elements in the hybrids is one plausible molecular mechanism underlying heterotic gene action and thus heterosis in rice.

关键词：基因基因表达基因组启动区遗传嵌合体稻属杂种优势转录遗传

Sagittal plane analysis of the spine and pelvis in adult idiopathic scoliosis

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Chinese Medical Journal 2010年第21期123卷 2978-2982页

作者： li Wei-shi li {2. CHEN Zhong-qiang Kirkham B Wood Department of Orthopaedics Massachusetts General Hospital Harvard Medical School Boston 02114 MA USA Department of Orthopaedics Peking University Third HospitalBeijing 100191 China

Background There has been an increasing recognition of the importance of sagittal spinopelvic alignment in patients with scoliosis as it relates to clinical outcomes. However, the changes seen in sagittal spinopelvic alignment in adult idiopathic scoliosis patients is poorly defined. This study was conducted to evaluate the sagittal alignment of pelvis and spine in adult idiopathic scoliosis *** The sagittal parameters of the spine and pelvis were analyzed in lateral standing radiographs of 12. patients （mean age 47.4 years） with adult idiopathic scoliosis, including thoracic kyphosis （TK）, thoracolumbar junction kyphosis （TLJ）, lumbar lordosis （LL）, pelvic incidence （PI）, sacrum slope （SS）, pelvic tilt （PT） and C7 plumb line （C7PL）. The patients were divided into three groups according to the age： 2.-40 years, 41-64 years, and ≥65 years. The parameters were compared with those in normal adults and adolescent idiopathic scoliosis （AIS） patients. The relationship between all parameters as well as age and sagittal parameters were *** The PI in patients with adult idiopathic scoliosis was 58.1°±13.0°, which was significantly higher than that in normal adults. The PT （19.9°±10.6°） was also higher than that in both normal adults and AIS patients, while the SS （38.1°±12.0°） was similar or smaller. As age increased, C7PL, PT and TJL increased while LL decreased. There was no relationship between age and both PI and TK. PT had the strongest statistical association with the *** PI is higher in adult idiopathic scoliosis than normal subjects. The PT is the most relevant pelvic parameter to the global sagittal alignment of the spine. Age significantly influences sagittal parameters of the spine and pelvis except the PI and TK.

关键词： adult idiopathic scoliosis sagittal balance radiographic measures pelvic morphology

扫描电镜观察脂欣康胶囊对载脂蛋白E基因敲除小鼠动脉粥样硬化主动脉内膜超微结构的影响

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生物医学工程研究 2004年第1期23卷 28-30页

作者：张文高郑广娟李军山孟宪忠马学盛王显刚刘龙涛山东中医药大学济南250014 济南孟氏生物科技研究所济南250002

为观察扫描电镜下脂欣康胶囊对载脂蛋白E(ApoE)基因敲除小鼠动脉粥样硬化 (As)主动脉内膜超微结构的影响 ,随机将 6周龄ApoE基因敲除小鼠分为模型组与脂欣康组 ,以有相同遗传背景的同龄正常C57BL/6J小鼠为正常对照组。脂欣康组灌服脂欣... 详细信息

为观察扫描电镜下脂欣康胶囊对载脂蛋白E(ApoE)基因敲除小鼠动脉粥样硬化 (As)主动脉内膜超微结构的影响 ,随机将 6周龄ApoE基因敲除小鼠分为模型组与脂欣康组 ,以有相同遗传背景的同龄正常C57BL/6J小鼠为正常对照组。脂欣康组灌服脂欣康粉剂 ,模型组、正常对照组均灌服生理盐水。连续灌胃14周后 ,取新鲜的主动脉用 2..5 %戊二醛固定 ,扫描电镜观察并拍照。结果表明 ,模型组主动脉内膜病变显著且多样化。

关键词：欣康主动脉内膜基因敲除小鼠超微结构对照组正常敲除扫描电镜观察遗传背景

Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study

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Cancer Communications 2021年第12期41卷 1373-1386页

