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World Journal of Clinical Cases 2024年第12期12卷 2050-2055页

作者： Lan Wang Yan-Fei li li-feng dong Department of Gastroenterology Beijing Chuiyangliu HospitalBeijing 100022China

BACKGROUND The severity of nonalcoholic fatty liver disease(NAFLD)and lipid metabolism are related to the occurrence of colorectal ***-controlled attenuation parameters(liver-CAPs)have been established to predict the prognosis of hepatic steatosis *** To explore the risk factors associated with colorectal polyps in patients with NAFLD by analyzing liver-CAPs and establishing a diagnostic *** Patients who were diagnosed with colorectal polyps in the Department of Gastroenterology of our hospital between June 2021 and April 2022 composed the case group,and those with no important abnormalities composed the control *** area under the receiver operating characteristic curve was used to predict the diagnostic *** were considered statistically significant when Pliver-CAP in the case group were significantly greater than those in the control group(mmol/L,1.74 vs 1.05;dB/m,282 vs 254,Pliver-CAP were found to be independent risk factors for colorectal polyps,with ORs of 2.338(95%CI:1.154–4.733)and 1.019(95%CI:1.006–1.033),respectively(Pliver-CAP and TG combined with liver-CAP(TG+CAP)(P>0.05).When the liver-CAP was greater than 291 dB/m,colorectal polyps were more likely to *** The levels of TG and liver-CAP in patients with colorectal polyps are significantly greater than those patients without ***-CAP alone can be used to diagnose NAFLD with colorectal polyps.

关键词： Colorectal polyps Nonalcoholic fatty liver disease liver-controlled attenuation parameter liver fibroscan Diagnostic model

血栓弹力图和凝血实验对指导创伤骨折手术后DVT发生的价值

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黔南民族医专学报 2024年第2期37卷 156-159页

作者：李东风巨野县人民医院山东巨野274900

目的:明确血栓弹力图和凝血试验指导对预防创伤骨折手术术后DVT的应用价值。方法:根据临床检测结果将80例发生创伤骨折患者分为观察组(DVT组,n=41)与39例对照组(非DVT组,n=39),评估术前血栓弹力图与凝血指标对创伤性骨折术后DVT的预测... 详细信息

目的:明确血栓弹力图和凝血试验指导对预防创伤骨折手术术后DVT的应用价值。方法:根据临床检测结果将80例发生创伤骨折患者分为观察组(DVT组,n=41)与39例对照组(非DVT组,n=39),评估术前血栓弹力图与凝血指标对创伤性骨折术后DVT的预测效能。结果:对照组手术时间、术中出血量、切口大小分别为(85.34±12.33)min、(113.53±25.79)ml、(5.34±1.54)cm,手术相关指标改善情况较观察组更好;对照组骨折愈合时间为(11.18±1.37)d,较观察组(15.26±1.75)d更短(t=11.571,P=0.001);对照组凝血功能指标优于观察组(P<0.05);T2时间段内,观察组血液凝固时间(K)、凝血反应时间(R)、凝固角(α)及最大振幅(MA)均较对照组更高(P<0.05),观察组患者处在高凝状态;术后K、α角、MA、PT、TT及PLT的AUG在0.7~1.0间,预测价值较高。结论:血栓弹力图中的K、α角、MA三项参数与凝血实验中PT、TT、PLT能有效筛查创伤骨折患者中术后发生DVT的高危人群。

关键词：血栓弹力图凝血实验创伤骨折下肢深静脉血栓

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某三级医院EB病毒感染的临床数据分析

医学检验与临床 2024年第6期35卷 33-36页

作者：刘艳李东风巨野县人民医院检验科山东菏泽274900

目的:探讨某三级医院EB病毒(EBV)感染的相关疾病分析。方法:利用回顾性方法选取了2021年11月-2023年2月某三甲医院503例EBV-DNA阳性病例,分析了各种疾病的比例以及血液病造血干细胞移植前后比例。结果:503例EBV-DNA阳性病例中,鼻咽癌患... 详细信息

