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Synthesis and Crystal Structure of a Novel 1D Magnesium(II) Coordination Polymer Constructed by L-Cysteic Acid

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Chinese Journal of Structural Chemistry 2007年第8期26卷 907-910页

作者： li Hai-Ye liAO Bei-ling JIANG Yi-min ZHANG Shu-Hua li Jun-Xia College of Chemistry and Chemical engineering Guangxi Normal University Guilin 541004 China

A novel coordination polymer [Mg（L）（H2O）2]·H2O] （LH2=L-cysteic acid） has been synthesized and characterized by elemental analysis, IR and single-crystal X-ray *** crystal crystallizes in orthorhombic system, space group P212121, with a=5.962（3）, b=11.224（6）, c=13.664（7）A, V=914.3（8）A^3, Z=4, Mr=245.50, Dc=1.783 g/cm^3,μ=0.445 mm-1,flack parameter=0.32（16）, F（000）=512, the final R=0.0458 and wR=0.1172 for 1578 observed reflections with I 〉 2σ（Ⅰ）. The Mg（Ⅱ） atom shows an octahedral geometry defined by two carboxyl O atoms from two different L-cysteic acid ligands, one carboxyl O atom and one amino N atom from the adjacent ligand, and two aqua ligands. The Mg（Ⅱ） atoms are bridged by L-cysteic acid ligands, leading to a 1D infinite zigzag chain. In the structure there are extensive hydrogen bonds,through which the complex completes its 3D framework structure.

关键词： magnesium(Ⅱ) complex L-cysteic acid synthesis crystal structure

左心房与肺静脉形态学特征对心房颤动射频消融术后早期复发的预测价值

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临床心血管病杂志 2024年第3期40卷 188-193页

作者：严卉谢丽响陈文苏李承宗韦敏朱丽平李晓乐胡春峰徐州医科大学附属医院放射科江苏徐州221000 徐州医科大学附属医院心内科江苏徐州221000

目的:基于左心房和肺静脉CT血管成像(CT angiography,CTA)评估左心房和肺静脉形态学特征与射频消融术后心房颤动(房颤)早期复发的临床相关性。方法:回顾性分析我院2018年8月—2022年10月首次行射频消融术的患者,测量相关影像形态学参数... 详细信息

目的:基于左心房和肺静脉CT血管成像(CT angiography,CTA)评估左心房和肺静脉形态学特征与射频消融术后心房颤动(房颤)早期复发的临床相关性。方法:回顾性分析我院2018年8月—2022年10月首次行射频消融术的患者,测量相关影像形态学参数,并于初始治疗后定期规律随访。收集患者临床资料,依据术后3个月内随访结果,将患者分为复发组和未复发组,对比分析两组患者临床及影像资料。采用logistic回归分析房颤复发的危险因素。采用受试者工作特征(receiver operating characteristic,ROC)曲线验证危险因素的预测价值。结果:共纳入229例患者,其中复发组87例,未复发组142例。未复发组与复发组患者左心房横径[LAD:(3.72±0.55)cm vs (4.37±0.82)cm,P<0.001]、左心房横径/同层面胸椎椎体横径(LAVD:2.36±0.43 vs 2.83±0.66,P<0.001)、左上肺静脉上下径[LSPV1:(1.97±0.46)cm vs (2.20±0.66)cm,P=0.002]、左心房容积[LAV:(56.07±24.40)cm~3 vs (67.48±21.58)cm~3,P<0.001]、左心房球度(LASP:0.63±0.05 vs 0.58±0.08,P<0.001),以及饮酒史比例(16.9%vs 33.3%,P=0.004)均差异有统计学意义。多因素logistic回归分析结果显示,LAD(OR=1.002,95%CI:1.000~1.097,P=0.001)、LAV(OR=3.056,95%CI:2.821~3.327,P=0.003)、LASP(OR=1.000,95%CI:1.000~1.001,P=0.010)以及饮酒史(OR=10.392,95%CI:3.068~132.555,P=0.024)为房颤术后早期复发的独立危险因素。ROC曲线分析结果显示,LAD、LAV、LASP、饮酒史联合预测房颤射频消融术后早期复发的曲线下面积为0.793(95%CI:0.735~0.851,P<0.001),灵敏度为70.42%,特异度为73.56%。结论:左心房相关CTA指标LAD、LAV、LASP及饮酒史可有效预测房颤患者射频消融术后早期复发。