作者： Ya Wang Long Qiao Jie Yang Xiong li Yaqi Duan Jiahao liu Shaoqi Chen Huayi li Dan liu Tian Fang Jingjing ma Xiaoting li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang gang Chen Qinghua Zhang Xingrui li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding ma Qinglei Gao Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Cancer Biology Research Center(Key Laboratory of the Ministry of Education) Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Department of Obstetrics and Gynecology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450000P.R.China Department of Gynecology and Obstetrics The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430014P.R.China Department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Department of Obstetrics and Gynecology Wuhan Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022P.R.China Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCalifornia 90001USA Department of Thyroid and Breast Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030P.R.China Department of Breast Surgery Hubei Cancer HospitalWuhanHubei 430079P.R.China Department of Gynecology and Obstetrics Qilu Hospital of Shandong UniversityJinanShandong 250012P.R.China Yidu Cloud(Beijing)Technology Co. Beijing 100000P.R.China mammoCare The Breast Clinic&SurgerySingapore 329563Singapore Department of Surgery and the massey Cancer Centre Virginia Commonwealth University School of MedicineRichmondVirginia 23298USA Department of Breast Surgery Qilu Hospital of Shandong UniversityNo.107Jinan Culture RoadJinanShandong 250012P.R.China

Background:To date,there is no approved blood-based biomarker for breast cancer ***,we aimed to assess semaphorin 4C(SEma4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic ***:We included 6,2.3 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer *** cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEma4C among solid *** cancer patients who underwent mass excision prior to modified radical mastectomy were also *** hypothesized that increased pretreatment serum SEma4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast *** endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and ***-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM *** was no restriction on disease stage for ***:We included 2.67 inpatients with breast lesions,2.78 patients with other solid tumors,and 1168 healthy ***,118 patients with breast cancer were diagnosed with stage 0(5.71%),62. with stage I(30.00%),966 with stage II(46.73%),2.7 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEma4C levels than benign breast tumor patients and normal controls(Pma4C levels had AUC of 0.92.(95%confidence interval[CI]:0.900–0.941)and 0.932.95%CI:0.911–0.953)for breast cancer detection in the two validation *** AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832.0.92.),*** SEma4C levels significantly decreased after surgery,and the reduction was more str

关键词： breast cancer semaphorin 4C serum biomarker diagnosis early detection ductal carcinoma in situ pan-cancer analysis enzyme-linked immunosorbent assay

Green‑Solvent Processed Blade‑Coating Organic Solar Cells with an Efficiency Approaching 19%Enabled by Alkyl‑Tailored Acceptors

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Nano-Micro Letters 2023年第12期15卷 449-462页

作者： Hairui Bai Ruijie ma Wenyan Su Top Archie Dela Pea Tengfei li lingxiao Tang Jie Yang Bin Hu Yilin Wang Zhaozhao Bi Yueling Su Qi Wei Qiang Wu Yuwei Duan Yuxiang li Jiaying Wu Zicheng Ding Xunfan liao Yinjuan Huang Chao Gao Guanghao Lu Mingjie li Weiguo Zhu gang li Qunping Fan Wei ma State Key Laboratory for Mechanical Behavior of materials Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China Jiangsu Engineering Research Center of light‑Electricity‑Heat Energy‑Converting materials and Applications School of Materials Science and EngineeringChangzhou UniversityChangzhou 213164People’s Republic of China Key Lab of Fluorine and Silicon for Energy materials and Chemistry of Ministry of Education/National Engineering Research Center for Carbohydrate Synthesis Jiangxi Normal University99 Ziyang AvenueNanchang 330022People’s Republic of China Department of Electronic and Information Engineering Research Institute for Smart Energy(RISE)The Hong Kong Polytechnic UniversityKowloon 999077Hong KongPeople’s Republic of China School of materials Science and Engineering Xi’an University of Science and TechnologyXi’an 710054People’s Republic of China Department of Applied Physics The Hong Kong Polytechnic UniversityKowloon 999077Hong KongPeople’s Republic of China Advanced materials Thrust Function HubThe Hong Kong University of Science and TechnologyNanshaGuangzhouPeople’s Republic of China School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationShaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119People’s Republic of China Frontier Institute of Science and Technology Xi’an Jiaotong UniversityXi’an 710054People’s Republic of China Xi’an Key Laboratory of liquid Crystal and Organic Photovoltaic materials State Key Laboratory of Fluorine&Nitrogen ChemicalsXi’an Modern Chemistry Research InstituteXi’an 710065People’s Republic of China

