检索结果-南通市图书馆

Chinese Geographical Science 2007年第3期17卷 280-287页

作者： Zhong Jing Zhang Jie li donghe Zhao Yong Lu Song Shi Chunyun Nanjing Univ Dept Land Resources & Tourism Sci Nanjing 210093 Peoples R China Anhui Univ Dept Tourism Management Hefei 230039 Peoples R China Anhui Normal Univ Coll Territorial Resource & Tourism Wuhu 241000 Peoples R China

Based on Hagget's theory of spatial structure,researches on the nodes and field of tourist origins to Huang-cheng Village in Shanxi Province of China have been *** hierarchy structure of tourist origins is analyzed with cluster analysis and the gravity *** field of tourist origins is analyzed with attraction radius index(R)and geography concentration index(G).In the field analysis,R and G of Huangcheng Village are compared with Xidi Village that is a world heritage located in Huangshan City of Anhui Province in *** to comparison of loca-tions of two areas,influential factors for field area of Huangcheng Village are *** is concluded that:1)cluster analysis and gravity model can be complementary methods to each other for nodal hierarchy structure analysis of tour-ist origins;and 2)as far as location is concerned,the weak intensity effect of tourism resources in the tourist region is a major cause for explaining why tourist origins to Huangcheng Village are mainly its neighboring ***,it is suggested that the regional effect of tourist resources should be regarded as a component of destination attractiveness when applying gravity model.

关键词： ancient village tourist origin Huangcheng Village nodal hierarchy structure field

Zfyve16 regulates the proliferation of β-lymphoid cells

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Frontiers of Medicine 2018年第5期12卷 559-565页

作者： Xuemei Zhao donghe li Qingsong Qiu Bo Jiao Ruihong Zhang Ping liu Ruibao Ren State Key Laboratory for Medical Genomics Shanghai Institute of Hematology Collaborative Innovation Center of HematologyCollaborative Innovation Center of System Biology Ruo'in Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai200025 China Department of Biology Brandeis University Waltham MA 02454 USA

Zfyve16 (a.k.a. endofin or endosome-associated FYVE-domain protein), a member of the FYVE-domain protein family, is involved in endosomal trafficking and in TGF-β, BMP, and EGFR signaling. The FYVE protein SARA regulates the TGF-β signaling pathway by recruiting Smad2/3 and accelerating their phosphorylation, thereby altering their susceptibility to TGF-β-mediated T cell suppression. Zfyve16 binds to Smad4 and their binding affects the formation of Smad2/3-Smad4 complex in TGF-β signaling. However, the in vivo function of Zfyve16 remains unknown. In this study, we generated a Zfyve16 knockout mouse strain (Zfyve16KO) and examined its hematopoietic phenotypes and hematopoietic reconstruction ability. The proportion of T cells in the peripheral blood of Zfyve16KO mice increases compared with that in wild-type mice. This finding is consistent with the role of Zfyve16 in facilitating TGF-β signaling. Unpredictably, B cell proliferation is inhibited in Zfyve16KO mice. The proliferation potential of Zfyve16KO B-lymphoid cells also significantly decreases in vitro. These results suggest that Zfyve16 inhibits the proliferation of T cells, possibly through the TGF-β signaling, but upregulates the proliferation of B-lymphoid cells.

关键词： Zfyve16 endofin hematopoiesis TGF-β lymphocytes

DDB1-and CUL4-associated factor 8 plays a critical role in spermatogenesis

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Frontiers of Medicine 2021年第2期15卷 302-312页

作者： Xiuli Zhang Zhizhou Xia Xingyu Lv donghe li Mingzhu liu Ruihong Zhang Tong Ji Ping liu Ruibao Ren Shanghai Institute of Hematology State Key Laboratory for Medical GenomicsNational Research Center for Translational Medicine at ShanghaiCollaborative Innovation Center of HematologyRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Laparoscopic Technology of Zhejiang Province Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310058China Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310058China

Cullin-RING E3 ubiquitin ligase(CRL)-4 is a member of the large CRL family in *** plays important roles in a wide range of cellular processes,organismal development,and physiological and pathological ***1-and CUL4-associated factor 8(DCAF8)is a WD40 repeat-containing protein,which serves as a substrate receptor for *** physiological role of DCAF8 is *** this study,we constructed Dcaf8 knockout *** mice were viable with no noticeable ***,the fertility of Dcaf8-deficient male mice was markedly impaired,consistent with the high expression of DCAF8 in adult mouse *** movement characteristics,including progressive motility,path velocity,progressive velocity,and track speed,were significantly lower in Dcaf8 knockout mice than in wild-type(WT)***,the total motility was similar between WT and Dcaf8 knockout *** than 40%of spermatids in Dcaf8 knockout mice showed pronounced morphological abnormalities with typical bent head *** acrosome and nucleus of Dcaf8 knockout sperm looked similar to those of WT *** vitro tests showed that the fertilization rate of Dcaf8 knockout mice was significantly *** results demonstrated that DCAF8 plays a critical role in spermatogenesis,and DCAF8 is a key component of CRL4 function in the reproductive system.