关键词：心房颤动 CT血管造影射频消融术

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Book Information

China City Planning Review 2017年第4期26卷 79-80页

作者： li min

The Planning of Eight Key New Industrial Cities:Urban Planning Histor y of *** in 1950s Author:li Hao Year:2016 Publisher:China Architecture & Building Press ISBN:9787112191826(640 pages,in Chinese)The planning for ei... 详细信息

关键词： line Book Information

BioLeT: A new design strategy for functional bioluminogenic probes

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Chinese Chemical Letters 2015年第8期26卷 919-921页

作者： Tian-Chao Zhang Lu-Pei Du min-Yong li Department of Medicinal Chemistry Key Laboratory of Chemical Biology (MOE) School of Pharmacy Shandong University

By integrating photoinduced electron transfer（PET） into the design of functional bioluminogenic probes,Urano and his coworkers recently developed a new rational design strategy, BioLeT. It is expected that this BioLeT strategy will enable us to design and develop new bioluminescence probes for detecting various biomolecules with no catalytic or reactive activity.

关键词： probes detecting enable integrating rational utilized challenging instead absolute moiety

钙调神经蛋白抑制剂联合利妥昔单抗对激素耐药型肾病综合征的疗效

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中国临床药学杂志 2024年第3期33卷 210-214页

作者：唐敏李嘉雯任增金李金坤孙增先江苏省连云港市第一人民医院药剂科连云港222000 江苏省连云港市第一人民医院眼科连云港222000 江苏省连云港市疾病预防控制中心连云港222000

目的探究钙调神经蛋白抑制剂(CNI)联合利妥昔单抗治疗激素耐药型肾病综合征的临床疗效。方法选择2019年8月至2022年1月确诊为激素耐药型肾病综合征的患儿40例,随机分为研究组(n=21)与对照组(n=19),对照组接受CNI联合糖皮质激素治疗,研... 详细信息

目的探究钙调神经蛋白抑制剂(CNI)联合利妥昔单抗治疗激素耐药型肾病综合征的临床疗效。方法选择2019年8月至2022年1月确诊为激素耐药型肾病综合征的患儿40例,随机分为研究组(n=21)与对照组(n=19),对照组接受CNI联合糖皮质激素治疗,研究组在对照组的基础上予利妥昔单抗治疗。比较2组治疗结束6个月的治疗缓解率、生化指标、炎症指标和不良事件发生率。结果治疗6个月研究组治疗缓解率为90.48%,高于对照组的63.16%,差异有统计学意义(P0.05)。结论CNI联合利妥昔单抗治疗激素耐药型肾病综合征,在改善肝肾功能、缓解炎症状态方面效果优于单用CNI,并且不增加不良事件发生率,具有较好的临床推广应用价值。

关键词：钙调神经蛋白抑制剂利妥昔单抗激素耐药型肾病综合征炎症状态

度洛西汀在中国健康受试者中的群体药代动力学研究

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中国临床药理学杂志 2024年第4期40卷 598-602页

作者：黄志伟王蕊余一旻李妍沈一峰李华芳魏宇梅上海交通大学医学院附属精神卫生中心临床研究中心上海200000 江苏省中枢神经药物研究重点实验室江苏徐州221000

目的建立度洛西汀在中国受试者中的群体药代动力学模型。方法基于36例健康受试者单次/多次服用盐酸度洛西汀肠溶片后密集采样的数据,使用NONMEM软件建立度洛西汀的群体药代动力学模型,通过前进法和后退法考察性别、年龄、体质量、白... 详细信息