Power-conversion-efficiencies(PCEs)of organic solar cells(OSCs)in laboratory,normally processed by spin-coating technology with toxic halogenated solvents,have reached over 19%.However,there is usually a marked PCE drop when the bladecoating and/or green-solvents toward large-scale printing are used instead,which hampers the practical development of ***,a new series of N-alkyl-tailored small molecule acceptors named YR-SeNF with a same molecular main backbone are developed by combining selenium-fused central-core and naphthalene-fused *** to the N-alkyl engineering,NIR-absorbing YR-SeNF series show different crystallinity,packing patterns,and miscibility with polymeric *** studies exhibit that the molecular packing,crystallinity,and vertical distribution of active layer morphologies are well optimized by introducing newly designed guest acceptor associated with tailored N-alkyl chains,providing the improved charge transfer dynamics and stability for the PM6:L8-BO:YRSeNF-based *** a result,a record-high PCE approaching 19%is achieved in the blade-coating OSCs fabricated from a greensolvent o-xylene with high-boiling ***,ternary OSCs offer robust operating stability under maximum-power-point tracking and well-keep>80%of the initial PCEs for even over 400 *** alkyl-tailored guest acceptor strategy provides a unique approach to develop green-solvent and blade-coating processed high-efficiency and operating stable OSCs,which paves a way for industrial development.

关键词： Alkyl-tailored guest acceptors Blade-coating Green solvent processing Stability Organic solar cells

液体获取装置金属筛网内饱和液氢芯吸性能研究

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西安交通大学学报 2020年第10期54卷 124-130页

作者：马原雷刚徐元元谢福寿厉彦忠西安交通大学制冷与低温工程研究所西安710049 航天低温推进剂技术国家重点实验室北京100028

为了研究筛网通道式液体获取装置(LAD)对低温液氢推进剂的芯吸管理性能,采用绝热连续多孔介质模型,构建了计入筛网固体与周围气相环境热影响的蒸发修正芯吸模型,并采用液氮过热芯吸实验数据对构建的模型进行了有效性验证。针对常重力竖... 详细信息

为了研究筛网通道式液体获取装置(LAD)对低温液氢推进剂的芯吸管理性能,采用绝热连续多孔介质模型,构建了计入筛网固体与周围气相环境热影响的蒸发修正芯吸模型,并采用液氮过热芯吸实验数据对构建的模型进行了有效性验证。针对常重力竖直芯吸过程,计算获得了绝热、过热条件下3种编织密度(2.0×1400、32.×2.00和510×3600)的荷兰斜纹筛网(DTW)内饱和液氢芯吸速度和芯吸高度的变化,并对比分析了筛网与气相环境过热度对低温芯吸性能的影响规律。结果表明:绝热条件下,筛网编织密度越小,芯吸速度越大,而最大芯吸高度越小;经丝方向芯吸性能始终优于纬丝方向;液氢芯吸过程的热敏感性极强,芯吸速度和最大芯吸高度均随过热度增大而显著衰减,筛网越密性能衰减幅度越大;气相环境过热度对液氢芯吸性能起决定性影响,低温下筛网固体自身的热影响相对微弱。

关键词：液体获取装置金属筛网芯吸性能液氢

玻化微珠保温混凝土墙体温度场数值模拟与分析

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中国科技论文 2015年第5期10卷 528-531页

作者：张玉李珠马钢太原理工大学建筑与土木工程学院太原030024

为了对比玻化微珠保温混凝土墙体与普通混凝土墙体、包含保温层的普通混凝土墙体的传热性能,通过ANSYS软件模拟分析了3种墙体在某地区夏冬季极端气候环境下的内部稳态温度场分布,以及关闭室内调温设备之后墙体内部瞬态温度场随时间的变... 详细信息

为了对比玻化微珠保温混凝土墙体与普通混凝土墙体、包含保温层的普通混凝土墙体的传热性能,通过ANSYS软件模拟分析了3种墙体在某地区夏冬季极端气候环境下的内部稳态温度场分布,以及关闭室内调温设备之后墙体内部瞬态温度场随时间的变化情况,同时与试验实测结果进行对比。结果表明:本文所提出的模拟分析数据与实测数据符合较好,玻化微珠保温混凝土的保温效果与复合有外保温层的普通混凝土墙体保温效果接近,用作建筑围护结构时,其对外界温度的阻隔作用远优于普通混凝土。

关键词： ANSYS 玻化微珠保温混凝土传热温度场