目的:探讨某三级医院EB病毒(EBV)感染的相关疾病分析。方法:利用回顾性方法选取了2021年11月-2023年2月某三甲医院503例EBV-DNA阳性病例,分析了各种疾病的比例以及血液病造血干细胞移植前后比例。结果:503例EBV-DNA阳性病例中,鼻咽癌患者145例占总比例的28.83%,淋巴瘤患者69例占总比例的13.72%,血液系统恶性疾病患者156例占总比例的31.01%,传染性单核细胞增多症患者12例占总比例的2.39%,肾移植患者37例占总比例的7.36%,自身免疫系统疾病患者21例占总比例的4.17%,其他疾病患者63例占总比例的12.52%。血液系统恶性疾病患者包括急性非淋巴细胞白血病占36.54%,急性淋巴细胞白血病占13.46%,地中海贫血占28.21%,再生障碍性贫血占12.18%,骨髓异常综合征占5.77%及其他一些血液疾病占3.85%。156例血液系统疾病中有140例进行了造血干细胞移植,其中EBV-DNA移植前阴性移植后阳性的有86例,移植前阳性移植后阴性的有18例,移植前阳性移植后阳性的有36例。结论:血液系统恶性疾病在EBV-DNA阳性病例中占有最高的比例,且移植后的感染率高于移植前。鼻咽癌和淋巴瘤占EBV-DNA阳性的第二、三位,说明两种疾病的发生与EBV有极大的相关性。

关键词： EBV 鼻咽癌淋巴瘤血液系统疾病

Effect of Exogenous Carboxyl and Hydroxyl Groups on Pyrolysis Reaction of High Molecular Weight Poly(L-Lactide)under the Catalysis of Tin

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Chinese Journal of Polymer Science 2021年第8期39卷 966-974,I0005页

作者： li-dong feng Xin-Chao Bian Gao li Xue-Si Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China

The effect of exogenous hydroxyl,carboxyl groups and/or Sn^(2+) on pyrolysis reactions of poly(L-lactide)(PLLA)was investigated by thermogravimetric analysis(TGA).The activation energy(fa)of pyrolysis reactions was estimated by the Kissinger-Akahira-Sunose *** kinetic models were also explored by the Malek method,and the random degradation behavior was determined by comparing the plots of ln{-ln[1-(1-w)05]}versus 1/7for experimental data from TGA with model *** pyrolysis reaction rate of PLLA was affected slightly by exogenous hydroxyl and carboxyl groups at lower levels of Sn with 65-70 mg·kg^(-1)but increased appreciably in the presence of extraneous Sn^(2+),-COOH/Sn^(2+),or-OH/Sn^(2+).The Ea values for the pyrolysis reactions of the PLLAs that provided lactide were different under the catalysis of Sn2+in different chemical environments because Sn^(2+) can form the new Sn-carboxylate and Sn-alkoxide with exogenous carboxyl and hydroxyl groups,which were different in steric hindrance for the formation of activated complex between Sn^(2+) and *** the catalysis of Sn^(2+),a lactide molecule can be directly eliminated selectively at a random position of PLLA molecular chains,and the molecular chain of PLLA cannot change two PLLA fragments at the elimination site of ***,it was regenerated into a new PLLA molecule with the molecular weight reduced by 144 g·mol^(-1).

关键词： Poly(L-lactide) Pyrolysis mechanism Carboxyl group Hydroxyl group Tin

Influence of Chain Architectures on Crystallization Behaviors of PLLA Block in PEG/PLLA Block Copolymers

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Chinese Journal of Polymer Science 2019年第3期37卷 258-267页

作者： Sheng Xiang dong-dong Zhou li-dong feng Xin-Chao Bian Gao li Xue-Si Chen Tian-Chang Wang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Jilin Biomedical Polymers Engineering Laboratory University of Chinese Academy of Sciences South China Advanced Institute for Soft Matter Science and Technology South China University of Technology