关键词： Dcaf8 male infertility spermatogenesis

Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma

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Frontiers of Medicine 2022年第5期16卷 784-798页

作者： Yan Zhang Baoyuan Zhang Yongyun li Yuting Dai Jiaoyang li donghe li Zhizhou Xia Jianming Zhang Ping liu Ming Chen Bo Jiao Ruibao Ren Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiCollaborative Innovation Center of HematologyRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Orbital Diseases and Ocular OncologyShanghai 200001China Department of Biology Brandeis UniversityWalthamMA 02454USA

More than 85%of patients with uveal melanoma(UM)carry a GNAQ or GNA11 mutation at a hotspot codon(Q209)that encodes G proteinαsubunit q/11 polypeptides(Gα_(q/11)).GNAQ/11 relies on palmitoylation for membrane association and signal *** the palmitoylation of GNAQ/11 was discovered long before,its implication in UM remains ***,results of palmitoylation-targeted mutagenesis and chemical interference approaches revealed that the loss of GNAQ/11 palmitoylation substantially affected tumor cell proliferation and survival in UM *** inhibition through the mutation of palmitoylation sites suppressed GNAQ/11^(Q209L)-induced malignant transformation in NIH3T3 ***,the palmitoylation-deficient oncogenic GNAQ/11 failed to rescue the cell death initiated by the knock down of endogenous GNAQ/11 oncogenes in UM cells,which are much more dependent on Gα_(q/11) signaling for cell survival and proliferation than other melanoma cells without GNAQ/11 ***,the palmitoylation inhibitor,2-bromopalmitate,also specifically disrupted Gα_(q/11) downstream signaling by interfering with the MAPK pathway and BCL2 survival pathway in GNAQ/11-mutant UM cells and showed a notable synergistic effect when applied in combination with the BCL2 inhibitor,ABT-199,in *** findings validate that GNAQ/11 palmitoylation plays a critical role in UM and may serve as a promising therapeutic target for GNAQ/11-driven UM.

关键词： uveal melanoma mutant GNAQ/11 palmitoylation BCL2 combination target therapy

Identification of TMEM217 as a novel prognostic biomarker and potential therapeutic target in acute myeloid leukemia

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Genes & Diseases 2024年第4期11卷 90-93页

作者： Yunying Yao Zhizhou Xi Min Wu Bo Jiao Jiaming Gao donghe li Xi Xie Pengfei Xu Jiaoyang li Lei Yan Ruibao Ren Ping liu Shanghai Institute of Hematology State Key Laboratory for Medical GenomicsNational Research Center for Translational MedicineCollaborative Innovation Center of HematologyRuijin Hospital affiliated with Shanghai Jiao Tong University School of MedicineShanghai 200025China International Center for Aging and Cancer Hainan Medical UniversityHaikouHainan 570102China

Despite remarkable advances in molecular and cell biology of acute myeloid leukemia(AML),AML patients still frequently relapse and have low 5-year overall survival(OS)rates.1 It is worth noting that a recent study from the registry or clinical trial compilation has reported an improvement in the OS of adult AML patients,especially those under 60 years of age.

关键词： acute myeloid leukemia

基于TAM的旅游App下载使用行为影响因素研究

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旅游学刊 2015年第8期30卷 26-34页

作者：李东和张鹭旭安徽大学商学院旅游管理系安徽合肥230601

旅游App是实现智慧旅游的一个重要工具,研究其下载使用影响因素有重要意义。文章在对技术接受模型(TAM)进行修正的基础上,通过结构方程模型(SEM)建立起旅游App下载使用行为影响因素模型。研究结果表明:(1)旅游者认知维度中的感知有用、... 详细信息

旅游App是实现智慧旅游的一个重要工具,研究其下载使用影响因素有重要意义。文章在对技术接受模型(TAM)进行修正的基础上,通过结构方程模型(SEM)建立起旅游App下载使用行为影响因素模型。研究结果表明:(1)旅游者认知维度中的感知有用、感知易用对行为维度有显著影响,并且易用性感知显著影响有用性感知;(2)外部变量维度通过影响认知维度间接影响行为维度,其中,对感知易用性的影响最大;(3)旅游者认知维度中风险感知的强烈程度并不对其态度及行为产生负向影响。根据研究结果,向旅游App开发运营商提出建议:(1)重点关注信息查找和预订类工具的优化和开发;(2)总结并充分汲取现有应用的操作设计优点;(3)结合使用群体对自身能力的评估进行新应用开发;(4)重视应用的使用安全性。