目的建立度洛西汀在中国受试者中的群体药代动力学模型。方法基于36例健康受试者单次/多次服用盐酸度洛西汀肠溶片后密集采样的数据,使用NONMEM软件建立度洛西汀的群体药代动力学模型,通过前进法和后退法考察性别、年龄、体质量、白蛋白、血肌酸酐、谷丙转氨酶和剂量对药代动力学参数的影响。模型验证包括拟合优度图、可视化检验和自举法。结果度洛西汀的群体药代动力学模型为一级消除的一房室模型,吸收特征由转移室模型描述,剂量为清除率的协变量。清除率、分布容积、平均转移时间和转移室个数的个体间变异分别为54.71%、56.86%、27.30%和87.71%。结论转移室模型更合理地描述度洛西汀在中国受试者中的吸收特征。

关键词：度洛西汀转移室模型群体药代动力学吸收

entropy Function-Based Algorithms for Solving a Class of Nonconvex minimization Problems

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Journal of the Operations Research Society of China 2015年第4期3卷 441-458页

作者： Yu-Fan li Zheng-Hai Huang min Zhang Department of Mathematics School of ScienceTianjin UniversityTianjin 300072China Center for Applied Mathematics of Tianjin University Tianjin 300072China

Recently,the l_(p)minimization problem(p∈(0,1))for sparse signal recovery has been studied a lot because of its *** this paper,we propose a general smoothing algorithmic framework based on the entropy function for solving a class of l_(p)minimization problems,which includes the well-known unconstrained l_(2)-l_(p)problem as a special *** show that any accumulation point of the sequence generated by the proposed algorithm is a stationary point of the l_(p)minimization problem,and derive a lower bound for the nonzero entries of the stationary point of the smoothing *** implement a specific version of the proposed algorithm which indicates that the entropy function-based algorithm is effective.

关键词： l_(p)minimization problem entropy function Smoothing conjugate gradient method

Long duplication of 18S ribosomal DNA in Cynoglossus lineolatus(Pleuronectiformes： Cynoglossidae)： novel molecular evidencefor unequal crossing over model

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Acta Oceanologica Sinica 2016年第12期35卷 38-50页

作者： GONG li SHI Wei YANG min SI lizhen KONG Xiaoyu Guangxi Key Laboratory of Mangrove Conservation and Utilization Guangxi Mangrove Research Center Guangxi Academy of Sciences Beihai 536000 China Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Provincial Key Laboratory of Applied Marine Biology South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou 510000 China University of the Chinese Academy of Sciences Beijing 100049 China

Although 18 S r DNA sequence is extremely conservative, the polymorphism still has been found in few *** the present study, three types(Type A, B and C) of 18 S r DNA sequence coexisted in Cynoglossus lineolatus genome, suggesting a non-concerted evolution process, rather than a strictly concerted evolution *** on the differences of sequence variation, GC content, secondary structure and minimum free energy,Types A and B were speculated as the potential pseudogenes. Additionally, a fascinating finding was a 189-bp duplication of 18 S r DNA in Type A sequence. To our knowledge, this is the first report on such a long duplication in teleostean ribosomal DNA. Compared with several theories accounting for the formation of tandem repeats, the unequal crossing over model was thought to be the most likely mechanism to generate the189-bp duplication of 18 S r DNA. These results not only provide a novel molecular evidence for the unequal crossing over model, but also benefit for the further study on 18 S r DNA in fishes.

关键词： nrDNA Cynoglossus lineolatus tandem repeat pseudogene polymorphism non-concerted evolution

Mixture Normal Models in which the Proportions of Susceptibility are Related to Dose Levels

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Acta Mathematicae Applicatae Sinica 2010年第3期26卷 463-472页

作者： Bing He min Chen li-xin Song De-hui Wang College of Mathematics Jilin University Changchun Jilin 130012 China Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China Department of Mathematics Dalian University of Technology Dalian 116024 China

A problem that frequently occurs in biological experiments with laboratory animals is that some subjects are less susceptible to the treatment group than others. Finite mixture models have traditionally been used to describe the distribution of responses in treated subjects for such studies. In this paper, we first study the mixture normal model with multi-levels and multiple mixture sub-populations under each level, with particular attention being given to the model in which the proportions of susceptibility are related to dose levels, then we use EM-algorithm to find the maximum likelihood estimators of model parameters. Our results are generalizations of the existing results. Finally, we illustrate realistic significance of the above extension based on a set of real dose-response data.

关键词： Dose-response EM-algorithm mixture normal models susceptibility