The effect of the architecture of poly(ethylene glycol)/poly(L-lactide)(PEG/PLLA) block copolymers on the non-isothermal crystallization behaviors of PLLA blocks was investigated by differential scanning calorimetry(DSC) and wide angle X-ray diffraction(WAXD). 1-Arm MPEG-b-PLLA and 4-arm PEG-b-PLLA(4PEG-b-PLLA) were synthesized by the ring-opening polymerization of Llactide in the presence of poly(ethylene glycol) methyl ether(MPEG) and 4-arm poly(ethylene glycol)(4PEG). 4-Arm PLLA-b-MPEG(4PLLA-b-PEG) was synthesized by coupling 4-arm PLLA and MPEG. The WAXD results indicated that the crystalline structure of PLLA blocks did not alter due to the different chain architectures. The average values of Avrami index(ˉn) were all above 4, which indicated that the nucleation mechanism of PLLA blocks was heterogeneous nucleation, regardless of the architectures. The overall crystallization rates were decreased markedly as following: MPEG-b-PLLA > 4PEG-b-PLLA > 4PLLA-b-PEG, ascribed to the different confinement by PEG blocks and to the steric hindrance of chain architectures. Therefore, the crystallization of PLLA blocks became more difficult and the crystallization activation energy of the PLLA blocks increased due to the confinement of chain architectures.

关键词： Poly(L-lactide) Poly(ethylene glycol)/poly(L-lactide)block copolymer Non-isothermal crystallization Chain architecture

Genome-wide detection for runs of homozygosity analysis in three pig breeds from Chinese Taihu Basin and Landrace pigs by SLAF-seq data

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Journal of Integrative Agriculture 2022年第11期21卷 3293-3301页

作者： TONG Shi-feng ZHU Mo XIE Rui li dong-feng ZHANG li-fan liU Yang Department of Animal Genetics Breeding and ReproductionCollege of Animal Science and TechnologyNanjing Agricultural UniversityNanjing 210095P.R.China Key Laboratory of Urban Agriculture Ministry of Agriculture and Rural AffairsShanghai 200240P.R.China

Erhualian(E),Meishan(MS)and Mi(MI)pigs are excellent indigenous pig breeds in Chinese Taihu Basin,which have made great contributions to the genetic improvement of commercial *** of the genetic structure and inbreeding level of the 3 pig breeds is of great significance for the sustainable breeding of commercial *** length and number of runs of homozygosity(ROH)as well as the frequency of genomes covered by ROH can be used as indicators to evaluate the level of inbreeding and the origin of the *** this study,the ROH characteristics of E,MS,MI and Landrace(L)pigs were analyzed by SLAF-seq data,and the inbreeding coefficient based on ROH(F_(ROH))was *** addition,we have identified candidate genes in the genomic regions associated with ROH.A total of10568 ROH were detected in 116 individuals of 4 pig *** analysis showed that there were significant differences in genetic structure between 3 Taihu Basin pig breeds and L,and the genetic structure of E and MI was *** results of F_(ROH)showed that the inbreeding level of MS was the highest(0.25±0.07),while E and MI were lower than *** with the other 3 pig populations,MS showed a higher frequency of long ROH(>5 Mb),indicating higher inbreeding in MS in recent generations.A large number of candidate genes related to reproductive traits are located in the genomic regions with a high frequency of ROH,and these genes are expected to be used as candidate genes in marker-assisted selection(MAS)breeding *** findings can provide theoretical support for genetic conservation and genetic improvement of 3 pig breeds in Chinese Taihu Basin.

关键词： runs of homozygosity inbreeding coefficient pig candidate gene

Preparation of Copolymer of Salen-crown Ether Complexes and its Catalytic Activation for Molecular Oxygen

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Chinese Chemical Letters 2006年第2期17卷 265-268页

作者： Rong Min WANG Xiao dong li Yu feng HE Gansu Key Laboratory of Polymer Materials Northwest Normal University Lanzhou 730070

A new stable salen Schiff base cobalt and crown ether sodium complex （SalCo-NaB18C6） was prepared through copolymerization. This copolymer complex was applied to catalytic oxidation of hydrocarbon compound with molecular oxygen without reductant, which was shown the higher activity and selectivity for ketone, and reused effectively.

关键词： Copolymeric complexes cyclohexene catalysis salen Schiff base crown ether.