关键词：旅游App 影响因素技术接受模型

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黄山市旅游与城市互动发展关系模式研究

地域研究与开发 2013年第4期32卷 69-73,79页

作者：李东和吴晨汪燕安徽大学商学院合肥230039

通过全面梳理黄山市旅游发展的历程以及城市发展的阶段,对黄山市旅游和城市的发展关系进行了总结,并对未来发展的关系模式进行了预测。研究认为,黄山市旅游业与城市的关系主要是旅游作为一种城市化机制促进城市的发展。同时,黄山市旅游... 详细信息

通过全面梳理黄山市旅游发展的历程以及城市发展的阶段,对黄山市旅游和城市的发展关系进行了总结,并对未来发展的关系模式进行了预测。研究认为,黄山市旅游业与城市的关系主要是旅游作为一种城市化机制促进城市的发展。同时,黄山市旅游业在经历了30多年的发展以后,旅游产业自身的促进机制发挥已经趋于饱和状态,需要依托城市的发展提供外来动力机制,黄山市旅游与城市发展的关系进入了"城市作为旅游发展的动力机制,推动城市旅游发展"的新阶段,黄山市的城市发展应该充分考虑旅游产业发展的新要求,在更高层次上实现旅游与城市的协调发展。

关键词：城市发展旅游发展黄山市

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低碳旅游产品需求的经济学分析及其实现路径

生态经济 2014年第9期30卷 73-76页

作者：汪芳李东和安徽大学商学院安徽合肥230601

低碳旅游的发展就是旅游产品生产和消费的低碳化发展,其中旅游者对低碳旅游产品的需求是促进低碳旅游持续发展的巨大拉动力。但现实中旅游者不愿意自觉改变现有的旅游消费行为,对低碳旅游产品的需求不足。文章运用经济学中消费者行为理... 详细信息

低碳旅游的发展就是旅游产品生产和消费的低碳化发展,其中旅游者对低碳旅游产品的需求是促进低碳旅游持续发展的巨大拉动力。但现实中旅游者不愿意自觉改变现有的旅游消费行为,对低碳旅游产品的需求不足。文章运用经济学中消费者行为理论分析工具,分析了旅游者偏好和旅游产品价格对低碳旅游产品需求的影响过程,并在此基础上指出了提高旅游者对低碳旅游产品的认知、增强旅游者对低碳旅游产品的情感和降低低碳旅游产品的相对价格等增加低碳旅游产品需求的实现路径。

关键词：低碳旅游产品低碳旅游产品需求旅游者偏好旅游产品价格

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复杂信息系统视阈下西安鼓乐传承价值探究

西安交通大学学报（社会科学版） 2017年第3期37卷 112-117页

作者：曹耿献李东鹤西安交通大学人文社会科学学院陕西西安710049

历史上,西安鼓乐的传承延续的是一种古老的传承方式,即"主体对主体""人对人"的传承方式,乐谱在传承中仅为辅助。从复杂信息系统的角度观察,中国传统音乐的古谱本身就"映射和规定着关于自身历史、现状、未来的信息"。根据信息的分类,古... 详细信息

历史上,西安鼓乐的传承延续的是一种古老的传承方式,即"主体对主体""人对人"的传承方式,乐谱在传承中仅为辅助。从复杂信息系统的角度观察,中国传统音乐的古谱本身就"映射和规定着关于自身历史、现状、未来的信息"。根据信息的分类,古谱是一种以社会信息方式存在着的物质体。西安鼓乐的古谱是由世代的民间艺人传承下来,凝结了一代一代的抄写古谱和口传心授中人的自为、再生信息的成果。为了能够更加清晰的观察到中国传统音乐传谱中的差异性及其风格的不同,以西安鼓乐的传谱为例,对传谱的差异度和相关度进行了数据分析和计算。在这种差异和不确定性中,音乐的意义得以彰显。

关键词：复杂信息系统西安鼓乐古谱传承

论全域旅游的“四重四轻”——基于全域旅游发展实践的反思

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旅游学刊 2020年第2期35卷 6-8页

作者：李东和蒋璐璇安徽大学商学院旅游管理系

全域旅游的概念自提出以来,有关全域旅游的实践在全国范围内迅速展开,掀起了发展全域旅游和创建全域旅游示范区的热潮。基于全域旅游研究相对滞后于实践的事实,导致全域旅游实践热背后对于其本质理解的不足。笔者在主持编制若干地区全... 详细信息

全域旅游的概念自提出以来,有关全域旅游的实践在全国范围内迅速展开,掀起了发展全域旅游和创建全域旅游示范区的热潮。基于全域旅游研究相对滞后于实践的事实,导致全域旅游实践热背后对于其本质理解的不足。笔者在主持编制若干地区全域旅游发展规划中,感觉到各地在推进全域旅游实践方面还存在重"牌"轻"路"、重"创"轻"治"、重"行"轻"知"、重"纵"轻"横"等问题,有必要对其进行梳理和反思。

关键词：全域旅游四重四轻相对滞后反思