Effects of different feeding methods and space allowance on the growth performance, individual and social behaviors of Holstein calves

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Journal of Integrative Agriculture 2017年第6期16卷 1375-1382页

作者： dong li-feng XU Xian-cha ZHANG Nai-feng TU Yan DIAO Qi-yu Feed Research Institute Chinese Academy of Agricultural Sciences/Key Laboratory of Feed Biotechnology Ministry of Agriculture Beijing 100081 P.R. China

The importance of nutrient provisions and weaning methods for calves has been well established over the past few years,while as increasing interest has focused on contribution of animal behavior and their overall performance in production *** present study investigated the effects of feeding methods and space allowance on growth performance,individual and social behaviors in Holstein ***-four Chinese Holstein male and female calves were allocated to either an individual or group of 6 and fed either with a bucket or a *** replacer,calf starter,and Chinese wildrye were offered during the experiment.A fecal index used in the present study was defined as the total fecal scores/total number of calves in each *** results showed that there was no significant difference among the 4 treatments in terms of feed intake,body weight,average daily gain,and fecal *** the feeding behaviors,the ingesting milk time and ingesting milk rate were significantly affected by space allowance,while the feeding methods showed a significant influence on the bunting behavior of the *** was no significant difference among the 4 treatments in terms of licking fixtures,self-grooming,and lying down behaviors,irrespective of the feeding method or space ***,sucking an empty bucket or the teat was significantly affected by the feeding *** selected group behaviors were examined in the present study,and similar values for sniffing the other calves,social grooming,and cross-sucking behaviors were ***,the present study demonstrated that different feeding methods and space allowances had a significant effect on the feeding behavior of calves,while the feed intake,growth performance,health condition,individual and group social behaviors were not significantly ***,under intensified production systems,Holstein calves raised in a group may obtain a similar production performance,thus reducing management in

关键词： dairy calves feeding approach space allowance growth performance animal behavior

Weaning methods affect ruminal methanogenic archaea composition and diversity in Holstein calves

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Journal of Integrative Agriculture 2019年第5期18卷 1080-1092页

作者： dong li-feng MA Jun-nan TU Yan DIAO Qi-yu Feed Research Institute Chinese Academy of Agricultural Sciences/Beijing Key Laboratory for Dairy Cow Nutrition/Key Laboratory of Feed Biotechnology Ministry of Agriculture

The objective of the present study was to examine the effect of different weaning methods on the ruminal methanogenic archaea composition and diversity in Holstein ***-six newborn Holstein bull calves were assigned to 1 of 3 treatments:(1)conventional weaning(d 56)and fed a high proportion of solid feed(CWS);(2)conventional weaning(d 56)and fed a high proportion of liquid feed(CWL);(3)early weaning(d 42)and fed with a high proportion of solid feed(EWS).High-throughput sequencing of the methyl coenzyme M reductase(mcr A)gene,which encodes theα-subunit of methyl coenzyme M reductase-the enzyme that catalyzes the final step in methanogenesis was used to determine the composition and diversity of rumen *** significant difference(P>0.05)was observed for operational taxonomic units(OTUs)or richness indices,but diversity indices increased(Plies across the three treatments were Methanobacteriaceae,Thermoplasmataceae and *** in the EWS treatment had a higher(P<0.05)relative abundance of Methanobrevibacter *** AbM4 and Methanosphaera stadtmanae,while calves in the CWL treatment had a higher(P<0.05)abundance of Methanosphaera *** SM9.A positive(P<0.05)relationship was identified between butyrate and Methanobrevibacter *** *** conclusion,the composition and diversity of methanogens in the rumen of Holstein calves varied under the different weaning *** study identified a positive relationship between butyrate and Methanobrevibacter *** AbM4,potentially reflecting correlations between ruminal fermentation variables and methanogenesis *** in-depth analyses provide further understanding of weaning methods for intensified production systems.

关键词： calf methyl coenzyme M reductase(mcrA)gene methanogenic archaea diversity rumen fermentation weaning methods

Complete Closure of Gastric Defect with Improved Purse-String Suture Technique Using Single-Channel Endoscope

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Chinese Medical Journal 2018年第19期131卷 2349-2351页

作者： Min lin Qiang Wang feng-dong li Rui li Jin Huang Deparment of Gastroenterology The Affiliated Changzhou No. 2 People's Hospital Nanjing Medical University Changzhou Jiangsu 213000 China Department of Gastroenterology The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215006 China

To the Editor： Recently, with the development of endoscopic therapy technology, the incidence of iatrogenic perforation is also increasing, lfthe defect was not treated properly, subsequent gastrointestinal fistula and infection could lead to serious complications. This study evaluated a simple method for close gastric defect after endoscopic treatment, with endoloop and metallic clips using single-channel endoscope.

关键词： SYSTEM